November 7-9, 2012 Diplomat hotel, Prague, Czech Republic 2 ANNOUNCEMENT & CALL FOR ABSTRACTS.

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1 November 7-9, 2012 Diplomat hotel, Prague, Czech Republic ND 2 ANNOUNCEMENT & CALL FOR ABSTRACTS

2 CONTENT Welcome Commitees, Important date and adresses Scientific programme Abstract submission and Call for abstract Registration Accommodation Exhibition and sponsor ship Symposium dinner Guided tours , 7 8, International Symposium on MDS and Bone Marrow Failure Syndromes in childhood Prague, November 7-9, 2012

3 WELCOME MESSAGE BY EWOG-MDS CHAIR Dear Colleagues, Over e past years, e clinical and molecular insight in e contuining spectrum of pediatric bone marrow failure, myelodysplastic syndromes as well as juvenile myelomonocytic leukemia has improved considerably. Wiin EWOG, such progress was accelerated by international registration and collaboration on a Eurpean level, which set e scene for furer global collaboration. We are proud to present is interesting symposium, to be hosted by Prof. Dr. Starý and collegues in Prague and hope at it will furer contribute to e distribution of e knowledge of ese rare hematological diseases in children, ultimately leading to more effective treatment strategies and subsequent enhanced (quality of) survival. Marry M. van den Heuvel-Eibrink Chair EWOG-MDS WELCOME MESSAGE FROM LOCAL ORGANIZING COMMITEE CHAIR It is my pleasure to invite you to Prague venue of e 6 International Symposium on Childhood MDS and Bone Marrow Failure syndromes. Previous symposia organized between 1996 and 2009 in Titisee, Funen, Stresa, Freiburg and Rotterdam reflected enormous progress achieved during e last 20 years in e understanding of childhood MDS and juvenile myelomonocytic leukemia. Uniform attitude to e diagnosis and erapy based on common database practised by EWOG-MDS from e half of 1990s increased our knowledge of e epidemiology and biology of ese rare disorders. Progress in diagnostics enabled better differentiation of MDS from congenital and acquired bone marrow failures and AML. These achievements were included into WHO classification Remarkable improvement of prognosis has been achieved by early indication of hematopoietic stem cell transplantation using uniform conditioning regimen and GVHD prophylaxis. Anoer important step in European collaboration was recent establishement of e EWOG- SAA group. I have no doubts at symposium in Prague will show furer progress in research and clinical practice achieved since e last symposium in Rotterdam Come to Prague and enjoy bo scientific meeting and beauties of e historical capital of e Czech Republic! Looking forward to your visit Jan Starý on behalf of e Local Organizing Committee 2

4 COMMITEES Scientific Committee C.M. Niemeyer, chair B. Alter I. Baumann H. Hasle S. Kojima C. Kratz F. Locatelli M. Loh A. Manabe D. Pospisilova B. Schlegelberger B. Strahm M. van den Heuvel-Eibrink TJ Vulliamy N. Young Local Organising Commitee J. Starý, chair V. Campr E. Mejstříková K. Michalová H. Ptoszková P. Sedláček M. Suková KEY DATES TO REMEMBER Abstract submission deadline Abstract notification EARLY Registration deadline Accommodation deadline July 31, 2012 Early September 2012 August 15, 2012 October 3, 2012 IMPORTANT ADRESSES Symposium department CZECH-IN, s.r.o. 5. května 65 CZ Prague 4 Czech Republic Tel.: Fax: info@ewogmds2012.org Venue Hotel Diplomat Evropska 15 CZ Prague 6 Czech Republic LOC LOC Chair Prof. MUDr. Jan Starý, DrSc. Department of Paediatric Haematology and Oncology nd 2 Medical School, Charles University Prague University Hospital Motol V Úvalu 84 CZ Prague 5 Czech Republic Tel.: Fax.: jan.stary@lfmotol.cuni.cz Web: kdho.fnmotol.cz 3 6 International Symposium on MDS and Bone Marrow Failure Syndromes in childhood Prague, November 7-9, 2012

