PROGRAM DESCRIPTION & OVERALL GOAL

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1 FACULTY: NYC Health Department: Shama Ahuja, PhD, MPH Director of Epidemiology Tiffany Harris, PhD, MS Director of Surveillance Chrispin Kambili, MD Assistant Commissioner Director of Medical Affairs University of Medicine and Dentistry of NJ David Alland, MD, MSc, DTM&H Chair, Division of Infectious Diseases Lee Reichman, MD, MPH Executive Director, NJMS Global TB Institute Centers for Disease Control and Prevention John Jereb, MD Medical Epidemiologist, Division of TB Elimination Columbia University Neil Schluger, MD Chief, Div of Pulmonary, Allergy & Critical Care Medicine; Professor of Medicine, Epidemiology, & Environmental Health Sciences New York University School of Medicine Henry Pollack, MD Associate Professor; Director Pediatric Infectious Disease Fellowship Program Maryland Dept of Health and Mental Hygiene Wendy Cronin, PhD, MT(ASCP) Epidemiologist CME/CNE Certified Activity Jointly Sponsored by the NYC Department of Health and Mental Hygiene Bureau of TB Control, New Jersey Medical School Global Tuberculosis Institute and UMDNJ-Center for Continuing and Outreach Education This activity is supported by an educational grant from the Centers for Disease Control and Prevention, Division of Tuberculosis Elimination The New Jersey Medical School Global Tuberculosis Institute is the Tuberculosis Regional Training and Medical Consultation Center for the Northeastern United States PROGRAM DESCRIPTION & OVERALL GOAL In commemoration of World TB Day, this conference will bring together over 200 health care providers and TB experts to address TB control efforts in New York City as well as cover testing and outreach strategies with TB suspects and patients. Topics will include: epidemiology of TB in New York City, prioritization of high-risk groups, hospital discharge planning, and diagnostic testing. The entire afternoon session will be dedicated to the use of interferon gamma release assays. The 2011 World TB Day Theme is Innovation and it reminds us to scale up efforts and continue to seek new and innovative ways to stop TB in NYC. TARGET AUDIENCE This conference is open to providers (pulmonary, infectious disease, community health, infection control) and health care workers who manage patients at risk for or diagnosed with TB. STATEMENT OF NEED The management of TB requires and multidisciplinary approach which relies on knowledge of the most current information of TB rates, populations at risk, and

2 PLANNING COMMITTEE: ACTIVITY DIRECTOR: NJMS Global Tuberculosis Institute Nisha Ahamed, MPH Program Director, Education and Training MEMBERS: NJMS Global Tuberculosis Institute Rajita Bhavaraju, MPH Training & Consultation Specialist NYC Health Department Martha Alexander, MHS Director of Outreach and Training Xiomara Dorrejo, RN, BSN, BS Community Outreach Coordinator Director of Medical Affairs intervention that are successful. This conference will provide a forum for learning this information as well as for discussion among colleagues. OBJECTIVES At the end of this conference, participants will be able to: Apply epidemiology of TB in New York City to recognize risk factors when encountering a TB patient in the community and health care facility Recognize high-risk populations and focus outreach activities to increase awareness about TB in the community Develop awareness of the new health code reporting requirement and collaborate with the health department to ensure proper treatment and monitoring of patients Describe new methods to diagnose and guide treatment of TB patients Employ the current guidelines for use of interferon gamma release assays to diagnose infection with M. tuberculosis in at risk persons METHOD OF PARTICIPATION In order to meet the learning objectives and receive continuing education credits, participants are required to register in advance, attend the entire course, and complete an evaluation form.

3 AGENDA 8:00 am Registration 8:30 am Opening Remarks Chrispin Kambili, MD 8:40 am Working Towards TB Elimination in NYC Chrispin Kambili, MD 9:10 am Hospital Discharge of TB Patients: Collaborating with the Health Department 9:40 am Break 10:00 am 10:30 am Prioritizing High Risk Groups: The Contribution of Country of Origin to the Epidemiology of TB in NYC Speaker Introduction Keynote Address: Fighting TB Through Innovative Diagnostic Tools Shama D. Ahuja, PhD, MPH Lee Reichman, MD, MPH David Alland, MD, MSc, DTM&H 11:15 am Question and Answer Session Moderator: Chrispin Kambili, MD 11:45 am Lunch on Your Own 1:00 pm 1:30 pm Use of IGRAs in Diagnosing Infection with M. tuberculosis 1) IGRAs for the Detection of M. tuberculosis Infection 2) The NYC experience 1) John Jereb, MD 2) Tiffany G. Harris, PhD, MS 1:45 pm 2:05 pm IGRA Testing in Special Populations 1) Immunocompromised 2) Children 1) Neil Schluger, MD 2) Henry J. Pollack, MD 2:25 pm 2:45 pm Break IGRA Testing in Special Populations (cont d) 3) Health Care Workers 3:00 pm IGRA Panel Discussion 3) Wendy Cronin, PhD, MT(ASCP) Moderator: Chrispin Kambili, MD 3:45 pm Closing Remarks/Evaluation

