Trace Elements in Biology and Medicine June 3 rd June 8 th 2018 Tahoe City, CA

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1 Trace Elements in Biology and Medicine June 3 rd June 8 th 2018 Tahoe City, CA Organizers: Amanda Bird, Ph.D. The Ohio State University Paul Cobine, Ph.D. Auburn University Co-Organizers and Poster Blitz Martina Ralle, Ph.D. Oregon Health and Science University Mitchell Knutson, Ph.D. University of Florida Sunday, June, 3rd, :00 p.m. 9:00 p.m. Conference Registration 6:00 p.m. 7:00 p.m. Welcome Reception 7:00 p.m. 8:00 p.m. DINNER 8:00 p.m. 10:00 p.m. Keynote Session: 8:00 p.m. 9:00 p.m. The intersection of nutrition and infection at the Eric Skaar, (Vanderbilt U) host-pathogen interface 9:00 p.m. 10:00 p.m. Transition Metal Signaling in the Brain and Beyond Chris Chang, (UC Berkeley) Monday, June, 4th :30 a.m. 1:00 p.m., Conference Registration 4:00 p.m. 6:00 p.m. 7:30 a.m. 12:00 p.m. Conference Registration 8.45 a.m. - 12:00 p.m. Session 1. Trace element transport and homeostasis. Chair: Dennis Thiele (Duke U) 9:00 a.m. 9:30 a.m. Infectious niche-dependent gene regulation in response to Dennis Thiele (Duke U) copper in the pathogenic fungus Cryptococcus neoformans 9:30 a.m a.m. Structural Biology of the ZIP Metal Transporters Jian Hu (Michigan State U)

2 10:00 a.m. 10:15 a.m. To be selected from abstracts TBA 10:30 a.m. 11:00 a.m. A Role for The ATP7A Copper Transporter in Mick Petris, (U of Missouri) Tumorigenesis and Cisplatin Resistance 11:00 a.m. 11:30 a.m. Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo Vadim Gladyshev, (Harvard U) 11:30 a.m. 12:00 p.m. 10x 3-minute focused poster teasers Poster Blitz 1:00 p.m. 2:30 p.m. Career Development Workshop 2:30 p.m. 4:00 p.m. Free time 4:00 p.m. 6:00 p.m. Poster session 1 6:00 p.m. 7:00 p.m. Conference Registration 7:00 p.m. 9:35 p.m. Session 2. Trace element and host pathogen interactions Chair: Manuela Raffatellu (UC San Diego) 7:15 p.m. 7:45 p.m Bacterial competition for metal ions in the inflamed gut Manuela Raffatellu (UC San Diego) 7:45 p.m. 8:15 p.m Nickel Sequestration by the Host-Defense Protein Human Elizabeth Nolan (MIT) Calprotectin 8:15 p.m. 8:30 p.m Break 8:30 p.m. 8:45 p.m 8:45 p.m. 9: 15 p.m Role of Copper in Protection Against Urinary Tract Infection Sarguru Subashchandrabose, (Wake Forest) 9:15 p.m. 9:30 p.m To be selected from abstracts TBA Tuesday, June, 5th, :30 a.m. 1:00 p.m., Conference Registration 4:00 p.m. 6:00 p.m. 7:30 a.m. 12:00 p.m. Conference Registration 8.45 a.m. - 12:00 p.m. Session 3. Trace elements in human disease Chair: Gerhard Multhaup (McGill U) 9:00 a.m. 9:30 a.m. Systems Analyses of Menkes Disease Reveal Novel Victor Faundez (Emory U) Connections with Neurodegeneration and Neurodevelopmental Disorder Genes 9:30 a.m a.m. BMP-SMAD signaling coordinates hepcidin regulation by Jodie Babitt (Harvard) iron and erythropoietic drive. 10:00 a.m. 10:30 a.m. FASEB Sponsored Coffee Break and *Group Photo 10:30 a.m. 11:00 a.m. Epigenetic regulation of Wilson Disease Valentina Medici (UC Davis) 11:00 a.m. 11:30 a.m. The sulfur-rich transmembrane sequence of Alzheimer disease beta-secretase (BACE1) modulates cytosolic Gerhard Multhaup (McGill U)

