ABOUT THE REPORT About the 3-Month Report About the MassBioEd Foundation About The Digest of Biotech Jobs Trends in Massachusetts Acknowledgements

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1 THE DIGEST OF BIOTECH JOB TRENDS IN MASSACHUSET TS QUARTERLY LIFE SCIENCES JOB MARKET REPORT: Q3 2017

2 ABOUT THE REPORT About the 3-Month Report MassBioEd produces a 3-Month Report on biopharmaceutical job trends each quarter of the year. The report compares job listings for the most current three-month period with job listings for the same three-month period of the previous year to determine underlying trends in job listings. About the MassBioEd Foundation MassBioEd engages teachers, inspires students, and guides the life sciences workforce. Our BioTeach program supports Massachusetts teachers as they work to engage students through lab-centered, inquiry-based learning. Our Job Trends initiative identifies workforce needs and illuminates the pathway from the classroom to careers in the life sciences. About The Digest of Biotech Jobs Trends in Massachusetts The Quarterly Report is a part of MassBioEd s ongoing Digest of Biotech Jobs Trends in Massachusetts, which also includes Briefs, a Medical Device Snapshot, and an annual Job Trends Forecast. The Briefs present basic data and analysis on particular aspects of biopharma industry job trends. The objectives in publishing the Briefs is to provide basic information about job listings trends, skills required of candidates, prevalence of degree requirements for high trending occupations. The Annual Job Trends Forecast is intended to provide greater insight based on additional study in these areas. Acknowledgements The analysis found in the 3-Month Report was conducted by Mark Bruso, Manager of Labor Market Research, under the direction of MassBioEd Foundation Executive Director, Peter Abair. Erica Dickinson, Product Support Manager at Burning Glass provided able assistance to the MassBioEd research team in effectively using data from Burning Glass Technologies. MassBio, the industry council serving the biopharmaceutical community of the Massachusetts region, provided support for this series and MassBioEd s ongoing job trends initiative. For more MassBioEd job trends analysis, visit MassBioEd.org/Job_Trends. For Speaking Engagements or Consultations please Mark Bruso, Manager of Labor Market Research, at Mark.Bruso@MassBio.Org. 2

3 TABLE OF CONTENTS Employment Overview 4 Monthly Listings 5 Top Occupations 6 Regional Breakdown 7 Top Employers By Region 8 Data Tables 12 Appendix 26

4 Life Sciences Industry Employment MONTHLY EMPLOYMENT, MA LIFE SCIENCES INDUSTRY, Q Q Dec-16 69,942 69,482 56,730 As of March ,752 Jobs Since January ,441 Jobs Since January ,158 Jobs in Past 12 Months 7% 6% YEAR-OVER-YEAR EMPLOYMENT GROWTH 6.5% 6.4% 5% 4% 3% 2% 2.9% 2.3% 4.9% 1.6% 1% 0% 0.3% 1.4% 1.2% MA Life Sciences MA Economy US Economy YEARLY GROWTH 2012: +0.8% 2013: +2.0% 2014: +4.8% 2015: +4.0% 2016: +5.1%

5 2,555 2,360 2,441 2,250 2,231 1,878 1,980 1,976 2,263 2,200 2,435 2,199 1,964 2,298 1,966 2,296 1,997 2,380 2,337 2,258 2,795 3,016 2,628 2,486 Life Sciences Openings, Q MONTHLY JOB LISTINGS, PAST TWO YEARS Previous 12 Months (Oct Sept. 2016) Past 12 Months (Oct Sept. 2017) 5,000 4,500 4,000 3,500 3,000 2,500 2,000 1,500 1, TOTAL + ADJUSTED* MONTHLY JOB LISTINGS 5.0% 4.5% 4.0% 3.5% 3.0% 2.5% 2.0% 1.5% 1.0% 0.5% 0.0% *Adjusted Job Listings Totals controls for wild fluctuations of the entire universe of job listings in MA, i.e. it is the industry total divided by the state total of all sectors in a given month In both raw totals and adjusted totals* of job openings (at left), the life sciences industry in MA has been decelerating in the past two years. In Q3, total job listings declined by -3.5%, while adjusted job listings decline even more, by -14.7%, year-over-year.

6 Life Sciences Openings, Q Top Occupations By Listings Q Chg. From Trend Medical Scientist % Researcher / Research Associate 278-7% Chemical / Process Engineer % Chemist % Administrative Manager % Healthcare Administrator % Office / Administrative Assistant % Biologist % Business Development / Sales Manager % Quality Control Analyst 112-4% Medical Director % Software Developer / Engineer 95-4% Clinical Research Coordinator / Manager 95 +6% Project Manager 91-2% Sales Representative 86-9% Compliance Manager % Program Manager 84 +2% Marketing Manager 81-6% Biological Technician 79 +6% Biostatistician 78-7% Quality Control Systems Managers 70 +8% Natural Science Research Manager % Laboratory Technician 62-26% Regulatory Affairs Specialist % Product Manager 55-2% Listings for STEM openings in the life sciences industry in Massachusetts declined - 6.8% year-over-year in Q At left, many of the top occupations by listings in Q3 were STEM openings, which accounted for 55% of all listings in the quarter. They were measured against their 12-month quarterly trend. STEM-related positions that grew much faster than their average from the past year were Medical Director (+17%), Compliance Manager (+30%), Research Managers (+21%), Regulatory Affairs Specialists (+43%), Chemical Technicians (+49%), and Microbiologists (+28%). Lab Technicians, Technical Writers, and Statisticians saw their Q3 totals fall sharply against that average. If you from Industry, join our Skills Advisory Group! MassBioEd depends on input from industry experts in our Skills Advisory Group to interpret workforce data and provide guidance on skills needed for jobs in the industry. If you are from Higher Education, join our Higher Education Steering Council! MassBioEd requires feedback from our educational and training partners so that the reports we produce best reflect the information most vital to the alignment of their curricula and learning outcomes with workforce needs. For more information, please contact Mark Bruso at mark.bruso@massbio.org or