5 SCIENTIFIC PROGRAMME Wednesday November 7, 2012 Thursday November 8, 2012 Friday November 9, Welcome session Coffee break Coffee break Coffee break Lunch break Lunch break & Poster presentation Closure Lunch Coffee break Coffee break Welcome reception Symposium dinner The organisers reserve e right to alter e programme if and as is deemed necessary. The EWOG MDS and/or its agents have e right for any reason beyond eir control to alter or to cancel, wiout prior notice, e Conference or any of e arrangements, time tables, plans or oer items relating directly or indirectly to e 6 International Symposium. The EWOG MDS and/or its agents shall not be liable for any loss, damage, expenditure or inconvenience caused as a result of such alteration or cancellation. 4

6 ABSTRACT SUBMISSION & CALL FOR ABSTRACTS Abstracts for 6 International Symposium can be submitted for following topics: Refractory cytopenia of childhood Advanced MDS JMML Ph-negative myeloproliferative disorders Therapy related myeloid neoplasia Severe aplastic anaemia Congenital bone marrow failure disorders Morphology and classification Stem cell biology Molecular aberrations and potential targets Novel erapeutics Hematopoietic stem cell transplantation Abstracts will be considered only if e following guidelines are respected: All abstracts must be submitted rough e online submission system available on as of April Guidelines for submission are available at e same site. Abstracts submitted by , fax or hardcopy will not be accepted. Abstracts should be written in English and should be divided in Objective, Meods, Results and Discussion; When submitting your abstract, choose e most relevant topic from e list above. However, e Scientific Committee reserves e right to decide on a final topic assignment upon abstract selection. Please do not exceed 2000 characters (spaces included) and do not use symbols [i.e. use ->, 10(e)9, spell out Greek letters, alpha, beta, gamma]. Include all personal data of e corresponding auor to whom all correspondence will be sent. (Optional: You can also add 1 figure or 1 table to your abstract: follow onsite instructions for uploaing is kind of files). The automated system will let you submit a draft of your abstract and en edit it until e final submission will be requested. Accepted abstracts will be published in e Abstract Book at is supplement to Haematologica journal. The abstract submission system will be opened in Apríl The notification will be distributed by . In addition please check e website for actual changes (informations). Presenting auor will be notified of e acceptance or rejection of e abstract by at e beginning of September. Deadline for abstract submission is July 31, 2012 If you have difficulties in submitting your abstracts or if you need any furer information, please contact e Haematoliga journal directly: Michele Moscato, mikimos@haematologica.org. 5 6 International Symposium on MDS and Bone Marrow Failure Syndromes in childhood Prague, November 7-9, 2012

7 REGISTRATION All participants must be registered and it is advised to register in advance. People who are not registered will not have an access to e session halls and exhibition area. Guidelines Please read e instructions on e website carefully. Ÿ All participants are kindly recommended to register via e Online Registration Form. Ÿ To benefit from e reduced early registration fee, please process your registration before August 15, Ÿ Upon submitting e Registration Form, you will receive a PRN (Participant Registration Number) by to be included in payment details. Please do not send any payments wiout PRN included in payment details. Such payments cannot be identi?ed. Ÿ All participants are kindly requested to register in advance by completing and submitting e Registration Form wi e appropriate fees. Registration fee includes Ÿ Admission to all sessions, poster area and exhibition Ÿ Admission to a "Welcome Reception Ÿ Symposium bag including Abstracts, Final program, City map Ÿ Name badge + voucher for tours (if required and paid for) Ÿ Coffee breaks Ÿ List of participants Ÿ All Participants need to re-confirm attendance of all functions in eir Registration Form. REGISTRATION FEE EARLY Until EUR LATE EUR ONSITE as of EUR SYMPOSIUM DINNER 70 EUR Fees are including VAT 20 %. Confirmation Upon receipt of e correct registration fee, each participant will receive a confirmation of registration. Please bring is confirmation to e Registration desk at Hotel Diplomat as proof of your registration. Confirmation will be sent upon receipt of payment. Please note at registration for e various tours and events will be confirmed upon payment on a first come, first served basis and numbers may be restricted. Registration opening hours Registration desk will be operated at e times indicated below: Tuesday November 6, :00 19:00 Wednesday November 7, :30 18:00 Thursday November 8, :00 18:00 Friday November 9, :00 13:00 6

