PROTEIN PHOSPHATASES July 15-20, 2018 Snowmass, CO. Organizers: Martha Cyert, Ph.D. Stanford University Stanford, CA

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1 PROTEIN PHOSPHATASES July 15-20, 2018 Snowmass, CO Organizers: Martha Cyert, Ph.D. Stanford University Stanford, CA Nunzio Bottini, M.D., Ph.D. University of California San Diego, CA

2 Sunday, July 15, :00 p.m. -9:00 p.m. Conference Registration 6:00 p.m. -7:00 p.m. Welcome Reception 7:00 p.m. -8:00 p.m. Dinner 8:00 p.m. -9:30 p.m. Opening Welcome & Keynote Speaker: Nicholas Tonks, Cold Spring Harbor Laboratories 30 Years of Research on Protein Tyrosine Phosphatases Monday, July 16, :30 a.m.-12:00 p.m. Conference Registration SESSION 1 (Mon AM): PHOSPHATASE SIGNALING NETWORKS 8:30 a.m.-12:00 p.m. Chair: Rosalie Sears 8:30 a.m. 8:45 a.m. Welcome from FASEB 8:45 a.m. -9:15 a.m. Jin Zhang, University of California-San Diego Illuminating the Biochemical Activity Architecture of the Cell 9:15 a.m. -9:45 a.m. Anne-Claude Gingras, University of Toronto Phosphatase Interactomes 9:45 a.m. -10:15 a.m. Arminja Kettenbach, Dartmouth School of Medicine Proteomic Approaches to Understand Phosphoprotein Phosphatase Signaling 10:15 a.m. -10:30 a.m. Speaker TBD, chosen from submitted abstracts 10:30 a.m. -11:00 a.m. Coffee Break 11:00 a.m. -11:30 a.m. David Virshup, NUS Singapore How to set your clock: Regulation of circadian rhythms by protein phosphorylation 11:30 a.m. -12:00 p.m. William Hahn, Dana-Farber Cancer Institute Identification of phosphatases in cancer using genomic approaches 12:00 p.m. - 12:15 p.m. Speaker TBD, chosen from submitted abstracts 12:15 p.m. -1:15 p.m. Lunch

3 1:15p.m. -4:00 p.m. Free Afternoon 4:00 p.m. -6:00 p.m. POSTER SESSION 1 (odd numbered posters) 6:00 p.m.-7:00 p.m. Dinner SESSION 2 (Mon PM): PHOSPHATASES IN DISEASE 7:00 p.m. -9:45 p.m. Chair: Beata Lontay 7:00 p.m. -7:30 p.m. Gen-Sheng Feng, University of California San Diego Multi-faceted roles of Shp2 in liver tumorigenesis 7:30 p.m. -8:00 p.m. Beata Lontay, Univeresity of Debrecen Myosin Phosphatase Regulates Gene Expression in Cancer 8:00 p.m. -8:15 p.m. Speaker TBD, chosen from submitted abstracts 8:15 p.m. -8:30 p.m. Coffee break 8:30 p.m. -8:45 p.m. Speaker TBD, chosen from submitted abstracts 8:45 p.m. -9:15 p.m. Ari Elson, Weizmann Institute Regulation of osteoclasts by PTPs 9:15 p.m. -9:45 p.m. Maria Kontaridis, Harvard University Using ipscs to delineate the molecular mechanisms that cause cardiovascular and gastrointestinal difficulties in RASopathy patients Tuesday, July 17, :30 a.m.-12:00 p.m. Conference Registration SESSION 3 (Tues AM): STRUCTURE & FUNCTION OF PHOSPHATASES 8:30 a.m.-12:00 p.m. Chair: Jessie Zhang 8:30 a.m. -9:00 a.m. Jessie Zhang, University of Texas, Austin The combinatorial CTD code generated by the interplay of kinases and phosphatases for eukaryotic transcription 9:00 a.m. -9:30 a.m. Yongna Xing, University of Wisconsin-Madison The structural and biochemical basis for decommissioning of PP2A holoenzymes 9:30 a.m. -9:45 a.m. Speaker TBD, chosen from submitted abstracts 9:45 a.m. -10:30 a.m. Coffee break and Group Photo