7 STEM Openings By Region, Q % Boston/Cambridge 2,130 1,397 3,527 Metrowest ,101 North Central South & Cape West STEM Non-STEM Total Openings Year-Over-Year Job Listings Growth, All Occupations & STEM Occupations, Q3 All Occupations STEM Occupations +74% +56% +18% -21% -15% -18% -1% -4% 0% -11% -3% -32% Central North Boston/Cambridge Metrowest South & Cape West

Top Employers By STEM Listings, Q3 2017 Complete list of employers, and map of regions begins on Page 12 In Boston/ Cambridge, Q3 STEM occupational job listings (60% of region s total) were dominated

TOP EMPLOYERS, PAST 12 MONTHS, ALL JOBS (by listings) Takeda (1,189) Biogen (1,115) MGH (989) Pfizer (844) Novartis (772) Sanofi (763) Dana Farber (450) Harvard (400) Merck (350) The South & Cape had

8 Top Employers By STEM Listings, Q Complete list of employers, and map of regions begins on Page 12 In Boston/ Cambridge, Q3 STEM occupational job listings (60% of region s total) were dominated by a few large firms, universities, and research hospitals. TOP EMPLOYERS, PAST 12 MONTHS, ALL JOBS (by listings) Takeda (1,189) Biogen (1,115) MGH (989) Pfizer (844) Novartis (772) Sanofi (763) Dana Farber (450) Harvard (400) Merck (350) The South & Cape had by a large margin the lowest percentage of STEM listings (20%) out of total listings. Merck, Cardinal Health, Life Technologies, and EMD Serono led the way. TOP EMPLOYERS, PAST 12 MONTHS, ALL JOBS (by listings) Merck (155) Cardinal Health (73) Life Technologies (54) C.C. Healthcare (32) Covance (23) Quest Diagnostics (21) Oxford Immun. (20) Upsher Smith (20) Corbus (18) 8

Top Employers By STEM Listings, Q3 2017 Complete list of employers, and map of regions begins on Page 12 TOP EMPLOYERS, PAST 12 MONTHS, ALL JOBS (by listings) Pfizer (714) Merck (506) Life

Technologies have dominated the hiring of STEM talent in the Life Sciences industry in the northeast region. Metrowest was the least concentrated region by employer listings in Q3 2017.

9 Top Employers By STEM Listings, Q Complete list of employers, and map of regions begins on Page 12 TOP EMPLOYERS, PAST 12 MONTHS, ALL JOBS (by listings) Pfizer (714) Merck (506) Life Technologies (138) Charles River (74) Parexel (74) Abbott Labs (47) Millipore (45) Millipore Sigma (34) Lahey Health (33) During Q3 and in the past 12 months - Pfizer, Merck & Company, and Life Technologies have dominated the hiring of STEM talent in the Life Sciences industry in the northeast region. Metrowest was the least concentrated region by employer listings in Q Shire listed the most openings within the region during that time. TOP EMPLOYERS, PAST 12 MONTHS, ALL JOBS (by listings) Sanofi (499) Shire(463) Sunovion (215) Alkermes (212) Biogen (198) Quest Diagnostics (193) PerkinElmer (193) Astrazeneca (135) Astellas (119) 9

Top Employers By STEM Listings, Q3 2017 Complete list of employers, and map of regions begins on Page 12 Bristol-Myers Squibb of Devens, and AbbVie of Worcester represent the lion s share of STEM

10 Top Employers By STEM Listings, Q Complete list of employers, and map of regions begins on Page 12 Bristol-Myers Squibb of Devens, and AbbVie of Worcester represent the lion s share of STEM openings at Pharma companies in the region. TOP EMPLOYERS, PAST 12 MONTHS, ALL JOBS (by listings) BMS (195) Pfizer (179) AbbVie (146) UMass Medical (129) Sanofi (97) Lab Corp. (79) Danaher Corp. (78) UMass Memorial (34)Charles River (33) TOP EMPLOYERS, PAST 12 MONTHS, ALL JOBS (by listings) Baystate Health (66) UMass Amherst (43) Smith College (12) Berkshire M.C. (12) Cardinal Health (9) Takeda (9) Sisters of Providence (7) Pfizer (6) Williams College (6) The smallest region by size, Western MA saw their biotechrelated STEM openings occur primarily at local universities or hospitals. 10

Top Employers By STEM Listings, Q3 2017 Complete list of employers, and map of regions begins on Page 112 At

Fifteen organizations made up roughly 50% of all job openings in Q3.

