Symposium on Biomolecular Structure, Dynamics & Function. April 29 May 1, 2016 Providence, RI.

Transcription

1 Symposium on Biomolecular Structure, Dynamics & Function April 29 May 1, 2016 Providence, RI

2 Acknowledgements Organizing Committee (alphabetical order) Alexandra Deaconescu, Brown University, Providence, RI Nicolas Fawzi, Brown University, Providence, RI Rebecca Page, Brown University, Providence, RI Wolfgang Peti, Brown University, Providence, RI Local Organizing Committee (alphabetical order) Laura Bailey, Department of Molecular Pharmacology, Physiology and Biotechnology Megan Dupre, Facilities Management Brown Tim Durning, Department of Molecular Pharmacology, Physiology and Biotechnology Crystal Miller, Department of Molecular Pharmacology, Physiology and Biotechnology Brown University, Providence, RI Sponsors Bruker (BioSpin, AXS & Daltonics), Sigma Aldrich-Isotec, Cambridge Isotope Laboratories, Nanotemper, Art Robbins Instruments, Rigaku, Molecular Dimensions, Fisher Scientific, Eppendorf, Thermo Scientific, New Era Scientific and The Protein Society Site Arrangements We thank Chairs Kimberly Mowry (Department of Molecular Biology, Cell Biology and Biochemistry), Wayne Bowen (Department of Molecular Pharmacology, Physiology and Biotechnology) and Dean of Medicine Jack Elias for access to the resources of Brown University, Providence, RI for this symposium. 1

3 Directions for the Symposium The Brown University campus is a residential campus and thus it will be possible to enter and leave the symposium facilities at any time during the event. Upon registration you will receive a name tag that will show that you attend the conference which will allow you to enter the Brown University buildings where the symposium will take place. The symposium registration desk will be located on Friday at Sayles Hall, which is at the heart of Brown University and start at ~4 pm. Registration on Saturday and Sunday will be possible next to the main auditorium at 85 Waterman Street, Providence, RI, where all lectures will be held. Driving directions to Brown University: From the North or South on Interstate 95: Take Exit 22A to Downtown Providence. Continue straight on Memorial Boulevard. At the fourth set of lights, turn left onto College Street. At the top of the hill, turn left onto Prospect Street. Take your first right onto Waterman Street. The Stephen Robert 62 Campus Center will be on your right. From the East on Interstate 195: Take Exit 2 to South Main Street and continue for half a mile until the first set of traffic lights. Turn right onto College Street and then left at the top of the hill onto Prospect Street. Take your first right onto Waterman Street. The Stephen Robert 62 Campus Center will be on your right. From the Northwest: Follow Route 146 to I-95 South then follow directions above (from north and south). Parking Visitors may find parking on the streets in and around campus, or in Lot 68, also called the Power Street Parking Garage. Entrance to the garage is located at the intersection of Power and Thayer streets. The lot contains two Pay and Display parking pay stations. One is located at the Power Street entrance and the second is in the far corner of the lot by Brook Street. The Pay Stations accept credit cards (Visa, MasterCard, American Express, and Discover) and U.S. bills. (Note that the pay stations do not give change.) Brown maintains visitor spaces that meet ADA standards for accessibility in Lot 65, which is located on the south side of Benevolent Street between Thayer and Brook streets. Taxi from the airport: The fare from the airport to Downtown Providence is ~$35 and will take minutes. To Brown from the downtown hotels: Brown is a short 5-10 minute walk from the Downtown Hotels. Please see attached map. The Hilton Hotel will have a shuttle van available for transport upon request please inquire at the front desk of the hotels. 2

4 Luggage Storage on Sunday Luggage storage is available at 85 Waterman Street on Sunday morning (Room 015 lower level). Luggage can be claimed at the end of the symposium (~1 pm), or upon request at earlier times on Sunday. Poster Presentations If you indicated you will be presenting a poster, your abstract has been assigned a number please find the correlating number on the poster boards to locate your poster board. Pins will be provided. All posters will be presented on Friday, April 29, You should plan to put your poster up when you arrive and take it down at the end of the night. Student and postdoc poster presenters will participate in a contest with three prizes for each session. Bring your A-game and let the best science and presenters win! The Poster Session is generously sponsored by the Protein Society. Note: PIs, and students and postdocs selected for oral presentations are not eligible to participate in the poster competition. Transportation in Providence 3

5 MAPS AND DIRECTIONS Providence, Hotels and the Brown Campus Conference Biltmore Hilton Providence Hampton Inn 4

6 Meeting Location on the Brown Campus Kasper, Saturday Dinner Auditorium, 85 Waterman Street Sayles Hall 5

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8 Symposium on Biomolecular Structure, Dynamics and Function Brown University, Providence, RI April 29 - May 1, 2016 PROGRAM Friday, April 29, 2016 Afternoon Arrive / check in to hotel 4:00 pm Registration opens Sayles Hall 5:00 5:05 pm Welcome / Keynote speaker I intro (W. Bowen & W. Peti) Session Chair: W. Peti 5:05 5:50 pm Keynote lecture I Peter Wright The Scripps Research Institute Navigating the protein seascape: role of disorder and dynamics in protein function and dysfunction 85 Waterman Street Main Auditorium 5:50 6:05 pm Yana K. Reshetnyak University of Rhode Island 7