4 10:30 a.m. -11:00 a.m. Wolfgang Peti, University of Arizona Understanding regulation and substrate specificity of Phosphatases 11:00 a.m. -11:30 a.m. Zhenghe Wang, Case Western Reserve The pseudo-phosphatase domain of PTPRT is a tumor suppressing denitrase 11:30 a.m. - 11:45 a.m. Speaker TBD, chosen from submitted abstracts 11:45 a.m. -12:45 p.m. Lunch and Meet the Expert 12:45 p.m. -1:45 p.m. Career Development Workshop 1:45p.m. -4:00 p.m. Free Afternoon 4:00 p.m. -6:00 p.m. POSTER SESSION 2 (even numbered posters) 6:00p.m.-7:00 p.m. Dinner SESSION 4 (Tues PM): PHOSPHATASES IN CANCER 7:00 p.m. -9:45 p.m. Chair: William Hahn 7:00 p.m. -7:30 p.m. Jukka Westermarck, University of Finland Targeting of PP2A inhibitors for cancer therapy 7:30 p.m. -8:00 p.m. Tony Tiganis, Monash University Targeting phosphatases to promote anti-tumour immunity 8:00 p.m. -8:15 p.m. Speaker TBD, chosen from submitted abstracts 8:15 p.m. -8:30 p.m. Coffee break 8:30 p.m. -8:45 p.m. Speaker TBD, chosen from submitted abstracts 8:45 p.m. -9:15 p.m. Ben Neel, NYU School of Medicine Shp2 in cell signaling and cancer therapy 9:15 p.m. -9:45 p.m. Jessica Blackburn, University of Kentucky The tyrosine phosphatase PRL3 as a pro-survival oncogene in leukemia Wednesday, July 17, :30 a.m.-12:00 p.m. Conference Registration SESSION 5 (Wed AM): CELL BIOLOGY OF PHOSPHATASES

5 8:30 a.m.-11:45 a.m. Chair: Matthieu Bollen 8:30 a.m. -9:00 a.m. Matthieu Bollen, University of Leuven Spatiotemporal regulation of the phosphatase scaffold RepoMan 9:00 a.m. -9:30 a.m. Jakob Nilsson, University of Copenhagen Protein Phosphatase Specificity in Cellular Signaling 9:30 a.m. -9:45 a.m. Speaker TBD, chosen from submitted abstracts 9:45 a.m. -10:00 a.m. Yessim Khew-Goodall, University of South Australia The PTPN14-PKCδ-TK axis in health and disease 10:00 a.m. -10:30 a.m. Coffee break 10:30 a.m. -11:00 a.m. Michelle Mendoza, University of Utah ERK and Cell Migration, a RSKy adventure in Myosin Phosphatase 11:00 a.m. -11:30 a.m. Rosalie Sears, Oregon Health and Science University Dynamic Spatial and Temporal Regulation of the c-myc Oncoprotein by Reversible Protein Phosphorylation 11:30a.m. -11:45 a.m. Speaker TBD, chosen from submitted abstracts 11:45 a.m. -12:45 p.m. Lunch 1:00p.m. -5:00 p.m. 6:00p.m.-7:00 p.m. Free Afternoon & Scheduled Activity Options Dinner SESSION 6 (Wed PM): PHOSPHATASES AND THE IMMUNE SYSTEM 7:00 p.m.-9:45 p.m. Chair: David Brautigan 7:00 p.m. -7:30 p.m. David Brautigan, University of Virginia SAPS subunits for Protein Ser/Thr Phosphatase-6 7:30 p.m. -8:00 p.m. Nunzio Bottini, University of California-San Diego Functional genetics of PTPN2 in rheumatoid arthritis 8:00 p.m. -8:15 p.m. Speaker TBD, chosen from submitted abstracts 8:15 p.m. -8:30 p.m. Coffee break 8:30 p.m. -9:00 p.m. Mirela Delibegovic, University of Aberdeen Role of PTP1B in the immune system and inflammation

