FOLIC ACID, VITAMIN B12, AND ONE-CARBON METABOLISM July 29 August 3, 2018 The Atlantica, Oak Island Resort & Conference Center, Nova Scotia, Canada

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1 FOLIC ACID, VITAMIN B12, AND ONE-CARBON METABOLISM July 29 August 3, 2018 The Atlantica, Oak Island Resort & Conference Center, Nova Scotia, Canada Organizers: Ralph Green, MD PhD Chair University of California, Davis Sacramento, California Jesse Gregory, PhD Co-Chair University of Florida Gainesville, Florida Sunday, July 29, 2018 Time Title/Topic Event 4:00 p.m. 9:00 p.m. Conference Registration 6:00 p.m. 7:00 p.m. Welcome Reception 7:00 p.m. 8:00 p.m. DINNER 8:00 p.m. 9:30 p.m. Keynote Speakers Vitamin B6 - The enigmatic roles in human health and one-carbon metabolism The prevalence of clinical folate deficiency is underestimated Vitamin B9 may not always be Benign Jesse Gregory, Univ. of Florida Ashok Antony, Indiana University Irwin Rosenberg, Tufts University Monday, July 30, 2018 Time Title/Topic Event Session Chairs and Speakers 9:00 a.m. 12:00 p.m. General Session I Vitamin B12 and folate transporters: binders, receptors & chaperones Ebba NexØ, Aarhus Univ. Epi cblc a novel mechanism of gene silencing caused by epigenetic-genetic heterozygosity Intracellular trafficking of B12 Jean-Louis Gueant, Univ. Hospital Centre of Nancy

2 Mother-to-infant cobalamin transport during and beyond pregnancy: evidence from epidemiological studies Update on the proton-coupled folate transporter and the defects that occur in hereditary folate malabsorption Luciana Hannibal, Univ. of Freiburg Rima Obeid, Univ. Hospital of the Saarland David Goldman, Albert Einstein College of Medicine 1:00 p.m. 4:00 p.m. Free time 4:00 p.m. 6:00 p.m. Poster Session 7:00 p.m. 9:00 p.m. General Session II Oxidative stress, one-carbon metabolism and development The possible role of H2S producing enzymes in neoplastic and non-neoplastic brain tissue Nitric oxide and one-carbon metabolism Histidine catabolism: a major determinant of methotrexate sensitivity Steven Gross, Weil Cornell Medicine Mirna Lechpammer, Univ. of California, Davis Steven Gross, Weil Cornell Medicine Naama Kanarek, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Tuesday, July 31, 2018 Time Title/Topic Event Session Chairs and Speakers 9:00 a.m. 12:00 p.m. General Session III Mitochondrial roles in one-carbon metabolism Formate: The Neglected Member of the One-Carbon Family The human knockout gene CLYBL connects Itaconate to Vitamin B12 Mitochondrial DHFR Folate, Formate and Formaldehyde: Vitamin, Nutrient or Toxin? 10:00 a.m. 10:30 a.m. Morning Coffee Break and Group Photo 12:00 p.m. 1:30 p.m. LUNCH and Meet-the-Experts Session 1:30 p.m. 6:00 p.m. Free time 7:00 p.m. 9:00 p.m. General Session IV Dean Appling, Univ. of Texas at Austin Margaret Brosnan, Memorial Univ. of Newfoundland Hoy Shen, Harvard Univ. Anne Parle-McDermott, Dublin City University Alexei Vazquez, Cancer Research UK Beatson Institute

3 In utero factors influencing one-carbon metabolism The effects of folate intake levels on brain development. Implications for autism spectrum disorders Materno-fetal transport of B12 in a pregnant rat model Angela Devlin, Univ. of British Columbia Konstantinos Zarbalis, Univ. of California, Davis Ole Nymark, Aarhus Univ. Wednesday, August 1, :00 a.m. 12:00 p.m. General Session V One-Carbon metabolism and neurodegenerative disease Epidemiology of B12 and cognition Effect of B vitamin supplementation on cognition, depression and brain function: findings from the BrainHOP trial Interactions between B vitamins and omega-3 fatty acids in relation to cognition Randomised trials on the effect of vitamin B12 supplementation on early child development and cognitive functioning during school age Beta-amyloid and DNA methylation in Alzheimer s disease A David Smith, Univ. of Oxford Babak Hooshmand, Karolinska Institutet, Stockholm Univ. Katie Moore, Ulster University Fredik Jernerén, Uppsala Univ Tor Strand, University of Bergen Claudio Cuello, McGill Univ. (in lieu of Sonia Do Carmo) 1:00 p.m. 4:00 p.m. Free time 4:00 p.m. 6:00 p.m. Poster Session 7:00 p.m. 9:00 p.m. General Session VI Choline and TMAO: the good, the bad and the unknown Inflammatory signaling in methionine and choline deficient mice Choline and cognition Intersection of choline and lipid metabolism Genetic control of TMAO and its effects on cardiometabolic disease Rene Jacobs, Univ. of Alberta (both chair and speaker) Robin da Silva, Univ. of Florida Tammy Scott, Tufts Univ. René Jacobs, Univ. of Alberta Brian Bennett, Western Human Nutrition Research Center USDA-ARS

4 Thursday, August 2, :00 a.m. 12:00 p.m. General Session VII Interactions between pharmacologic agents, xenobiotics and 1C metabolism Regulation of Folate-Mediated 1C Metabolism by Glycine N-Methyltransferase (GNMT) and MTHFR The role of folate-binding protein in neural crest formation - studies in Xenopus laevis Role of SNPs in arsenic methylation Mary Gamble, Columbia Univ. En-Pei Chiang, National Chung Hsing Univ. Laura Borodinsky, UC Davis Megan Niedzwiecki, Mt. Sinai Effect of folic acid and folate antagonists on neural tube formation in a pluripotent stem cell model 1:00 p.m. 5:00 p.m. Free time 5:00 p.m. 6:00 p.m. Business Meeting 7:00 p.m. 9:00 p.m. General Session VIII Novel aspects of transsulfuration Enzyme replacement with PEGylated cystathionine β-synthase ameliorates homocystinuria in murine model Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress Cardiovascular risk associated with elevated cystathionine Vardine Sahakyan, Univ. of Leuven Barry Shane, Univ. of California, Berkeley Jan Kraus, University of Colorado Omer Kabil, Univ. of Michigan Indu Dhar, Univ. of Bergen Friday, August 3, :00 a.m. 11:30 a.m. General Session IX The many faces of MTHFR Anne Molloy, Trinity College Dublin

5 Riboflavin status and MTHFR activity MTHFR and other genetic modifiers of folate status bio-markers Testicular MTHFR deficiency and sperm DNA hypomethylation caused by high dose folic acid Helene McNulty, Ulster Univ. Barry Shane (also a session chair), UC Berkeley Jacquetta Trasler, McGill Univ. 12:00 p.m. LUNCH to Go And DEPARTURES END OF CONFERENCE For additional information contact: FASEB Science Research Conferences 9650 Rockville Pike Bethesda, MD