IBM Watson Health Empowering Heroes. Transforming Health.

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1 35 th Annual J.P. Morgan Healthcare Conference January 11, 2017 IBM Watson Health Empowering Heroes. Transforming Health. Deborah DiSanzo General Manager, IBM Watson Health

2 Forward Looking Statements Certain statements contained in this presentation may constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of Forward-looking statements are based on the company s current assumptions regarding future business and financial performance. These statements involve a number of risks, uncertainties and other factors that could cause actual results to differ materially, including the following: a downturn in the economic environment and client spending budgets; the company s failure to meet growth and productivity objectives; a failure of the company s innovation initiatives; risks from investing in growth opportunities; failure of the company s intellectual property portfolio to prevent competitive offerings and the failure of the company to obtain necessary licenses; cybersecurity and data privacy considerations; fluctuations in financial results; impact of local legal, economic, political and health conditions; adverse effects from environmental matters, tax matters and the company s pension plans; ineffective internal controls; the company s use of accounting estimates; the company s ability to attract and retain key personnel and its reliance on critical skills; impacts of relationships with critical suppliers; product quality issues; impacts of business with government clients; currency fluctuations and customer financing risks; impact of changes in market liquidity conditions and customer credit risk on receivables; reliance on third party distribution channels and ecosystems; the company s ability to successfully manage acquisitions, alliances and dispositions; risks from legal proceedings; risk factors related to IBM securities; and other risks, uncertainties and factors discussed in the company s Form 10-Qs, Form 10-K and in the company s other filings with the U.S. Securities and Exchange Commission (SEC) or in materials incorporated therein by reference. The company assumes no obligation to update or revise any forward-looking statements. These charts and the associated remarks and comments are integrally related, and are intended to be presented and understood together. 2

3 IBM Leadership in AI and Health: More than a Decade in Development Cognitive test case results in creation of Watson 7,000 employees Over 10,000 clients & partners IBM enables an evidence-based healthcare eco-system 3

4 Global Trends Drive Momentum for IBM Watson Health Unprecedented Shifts in R&D, Access, Delivery & Engagement Data Explosion Dynamic Delivery Environment Value Versus Volume Efficient and Effective R&D 150+ exabytes Amount of healthcare data today 1 50% Expected alternative payments from the Centers of Medicare and Medicaid by $47 trillion Estimated global economic impact of chronic disease by in 10 Clinical Trials in cancer that are shut down due to lack of participation 10 Over 230K active clinical trials 2 75%+ Percentage of patients expected to use digital health services in the future 5 $3 trillion Estimated U.S. healthcare spending 8 $2.6B Average costs to develop a new pharma drug 11 80% Healthcare data that comes from unstructured data sources 3 90K Expected shortage of physicians by s Approx. amount of decisions a person living with Type 1 Diabetes makes a day 9 < 10% Amount of drugs currently in development that make it to market 12 Sources: 1: NCBI. Big data analytics in healthcare: promise and potential 2: ClincalTrials.gov 3: NIH 4:CMS 5: McKinsey Healthcare s Digital Future July : AAMC Report The Complexities of Physician Supply and Demand: Projections from 2014 to : WEF Global Economic Burden Non-Communicable Diseases 8: Health Affairs, Team analysis 9: OpenAps.org 10: Bio- Clinical Development Success Rates :Bipartisan Policy Center 12: Journal of Health Economics Volume 47, May

5 Significant Opportunity 8 trillion industry size 2 trillion waste in Industry better experience lower cost better outcomes Imaging: Unnecessary tests Oncology: Variability of Care Life Sciences: Failed Clinical Trials Government: Fraud, Waste and Abuse Value Based Care: Cost of Chronic Disease 360 billion total IT and healthcare market opportunity Source: Health Affairs, Team analysis Note: Numbers estimated for

6 IBM Watson Health Breadth, Depth and Scale 7,000 employees globally Over 10,000 clients and partners Nearly 9,000 patients reached by Oncology offerings Nearly 100 cognitive health patents filed in 2016 Working globally within a Quality Management System Watson Health at work 6