11 Top Employers By STEM Listings, Q Complete list of employers, and map of regions begins on Page 112 At left are the leading companies in Q3 by their statewide job listings for all job types. Fifteen organizations made up roughly 50% of all job openings in Q3. For STEM positions, generally the same organizations topped the list. Research hospitals and universities generally had a higher share of STEM openings than biopharma companies. 11

Top Regional Employers By STEM Listings, Q3 2017 West Region Listings Baystate Health 14 University of Massachusetts Amherst 11 Cardinal Health 5 Berkshire Medical Center 5 Astrazeneca 3 Abbott

12 Top Regional Employers By STEM Listings, Q West Region Listings Baystate Health 14 University of Massachusetts Amherst 11 Cardinal Health 5 Berkshire Medical Center 5 Astrazeneca 3 Abbott Laboratories 2 Bristol-Myers Squibb 2 Smith College 2 Amgen 1 Astellas 1 Mount Holyoke College 1 Novartis 1 Pfizer 1 Sisters Of Providence Health Systems 1 Takeda 1 Williams College 1 Central Region Listings AbbVie 28 UMass Medical School 26 Bristol-Myers Squibb 23 Danaher Corporation 12 Laboratory Corporation of America 9 Charles River 8 Worcester State University 6 UMass Memorial Healthcare 5 Sanofi Genzyme 3 IDEXX Laboratories, Inc. 3 Joule 3 Abbott Laboratories 2 Clark University 2 Leica Biosystems 2 Life Technologies 1 Pfizer 1 Allergan 1 Alpha Analytical 1 Arbour Counseling Services 1 Baystate Health 1 Inteplast Corporation 1 Iphotonics 1 Karl Storz Gmbh & Co Kg 1 Lilly 1 Mcphs University 1 Medtronic 1 Microbac Laboratories Incorporated 1 New England Herc 1 Novartis 1 Central Region (continued) Listings Pharmaceutical Product Development 1 Quest Diagnostics Incorporated 1 Rockwell Automation Incorporated 1 Teva Pharmaceuticals 1 The Hospitals Of Providence 1 Tufts University 1 Universal Health Services, Inc. 1 Worcester Polytechnic Institute 1 World Emblem International Incorporated 1 12

13 Top Regional Employers By STEM Listings, Q North Region Listings Pfizer 115 Merck & Company 52 Life Technologies 21 Abbott Laboratories 17 Amgen 8 Cell Signaling 8 Charles River 6 EMD Serono 6 New England Biolabs 6 Caraco 5 Sun Pharmaceutical Industries Ltd 5 Cambridge Isotope Laboratories 5 University of Massachusetts Lowell 4 Cardinal Health 3 Lahey Clinic 3 Massachusetts General Hospital 3 Parexel 3 Flexion Incorporated 2 Aphios Corporation 2 Integrated Project Services 2 Lancaster Laboratories 2 Mettler Toledo 2 Pharmaceutical Strategies 2 Sarepta Therapeutics 2 Society For Applied Spectroscopy 2 Thermo Fisher Scientific Inc 2 TRC Company 2 Amri Incorporated 1 Cutispharma Incorporated 1 Integra Lifesciences 1 Qualitest 1 Abiomed Incorporated 1 Amri Global 1 Arbour Counseling Services 1 Astrazeneca 1 Biofrontera Inc 1 Boehringer Ingelheim 1 Continuus Pharmaceuticals 1 Dsm 1 Emd Millipore 1 Gortons Incorporated 1 Hntb 1 Insulet Corporation 1 Integrated Resources Incorporated 1 Ipsdb 1 Lahey Health 1 Lahey Hospital & Medical Center 1 Valeant 1 South & Cape Region Listings Merck & Company 14 Cardinal Health 8 Life Technologies 5 EMD Serono 5 Integra Lifesciences 3 Upsher Smith Laboratories 3 Cape Cod Hospital 3 Oxford Immunotec 3 Qualitest 3 Bristol-Myers Squibb 2 Cape Cod Healthcare 2 Dps Engineering 2 Organogenesis Incorporated 2 Pfizer 2 Alkermes Incorporated 1 Animal & Plant Health Inspection Service 1 Arbor Pharmaceuticals 1 Bayer Corporation 1 Beth Israel Deaconess Medical Center 1 Corbus Pharmaceuticals 1 Cottage Hospital 1 Covance Incorporated 1 Depomed Incorporated 1 Dps 1 Emerson Electric Company 1 Gatti & Associates 1 Lilly 1 NC State University 1 Pharmaceutical Strategies 1 Stonehill College 1 Thermo Fisher Scientific Inc 1 Ul Llc 1 North Region (continued) Listings Leica Biosystems 1 Millipore Sigma 1 Novartis 1 Ran Biotechnologies 1 Sample6 1 Sanofi Genzyme 1 Skyworks 1 Softworld Incorporated 1 Triton Systems Incorporated 1 Universal Health Services, Inc. 1 UMass Central Office 1

14 Top Regional Employers By STEM Listings, Q Metrowest Region Listings Shire 65 Astellas 39 Sanofi Genzyme 32 Astrazeneca 23 Quest Diagnostics 22 Sunovion 21 Alkermes 19 Cardinal Health 13 PerkinElmer 13 Biogen 12 Immunogen 11 Life Technologies 10 Enanta Pharmaceuticals 10 Merck & Company 8 Dps Engineering 8 X Chem 7 Partners Healthcare 6 Massachusetts General Hospital 5 Parexel 5 Icon Clinical Research 4 Palleon Pharma 4 Uniqure 4 Amag Pharmaceuticals, Inc 3 Berg 3 Cugene, Inc 3 Danaher Corporation 3 Instrumentation Laboratory 3 Barrington James Medical / Executive 2 Agenus 2 Baxter International Incorporated 2 Bristol-Myers Squibb 2 Concert Pharmaceuticals 2 Hologic Incorporated 2 Hyde Engineering Consulting 2 Nova Biomedical Corporation 2 Thermo Fisher Scientific Inc 2 Translate Bio 2 Syndax Pharmaceuticals 1 Agilent Technologies, Inc. 1 Allena Pharmaceuticals, Inc 1 Arsenal Medical, Inc 1 Avedro, Inc 1 Bentley University 1 Beth Israel Deaconess Medical Center 1 Bioverativ 1 Boston Children's Hospital 1 Boston Heart Diagnostics 1 Celldex Therapeutics Incorporated 1 Metrowest Region (continued) Listings Extend Biosciences 1 First Light Biosciences 1 Forma Therapeutics 1 Global Channel Management, Inc 1 Harvard Bioscience Incorporated 1 Integral Biosystems, Llc 1 Integrated Resources Incorporated 1 Juno Therapeautics 1 Lincoln Laboratory 1 Medtronic 1 Mettler Toledo 1 Millipore Corporation 1 Millipore Sigma 1 Mspcc 1 New England Irb 1 Ocular Therapeutix 1 Omniguide Inc 1 Pfizer 1 Pulmatrix Incorporated 1 Rana Therapeutics 1 Rbw Consulting 1 Ribon Therapeutics, Inc 1 Sbh Sciences Incorporated 1 Selecta Biosciences 1 Shepherd Therapeutics 1 Siamab Therapeutics, Inc 1 Sqz Biotechnologies 1 Stealth Bio Therapeutics 1 T2 Biosystems, Inc 1 Tetraphase Pharmaceuticals 1 The Wirb Copernicus Group Wcg 1 Tufts Health Plan 1 Wave Life Sciences 1 Dana Farber Cancer Institute 1 Epharmasolutions 1 14

