Cell Signaling in Cancer: from Mechanisms to Therapy June 3 8, 2018 Steamboat Springs, Colorado. John Brognard National Cancer Institute

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1 Cell Signaling in Cancer: from Mechanisms to Therapy June 3 8, 2018 Steamboat Springs, Colorado Organizers: John Brognard National Cancer Institute Claus Jorgensen CRUK Manchester Institute Deborah Morrison National Cancer Institute Sunday, June 3, :00 p.m. 9:00 p.m. Conference Registration 5:00 p.m. 6:00 p.m. Welcome Reception 7:15 p.m. Opening remarks Session 1: Novel Signaling Chair: John Scott, UW Pathways 7:30 p.m. 8:00p.m. Functional genomics in cell signaling Gordon Mills, MD Anderson 8:00 p.m. 8:30 p.m. PHLPP phosphatases in Cancer Alexandra Newton, UCSD 8:30 p.m. 9:00 p.m. Histidine kinases are new Tony Hunter, Salk therapeutic targets in cancers 9:00 p.m. 9:30 p.m. Driver kinases on the 3q amplicon in John Brognard, NIH lung and head and neck cancers Monday, June 4, :55 a.m. Additional Opening remarks 9:00 a.m. 12:00 p.m. Session 1: Novel Signaling Pathways 2 Chair: Ben Neel, NYU

2 9:00 a.m. Keynote Joan Brugge, HMS 10:00 a.m. Short talk from submitted abstracts 10:15 a.m 10:45 a.m. Group Photo and Coffee Break 10:45 a.m. AKT and SGK in cancer Dario Alessi, Dundee 11:15 a.m. Copper is required for oncogenic Donita Brady, Perleman BRAF signalling and tumorigenesis. 11:45 a.m. Short talk from submitted abstracts 4:00 p.m. 6:00 p.m. Poster Session 7:00 p.m. 10:00 p.m. Session 2: Dynamics of Kinase Signaling in Cancer Cancer Institute 7:00 p.m. Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. 7:30 p.m. Local protein kinase A action proceeds through intact holoenzymes. 8:00 p.m 8:15 p.m. Break 8:15 p.m. A high throughput assay to identify substrate-selective inhibitors of the ERK protein kinases. Chair: Deborah Morrison, NIH/National Susan Taylor, University of California San Diego John Scott, UW Ben Turk, Yale 8:45 p.m. TBA John Blenis, Cornell 9:15 p. m. Short talk from selected abstracts 9:30 p.m. Short talk from selected abstracts Tuesday, June 5, :00 a.m. 12:00 p.m. Session 3: Protein Kinase C Signaling in Cancer 9:00 a.m. Protein Kinase C Epsilon Cooperates with PTEN Loss for Prostate Tumorigenesis 9:30 a.m. TBA Alan Fields, Mayo Clinic 10:00 a.m. Short talk from submitted abstracts 10:15 a.m 10:45 a.m. Morning Coffee Break 10:45 a.m. Co-dependency of PKCδ and K-Ras in lung cancer. 11:15 a.m. PKCɛ switches Aurora B specificity to exit the abscission checkpoint. 11:45 p.m. Short talk from submitted abstracts 4:00 p.m. 6:00 p.m. Poster Session Chair: Tony Hunter, Salk Institute Marcelo Kazanietz, University of Pennsylvania Mary Reyland, University of Colorado Peter Parker, CRUK

3 7:00 p.m. 10:00 p.m. Session 4: Oncogenic kinases Chair: Marcelo Kazanietz 7:00 p.m. Adaptive Reprogramming of De Alex Toker, Harvard Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple- Negative Breast Cancer 7:30 p.m. EGF and NRG induce Natalia Jura, UCSF phosphorylation of HER3/ERBB3 by EGFR 8:00 p.m 8:15 p.m. Break 8:15 p.m. TORC1 Inhibits GSK3-Mediated Elo2 Jorrit Ensenrik, University of Oslo Phosphorylation to Regulate Very Long Chain Fatty Acid Synthesis and Autophagy. 8:45 p.m. 1 Short talk from selected abstract 9:00 p. m. 1 Short talk from selected abstract Wednesday, June 6, 2016 a.m. p.m. 9:00 a.m. 12:00 p.m. Session 5: RAS Signaling In Cancer Chair: Susan Taylor, UCSD 9:00 a.m. RAS signalling through PI3-Kinase controls cell migration via Julian Downward, Francis Crick Institute, CRUK modulation of Reelin expression 9:30 a.m. Loss of RasGAP Tumor Suppressors Karen Cichowski, BWH Harvard Underlies the Aggressive Nature of Luminal B Breast Cancers 10:00 a.m. Short talk from selected abstract 10:15 10:45 a.m. Morning Coffee Break 10:45 a.m. Inhibition of Ras/Raf/MEK/ERK Deborah Morrison, NCI Pathway Signaling by a Stress- Induced Phospho-Regulatory Circuit 11:15 a.m. Cellular interplay via cytokine Ben Neel, NYU hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome 11:30 a.m. Short talk from selected abstract 12:00 p.m. 1:00 p.m. LUNCH and 7:00 p.m. 10:00 p.m. Session 6: Therapeutic Targeting in Chair: Alex Toker, Harvard University Cell Signaling RAS-RAF pathway 7:00 p.m. Lysyl oxidase drives tumour Richard Marias, CRUK progression by trapping EGF receptors at the cell surface. 7:30 p.m. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Arvin Dar, Mount Sinai, NY

4 8:00 p.m 8:15 p.m. Break 8:15 p.m. Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. 8:45 p.m. Short talk from selected abstract 9:00 p.m. Workshop: How to publish in Science journal Shiva Malik, Genentech TBD Thursday, June 7, 2016 a.m. p.m. 9:00 a.m. 12:00 p.m. Session 7: Signaling in 4D Chair: Claus Jorgensen, CRUK MI 9:00 a.m. An engineering design approach to Douglas Lauffenburger MIT systems biology. 9:30 a.m. Impaired coordination between Ken Lau, Vanderbilt signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks 10:00 a.m. Short talk from selected abstract 10:15 a.m. 10:45 a.m. Morning Coffee Break 11:00 a.m. Profiling Subcellular Protein Kevin Janes, UV Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes 11:15 a.m. Illuminating the cell s biochemical Jin Zhang, UCSD activity architecture 11:45 a.m. Short talk from selected abstract 7:00 p.m. 10:00 p.m. Session 8: Signaling in situ Chair: Jin Zhang 7:00 p.m. The role of Tks adaptor proteins in Sara Courtneidge, OHSU invadopodia formation, growth and metastasis of melanoma. 7:30 p.m. Identification and evaluation of Esther Baena, CRUK clinically significant prostate cancer 8:00 8:15 Break 8:15 p.m. Erk5 Is a Key Regulator of Naive- Greg Findlay, Dundee Primed Transition and Embryonic Stem Cell Identity. 8:45 p.m. Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Claus Jorgensen, Cancer Research UK Manchester Institute Reciprocation. 9:15 p. m. Short talk from selected abstract 9:45 p. m. Short talk from selected abstract Friday, June 8, 2016

5 a.m. p.m. and DEPARTURES END OF CONFERENCE For additional information contact: FASEB Science Research Conferences 9650 Rockville Pike Bethesda, MD