Highlights of ASH. 4 Dates 6 Locations 1 Great Program. Jan , 2010 Toronto, Canada Hyatt Regency

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1 4 Dates 6 Locations 1 Great Program Jan , 2010 Toronto, Canada Hyatt Regency Jan , 2010 San Antonio, TX Marriott Riverwalk Jan , 2010 Washington, DC Ritz Carlton Jan , 2010 Marina del Rey, CA Ritz Carlton Feb. 5-6, 2010 Atlanta, GA W Atlanta Midtown Feb. 5-6, 2010 San Francisco, CA The Westin San Francisco Market Street The American Society of Hematology presents the only official Highlights of ASH These meetings are sponsored by the American Society of Hematology (ASH) and presented in partnership with the following societies: Association of Northern California Oncologists (ANCO), Canadian Hematology Society (CHS), Georgia Society of Clinical Oncology (GASCO), La Agrupación Mexicana para el Estudio de la Hematología (AMEH), Maryland/DC Society of Clinical Oncology (MDSCO), Medical Oncology Association of Southern California (MOASC), Texas Society of Medical Oncology (TSMO), and the Virginia Association of Hematologists and Oncologists (VAHO).

2 Greetings See you at one of the six official Highlights of ASH meetings! We are excited to invite you to the fifth official Highlights of ASH, which is the only Highlights meeting that is sponsored by the American Society of Hematology. In 2010, Highlights of ASH will occur in six locations: Toronto; San Antonio; Atlanta; Washington, DC; Marina del Rey; and San Francisco. These exceptional educational opportunities will feature leading hematology experts who will present unbiased analysis from the 51st ASH Annual Meeting abstracts and sessions, including evolving therapies, the latest treatment options, and their clinical applications. ASH is very pleased to sponsor the six Highlights of ASH meetings in partnership with the following societies: Association of Northern California Oncologists (ANCO),Canadian Hematology Society (CHS), Georgia Society of Clinical Oncology (GASCO), La Agrupación Mexicana para el Estudio de la Hematologia (AMEH), Maryland/DC Society of Clinical Oncology (MDSCO), Medical Oncology Association of Southern California (MOASC),Texas Society of Medical Oncology (TSMO), and the Virginia Association of Hematologists and Oncologists (VAHO). The program format is designed to allow practitioners, fellows, academicians, and allied health professionals to discuss some of the most rapidly evolving developments in the field with experts as well as colleagues. The limited attendance, panel discussions, lunches, and Breakfast with the Experts will provide numerous opportunities for attendees to discuss real patient cases with leaders in the field, network with colleagues, and gain knowledge that can affect practice strategies. This program has been approved for a maximum of 10.5 AMA PRA Category 1 Credits. Register today! Sincerely, Armand Keating, MD 2010 Highlights of ASH Program Co-Chair Alexis Thompson, MD, MPH 2010 Highlights of ASH Program Co-Chair Richard Van Etten, MD, PhD 2010 Highlights of ASH Program Co-Chair

3 General Information Who should attend? This meeting has been designed to be a rewarding educational event for: Hematologists Hematologist/Oncologists Oncologists Trainees Allied Health Professionals Hematopathologists Register Online at payment by MasterCard, Visa, or American Express is accepted. Mail the registration form to: ASH Administration, P.O. Box , Baltimore, MD ; payment by American Express, MasterCard, Visa, or check is accepted. Cancellation Deadline: Friday, December 18. To request a refund, cme@hematology.org. If your request is received by December 18, you will receive a refund minus a $25 processing fee. Registration In order to maximize each participant s experience, attendance at Highlights of ASH is limited. Advance registration is strongly encouraged. Your registration fee includes admission to the educational sessions, access to the exhibits, breakfast and lunch on Saturday, and CME processing. Questions? Contact the ASH Education and Training Department at or cme@hematology.org. Registration Rates Registration Type Advance Registration On-Site Registration ASH Member $175 $225 Member of Partner Society 1 $175 $225 ASH Associate Member $125 $150 Non-Member $250 $300 Allied Health Professional 1 $150 $185 Non-Member Resident or Fellow 2 $150 $185 Advance Registration Deadlines: Toronto, Canada January 5, 2010 San Antonio, TX January 12, 2010 Washington, DC, and Marina del Rey, CA January 19, 2010 Atlanta, GA, and San Francisco, CA January 26, Allied health professionals and members of AMEH, ANCO, CHS, GASCO, MDSCO, MOASC, TSMO, and VAHO: You may register by mail or online. Prior to registering online, please contact the ASH Education and Training Department at or cme@hematology.org for the code needed to register at this rate. 2 Non-member residents and fellows: You must provide an original letter on your institution s letterhead signed by a training program director, stating that the registrant is enrolled in a training program. Since this letter must accompany the registration form and payment, non-members in training must register by mail. ASH is pleased to partner with the following societies: Association of Northern California Oncologists Virginia Association of Hematologists and Oncologists (VAHO)