15 Top Regional Employers By STEM Listings, Q Boston/Cambridge Region Listings Massachusetts General Hospital 229 Takeda 180 Pfizer 177 Novartis 107 Biogen 99 Boston University 74 Harvard University 67 Merck & Company 66 Dana Farber Cancer Institute 62 Sanofi Genzyme 60 Massachusetts Institute of Technology 56 Partners Healthcare 56 Amgen 53 Beth Israel Deaconess Medical Center 22 Tufts University 19 Boston Children's Hospital 16 Ironwood Pharmaceuticals 15 Syros Pharmaceuticals 13 Vertex Pharmaceuticals 12 Boston Medical Center 11 New England Herc 11 Astrazeneca 10 AbbVie 10 Celgene Corporation 10 Intellia Therapeutics 10 Broad Institute 9 Draper Laboratory 9 Foundation Medicine 9 Momenta Pharmaceuticals Incorporated 8 Moderna Therapeutics 8 Northeastern University 8 Omega Therapeutics 8 Shire 8 Aegerion Pharmaceuticals 7 Alnylam Pharmaceuticals Incorporated 7 Joslin Diabetes Center 7 Tufts Medical Center 7 Grifols 6 Quintiles 6 Rbw Consulting 6 Sage Therapeutics 6 Merrimack Pharmaceuticals 5 Allergan 5 Bluebird Bio 5 Daiichi Sankyo, Inc 5 Jounce Therapeutics 5 Teva Pharmaceuticals 5 Life Technologies 4 Boston/Cambridge Region (continued) Listings Alexion Pharmaceuticals 4 Allied Search Partners 4 Potenza Therapeutics 4 UMass Medical School 4 Regeneron 3 Aegerion Pharmaceuticals, Inc 3 Akcea Therapeutics 3 Astellas 3 Axcella Health 3 Covance Incorporated 3 Crispr Therapeutics 3 Exosome Diagnostics 3 Flexion Therapeutics 3 Genocea Biosciences 3 Icon Clinical Research 3 Lundbeck 3 Magenta Therapeutics 3 Oncorus 3 Platelet Biogenesis 3 Prometrika 3 Ra Pharmaceuticals 3 Sarepta Therapeutics 3 United Therapeutics Corporation 3 Vericel Corporation 3 Glaxosmithkline 2 Integra Lifesciences 2 Novo Nordisk 2 Dicerna Pharmaceuticals 2 Acceleron Pharma 2 Advanced Clinical 2 Akebia Therapeutics 2 Back To Search Previous Next 2 Boehringer Ingelheim 2 Cambridge 2 Cambridge Health Alliance 2 Execunet 2 Ginkgo Bioworks 2 Hire4Group 2 Sloan-Kettering Cancer Center 2 Merrimack Group 2 Optum 2 PerkinElmer 2 Raytheon 2 Revitope Oncology 2 Stratacuity 2 Sysmex 2 The Charles Stark Draper Laboratory 2 Ultivue, Inc 2 15

16 Top Regional Employers By STEM Listings, Q Boston/Cambridge Region (continued) Listings University Of Minnesota Public Health 2 Wave Life Sciences 2 Agios Pharmaceuticals 1 Abbott Laboratories 1 Atlantic Management Resources 1 Eli Lilly 1 Lilly 1 Pharmaceutical / Biomedical Research Company 1 Pharmaceutical Calibrations And Instrumentation, Llc 1 Akorn Incorporated 1 Alpha Net Consulting Llc 1 Anokion Us 1 Arbour Counseling Services 1 Baim Institute For Clinical Research 1 Barrington James Medical / Executive 1 Baxter International Incorporated 1 Bayer Corporation 1 Bio Rad 1 Biotie Therapies 1 Bmc Company Boston University Medical Center 1 Camargo Pharmaceutical Services 1 Canon Virginia Incorporated 1 Codiak Biosciences 1 Combined Therapeutics 1 Commonwealth Sciences 1 Complete Genomics 1 Constellation Pharmaceuticals 1 Danaher Corporation 1 Decision Resources Incorporated 1 Dps Engineering 1 Econosoft 1 Emerson College 1 Epm Scientific 1 Eutropics 1 Fahrenheit It 1 Fog Pharmaceuticals 1 Fogpharma 1 Gardner Resources Consulting, Llc 1 Getinge 1 Hebrew Senior Life 1 Human Services Research Institute 1 Imabiotech Corp 1 Keryx Biopharmaceuticals Incorporated 1 Klingberg Family Centers Incorporated 1 Logicbio Therapeutics 1 Mcphs University 1 Medpace 1 Mersana Therapeutics 1 Boston/Cambridge Region (continued) Listings Mitx 1 Nimbus Therapeutics 1 Okaya Infocom 1 Patheon 1 Pharma Search Partners, Inc 1 Pharmaceutical And Biomedical Research Company 1 Pharmaceutical Calibrations And Instrume 1 Pharmaceutical Calibrations And Instrumentation 1 Philips North America 1 Q State Biosciences, Inc 1 Qualitest 1 Quincy College 1 S&R Resources, Inc 1 Schepens Eye Research Institute/Massachusetts Eye And Ear 1 Scholar Rock, Inc 1 Semma Therapeutics 1 Sigilon Therapeutics Inc 1 Spectraforce 1 Stantec, Inc. 1 Tango Therapeutics 1 Thermo Fisher Scientific Inc 1 Ultivue 1 Universal Health Services, Inc. 1 University of Washington 1 University Of Washington School Of Public Health 1 Va Boston Healthcare System 1 Vanderbilt University Medical Center 1 Vedanta Biosciences 1 Vitaver & Associates Incorporated 1 Vl42 Inc 1 Vl45 Inc 1 Voyager Therapeutics 1 16

