Organizers: Titia Sixma The Netherlands Cancer Institute Amsterdam, The Netherlands

Transcription

1 UBIQUITIN & CELLULAR REGULATION June 17-22, 2018 Snowmass, CO Organizers: Titia Sixma The Netherlands Cancer Institute Amsterdam, The Netherlands Michele Pagano New York University School of Medicine New York, New York Sunday, June 17, :00 p.m. 9:00 p.m. Conference Registration 6:00 p.m. 7:00 p.m. Welcome Reception 7:00 p.m. 8:00 p.m. DINNER 8:00 p.m. 9:00 p.m. Keynote Speaker / Opening Scientific Session The ubiquitin system, disease, and therapy Monday, June 18, 2018 Raymond Deshaies Amgen/Caltech 9:00 a.m. 12:30 p.m. Session 1 Co-Chairs: David Komander & Rachel Klevit Regulation of histone ubiquitination Cynthia Wolberger Roles of single protein-catalyzed ubiquitination in bacterial virulence The molecular basis of zinc finger degradation in multiple myeloma therapy Johns Hopkins University Zhao-Qing Luo Purdue University Nicolas Thomä FMI Basel

2 Regulation of ubiquitin signalling by DUBs 1:00 p.m. 2:30 p.m. Career Development Workshop 1:00 p.m. 4:00 p.m. Free time 4:00 p.m. 6:30 p.m. Session 2 Role of chain specificity and DUB regulation in cellular regulation New and unusual ways to activate Ubiquitin E3 ligases Ubiquitin-like protein modification and the DNA damage response 7:30 p.m. 10:00 p.m. Poster Session One (Abstract #..) Yogesh Kulathu University of Dundee Co-Chairs: Andreas Martin David Komander Rachel Klevit University of Washington Chris Lima Memorial Sloan Kettering Cancer Center Tuesday, June 19, :00 a.m. 12:30 p.m. Session 3 Co-Chairs: Frauke Melchior & Sandra Pellegrini Role on linear - ubiquitin Vishva Dixit modification in innate immunity Proteasome structure and function and *Group Photo Regulating Protein Breakdown through Control of Proteasome Activity The Cdc48-Rad23/Dsk2 Axis Contributes to K48 Ubiquitin Chain Specificity of the Proteasome Genentech Andreas Martin UC Berkeley Alfred Goldberg Harvard Medical School Yasushi Saeki Tokyo Metropolitan Institute of Medical Science

3 1:30 p.m. 4:00 p.m. Free time 4:00 p.m. 6:30 p.m. Session 4 SUMOylation in signal transduction Type I interferon on cell cycle regulation: also a matter of ISG15 DDK-mediated regulation of the desumoylating enzyme Ulp2 facilitates early steps of DNA replication 7:30 p.m. 10:00 p.m. Poster Session Two (Abstracts #..) Co-Chairs: Ramanujan Hegde & Judith Frydman Frauke Melchior ZMBH, Heidelberg Sandra Pellegrini Institute Pasteur, Paris Dana Branzei IFOM, Milan Wednesday, June 20, :00 a.m. 12:30 p.m. Session 5 Co-Chairs: Richard Youle & Ivan Dikic Quality control of proteins orphaned Ramanujan Hegde in the cytosol Pathways of protein quality control in the eukaryotic cytosol Surviving protein quality control failure and neurodegenerative diseases Mechanisms of ubiquitin-dependent protein quality control 1:30 p.m. 6:30 p.m. Free time 7:30 p.m. 10:00 p.m. Session 6 In vivo roles of the ubiquitin ligase Parkin and ubiquitin kinase PINK1 Novel ubiquitin conjugation in Judith Frydman Stanford University Anne Bertolotti Ron Kopito Stanford University Co-Chairs: Michael Rape & Kylie Walters Richard Youle NINDS Ivan Dikic

4 bacterial infection and inflammation Writing and reading the ubiquitin code in membrane trafficking pathways Goethe University, Frankfurt Scott Emr Cornell University *(confirm the actual day with your Conference Manager) Thursday, June 21, :00 a.m. 12:30 p.m. Session 7 Co-Chairs: Ingrid Wertz & Benjamin Ebert Ubiquitylation at the crossroads of Michael Rape human development and disease Substrate receptors of the proteasome The role of small modifier proteases in the fidelity of DNA double-strand break repair 12:30 a.m. 1:00 p.m. Business Meeting 1:00 p.m. 2:00 p.m. LUNCH and 1:30 p.m. 4:00 p.m. Group Activity (optional) 2:00 p.m. 4:00 p.m. Free time 4:00 p.m. 6:30 p.m. Session 8 6:30 p.m. 7:30 p.m. SOCIAL HOUR 7:30 p.m. DINNER Targeting the ubiquitin system for therapeutic indications Therapeutic modulation of the CRL4-CRBN ubiquitin ligase to alter immune cell function Aberrant ubiquitin networks in B-cell malignancies UC Berkeley Kylie Walters National Cancer Institute Jo Morris University of Birmingham Co-Chairs: Ryan Potts & Daniela Rotin Ingrid Wertz Genentech Benjamin Ebert Harvard University Florian Bassermann Technical University Munich

5 Friday, June 22, 2018 Option 2 Time Title/Topic Event 7:30 a.m. 12:00 p.m. Conference Registration 9:00 a.m. 11:30 a.m. Session 9 CRL3/SPOP promotes Nanog destruction to suppress stem cell traits and prostate cancer progression Regulation of Nedd4 family ubiquitin ligases and their role in disease 10:00 a.m. 10:20 a.m. FASEB Sponsored Coffee Break Mechanistic studies of antigenic MAGE ubiquitin ligases Final Wrap-up & Goodbye 12:00 p.m. LUNCH to Go and DEPARTURES Co-Chairs: Cynthia Wolberger & Zhao-Qing Luo Wenyi Wei Harvard Medical School Daniela Rotin University of Toronto Ryan Potts St Jude Children s Research Hospital END OF CONFERENCE For additional information contact: FASEB Science Research Conferences 9650 Rockville Pike Bethesda, MD