6 9:00 p.m. -9:15 p.m. Speaker TBD, chosen from submitted abstracts 9:15 p.m. -9:45 p.m. Ed Skolnik, Skirball Institute of Molecular Medicine Histidine Phosphorylation/Dephosphorylation in Immune Regulation Thursday, July 19, :30 a.m.-12:00 p.m. Conference Registration SESSION 7 (Thurs AM): THERAPEUTIC TARGETING OF PHOSPHATASES 8:30 a.m.-12:15 p.m. Chair: Yongna Xing 8:30 a.m. -9:00 a.m. Goutham Narla, Case Western Reserve University Allosteric regulation of PP2A: lessons from cancer mutants and small molecules 9:00 a.m. -9:30 a.m. Michel Tremblay, McGill University Battling Cancer by Controlling Protein Tyrosine Phosphatases 9:30 a.m. -10:00 a.m. Zhong-Yin Zhang Targeting PRLs for PTEN restoration therapy 10:00 a.m. -10:15 a.m. Speaker TBD, chosen from submitted abstracts 10:15 a.m. -10:45 a.m. Coffee break 10:45 a.m. -11:15 a.m. Maja Koehn, University of Freiburg Selective chemical modulators of PP1 and PP2A - from basic design principles to applications in heart failure 11:15 a.m. -11:30 a.m. Speaker TBD, chosen from submitted abstracts 11:30 a.m. -12:00 p.m. Anna DiPaouli-Roach, Indiana University School of Medicine Small Molecules that Decrease Glycogen as a Therapeutic Approach to Lafora Disease 12:00 p.m. - 12:15 p.m. Speaker TBD, chosen from submitted abstracts 12:15 p.m. -12:45 p.m. Business Meeting 12:45 p.m.-1:45 p.m. Lunch and Meet the Expert 1:45p.m. -5:00 p.m. 6:00p.m.-7:00 p.m. Free Afternoon Dinner

7 SESSION 8 (THURS PM): PHOSPHATASES AND NEUROBIOLOGY 7:00 p.m. -9:45 p.m. Chair: Anna DiPaouli-Roach 7:00 p.m. -7:30 p.m. Shuya Fukai, University of Tokyo Structural Roles of PTPδ in Synapse Formation 7:30 p.m. -7:45 p.m. Sheila Harroch, NYU School of Medicine Title TBD 7:45 p.m. -8:15 p.m. Matt Gentry, University of Kentucky Personalized biochemistry for Lafora disease and putative therapies 8:15 p.m. -8:30 p.m. Coffee break 8:30 p.m. -9:00 p.m. Anne Bertolotti, MRC Laboratory of Molecular Biology Decoding and exploiting the selectivity of PP1 holoenzymes 9:00p.m. -9:30 p.m. 9:30p.m. -9:45 p.m. Angus Nairn, Yale University Regulation of Dopamine Signaling by Phosphatases Speaker TBD, chosen from submitted abstracts Friday, July 20, :30 a.m.-11:15 a.m. Conference Registration SESSION 9 (Fri AM): PHOSPHATASES AND METABOLISM 8:30 a.m. -11:15 a.m. Chair: Nunzio Bottini 8:30 a.m. -9:00 a.m. Stephanie Stanford, LaJolla Institute for Allergy and Immunology LMPTPs regulate Diabetes 9:00 a.m. -9:30 a.m. Anton Bennett, Yale University Signaling Interplay Between Dual-Specificity and Tyrosine-Specific Protein Tyrosine Phosphatases in Metabolism 9:30 a.m. -9:45 a.m. Speaker TBD, chosen from submitted abstracts 9:45 a.m. -10:15 a.m. Marco Foiani, Fondazione Istituto FIRC di Oncologia Molecolare DNA damage response and repair efficiency rely on metabolic tuning of PP2A activity 10:15 a.m. -10:30 a.m. Coffee break 10:30 a.m. -11:00 a.m. Richard Honkanen, University of Alabama

8 CRISPR/Cas9 mediated disruption of PPP5C in human cells reveals novel roles for PP5C is signaling networks regulating metabolism 11:00 a.m. -11:15 a.m. Speaker TBD, chosen from submitted abstracts 11:15 a.m. Lunch to Go DEPARTURES

Cell Signaling in Cancer: from Mechanisms to Therapy June 3 8, 2018 Steamboat Springs, Colorado. John Brognard National Cancer Institute

Cell Signaling in Cancer: from Mechanisms to Therapy June 3 8, 2018 Steamboat Springs, Colorado Organizers: John Brognard National Cancer Institute Claus Jorgensen CRUK Manchester Institute Deborah Morrison