17 Top Statewide Employers By Total Listings, Q Organization Listings Pfizer 493 Takeda 416 Massachusetts General Hospital 272 Merck & Company 265 Biogen 227 Novartis 215 Sanofi Genzyme 184 Shire 161 Dana Farber Cancer Institute 153 Life Technologies 128 Partners Healthcare 119 Amgen 93 Cardinal Health, Inc. 93 Boston University 90 Harvard University 77 Quest Diagnostics 76 Lincoln Laboratory 70 Massachusetts Institute of Technology 64 PerkinElmer 62 Astrazeneca 60 AbbVie 52 Bristol-Myers Squibb 52 Sunovion 49 Alkermes Incorporated 46 Charles River Company 44 Beth Israel Deaconess Medical Center 43 Laboratory Corporation of America 39 Boston Children's Hospital 38 Draper Laboratory 33 Parexel 33 Abbott Laboratories 32 UMass Medical School 30 Vertex Pharmaceuticals 28 Tufts Medical Center 27 Astellas Pharma 26 Astellas 25 Broad Institute 24 Tufts University 24 Instrumentation Laboratory 23 Baystate Health 23 Integra Lifesciences 22 The Charles Stark Draper Laboratory, Inc 20 University of Massachusetts Amherst 20 Boston Medical Center 20 New England Herc 19 Ironwood Pharmaceuticals 19 Raytheon 19 Danaher Corporation 18 Organization Listings Syros Pharmaceuticals 18 Optum 17 Millipore Corporation 15 Immunogen 15 Emd Serono 14 Clearesult Consulting Incorporated 14 Thermo Fisher Scientific Inc 13 Covance Incorporated 13 Aegerion Pharmaceuticals 13 Enanta Pharmaceuticals 13 Momenta Pharmaceuticals 13 Waters Corporation 13 Mobilexusa 13 Alnylam Pharmaceuticals 12 Celgene Corporation 12 Ironwood Pharmaceuticals, Inc 12 Berkshire Medical Center 12 Dps Engineering 11 Intellia Therapeutics 11 Moderna Therapeutics 11 Upsher Smith Laboratories 11 Northeastern University 11 Quintiles 11 Cape Cod Healthcare 10 Foundation Medicine 10 Bluebird Bio 10 Cell Signaling Technology 10 Icon Clinical Research 10 Sage Therapeutics 9 Worcester State University 9 Rbw Consulting 9 Alliance Healthcare Services 9 UMass Memorial Healthcare 9 Joslin Diabetes Center 9 QinetiQ North America 8 Union Of Concerned Scientists 8 Lahey Clinic 8 Sarepta Therapeutics 8 Amag Pharmaceuticals, Inc 8 Flexion Therapeutics 8 Glaxosmithkline 8 Jounce Therapeutics 8 Omega Therapeutics 8 The Marine Biological Laboratory 8 Lahey Health 7 Caraco Pharmaceutical Laboratories, Ltd 7 Universal Health Services, Inc. 7 New England Biolabs 7 17

18 Top Statewide Employers By STEM Listings, Q Organization Listings Pfizer 297 Massachusetts General Hospital 237 Takeda 181 Merck & Company 140 Biogen 111 Novartis 110 Sanofi Genzyme 96 Boston University 75 Shire 73 Harvard University 67 Dana Farber Cancer Institute 63 Amgen 62 Partners Healthcare 62 Massachusetts Institute of Technology 56 Astellas 43 Life Technologies 41 AbbVie 38 Astrazeneca 37 UMass Medical School 30 Bristol-Myers Squibb 29 Cardinal Health 29 Beth Israel Deaconess Medical Center 24 Abbott Laboratories 22 Quest Diagnostics 22 Sunovion 21 Alkermes 20 Tufts University 20 Boston Children's Hospital 17 Danaher Corporation 16 Baystate Health 15 Ironwood Pharmaceuticals 15 PerkinElmer 15 Charles River 14 Syros Pharmaceuticals 13 New England Herc 12 Vertex Pharmaceuticals 12 Boston Medical Center 11 Dps Engineering 11 EMD Serono 11 Immunogen 11 UMass Amherst 11 Celgene Corporation 10 Enanta Pharmaceuticals 10 Intellia Therapeutics 10 Broad Institute 9 Draper Laboratory 9 Foundation Medicine 9 Organization Listings Laboratory Corporation of America 9 Cell Signaling 8 Moderna Therapeutics 8 Momenta Pharmaceuticals 8 Northeastern University 8 Omega Therapeutics 8 Parexel 8 Aegerion Pharmaceuticals 7 Alnylam Pharmaceuticals 7 Icon Clinical Research 7 Joslin Diabetes Center 7 Rbw Consulting 7 Tufts Medical Center 7 X Chem 7 Allergan 6 Grifols 6 Integra Lifesciences 6 New England Biolabs 6 Quintiles 6 Sage Therapeutics 6 Teva Pharmaceuticals 6 Thermo Fisher Scientific Inc 6 Worcester State University 6 Berkshire Medical Center 5 Bluebird Bio 5 Cambridge Isotope Laboratories 5 Caraco 5 Daiichi Sankyo, Inc 5 Flexion Therapeutics 5 Jounce Therapeutics 5 Merrimack Pharmaceuticals 5 Qualitest 5 Sarepta Therapeutics 5 Sun Pharmaceutical Industries Ltd 5 UMass Memorial Healthcare 5 Alexion Pharmaceuticals 4 Allied Search Partners 4 Covance Incorporated 4 Palleon Pharma 4 Potenza Therapeutics 4 Uniqure 4 UMass Lowell 4 Aegerion Pharmaceuticals, Inc 3 Akcea Therapeutics 3 Amag Pharmaceuticals 3 Axcella Health 3 Baxter International 3 18