4 CONTINUING EDUCATION INFORMATION This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of UMDNJ- Center for Continuing and Outreach Education and UMDNJ-NJMS Global Tuberculosis Institute and NY City Bureau of TB Control. UMDNJ Center for Continuing and Outreach Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. UMDNJ Center for Continuing and Outreach Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. UMDNJ Center for Continuing and Outreach Education designates this educational activity for a maximum of 5.75 AMA PRA Category 1 Credits. Physicians should only claim credit commensurate with the extent of their participation in the activity. UMDNJ-Center for Continuing and Outreach Education is an approved provider of continuing nursing education by NJSNA, an accredited approver by the American Nurses Credentialing Center's Commission on Accreditation. Provider Number P173-11/ Provider Approval is valid through November 30, This activity is awarded 5.75 contact hours. (60 minute CH) Provider approved by the California Board of Registered Nursing, Provider Number CEP Disclosure Disclaimer In accordance with the disclosure policies of UMDNJ and to conform with ACCME and FDA guidelines, individuals in a position to control the content of this education activity are required to disclose to the activity participants: 1) the existence of any relevant financial relationship with any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients, with the exemption of non-profit or government organizations and non-health care related companies, within the past 12 months; and 2) the identification of a commercial product/device that is unlabeled for use or an investigational use of a product/device not yet approved. The following individuals have no relevant financial relationships to disclose: Nisha Ahamed, MPH Program Director, NJMS Global TB Institute Shama Desai Ahuja, PhD, MPH - Director, Office of Epidemiology,, NYC Health Department Martha Alexander, MHS Director of Outreach Education, NYC Health Department Rajita Bhavaraju, MPH Training & Consultation Specialist, NJMS Global TB Institute Wendy Cronin, PhD, MT(ASCP) Epidemiologist, Maryland Department of Health and Mental Hygiene Xiomara Dorrejo, RN, BSN, BS, Community Outreach Coordinator, NYC Health Department Tiffany Harris, PhD - Director of Surveillance, Bureau of TB Control, NYC Health Department John Jereb, MD - Medical Officer, Division of TB Elimination, Centers for Disease Control and Prevention Chrispin Kambili, MD - Assistant Commissioner, Bureau of TB Control,, NYC Health Department - Director of Medical Affairs, Bureau of TB Control, NYC Health Department Henry Pollack, MD - Associate Professor, Pediatrics, New York University Medical Center Neil Schluger, MD - Professor of Medicine and Environmental Sciences, Columbia University Medical Center David Alland, MD, MSc, DTM&H has disclosed the following relevant financial relationships: Patent Holder License revenue for molecular beacons including Xpert MTB RIF Assay (salary and laboratory revenue is capped) Stock Shareholder Wife is employed by Bristol Meyer-Squibb and receives company stockholder shares Lee Reichman, MD, MPH has disclosed the following relevant financial relationships: Consultant and Stock Shareholder Cellestis, Inc.

5 Off-Label/Investigational Use Disclosure Dr. Alland s presentation will discuss the Xpert MTB RIF Assay. Dr. Jereb, Dr. Schluger, and Dr. Pollack s presentations will cite ongoing studies of interferon gamma release assays Content Disclaimer The views expressed in this activity are those of the faculty. It should not be inferred or assumed that they are expressing the views of any manufacturer of pharmaceuticals, or UMDNJ-Center for Continuing and Outreach Education, NJMS Global TB Institute, or NYC Health Department. It should be noted that the recommendations made herein with regard to the use of therapeutic agents, varying disease states, and assessments of risk, are based upon a combination of clinical trials, current guidelines, and the clinical practice experience of the participating presenters. The drug selection and dosage information presented in this activity are believed to be accurate. However, participants are urged to consult the full prescribing information on any agent(s) presented in this activity for recommended dosage, indications, contraindications, warnings, precautions, and adverse effects before prescribing any medication. Copyright Copyright 2011 UMDNJ-Center for Continuing and Outreach Education and NJMS Global Tuberculosis Institute, and NY City Health Department. All rights reserved including translation into other languages. No part of this activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval systems, without permission in writing from UMDNJ-Center for Continuing and Outreach Education.

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