8 REGISTRATION Payment All fees for e symposium registration should be paid in EUR. In case you are paying via bank transfer please note at we must receive e full amount clear of all bank charges except of payments done by European Union citizens or in EU based institutions for which SHA payment conditions applies. Options: Ÿ credit card (Visa, Eurocard/Mastercard) Ÿ bank transfer KOMERCNÍ BANKA a.s. Bank Address: Na Příkopě 33, CZ Prague 1, Czech Republic IBAN Number: CZ BIC Code: KOMBCZPPXXX Beneficiary: CZECH-IN s.r.o. Please include PRN (Participant s Registration Number) as variable symbol to identify your payment. Please, forward a copy of e transfer stating e participant s name. After October 31, 2012 you are kindly requested to make all payments by credit card exclusively or to register on-site. Payment by bank transfer will no longer be available by en. Cancellation / Refund Policy All cancellations must be notified in writing (by mail, fax or ) to e symposium secretariat according to e following conditions. Please note cancellations received: Ÿ Until August 15, EUR will be wiheld for administrative fees Ÿ From August 15, 2012 till September 30, reimbursement of 50% of e fees paid Ÿ As of October 1, no refund can be processed Registrants may transfer eir registration to a colleague at any time. For any change of name a fee of 30 EUR will be charged. All registrations received at e symposium secretariat - CZECH-IN, by October 26, 2012 will be included in e list of participants. Consent to e processing of personal data I agree to e collection, preservation and processing of personal data contained in is form, by e administrator CZECH-IN s.r.o., Prague Congress Centre, 5. kvetna 65, Prague 4, (or its employees) for e purpose stated below. This consent is granted for all of e information contained in is form, and roughout e 5 (five) years from e date of consent. At e same time I am aware of / and of eir rights under 12 and 21 of Act No. 101/2000 Coll. on e protection of personal data. Purpose of processing personal data In accordance wi 5 of Act No. 101/2000 Coll. on e protection of personal data, all information given on is form is collected and processed solely for purposes of processing registration and accommodation requirements for e 6 International Symposium on MDS and Bone Marrow Failure Syndromes in childhood 2012 and for sending commercial messages to e data subject via electronic means pursuant to Act No. 480/2004 Coll. This agreement should not exceed 5 years and cancelled at any time upon request. Summarized data from is form may be used by e administrator for statistical purposes and for internal use by e administrator. Statement by Administrator The data administrator declares at ey will collect personal data to e extent necessary to accomplish e intended purpose and may be processed only in accordance wi e purpose for which ey were collected. Employees of e administrator or oer individuals who process personal data under contract wi e administrator and oer persons are obliged to maintain e confidentiality of personal data, even after termination of employment or work. Responsibility The participant acknowledges at he/she has no right to lodge damage claims against e organisers should e holding of e symposium be hindered or prevented by unexpected political or economic events or generally by force majeure, or should e non-appearance of speakers or oer reasons necessitate programme changes. Wi registration, e participant accepts is proviso. 7 6 International Symposium on MDS and Bone Marrow Failure Syndromes in childhood Prague, November 7-9, 2012