3 copper 11:30 a.m. 11:45 a.m. To be selected from abstracts TBA 1:00 p.m. 4:00 p.m. Free time 4:00 p.m. 6:00 p.m. Poster session 2 6:00 p.m. 7:00 p.m. Conference Registration 7:00 p.m. 9:35 p.m. Session 4. Imaging, quantifying and sensing trace elements Chair: Yan Qin (University of Denver) 7:15 p.m. 7:45 p.m Optical recording of zinc dynamics with GZnP sensors Yan Qin (University of Denver) 7:45 p.m. 8:15 p.m Mapping the impact of copper on a neurodegenerative disease 8:15 p.m. 8:30 p.m Break Lisa Miller, (Brookhaven National Lab) 8:30 p.m. 8:45 p.m To be selected from abstracts TBA 8:45 p.m. 9:15 p.m Tracking iron and manganese compartmentalization in Arabidopsis development Tracy Punshon, (Dartmouth College) 9:15 p.m. 9:45 p.m TBA Wednesday, June, 6th, 2018 a.m. p.m a.m. - 12:00 p.m. Session 5. Signaling and regulation Chair: Nigel Robinson, (Durham U, UK) 9:00 a.m. 9:15 a.m. Selectivity and sensitivity of metal sensors Nigel Robinson, (Durham U, UK) 9:15 a.m. 9:30 a.m. Computing the responses of metal-sensors by measuring Maria Martini (Durham U, UK) and combining multiple thermodynamic parameters 9:30 a.m a.m. Zinc Binding to MG53 Facilitates Repair of Injury to Cell Zui Pan, (UT Arlington) Membrane 10:00 a.m. 10:15 a.m. To be selected from abstracts TBA 10:30 a.m. 11:00 a.m. Glutathione at the Nexus of Iron and Redox Regulation Caryn Outten (USC) 11:00 a.m. 11:30 a.m. Cardiac dysfunction and the role of zinc in sarcoplasmic Samantha Pitt (St Andrews U) reticulum remodeling 11:30 a.m. 11:45 a.m. To be selected from abstracts TBA 12:00 p.m. 12:30 p.m. Business Meeting 12:30 p.m. 2:00 p.m. LUNCH and 2:00 p.m. 4:00 p.m. Free time 4:00 p.m. 6:00 p.m. Poster Session 3 7:00 p.m. 9:35 p.m. Session 6. Trace elements in model systems Chair: Simon Labbe (U Sherbrooke,

4 7:15 p.m. 7:45 p.m Str3 is an additional cell surface heme acquisition protein in fission yeast 7:45 p.m. 8:15 p.m Heme transport and utilization by Trypanosoma cruzi: Implications for Chagas disease Quebec) Simon Labbe (U Sherbrooke, Quebec) Julia Cricco (CONICET, Argentina) 8:15 p.m. 8:30 p.m To be selected from abstracts TBA 8:30 p.m. 8:45 p.m Break 8:45 p.m. 9:15 p.m Meeting your quota: the cellular economy of the zinc David Eide, (UW-Madison) proteome 9:15 p.m. 9:45 p.m Heme Transport and Recycling Iqbal Hamza, (U of Maryland) Thursday, June, 7th, 2018 a.m. p.m a.m. - 12:00 p.m. Session 7. Cofactor assembly and trafficking Chair: Megan McEvoy (UCLA) 9:00 a.m. 9:30 a.m. Adaptor protein mediates dynamic pump assembly Megan McEvoy (UCLA) for bacterial copper efflux. 9:30 a.m a.m. TBA 10:00 a.m. 10:15 a.m. MMOD binding allows the access of hydrocarbon Uhn-Soo Cho (U. Michigan) to the active site in soluble methane monooxygenase 10:30 a.m. 11:00 a.m. The Yeast Copper Chaperone for Sod1 (Ccs1) is a Duane Winkler (UT Dallas) Multifaceted Chaperoning Molecule that Promotes All Levels of Sod1 Maturation 11:00 a.m. 11:30 a.m. CIA secrets revealed: new mechanistic insights into Debbie Perlstein, (Boston U) the early steps of cytosolic iron sulfur cluster assembly 11:30 a.m. 11:45 a.m. Sequence proximity between Cu(II) and Cu(I) Kathryn Haas (St Marys College) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and oxygen. 1:00 p.m. 4:00 p.m. Group Activity (optional) 4:00 p.m. 6:00 p.m. Poster Session 4 7:00 p.m. 9:45 p.m. Session 8. New aspects of trace element Chair: Caroline Philpott, (NIDDK). metabolism 7:15 p.m. 7:45 p.m TBA 7:45 p.m. 8:15 p.m The liver releases a systemic signal in response to bioenergetic deficiency that suppresses the adaptive immune system Scot Leary, (U of Saskatchewan)

5 8:15 p.m. 8:30 p.m Break 8:30 p.m. 8:45 p.m To be selected from abstracts TBA 8:45 p.m. 9:15 p.m Copper distribution networks in Pseudomonas Jose Arguello, (WPI) aeruginosa 9:15 p.m. 9:45 p.m PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis Caroline Philpott, (NIDDK). Friday, June, 8th 2018 a.m. p.m. 7:30 a.m. 9:00 a.m. Conference Registration 9:00 a.m. Boxed Snacks to Go and DEPARTURES END OF CONFERENCE For additional information contact: FASEB Science Research Conferences 9650 Rockville Pike Bethesda, MD