19 Top Occupations Occupations Q change vs. avg. Q Q Q AVG Medical Scientist 637 6% Researcher / Research Associate 278-7% Chemical / Process Engineer 218 2% Chemist 193 3% Administrative Manager % Healthcare Administrator % Office / Administrative Assistant % Biologist % Business Development / Sales Manager 114 3% Quality Control Analyst 112-4% Medical Director % Software Developer / Engineer 95-4% Clinical Research Coordinator / Manager 95 6% Project Manager 91-2% Sales Representative 86-9% Compliance Manager 85 30% Program Manager 84 2% Marketing Manager 81-6% Biological Technician 79 6% Biostatistician 78-7% Quality Control Systems Managers 70 8% Natural Science Research Manager 63 21% Laboratory Technician 62-26% Regulatory Affairs Specialist 61 43% Product Manager 55-2% Quality Inspector / Technician 52-1% Human Resources / Labor Relations Specialist 51-7% Accountant 51 18% Operations Manager / Supervisor 49 1% General Manager 48-14% Production Worker 48 37% Business / Management Analyst 45-4% Executive Assistant 45 7% Computer Programmer 44 33% Customer Service Representative 43 6% Technical Writer 43-23% Chemical Technician 42 49% Laboratory Technologist 40-28% Attorney 40-2% Financial Manager 38-23%

20 Top Occupations Occupations Q change vs. avg. Q Q Q AVG Phlebotomist 34 31% Systems Analyst 34-25% Mechanical Engineer 34-9% Engineering Manager 32 29% Statistician 32-20% Data / Data Mining Analyst 32-6% Microbiologist 32 28% Medical Assistant 31 8% Communications / Public Relations Manager 28 12% Account Manager / Representative 28-14% College Professor / Instructor 26-10% Production Supervisor 26-3% Nursing Assistant 26 27% Computer Systems Engineer / Architect 25 0% College / University Administrator 25 14% Financial Analyst 25 4% Industrial Engineer 24 3% Validation Engineer 24-6% Recruiter 24 22% Physician 23-15% Registrar / Patient Service Representative 21 51% Human Resources Manager 21 4% Office Manager 19 14% Medical Secretary 19 25% Biochemist 19-8% Market Research Analyst 19 20% Contract Administrator 18 3% Chief Information Officer / Director of Information Technology 18 11% Bookkeeper / Accounting Clerk 17-10% Procurement / Sourcing Manager 17 6% Compensation / Benefits Analyst % Security Officer 16 82% Cyber / Information Security Engineer / Analyst 16 41% Fundraising Manager 16 9% Manufacturing Machine Operator 15 27% Biomedical Engineer 15 28% Network Engineer / Architect 15-30% Maintenance Technician 15-15%

21 Top Occupations Occupations Q change vs. avg. Q Q Q AVG Chief Executive Officer 14-12% Mental Health / Behavioral Counselor 13 33% Health Technician / Technologist (Other) 13 0% Cytogenetic Technologist / Cytotechnologist 13 3% Electrical Engineer 13-21% IT Project Manager 13-45% Auditor 13-10% Sterile Processing Technician 12-17% Field Service Technician 12 32% Treasurer / Controller 12 22% Production Plant Manager 12-47% Clinical Data Systems Specialist / Manager 12 33% Computer Scientist 12 4% Database Administrator 12-8% Manufacturing / Production Technician 12-41% Judge Retail Store Manager / Supervisor 12-23% Public Relations / Communications Specialist 11-18% Business Intelligence Analyst 11-5% Software QA Engineer / Tester 11-35% Buyer / Purchasing Agent 11 45% Safety Manager 11 45% Account Executive 11 62% Data Scientist 10-51% Surveillance Officer / Investigator 10-25% Scheduler / Operations Coordinator 10-9% Restaurant / Food Service Supervisor 9 7% Janitor / Cleaner 9 371% Civil Engineer 9-63% Repair / Service Technician 9 12% Sales Supervisor 9 128% Training and Development Specialist 8-22% Compliance Officer / Analyst 8-71% Compensation and Benefits Manager 8-13% Physicist 8 61% Manufacturing Engineer 8-55% Network / Systems Administrator 8-68% Coach 8 69% Social / Human Services Manager 8 648% Merchandiser / Ad Set Associate 8 665%

