Patient-Centered Analytics Tools and technologies to enable patient centered insight

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1 Patient-Centered Analytics Tools and technologies to enable patient centered insight Nina Mian, Head of Biomedical Informatics Advanced Analytics Center, AstraZeneca April 2015

2 The Advanced Analytics Centre Transforming drug development decision making through applied data science

3 Patient centered analytics? Solicit and acquire patient views & data Derive insight from data: analytics Deliver actionable insights to AstraZeneca and patients 3

4 Challenges you might have come across...

5 ..and why we need to resolve them Motivation to do great things for patients Impact of disease Status of current treatment Unmet need Endpoints that matter Recruitment & retention Reducing missing data Adherence + efficacy Benefit-Risk (tolerability) Transparency True patient journey Patient group education and advocacy Brand awareness Medicines Access Improved health outcomes & experiences 5

6 Data & Insights Active and passive Tools & Technologies Peak of Inflated Expectation Forums PRO/ PRE YouTube Patient health record Biomarkers Blogs Podcasts Consumer reports Location and movement Searches Mobile Social Wearable 6

7 PatientsLikeMe 7

8 Ovarian Cancer In your own words Total # 30 (56.3 ± 9.2 y.o) Caucasian females BRCA+ n = 4 BRCA - n = 11 BRCA Unknown n = 15 8 Treatment pathway

9 The approach Structured Longitudinal Targeted additional data Fast Account for bias (population, recall) Where the patients already are 9

10 Patient centric learning Listening, and understanding what patients are willing to share I spent Sunday in bed shaking off a headache and feeling unwell. the rash is gone from my face and is greatly reduced on my chest... My skin continues to be dry but is responding to XXX and is not a problem. Still there has been no return of the swelling to my ankle or foot and No discomfort while eating. So I'm in pretty good shape really the taste of the pills is unpleasant even though they are in the mouth for only a couple of seconds,... I'm not doing an awful lot because of the fatigue that is really quite, quite overwhelming. 10

11 Insight to Interpretation Safety Skin Gastrointestinal Dry skin Pimply rash Diarrhoea Constipation 11

12 How does it help the patients? How does it help us? Characterisation of issues Impact Management Informed medical teams Informed patients Gives our patients a voice, and us a way to listen, so that we can strengthening the link between our science and patient-driven needs 12

13 Finalist: Customer Innovator Award

14 Me&My: Global Patient and Physician Support Key Modules Patient Profiling based on behaviour and disease state guides messaging strategy and other interventions Data Collection from Patients Integration of devices for adherence support and detecting change in disease state Devices to collect physiological data Patient reported outcomes Supported self management Individualised messages based on data collected Content from medically valid sources Goal setting and tracking Decision support Links to HCP and HCP services

15 Navigating the trough of disillusionment 15

16 > Patients making medical decisions > New methods of data capture > Holistic view of patient experience Patient + Provider + Payer + Pharma Improved health outcomes & experience

17 Acknowledgements Jenny Royle, Patient Safety Åsa Strom, Clinical informatics, R&D Information Stephanie Roberts, Advanced Analytics Center Christelle Gendrin, Advanced Analytics Center Amrik Mahal, R&D Information Lili Peng, R&D Information Donal Landers, Early Clinical Development Andrew Hughes, Early Clinical Development Shirley Spratt, Patient Safety Katarina Halling, PRO Group Daniel Eek, PRO Group Lisa Banks, Intelligent Pharmaceuticals Matt Bonam, Intelligent Pharmaceuticals Jan Frövenholt, R&D Information Sarah Keegans, Intelligent Pharmaceuticals Our partners at PLM and many other collaborators. 17

18 Confidentiality Notice This file is private and may contain confidential and proprietary information. If you have received this file in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this file is not permitted and may be unlawful. AstraZeneca PLC, 2 Kingdom Street, London, W2 6BD, UK, T: +44(0) , F: +44 (0) , 18