4 Continuing Medical Education The American Society of Hematology is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The American Society of Hematology designates this educational activity for a maximum of 10.5 AMA PRA Category 1 Credits. Physicians should claim credit commensurate with the extent of their participation in the activity. The American Medical Association has determined that physicians not licensed in the U.S. who participate in this CME activity are eligible for AMA PRA Category 1 credit.

5 Educational Objectives This Highlights of ASH program is based on a selection of abstracts presented at the 51st ASH Annual Meeting that are of greatest interest to practitioners. The 2010 program focuses on pathophysiology, diagnosis, and management of common malignant and benign hematologic disorders, including acute and chronic leukemias, lymphomas, myeloma, thrombotic disorders, myelodysplastic syndromes, and myeloproliferative disorders. At the completion of the program, attendees will be able to: Characterize new insights into the biology of acute leukemia; summarize current assessments of potential new agents for treatment of acute myeloid leukemia. Better understand the etiology of MDS and the new agents available to treat MDS. Summarize updates on management of CML, including monitoring and relapsed/refractory disease; summarize new information on the diagnosis, prognosis, and therapy of Ph-negative myeloproliferative neoplasms. Describe the role of new specific treatments for CLL, including immunomodulatory agents, purine analogues, monoclonal antibodies, immunotherapeutics, and other newly tested agents. Explore newer insights into molecular biology of B-cell neoplasms; examine new data on effectiveness and toxicity of targeted agents for B-cell lymphomas. Understand updated data on effectiveness of standard and experimental treatments for Hodgkin lymphoma; describe the best integration of the twin goals of effective treatment and minimization of toxicity for Hodgkin lymphoma. Describe new insights into the basic abnormalities of hemostasis that lead to abnormal clotting. Review newly available information about the role, effectiveness, and complications of newer treatments for ITP. Summarize updated information about newer anti-thrombotic agents; describe new insights into management of complex situations in which abnormal thrombosis occurs. Summarize updated information about basic mechanisms of iron absorption and utilization; understand new information about classification of anemic states. Summarize the latest results from major studies of new approaches to myeloma treatment; examine the evidence justifying new approaches to management of newly diagnosed and relapsed myeloma. Summarize updated information on new aspects of management of patients during high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT); summarize information on new insights into the appropriate integration of HSCT into the management of lymphoid and myeloid malignancies. Questions? Contact the ASH Education and Training Department at or cme@hematology.org. For more information, visit

6 Program Schedule Friday All six Highlights of ASH meetings have the same program schedule; however, speakers for each of the locations vary. Below is a complete list of speakers. 12:00 Noon Registration and Lunch (provided) Exhibits Open 1:00 p.m. Welcome and Introductions 1:10 p.m. Acute Myeloid Leukemia: New Therapeutic Targets Richard A. Larson, MD University of Chicago (Toronto, Ontario, and San Antonio, TX) Aaron Schimmer, MD, PhD Princess Margaret Hospital (Marina del Rey, CA, and San Francisco, CA) Nancy Berliner, MD Brigham and Women s Hospital 1:50 p.m. Myelodysplastic Syndromes Mikkael A. Sekeres, MD, MS Cleveland Clinic Taussig Cancer Center (Toronto, Ontario, and San Antonio, TX) Heather Leitch, MD, PhD St. Paul s Hospital, University of British Columbia (Marina del Rey, CA, and San Francisco, CA) David P. Steensma, MD Mayo Clinic 2:30 p.m. Chronic Myeloid Leukemia and Other Myeloproliferative Diseases Armand Keating, MD Princess Margaret Hospital (Toronto, Ontario, and San Francisco, CA) Michael J. Mauro, MD Oregon Health and Science University (San Antonio, TX, and Marina del Rey, CA) Richard Van Etten, MD, PhD Tufts Medical Center 3:10 p.m. Panel Discussion 3:40 p.m. Coffee Break and Exhibits Open 4:00 p.m. Chronic Lymphocytic Leukemia: Novel Therapies Susan O Brien, MD M. D. Anderson Cancer Center (Toronto, Ontario) Neil E. Kay, MD Mayo Clinic (San Antonio, TX) William G. Wierda, MD, PhD M. D. Anderson Cancer Center (Marina del Rey, CA) Tait D. Shanafelt, MD Mayo Clinic (San Francisco, CA) John C. Byrd, MD Ohio State University 4:40 p.m. B-Cell Lymphomas: New Molecular Targets Laurie Sehn, MD British Columbia Cancer Agency (Toronto, Ontario, and Marina del Rey, CA) David G. Maloney, MD, PhD Fred Hutchinson Cancer Research Center (San Antonio, TX, and San Francisco, CA) Steven H. Bernstein, MD University of Rochester 5:20 p.m. Hodgkin Lymphoma: Clinical Challenges and New Approaches John Kuruvilla, MD Princess Margaret Hospital (Toronto, Ontario, and Marina del Rey, CA) Andrew M. Evens, DO, MSc Northwestern University (San Antonio, TX, and San Francisco, CA) Nancy L. Bartlett, MD Washington University 6:00 p.m. Panel Discussion 6:30 p.m. Program Concludes for the Day