22 Top Occupations Occupations Q change vs. avg. Q Q Q AVG Claims Specialist / Adjuster / Examiner % Middle / High School Teacher % Administrative Supervisor 7 321% Risk Manager / Analyst 7 69% Graphic Designer / Desktop Publisher 7 95% Courier / Messenger 7 189% Operations Analyst 7 133% Medical / Pharmaceutical Sales Representative 7 32% 5 6 General / Electrical Engineering Technician 7-36% Training and Development Manager 7-27% Laborer / Warehouse Worker 7-41% Pet Care Workers / Managers 7 1% Medical / Clinical Social Worker 7 69% Data Entry Clerk 6 17% Maintenance / Service Supervisor 6-35% Machinist % Health and Safety Engineer 6 50% Data Warehousing Specialist 6-54% Supply Chain / Logistics Manager 6-52% Elementary and Secondary School Administrator 6 154% Receptionist 5 21% Health Educator / Coach 5-17% Dental Laboratory Technician 5 32% Talent Acquisition / Recruiting Manager % Shipping / Receiving Clerk 5 969% Product Development Engineer 5-34% Bill and Account Collector 5 186% Radiology Technician 5-11% Registered Nurse 5-75% Inventory Associate 5 134% Writer 5 7% Payroll Specialist 5-61% Interpreter / Translator 5 127% Logistics / Supply Chain Analyst 4 211% Human Resources Assistant 4 36% Food Service Team Member 4 3% Editor 4-12% Inventory Specialist 4 208% Economist 4 0%

23 Top Occupations Occupations Q change vs. avg. Q Q Q AVG Social / Human Service Assistant 4 388% Industrial / Mechanical Engineering Technician 4 0% Document Control / Management Specialist 4-76% Paralegal / Legal Assistant 4-33% Billing Clerk / Specialist 4-46% Dispatcher 4 605% Family / School / General Social Worker 4-27% Sales Delivery Driver Facilities Manager 4-23% Estimator 4 21% Chemical Operator Fundraising / Development Specialist 4 356% Marketing Specialist 3-70% Clinical Nurse Educator 3 95% Safety Specialist / Coordinator 3 40% Wind Turbine Technician Dishwasher 3-13% Loan Processor / Assistant Real Estate Agent / Broker 3-32% Customer Service Manager 3-27% Tax Manager 3 127% Engineering Technologist 3 0% Histotechnologist / Histotechnician 3-18% Business Intelligence Architect / Developer 3-25% Database Architects 3-40% Epidemiologist 3-62% Data Engineer RF Engineer 3 3 HVAC Mechanic / Installer 3 45% Special Education / Reading / Bilingual Teacher 3 615% Event Specialist 3 260% Grants Manager / Administrator 3-23% Satellite / Broadband Technician Payroll Manager % Cook 3 35% Emergency Management Director % Vocational Education Instructor 3-5% 3 3 Retail Sales Associate 3-6% Insurance Claims / Policy Clerk 3-4%

24 Historical Employment By Sector, Month Industry Sector Totals Jan-11 8,383 32, ,635 2,025 8,805 3,396 56,730 Feb-11 8,377 32, ,655 2,183 8,810 3,426 56,839 Mar-11 8,411 32, ,646 2,190 8,828 3,440 56,910 Apr-11 8,394 32, ,643 2,206 8,807 3,442 57,192 May-11 8,436 32, ,642 2,159 8,807 3,466 57,257 Jun-11 8,676 32, ,658 1,993 8,883 3,476 57,722 Jul-11 8,667 32, ,691 1,981 8,914 3,492 58,019 Aug-11 8,694 32, ,688 1,960 8,901 3,528 57,959 Sep-11 8,577 32, ,678 2,164 8,867 3,535 57,754 Oct-11 8,540 32, ,674 2,227 8,838 3,573 57,730 Nov-11 8,586 32, ,682 2,247 8,862 3,582 57,902 Dec-11 8,707 32, ,688 2,208 8,862 3,595 58,177 Jan-12 8,764 32, ,664 2,049 8,872 3,487 57,356 Feb-12 8,798 32, ,667 2,219 8,861 3,483 57,481 Mar-12 8,852 32, ,680 2,242 8,871 3,504 57,748 Apr-12 8,919 32, ,682 2,231 8,862 3,520 57,858 May-12 8,941 32, ,680 2,191 8,861 3,528 57,853 Jun-12 9,122 32, ,715 2,047 8,939 3,566 58,484 Jul-12 9,108 32, ,723 1,996 8,932 3,560 58,294 Aug-12 9,095 32, ,715 1,977 8,917 3,556 58,239 Sep-12 8,950 32, ,706 2,192 8,881 3,557 57,939 Oct-12 8,913 32, ,710 2,264 8,843 3,558 57,886 Nov-12 8,982 32, ,718 2,281 8,869 3,594 58,109 Dec-12 9,103 32, ,724 2,251 8,873 3,632 58,426 Jan-13 9,246 32, ,936 2,097 8,819 3,785 58,773 Feb-13 9,310 32, ,918 2,312 8,798 3,821 59,143 Mar-13 9,350 32, ,923 2,322 8,812 3,807 59,227 Apr-13 9,345 32, ,925 2,341 8,810 3,778 58,822 May-13 9,336 32, ,937 2,282 8,832 3,781 58,880 Jun-13 9,505 32, ,966 2,084 8,903 3,832 59,434 Jul-13 9,486 32, ,979 2,001 8,929 3,814 59,450 Aug-13 9,484 32, ,963 1,997 8,924 3,806 59,360 Sep-13 9,393 32, ,943 2,196 8,891 3,787 59,067 Oct-13 9,192 32, ,945 2,280 8,831 3,821 58,957 Nov-13 9,103 32, ,958 2,305 8,889 3,864 59,126 Dec-13 9,122 32, ,966 2,276 8,901 3,886 59,241 INDUSTRY SECTORS: NAICS 3254: Pharmaceutical MFG, including Biologics (100%) NAICS : Research and Development in Biotechnology (100%) NAICS : R&D in Physical, Engineering, and Life Sciences (except biotech) (22%) NAICS : Analytical Laboratory Instrument MFG (30%) NAICS 54138: Testing Laboratories (9%) NAICS 622: Hospitals (4.5%) NAICS 61131: Universities (1.9%) NAICS : Medical Testing Laboratories (100%) 24

