Lipid Boot Camp Meet the Experts Career Development Workshop. Travel Awards! Poster Awards! Child Care Awards!

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1 Phospholipids: Dynamic Lipid Signaling in Health and Disease (Preliminary Program Agenda) July 29 August 03, 2018 Steamboat Springs, CO, USA Seth Field University of San Diego, CA Julie Saba Children s Hospital Oakland Research Institute, University of California, San Francisco San Francisco, CA Organizers: Julie Brill The Hospital for Sick Children, University of Toronto Toronto, ON, Canada Raymond Blind Vanderbilt University School of Medicine Nashville, TN 30 th Anniversary Celebration of Phospholipid Research Lipid Boot Camp s Career Development Workshop Beautiful Colorado 80 s Dance Party Travel Awards! Poster Awards! Child Care Awards! s Lewis Cantley Bertil Hille George Carman Lucio Cocco Ed Dennis Volker Haucke Vytas Bankaitis Julie Brill Alexandra Newton Richard Anderson Sharona Gordon Julie Saba Guangwei Du s Ray Blind Brooke Emerling John Burke Aurelia Lewis Meet the Publication Experts Ed Dennis (Editor in Chief, Journal of Lipid Research) George Carman (Associate Editor, Journal of Biological Chemistry) Sharona Gordon (Editor in Chief, Journal of General Physiology) Lucio Cocco (Editor in Chief, Advances in Biological Regulation)

2 Science Signaling Nature Chemical Biology s Kacee Sims (Avanti) Paul Neilsen (Echelon) Jeff Johnson (Cayman) Cell Signaling Technology Sunday, July, 29, 2018 Time 4:00 p.m. 9:00 p.m. 4:30 p.m. 6:00 p.m. LIPID BOOT CAMP Part 1 Part 2 6:00 p.m. 7:00 p.m. Welcome Reception 7:00 p.m. 8:00 p.m. DINNER 8:00 p.m. 9:30 p.m. Opening Scientific Session / Keynote Speaker PI 3-Kinase: Linking Obesity, Insulin Resistance and Cancer Chair: Ray Blind Ray Blind, Ph.D., Vanderbilt University School of Medicine Amy Kiger, Ph.D., University of Chairs: Seth Field and Julie Brill Lewis Cantley, Ph.D., Weill Cornell Medical Center Monday, July, 30, 2018 Time 7:30 a.m. 12:00 p.m. 9:00 a.m. 12:00 p.m. Scientific Session PI5P: A Riddle Wrapped in an Enigma Understanding the role of PIP4kgamma/TORC1 signaling in pancreatic beta cells Non-canonical phosphatidylinositol kinases in the control of cellular lipid metabolism and autophagy Chair: Lucia Rameh Lucia Rameh, Ph.D., Boston University School of Medicine Brooke Emerling, Ph.D., Sanford Burnham Prebys Medical Discovery Institute

3 PtdIns5P and Septins in Membrane Remodelling, Cell Polarity and Liver Diseases Role of phosphoinositides and individual subunits in the assembly, localization and function of Saccharomyces cerevisiae TORC2 Ama Gassama Diagne, Ph.D., Inserm, France Jeremy Thorner, Ph.D., University of California, Berkeley 10:00 a.m. 10:15 a.m. FASEB Sponsored Coffee Break 10:15 a.m. 11:00 a.m. Photo Session during Coffee Break 12:00 p.m. 1:00 p.m. LUNCH and 1:00 p.m. 2:30 p.m. Career Development Workshop How to Become a Prize Winning Scientist 2:30 p.m. 4:00 p.m. Free time Diacylglycerol, Protein Kinase C, and their Kin Spatiotemporal Dynamics of Signaling by Protein Kinase C Negative Control of the DAG/PKC Axis by Diacylglycerol Kinases PKC at the Leading Edge: Single Molecule Studies of Links Between PKC and PI3K Moderator: Seth Field Bertil Hille, Ph.D. Lasker Award, Gairdner Award, etc. Chair: Alexandra Newton Alexandra Newton, Ph.D., University of Isabel Mérida, Ph.D., Spanish National Center for Biotechnology Joseph Falke, Ph.D., University of Colorado, Boulder 6:00 p.m. 7:00 p.m. 7:00 p.m. 9:00 p.m. Poster Session Tuesday, July, 31, 2018 Time 7:30 a.m. 12:00 p.m. Scientific Session