7 Saturday Visit for the meeting schedule and speaker list specific to each location. 7:00 a.m. Breakfast with the Experts (All Speakers and Attendees) 8:00 a.m. Announcements and Introductions 8:15 a.m. Myeloma Keith Stewart, MBChB, MBA Mayo Clinic (Toronto, Ontario, and San Antonio, TX) S. Vincent Rajkumar, MD Mayo Clinic (Marina del Rey, CA, and San Francisco, CA) Raymond L. Comenzo, MD Tufts Medical Center 8:55 a.m. Hematopoietic Stem Cell Transplantation Corey Cutler, MD, MPH, FRCPC Dana-Farber Cancer Institute (Toronto, Ontario, and San Antonio, TX) Jerald Radich, MD Fred Hutchinson Cancer Research Center (Marina del Rey, CA) Sergio Giralt, MD M. D. Anderson Cancer Center (Washington, DC) Hans-Georg Klingemann, MD, PhD Tufts University (San Francisco, CA) Marcel van den Brink, MD, PhD Memorial Sloan-Kettering Cancer Center (Atlanta, GA) 9:35 a.m. Panel Discussion 10:00 a.m. Coffee Break and Exhibits Open 10:20 a.m. Pathophysiology of Hemorrhage and Thrombosis Barbara A. Konkle, MD University of Pennsylvania (Toronto, Ontario, and Washington, DC) David Green, MD, PhD Northwestern University (San Antonio, TX, and San Francisco, CA) Jorge A. DiPaola, MD University of Colorado Denver (Marina del Rey, CA, and Atlanta, GA) 11:00 a.m. Novel Treatments for Relapsed/ Refractory Chronic Idiopathic Thrombocytopenic Purpura James N. George, MD University of Oklahoma (Toronto, Ontario, and Washington, DC) Douglas B. Cines, MD University of Pennsylvania (San Antonio, TX, and Atlanta, GA) Kenneth Kaushansky, MD University of Southern California, San Diego (Marina del Rey, CA, and San Francisco, CA) 11:40 a.m. Panel Discussion 12:00 Noon Lunch (provided) and Exhibits Open 1:00 p.m. Management of Thrombotic Disease Thomas L. Ortel, MD, PhD Duke University Medical Center (Toronto, Ontario, and San Francisco, CA) Craig Sims Kitchens, MD University of Florida Shands Hospital (Marina del Rey, CA, and Atlanta, GA) Wendy Lim, MD St. Joseph s Hospital (San Antonio, TX) Agnes Y. Lee, MD University of British Columbia (Washington, DC) 1:40 p.m. Anemia: Hemoglobin, Iron, and Beyond Philip C. Hoffman, MD University of Chicago (Toronto, Ontario, and San Francisco, CA) Alexis Thompson, MD, MPH Northwestern University (San Antonio, TX, and Marina del Rey, CA) Mohandas Narla, DSc New York Blood Center (Washington, DC) Speaker TBD (Atlanta, GA) 2:20 p.m. Panel Discussion 2:45 p.m. Summary and Closing Remarks 3:00 p.m. Program Adjourned