25 Historical Employment By Sector, Present Month Industry Sector Totals Jan-14 9,809 34, ,949 2,167 8,906 3,885 61,041 Feb-14 9,840 34, ,943 2,305 8,882 3,899 61,184 Mar-14 9,900 34, ,946 2,321 8,912 3,890 61,403 Apr-14 9,904 34, ,956 2,332 8,900 3,938 61,429 May-14 9,996 34, ,964 2,238 8,928 3,978 61,635 Jun-14 10,055 34, ,987 2,017 8,994 4,009 62,052 Jul-14 10,069 34, ,006 2,075 9,112 4,068 62,459 Aug-14 10,053 34, ,982 2,051 9,108 4,071 62,302 Sep-14 9,985 34, ,965 2,242 9,055 4,059 62,078 Oct-14 10,379 34, ,987 2,339 9,045 4,128 62,357 Nov-14 10,411 34, ,002 2,371 9,086 4,129 62,647 Dec-14 10,500 34, ,021 2,352 9,107 4,127 63,070 Jan-15 10,903 34, ,063 2,129 9,036 4,057 63,184 Feb-15 10,890 34, ,067 2,321 9,012 4,038 63,133 Mar-15 10,908 34, ,070 2,359 9,040 4,073 63,645 Apr-15 10,865 35, ,095 2,375 9,058 4,069 63,917 May-15 10,789 35, ,099 2,288 9,080 4,133 64,169 Jun-15 10,760 36, ,108 2,139 9,158 4,177 64,729 Jul-15 10,675 36, ,105 2,113 9,197 4,153 64,752 Aug-15 10,583 36, ,095 2,073 9,177 4,171 64,843 Sep-15 10,468 36, ,068 2,258 9,132 4,168 64,641 Oct-15 10,421 36, ,093 2,356 9,104 4,218 65,330 Nov-15 10,273 37, ,105 2,375 9,143 4,155 65,438 Dec-15 10,300 37, ,118 2,364 9,163 4,122 65,714 Jan-16 10,094 37, ,140 2,157 9,095 4,413 65,539 Feb-16 10,140 37, ,139 2,346 9,080 4,441 65,944 Mar-16 10,169 37, ,147 2,364 9,107 4,480 66,324 Apr-16 10,188 38, ,159 2,377 9,120 4,517 66,759 May-16 10,269 38, ,156 2,324 9,147 4,526 67,025 Jun-16 10,507 38, ,185 2,109 9,241 4,526 67,860 Jul-16 10,450 39, ,206 2,124 9,329 4,495 68,733 Aug-16 10,437 39, ,204 2,097 9,316 4,488 68,600 Sep-16 10,460 39, ,182 2,296 9,297 4,467 68,253 Oct-16 10,054 40, ,199 2,357 9,288 4,485 68,868 Nov-16 10,113 40, ,199 2,357 9,288 4,465 69,117 Dec-16 10,192 41, ,199 2,357 9,288 4,491 69,942 Jan-17 9,930 40, ,210 2,191 9,355 4,539 68,758 Feb-17 9,852 40, ,205 2,356 9,320 4,524 69,146 Mar-17 9,987 40, ,210 2,360 9,328 4,491 69,482 INDUSTRY SECTORS: NAICS 3254: Pharmaceutical MFG, including Biologics (100%) NAICS : Research and Development in Biotechnology (100%) NAICS : R&D in Physical, Engineering, and Life Sciences (except biotech) (22%) NAICS : Analytical Laboratory Instrument MFG (30%) NAICS 54138: Testing Laboratories (9%) NAICS 622: Hospitals (4.5%) NAICS 61131: Universities (1.9%) NAICS : Medical Testing Laboratories (100%) 25

26 APPENDIX MassBioEd utilizes Burning Glass Labor Insight for the bulk of its real-time online job listing data. Per the description on Burning Glass website, their Labor Insight software, collects millions of online job postings [everyday] from close to 40,000 sources and applies [their] patented technology to mine and code detailed data from each posting describing the specific skills, education, experience, and work activities required for the job going well beyond the occupation and industry codes offered in other sources. All job listings data is sourced from Burning Glass Labor Insight, unless otherwise noted. Employment numbers were derived from the Department of Labor, Bureau of Labor Statistics Quarterly Census of Employment and Wages (QCEW), a survey of employers that covers 98 percent of all workers in the country. Staffing patterns, or the count of individual occupations by industry in the state, were found by using Department of Labor, Bureau of Labor Statistics Occupation Employment Statistics (OES) Research Estimates. These are derived from sample surveys and thus are approximations subject to sampling error, as well as nonsampling errors by respondents filling out the surveys. 26

ABOUT THE REPORT. About the 3-Month Report

ABOUT THE REPORT. About the 3-Month Report THE DIGEST OF BIOTECH JOB TRENDS IN MASSACHUSET TS QUARTERLY LIFE SCIENCES JOB MARKET REPORT (Abbreviated) Q2 2018 ABOUT THE REPORT About the 3-Month Report MassBioEd produces a Quarterly on biopharmaceutical