9 6:05 6:30 pm 6:30 11:00 pm Membrane-associated folding and unfolding: Molecular mechanism and applications in medical sciences Ranajeet Ghose The City College of New York Canonical and Non-canonical Docking-Mediated Phosphorylation by the MAP Kinase ERK2 Poster session sponsored by The Protein Society Vendors / Food & Drinks Saturday, April 30, 2016 Sayles Hall Breakfast 8:30 8:35 am Keynote speaker II intro (W. Peti) Session Chair: K. Gehring Jane Dyson The Scripps Research Institute 8:35 9:20 am Characterizing Interactions of Large Proteins by NMR and other methods Sanjay B. Hari 9:20 9:35 am Massachusetts Institute of Technology Quality Control of Membrane Proteins Mary Munson University of Massachusetts Medical School 9:35 10:00 am Subunit connectivity, assembly determinants, and architecture of the yeast exocyst complex Ariele Viacava Follis St. Jude Children s Research Hospital 10:00 10:15 am Small molecule modulation of the apoptotic regulator protein BAX 10:15 10:40 am Coffee break 10:40 10:45 am Keynote speaker III intro (N. Fawzi) Session Chair: N. Fawzi Marius Clore 10:45 11:30 am National Institute of Health Unveiling Dark Matter in Biology Ivan Peran Stony Brook University 11:30 11:45 am Critical Analysis of the Collapse Transition in Protein Folding: A Combined FRET and SAXS Study Ron Hills University of New England 11:45 12:05 pm Coarse grain modeling of lipid-protein interactions and ABC transporters Payel Das 12:05 12:25 pm IBM Thomas J Watson Research Center Hotels 85 Waterman Street Main Auditorium 8

10 12:25 12:50 pm Characterization of Alzheimer's Protective and Causative Amyloid-beta Variants Using a Combination of Simulations and Experiments Dimitry M. Korzhnev University of Connecticut Health Center Structural view of the early events of the ADA2h folding from relaxation dispersion NMR and computations 1:00 2:00 pm Sandwich lunch box Session Chair: D. Eliezer Arthur G. Palmer, III Columbia University 2:00 2:25 pm Protein dynamics from NMR and MD simulations: Lessons from ribonuclease H and GCN4 Bradley T. Falk University of North Carolina 2:25 2:40 pm Probing intersubunit communication in the singly ligated state of dimeric thymidylate synthase Kalle Gehring McGill University 2:40 3:05 pm Cysteine phosphorylation, a novel regulatory protein modification Andrei T. Alexandrescu 3:05 3:30 pm University of Connecticut Structural biology of phage proteins 3:30 4:30 pm Coffee break + Meet a NSF PO Optional: Martin Fuchs Brookhaven National Laboratory 3:30 3:50 pm NSLS-II beamlines for micro crystallography, FMX, and highly automated crystallography, AMX Session Chair: A. Palmer David Eliezer Weill Cornell Medical College 4:30 4:55 pm IDPs on the brain: Disordered proteins and their interactions in brain function and dysfunction Radhika Subramanian Harvard Medical School 4:55 5:10 pm Building micron-scale cellular structures from nanometer-sized proteins Francesca Massi University of Massachusetts Medical School 5:10 5:35 pm RNA-binding domain disorder modulates the RNA destabilizing activity in the TTP family of proteins Elizabeth Haglin University of Massachusetts - Amherst 5:35 5:50 pm Signaling-related structural changes of chemoreceptor nano-arrays 9 85 Waterman Street + Thayer Street 85 Waterman Street Main Auditorium

11 Blake Hill Medical College of Wisconsin 5:50 6:15 pm A Targeted Mutation Identified Through pka Measurements Indicates a Post-recruitment Role for Fis1 in Yeast Mitochondrial Fission Steffen Lindert Ohio State University 6:15 6:30 pm Molecular Effects of Cardiac Troponin DCM Mutations on Calcium Sensitivity and Myofilament Activation - An Integrated Multi-scale Modeling Study Vincenzo Venditti 6:30 7:00 pm Iowa State University Versatile dynamics in the C-terminal domain of bacterial Enzyme I Dima Kozakov 7:00 7:15 pm Stony Brook University Efficient global peptide docking using motif-derived fragments 7:15 7:30 pm Break Thayer Street 7:30 9:30 pm Isotec Conference Banquet Kasper Multi-Purpose Room 8:30 10:30 pm Shuttle Service to Downtown Providence 9:30 pm - Networking in Downtown Providence Discover the bars in Providence! Downtown Providence Sunday, May 1, :30 8:30 am Breakfast Hotels 8:30 8:35 am Keynote speaker IV intro (R. Page) Session Chair: R. Page 8:35 9:20 am Tania Baker Massachusetts Institute of Technology Unexpected activities and functions of the AAA+ protein unfoldases 9:20 9:35 am Michael J. Ragusa Dartmouth College Investigations into the Structure and Function of a Highly Conserved Cyanobacteria Protein 85 Waterman Street Main Auditorium 9:35 10:00 am Andrei A. Korostelev University of Massachusetts Medical School Ensemble cryo-em: high-resolution structural dynamics of the ribosome under cellular stress 10:00 10:15 am Piotr Sliz Harvard Medical School Data publication with the structural biology data grid supports live analysis 10

12 10:15 10:40 am Alexander Shekhtman University at Albany, SUNY Probing Protein quinary structures by in-cell NMR 10:40 10:55 am Coffee break 10:55 11:20 am 11:20 11:35 am 11:35 12:00 pm 12:00 12:15 pm David Cowburn Albert Einstein College of Medicine Selective diffusion in the nuclear pore at the atomic scale Ying Zhang University of Rhode Island Using PSAMM for the Annotation and Quality Control of Genome-scale Metabolic Models Sandor Vajda Boston University Statistical mechanics of protein-protein association Scott A. Showalter Pennsylvania State University Structural Biophysics of Intrinsically Disordered Proteins 12:15 12:20pm Closing Remarks 12:20 1:00 pm Sandwich lunch box 1:00 pm Farewell! See you hopefully in 2 years! 11