8 Hotel Accommodations Toronto, Ontario, Canada Hyatt Regency Toronto 370 King Street Toronto, ON M5V 1J9 CA Phone: Room Rate: $149 per night plus tax (currently 13%) for a single or double occupancy room. Triple occupancy rooms are available at $174 per night plus tax and quadruple occupancy rooms are available at $199 per night plus tax. All rates are in Canadian Dollar (CD) currency. Hotel Reservation Deadline: December 21, 2009 Ground Transportation: The Hyatt Regency Toronto is located about 11.5 miles from the Lester B. Pearson/ Toronto International Airport. Airport Express is available to transport guests between the airport and the hotel. The cost is $18.50 one way and $29.95 round trip. Guests can speak with the concierge or call to make a shuttle reservation. Taxis are also readily available from the airport to the hotel and cost approximately $60 CD. Local Attractions: CN Tower Eaton Center Mall Hockey Hall of Fame Ontario Place Princess of Wales Theatre Rogers Centre Roy Thompson Hall Royal Alexandra Theatre San Antonio, TX Marriott Riverwalk 889 E. Market Street San Antonio, TX Phone: Room Rate: $195 per night plus tax (currently %) for a single room. A charge of $20 will be applied for additional guests. Guests can obtain a concierge level upgrade for $40 extra or guarantee a balcony view for $20. Please be aware that the Marriott Riverwalk will immediately charge one night s room cost as deposit, payable by check or credit card, to secure your reservation. Hotel Reservation Deadline: January 5, 2010 Ground Transportation: The Marriott Riverwalk is located eight miles from San Antonio International Airport. Estimated taxi fare from the airport to the hotel is $22. Local Attractions: Alamo River Walk Rivercenter Mall San Antonio Botanical Gardens San Antonio Zoo Tower of the Americas Washington, DC The Ritz-Carlton, Washington DC nd Street, NW Washington, DC Phone: Room Rate: $249 per night plus tax (currently 14.5%) for a single or double occupancy room. Please be aware that the Ritz-Carlton, Washington DC, will immediately charge one night s room cost as deposit, payable by credit card, to secure your reservation. Hotel Reservation Deadline: January 5, 2010 Ground Transportation: The Ritz- Carlton, Washington DC, is four miles away from Ronald Reagan Washington National Airport. Taxis from Ronald Reagan Washington National Airport to the hotel are approximately $11. Local Attractions: Cathedral of St. Matthew the Apostle Lincoln Memorial National Zoo Smithsonian Museums The White House United States Capitol Vietnam Veterans Memorial Washington Monument

9 Marina del Rey, CA The Ritz-Carlton, Marina del Rey 4375 Admiralty Way Marina del Rey, CA Phone: Room Rate: $239 per night plus tax (currently 13.1%). Please be aware that the Ritz-Carlton, Marina del Rey, will immediately charge one night s room cost as deposit, payable by credit card, to secure your reservation. Hotel Reservation Deadline: December 18, 2009 Ground Transportation: The Ritz- Carlton, Marina del Rey, is located five miles away from Los Angeles International Airport and four miles away from Santa Monica Airport. Estimated taxi fare from Los Angeles International Airport is $25. Local Attractions: Fisherman s Village Santa Monica Pier Shopping on Abbot Kinney Boulevard Venice Beach Atlanta, GA W Atlanta Midtown th Street NE Atlanta, GA Phone: Room Rate: $155 per night plus tax (currently 15%) for single and double occupancy rooms. Please be aware that the W Atlanta Midtown will immediately charge one night s room cost as deposit, payable by credit card, to secure your reservation. Hotel Reservation Deadline: January 14, 2010 Ground Transportation: The W Atlanta Midtown is located 11 miles from Hartsfield-Jackson Atlanta International Airport. Taxi fare from the airport to the hotel is $32. Local Attractions: Atlanta Botanical Gardens Atlantic Station Centennial Olympic Park Fox Theatre Georgia Aquarium Georgia Dome High Museum of Art Tutankhamun The Golden King Woodruff Arts Center World of Coca-Cola San Francisco, CA The Westin San Francisco Market Street 50 Third Street San Francisco, CA Phone: Room Rate: $159 plus tax (currently %) for a single or double occupancy room. Please be aware that The Westin San Francisco Market Street will immediately charge one night s room cost as deposit, payable by credit card, to secure your reservation. Hotel Reservation Deadline: January 12, 2009 Ground Transportation: The Westin San Francisco Market Street is located 12 miles from San Francisco International Airport. Estimated taxi fare from the airport is $37. Shuttles are also available at the roadway center island in all terminals without a reservation for $ Local Attractions: AT&T Park Cartoon Art Museum Ferry Building Pier 39 San Francisco Museum of St. Mary Square Union Square Yerba Buena Gardens Modern Art When you call to make your hotel reservation for Highlights of ASH, please identify yourself as an American Society of Hematology meeting attendee. Rates cannot be adjusted at check-in or check-out for guests who fail to identify their affiliation at the time their reservation is made. Hotel cancellations must be made at least 48 hours prior to the scheduled arrival date to avoid a penalty. For cancellations made within 48 hours of the scheduled arrival date, or failure to check in, you will be charged one night s room rate.