7 IBM Watson Health is Clearly Differentiated in the Industry Cloud Content Cognitive Collaboration 7

8 Built Healthcare Cloud and an Extensive Data Repository Analytics/ Insights Platform Image Analytics Cognitive Knowledge Platform HIPAA Enabled/ GxP-Compatible End-to-End Security Purpose Built for Health Data Continuous Updates Business Continuity/ Resiliency 200M+ lives 100M+ patient records 30B+ images 1.2M medical abstracts 3B+ reference points 4M+ drug patents 40M+ research documents 8

Creating Innovative Cognitive Solutions with Watson APIs ONCOLOGY & GENOMICS GOVERNMENT LIFE SCIENCES VALUE

Health Suite Watson Imaging for cardiac disease Watson for Oncology Health & Human Services Watson for Drug

Trial Matching for Oncology Next Generation Program Integrity Watson for Patient Safety Next Generation

Technology Sequence Learning Capabilities Natural Language Processing Technology Highly Domain-specific

9 Creating Innovative Cognitive Solutions with Watson APIs ONCOLOGY & GENOMICS GOVERNMENT LIFE SCIENCES VALUE BASED CARE IMAGING Watson for Genomics Social Program Management Clinical trials Next Generation Population Health Suite Watson Imaging for cardiac disease Watson for Oncology Health & Human Services Watson for Drug Discovery Next Generation Payer Analytics Voice to Report (V2R) for Cardiologists and Radiologists Clinical Trial Matching for Oncology Next Generation Program Integrity Watson for Patient Safety Next Generation Provider Portable Analytics Cognitive Breast Advisor Highly Adaptable Cognitive API Services Deep Learning Technology Sequence Learning Capabilities Natural Language Processing Technology Highly Domain-specific Annotation and Curation Offerings currently available Offerings available; additional cognitive integration in process Offerings in development 9

10 Collaboration: It Takes an Ecosystem to Transform Healthcare z Partners Alliances Clients Watson Genomics from Quest Diagnostics Watson for Patient Safety Sugar.IQ with Watson Population Health Management Watson for Drug Discovery Watson Health Medical Imaging Collaborative Partial list of partners, alliances and clients 10

Robert Bowser, Barrow Neurological Institute, as told to Arizona Science and Innovation Magazine Source:

11 Empowering Researchers to Combat ALS Watson accomplished exactly what we hoped it did. It could identify and predict things that we ourselves had no idea were linked to this disease. Dr. Robert Bowser, Barrow Neurological Institute, as told to Arizona Science and Innovation Magazine Source: (2016) Sessions 1-11, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 17:sup1, 1-80, DOI: /

12 Empowering the Oncology Community for Cancer Care Genomics Clinical Trial Matching Oncology Watson Health s oncology clients span more than 35 hospital systems 12

35% of Council spending and the cost of an ageing

13 Empowering Healthier Communities In the London Borough of Harrow, Social Care accounts for some 35% of Council spending and the cost of an ageing population could soon exceed all other council spending. 13

14 IBM Watson Health is in the World Today Making a Difference Cloud Content Cognitive Collaboration Images: Dr. Robert Bowser, Barrow Neurological Institute; Dr. Ned Sharpless; UNC Lineberger Comprehensive Cancer Center; Dr. Ricardo Cury, Baptist Hospital of Miami 14

15 35 th Annual J.P. Morgan Healthcare Conference January 11, 2017 IBM Watson Health Empowering Heroes. Transforming Health. Deborah DiSanzo General Manager, IBM Watson Health

Insights as a Service. Balaji R. Krishnapuram Distinguished Engineer, Director of Analytics, IBM Watson Health

Insights as a Service. Balaji R. Krishnapuram Distinguished Engineer, Director of Analytics, IBM Watson Health Insights as a Service Balaji R. Krishnapuram Distinguished Engineer, Director of Analytics, IBM Watson Health Data & Knowledge Explosion: New data about individuals, used in new ways helps determines health