9 ACCOMMODATION Hotel Single Double Location Distance from e venue DIPLOMAT **** MASARYK DORMITORIES ***/** DENISA **** 114 EUR 74 EUR 78 EUR 114 EUR 86 EUR 88 EUR Prague 6 Prague 6 Prague 6 venue 1 minute, across e street 5 minutes walk Fees are including VAT 14 %. Accommodation Guidelines Rooms at special symposium rates are being held in Diplomat hotel Prague and hotels of different categories close to e venue. Rooms will be allocated on a first come, first served basis. Participants are recommended to reserve e accommodation by October 3, After is deadline requests will be accepted; however, hotel rooms are subject to availability and cannot be guaranteed. However, all hotels are located wiin walking distance. To make a reservation please use our Online registration & booking system. Reservations by phone cannot be processed. Confirmation of Reservation After completing e hotel booking, e participant will receive a system notification at e reservation request was received. Confirmation of e hotel booking (a hotel voucher) will be issued only after pre-payment is received and will be sent to e participant by togeer wi an invoice. The hotel voucher should be presented to e hotel reception during check-in. A final invoice will be issued by Symposium Secretariat CZECH-IN (for full pre-payment) and e respective hotel (for e extras). Local hotels will issue e bill in local currency (Czech Crowns) according to e daily exchange rate stated by e Czech National Bank. Payment Ÿ credit card (Visa, Eurocard/Mastercard) Ÿ bank transfer KOMERCNÍ BANKA a.s. Bank Address: Na Příkopě 33, CZ Prague 1, Czech Republic IBAN Number: CZ BIC Code: KOMBCZPPXXX Beneficiary: CZECH-IN s.r.o. Full pre-payment is e only payment option. Bank transfers will be accepted until October 15, 2012 only. Please do not complete e bank transfer before availability of requested room is confirmed by e Symposium Secretariat. Please include PRN (Participant s Registration Number) as e variable symbol to identify your payment. Please, forward a copy of e transfer stating e participant s name. All extras must be settled directly wi e hotel upon departure. Cancellation Conditions Cancellations/changes must be made in writing ( or fax) to Symposium Secretariat CZECH-IN. Cancellations/changes made by phone cannot be accepted. Please do not contact e hotels directly as reservations are held by CZECH-IN. In case of later arrival oer an e reserved dates please inform Symposium Secretariat - CZECH-IN in order to guarantee e room. Cancellation will be charged according to e Cancellation conditions below: For hotel reservations cancelled: Ÿ As of e date e booking is made till October 3, 2012 e deposit of 1 night will NOT be refunded. Ÿ After October 3, 2012 all nights as reserved will be charged and no refund will be made (CZECH-IN holds e right to charge your credit card for e rest of e nights OR not to refund e full pre-payment). In case of no-show or later arrival or earlier departure oer an reserved dates, all nights as reserved will be charged. Reimbursement will be processed after e symposium. 8

HOTELS Diplomant **** Evropská 15, CZ-160 00 Prague 6 Diplomat Hotel Prague **** is

and right next to e underground station Dejvicka (A line).

is located 2 subway stop from Charles Bridge and Old Town.

is close by and all e most important sights of e city can be easily reached.

Masaryk Dormitories ***/** Thákurova 1, CZ-160 00 Praha 6 Masarykova dormitory is

10 HOTELS Diplomant **** Evropská 15, CZ Prague 6 Diplomat Hotel Prague **** is situated in a very calm area of Prague just a few steps from e very famous Prague Castle and right next to e underground station Dejvicka (A line). Also e Prague international airport is easily reachable by public transportation or by car in approximately 20 minutes. Hotel Denisa **** Národní obrany 33, CZ Praha 6 Newly reconstructed hotel Denisa, is located 2 subway stop from Charles Bridge and Old Town. Wenceslas Square, e main Prague boulevard wi many shops, restaurants and open-air markets is close by and all e most important sights of e city can be easily reached. The metro station is 200m from e hotel, e airport is reachable in just 10 minutes. Masaryk Dormitories ***/** Thákurova 1, CZ Praha 6 Masarykova dormitory is renovated building wiin e main campus complex in Dejvice. The rents for private apartments are considerably higher an ose of student dorms. 9 6 International Symposium on MDS and Bone Marrow Failure Syndromes in childhood Prague, November 7-9, 2012

EXHIBITION & SPONSORHIP There will be an exhibition organised as a part of e symposium.

Secretariat Filip Psota CZECH-IN s.r.o. 5.

org Tel: +420 261 174 305 SYMPOSIUM DINNER Restaurant Vikarka Date: November 8, 2012 Time: 19:00 Price:

Vikarka restaurant located at Prague castle complex.