10 Highlights of ASH Important Dates Please use this page as a quick reference guide to help you keep track of the dates that pertain to the Highlights of ASH meeting you plan to attend. Toronto, Canada ADVANCE REGISTRATION DEADLINE: January 5, 2010 HOTEL INFORMATION Hyatt Regency Toronto 370 King Street Toronto, ON M5V 1J9 CA Phone: Room Reservation Deadline: December 21, 2009 Washington, DC ADVANCE REGISTRATION DEADLINE: January 19, 2010 HOTEL INFORMATION The Ritz-Carlton, Washington DC nd Street, NW Washington, DC Phone: Room Reservation Deadline: January 5, 2010 Atlanta, GA ADVANCE REGISTRATION DEADLINE: January 26, 2010 HOTEL INFORMATION W Atlanta Midtown th Street NE Atlanta, GA Phone: Room Reservation Deadline: January 14, 2010 San Antonio, TX ADVANCE REGISTRATION DEADLINE: January 12, 2010 HOTEL INFORMATION Marriott Riverwalk 889 E. Market Street San Antonio, TX Phone: Room Reservation Deadline: January 5, 2010 Marina del Rey, CA ADVANCE REGISTRATION DEADLINE: January 19, 2010 HOTEL INFORMATION The Ritz-Carlton, Marina del Rey 4375 Admiralty Way Marina del Rey, CA Phone: Room Reservation Deadline: December 18, 2009 San Francisco, CA ADVANCE REGISTRATION DEADLINE: January 26, 2010 HOTEL INFORMATION The Westin San Francisco Market Street 50 Third Street San Francisco, CA Phone: Room Reservation Deadline: January 12, 2010 The deadline to cancel your registration for any of the Highlights of ASH meetings is December 18, If a request is received on or before this date, a refund will be issued, minus a $25 processing fee. OTHER ASH MEETINGS: Highlights of ASH in Latin America May 14-15, 2010 Rio de Janeiro, Brazil * Please note: AMA PRA Category 1 credits will not be available ASH State-of-the-Art Symposium September 24-25, 2010 Chicago, IL 52nd ASH Annual Meeting and Exposition December 4-7, 2010 Orlando, FL

11 Registration Highlights of ASH 2010 First Name: M.I.: Last Name: Degree: Institution/Company: Street Address: City: State: Zip Code: Country: Phone: Fax: (For international numbers please include country and city codes.) I am planning to attend the 2010 Highlights of ASH held in (please check one): Toronto, Canada, January 15-16, 2010 Marina del Rey, CA, January 29-30, 2010 San Antonio, TX, January 22-23, 2010 Atlanta, GA, February 5-6, 2010 Washington, DC, January 29-30, 2010 San Francisco, CA, February 5-6, 2010 Advance Registration Fees (please check one): ASH Member: $175 Partnering Society Member: $175 ASH Membership ID Number: (Required if registering at ASH member rates) ASH Associate Member: $125 Allied Health Professional: $150 Non-Member in Training: $150 Non-member residents and fellows must provide an original letter on their institution s letterhead. This letter, which must accompany the registration form and payment, must be signed by a training program director and state that the registrant is enrolled in a training program. Non-Member: $250 Amount Due: $ Check Please make checks payable to the American Society of Hematology. Payment must be in U.S. dollars and drawn on a U.S. bank. Credit Card: VISA MasterCard American Express Card Holder s Name: Card Number: Exp. Date: Card Holder s Signature: Your signature authorizes your credit card to be charged for the total payment due. ASH reserves the right to charge the correct amount if different from the total listed. Cancellations must be ed to cme@hematology.org by December 18, 2009, to receive a refund. A $25 processing fee will be deducted from your refund. No refunds will be granted after December 18. REGISTRATION FORM AND PAYMENT MUST BE MAILED TO THE FOLLOWING ADDRESS: ASH Administration, P.O. Box , Baltimore, MD Do not send overnight packages to the above address. Registration forms received without full payment will not be processed. Please make a copy of your completed form before mailing your registration form. By completing this registration form, you agree to abide by the rules and regulations set forth for this meeting.

12 The American Society of Hematology presents the only official Highlights of ASH Visit for complete meeting details! NEW FOR Dates 6 Locations 1 Great Program American Society of Hematology 1900 M Street, NW, Suite 200 Washington, DC Phone: cme@hematology.org Web site: PRE-SORTED FIRST CLASS MAIL U.S. POSTAGE PAID DAYTONA BEACH, FL PERMIT NO. XX FPO FPO