4 New Technologies for Studying Phospholipids Uncharacterized Functions of PI3K Membrane Phospholipids, Dynamics and Signaling Functions in the Human Heart and Beyond Conformational Sampling of Membranes by AKT Controls its Activation and Inactivation Chair: Takanari Inoue Takanari Inoue, Ph.D., Johns Hopkins School of Medicine Richard Gross, Ph.D., Washington University in St. Louis Thomas Leonard, Ph.D., University of Vienna, Austria 12:00 p.m. 1:00 p.m. LUNCH and 1:00 p.m. 4:00 p.m. Free time/optional Strawberry Hot Springs Excursion Role of Phospholipids in Membrane Trafficking Phosphoinositide conversion in the endolysosomal system Phosphoinositide Lipid Signaling in the regulation of membrane trafficking and organelle identity Coordination of Class II PI3-kinase and Mtm PI3-phosphatase functions in membrane trafficking Chair: Volker Haucke Volker Haucke, Ph.D., Leibniz-Instituts für Molekulare Pharmakologie, Germany Scott Emr, Ph.D., Cornell University Amy Kiger, Ph.D., University of 6:00 p.m. 7:00 p.m. 7:00 p.m. 9:00 p.m. Poster Session Wednesday, August, 01, 2018 Time a.m. Time p.m.

5 7:30 a.m. 12:00 p.m. 9:00 a.m. 12:00 p.m. Scientific Session Expanding Roles for PI4P The Role of PI4KA in Controlling Membrane Lipid Dynamics Chair: Tamas Balla Tamas Balla, Ph.D., NICHD/NIH Identification of a pathway for PI4KII-dependent transport during secretory granule maturation The Great Escape: How PtdIns(4)P and GOLPH3 promote vesicle exit from the Golgi (and how that drives cancer) Julie Brill, Ph.D., The Hospital for Sick Children, Canada Seth Field, M.D., Ph.D., University of 10:00 a.m. 10:15 a.m. FASEB Sponsored Coffee Break 12:00 p.m. 12:30 p.m. Business Meeting 12:30 p.m. 2:00 p.m. LUNCH and 2:00 p.m. 4:00 p.m. Free time/optional Hike Phospholipids in Viral and Bacterial Pathogenesis Phospholipids in Intercellular Transmission of RNA Virus Populations Investigation of the Role of Plasma Membrane Lipids in Assembly and Budding of Filoviruses Chair: Nihal Altan-Bonnet Nihal Altan-Bonnet, Ph.D., NHLBI, NIH Robert Stahelin, Ph.D., Purdue University 6:00 p.m. 7:00 p.m. 7:00 p.m. 9:00 p.m. Poster Session

6 Thursday, August, 02, 2018 Time a.m. Time p.m. 7:30 a.m. 12:00 p.m. 9:00 a.m. 12:00 p.m. Scientific Session Lyso and Sphingolipids New insights into sphingosine phosphate lysase insufficiency syndrome (SPLIS), an inborn error of metabolism caused by failure to degrade sphingolipids Targeting Sphingosine-1-Phosphate Lyase as Osteoanabolic Therapy for Osteoporosis Sphingolipids in Immune System Life and Death Role of phosphoinositides and individual subunits in the assembly, localization and function of Saccharomyces cerevisiae TORC2 Chair: Julie Saba Julie Saba, M.D., Ph.D., CHORI/University of California, San Francisco Bodo Levkau, Ph.D., Virginia Commonwealth University Victoria Blaho, Ph.D., Weill Cornell Medical College Jeremy Thorner, Ph.D., University of California, Berkeley 10:00 a.m. 10:15 a.m. FASEB Sponsored Coffee Break 12:00 p.m. 12:30 p.m. Business Meeting 12:00 p.m. 1:00 p.m. LUNCH and 1:00 p.m. 4:00 p.m. Group Activity (optional) Featured Session on Phospholipid Regulation of Transmembrane Proteins Dynamic Plasma Membrane Pools of Phosphoinositides Regulate Membrane Proteins Reciprocal regulation among TRPV1 ion channels and PI3K in inflammatory hyperalgesia Chair: Bertil Hille Bertil Hille, Ph.D., University of Washington Sharona Gordon, Ph.D., University of Washington

7 Modulation of KV7 channel deactivation by PI(4,5)P2 Carlos Villalba-Galea, Ph.D., University of the Pacific 9:00 p.m. 12:00 a.m. Party Like It s 1988 Friday, August, 03, 2018 Time a.m. Time p.m. 7:30 a.m. 9:00 a.m. 7:30 a.m. 900 a.m. 9:00 a.m. Boxed Snacks to Go and DEPARTURES END OF CONFERENCE For additional information contact: FASEB Science Research Conferences 9650 Rockville Pike Bethesda, MD