Insights into NIH Funding of Hydrocephalus Research. Paul Gross Chairman, Hydrocephalus Association
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1 Insights into NIH Funding of Hydrocephalus Research Paul Gross Chairman, Hydrocephalus Association
2 Public Funding Landscape Totals, Categories, Institutes and Types Trends over time A view from inside of Advisory Council
3 Total Spending NIH with stimulus: $54,056,677 ARRA funding portion: $2,503,534 Funding less ARRA: $51,553,143* 59 grantees received 66 unique awards Only one hydrocephalus PA exists There is also one NICHD brain development PA * NINDS does not include ARRA funding in its portfolio analysis
4 Method Searched RePORTER with keyword hydrocephalus over period Reviewed all abstracts for relevance Checked edge cases with research advisors Consulted NIH regarding any gaps / questions Categorized scientific approach Tabulated, charted and analyzed results in XL
5 NIH Hydrocephalus Spending by Category $30,000,000 $25,000,000 $20,000,000 $15,000,000 $10,000,000 $5,000,000 $ Basic Science CSF dynamics Clinical(patientbased) Cognitivebehavioral Shunt device development Other device development $9,088,014 $4,896,398 $25,117,186 $1,843,638 $9,935,552 $2,929,013
6 NIH Hydrocephalus Spending by Institute NINDS NICHD NIBIB NIA NIMH OD NCRR NHLBI NIAID NIDDK NIEHS
7 Institutions Awarded > $1 MM GEORGE WASHINGTON UNIVERSITY $ 7,145,134 MOMS CHILDRENS HOSPITAL OF PHILADELPHIA $ 5,667,592 MOMS UNIVERSITY OF CALIFORNIA SAN FRANCISCO $ 5,002,538 MOMS+ Training VANDERBILT UNIVERSITY $ 4,276,221 MOMS NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES Basic Science on genes $ 3,882,788 and brain development UNIVERSITY OF CALIFORNIA LOS ANGELES $ 2,379,118 Shunts / ICP NEURODX DEVELOPMENT, LLC $ 2,306,402 Shunts CLEVELAND CLINIC LERNER COL/MED CWRU $ 2,197,334 CSF Dynamics AFFINERGY,INC $ 2,083,120 Shunts NEW YORK UNIVERSITY SCHOOL OF MEDICINE Clinical Core for Longitudinal Study (NPH tracked $ 1,998,577 otherwise minor) INFOSCITEX CORPORATION $ 1,461,623 Shunts MASSACHUSETTS GENERAL HOSPITAL Basic Science on CSF $ 1,424,228 and Choroid Plexus CSF Dynamics with CHILDREN'S HOSPITAL MEDICAL CENTER CINCI $ 1,358,206 Imaging H CUBED, INC. $ 1,326,417 Shunts RHODE ISLAND HOSPITAL UNIVERSITY OF UTAH $ 1,275,060 Basic and CSF Dynamics $ 1,206,548 Clinical (HCRN), Training, Conference UNIVERSITY OF MIAMI SCHOOL OF MEDICINE $ 1,168,695 Basic and Cognitive UNIVERSITY OF CHICAGO $ 1,152,191 Cognitive
8 Overall Funding Analysis Total funding is low based on prevalence / burden compared to other conditions over last four years. Compare $30M ($3 per person) to: Parkinson s Disease: $629M ($63 per person) Cystic Fibrosis: $341M ($10,443 per person) Epilepsy: $559M ($186 per person) MOMS trial is nearly 50% of expended funds Devices take second place with 24% of funds NINDS and NICHD are the only players
9 Total NIH Hydrocephalus Spending Millions
10 NIH Hydrocephalus Spending by Scientific Approach (not exclusive) $6,000,000 $5,000,000 $4,000,000 $3,000,000 $2,000,000 Biomarkers Genomics and proteomics Functional Imaging Drug development Therapeutic targets Animals Models Engineering and mathematical modeling Landscape Other $1,000,000 $
11 Number of Active Grants Active Grants
12 Grant Activity Non Competing Grants New Grants
13 NIH Hydrocephalus Spending by Institute Over Time $6,000,000 $5,000,000 $4,000,000 $3,000,000 $2,000,000 $1,000,000 NINDS NICHD NIBIB NIA NIMH OD NCRR NHLBI NIAID NIDDK NIEHS $
14 NIH Hydrocephalus Spending by Category $5,000,000 $4,500,000 $4,000,000 $3,500,000 $3,000,000 $2,500,000 $2,000,000 $1,500,000 Basic Science CSF dynamics Clinical(patient based) Cognitive behavioral Shunt device development Other device development $1,000,000 $500,000 $
15 Trend Analysis Funding declines due ARRA and MOMS wrap up NINDS is assuming the leadership role in hydrocephalus funding SBIRs and Devices are the key new program PA s definitely drive scientific submissions Four to five NEW grants per year Extrapolated from paylines, there are new grant applications per year but More likely based on SBIR paylines and grant mix There are not many researchers!
16 View from Inside Council Three meetings per year, 18 member group Scientific and Patient Advocates (6) Advisors plus NINDS leadership at the table Program directors and PUBLIC surround table Public session strategy, policy and budget Private session grant approval
17 Grant Approval Process Advisor committee (3) reviews all grants in payline Any grant can be called into question (rare) All grants within payline are approved w/out discussion (expedited reviewa) Specials list is main point of discussion Recommendations outside of payline Bridge awards Clinical trials there is no payline or percentile RFAs
18 Discussion of Specials Program Director sits at the table to provide overview Council asks questions and discusses score, merit, budget, etc. Vote on decision to fund or garner more info Attempt to avoid re reviewing in meeting Scientific members demonstrate depth of experience from study section and awards Patient advocates provide a business perspective
19 Where does Hydrocephalus Stand? Small bones with a PA need PAS or RFA Legislative buckshot having an effect Hydrocephalus to be tracked in RePORTER Internal workshop in January Proactive to avoid legislation: Epilepsy example HCRN is a huge asset HA presence at meetings, forums, and council Relationships and internal champions are key
20 What can you do? Continue to invite NIH to meetings Volunteer to sit on a CSR Review Committee Keep HA informed of your application efforts Participate in advocacy efforts as needed
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