11 EXHIBITION & SPONSORHIP There will be an exhibition organised as a part of e symposium. The detailed exhibitor services kit and Invitation to Industry can be obtained from: Symposium Secretariat Filip Psota CZECH-IN s.r.o. 5. kvetna 65, Prague 4 Czech Republic Exhibition@ewogmds2012.org Tel: SYMPOSIUM DINNER Restaurant Vikarka Date: November 8, 2012 Time: 19:00 Price: 70 EUR EWOG-MDS symposium 2012 will not only be about science, but ere will be also time for party. Sign up for is event and enjoy a fantastic evening in e company of your friends and colleagues. We will offer an exquisite blend of excellent food and entertainment at e mediaeval atmosphere of Vikarka restaurant located at Prague castle complex. Part of e dinner is short tour around Prague Castle complex. To buy a ticket please use e online registration form (if you are already registered to e Symposium, use your current login, select "I am already registered" option in Step 1 and reserve your ticket(s) in Step 2). 10

GUIDED TOURS Grand Tour of Prague Friday, November 9, 2012 14:00-18:00 The insightful historical tour lets you enjoy e city s most famous sights.

It established itself as e spiritual centre of e Bohemian sovereigns from 9 century and since 1918 (foundation of Czechoslovakia) it has served as e residence of presidents. A visit to St.

Winding down to Lesser Town where you will cross e famous Charles Bridge and continue to discover remarkable monuments in e Old Town area.

12 GUIDED TOURS Grand Tour of Prague Friday, November 9, :00-18:00 The insightful historical tour lets you enjoy e city s most famous sights. The tour starts at Prague Castle (Hradčany), registered as e biggest castle complex in e world. It established itself as e spiritual centre of e Bohemian sovereigns from 9 century and since 1918 (foundation of Czechoslovakia) it has served as e residence of presidents. A visit to St. Vitus Caedral is included. The tour en follows e Royal Route, e former promenade of kings and part of e official coronation by foot. Winding down to Lesser Town where you will cross e famous Charles Bridge and continue to discover remarkable monuments in e Old Town area. This remarkable journey ends in front of e Old Town City Hall wi its extraordinary astronomical clock. Please kindly note THIS IS A WALKING TOUR! Price per person: 39 EUR- partly - visit of St.Vitus caedral Duration: 4 hours Including A/C coach transfer to e Prague Castle and en from e city centre to e Prague Congress Centre, English speaking guide. Old Town and Jewish Quarter Friday, November 9, :00-17:00 This historical tour of e Old Town of Prague lets you enjoy e city s most famous sights such as e Powder Tower, e Estate Theatre, e Charles University, e Old Town Square, e Charles Bridge wi e Prague Castle Panorama, e Jewish Quarter and oer sights. You will discover astonishing history of e Jewish community in Prague, which can be traced back to e middle of e 10 century. Miraculously many outstanding monuments have remained intact rough WWII. The visit includes e Jewish Museum located in Prague Synagogues and Old Jewish Cemetery. Price per person: 50 EUR Duration: 3 hours Including A/C coach transfer to/from e city centre to e Prague Congress Centre, English speaking guide. Prague Castle in Detail Saturday, November 10, :00-13:00 The Prague Castle, an ancient symbol of e Czech lands, is e most significant Czech monument and one of e most important cultural institutions in e Czech Republic.The Prague Castle was most likely founded in around 880 by Prince Bořivoj of e Přemysl Dynasty (Přemyslovci). According to e Guinness Book of World Records, e Prague Castle is e largest coherent castle complex in e world, wi an area of almost 70,000 m2. A UNESCO World Heritage site, it consists of a large-scale composition of palaces and ecclesiastical buildings of various architectural styles, from Roman-style buildings from e 10 century rough Goic modifications in e 14 century. A visit includes: Old Royal Palace, Golden Lane, Bazilik of St. Georg, and St. Vitus Caedral. The tour en follows e Royal Route, e former promenade of kings and part of e official coronation by foot. Winding down to Lesser Town and ends e famous Charles Bridge. Please kindly note THIS IS A WALKING TOUR! Price per person: 49 EUR (incl. Prague Castle Old Royal Palace, St. Vitus Caedral, Golden lane) Duration: 4 hours Including A/C coach transfer to e Prague Castle and en from e city centre to e Prague Congress Centre, English speaking guide International Symposium on MDS and Bone Marrow Failure Syndromes in childhood Prague, November 7-9, 2012

13 SEE YOU IN PRAGUE IN NOVEMBER 2012! For more information please contact Symposium secretariat CZECH-IN s.r.o. 5. kvetna 65 CZ Prague 4 Czech Republic Tel.: info@ewogmds2012.org

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