Mayo Clinic Hospital Pharmacy Services. Rotation Summary
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1 Mayo Clinic Hospital Pharmacy Services Rotation Summary Rotation Title: Pediatric Infectious Disease Rotation Length: 6 weeks Primary Preceptors Names: Brian Gardner, Bernard Lee, Ron Sieve Phone: Hours: General Description: The Mayo Eugenio Litta Children s Hospital is a Hospital within a Hospital model based at the Saint Marys campus in Rochester, MN. The Children s Hospital is a 130-bed hospital that includes a General Care Area, Pediatric Intensive Care Unit, Neonatal Intensive Care Unit (level II and level III), Pediatric Transplant Unit, and a Pediatric Infusion Therapy Center. The General Care Area cares for a variety of medical and surgical patients. The General Pediatric Service is the primary Internal Medicine Service for the Children s Hospital and cares for a various types of medical patients ranging from routine childhood illnesses to rare complex disease states. The Pediatric Intensive Care Unit (PICU) is a 14-bed medical/surgical intensive care unit designed to provide care to critically ill pediatric patients. A wide variety of patients including multiple surgical subspecialty patients, trauma, oncology, cardiology, metabolic, neurology, pulmonology, ENT, and endocrine patients are routinely treated. The Pediatric Critical Care Service is the primary care service for all medical patients in the PICU. They also co-manage all patients in the adjoining 4 bed Pediatric Transplant Unit. Pediatric patients undergoing solid organ and stem cell/bone marrow transplant are cared for in the Pediatric Transplant Unit. The Neonatal Intensive Care Unit (NICU) is a 56-bed unit allowing for care of level II and level III neonates. Thirty beds are located at Saint Mary s Hospital which house level II and level III neonates. In addition, 26 beds are located at Rochester Methodist Hospital and house primarily level II neonates. A majority of the patients in the NICU are low birth weight or very low birth weight. Neonates with congenital surgical issues and congenital medical issues are also cared for in the NICU. Many babies are transported to the NICU from Rochester Methodist Hospital shortly after their premature birth; however, we do also admit babies born at other outside hospitals. The Medical Neonatal Service is the primary service for all patients in the NICU. The Pediatric Infectious Diseases Service is a consulting service to patients in the Children s Hospital, and to all pediatric patients cared for in other areas of Saint Marys and Rochester Methodist Hospitals, such as the post-op cardiac surgery and rehabilitation areas.
2 Disease States: The resident will be responsible for developing a knowledge base pertaining to the following pediatric disease states. This knowledge base should include, but will not be limited to etiology, epidemiology, pathogenesis, clinical presentation, diagnostic criteria, prognosis, common medication treatment regimens, therapeutic goals, pharmaceutical care monitoring parameters, and most up to date literature associated with medical conditions and their treatment of the following: Meningitis / Encephalitis Epiglottitis / Empyema Endocarditis Clostridium difficile enterocolitis Cellulitis / Skin & Soft Tissue Infection (SSTI) Osteomyelitis / Septic Arthritis Postoperative infectious prophylaxis Catheter-Related Bloodstream Infections Immunizations Neutropenic Fever / Fever of Unknown Origin (FUO) Pneumocystis jiroveci (PCP) / Cytomegalovirus (CMV) Candida Infection / Aspergillosis Mycobacterium Infections Parasitic Infections Septic shock/toxic shock The resident will be responsible for developing a knowledge base about the following antimicrobials as pertains to the pediatric patient and disease states above. This knowledge base should include, but will not be limited to; indications, pharmacology, dosing, and adverse reactions. Tobramycin Aminoglycosides Amikacin / Gentamicin / Streptomycin / Antifungals Amphotericin B deoxycholate and lipid formulations / Nystatin Flucytosine Fluconazole / Itraconazole / Ketoconazole / Voriconazole Caspofungin / Micafungin / Anidulafungin Meropenem Antivirals Acyclovir / Valacyclovir / Ganciclovir / Valganciclovir Oseltamavir / Zanamavir Foscarnet Cidofovir Carbapenems Ertapenem / Imipenem/Cilastatin / Cephalosporins Cephalexin / Cefadroxil / Cefazolin Cefuroxime / Cefprozil / Cefaclor & Cefoxitin / Cefotetan Cefotaxime / Ceftriaxone / Ceftizoxime & Ceftazidime Cefpodoxime / Cefixime / Ceftibuten / Cefdinir / Cefditoren Cefepime Isoniazid / Pyrazinamide / Ethambutol Immune Globulins / Antibodies IVIG / CMV IG Palivizumab / Motavizumab Macrolides Azithromycin / Clarithromycin / Erythromycin Metronidazole Clavulanate Vaccines Nebulized antibiotics Tobramycin Colistin Nitrofurantoin Penicillins Ampicillin & Ampicillin / Sulbactam Dicloxacillin / Oxacillin / Nafcillin Penicillin G / V Piperacillin / Tazobactam & Ticarcillin / Fluoroquinolones Ofloxacin / Ciprofloxacin Levofloxacin / Moxifloxacin Tetracyclines Doxycycline / Tetracycline / Minocycline Tigecycline Trimethoprim/sulfamethoxazole Glycopeptides Vancomycin Dalbavancin / Telavancin Oxazolidinones Linezolid Rifamycins Rifampin / Rifabutin Rifaximin Goals Selected:
3 R1.4: Demonstrate ownership of and responsibility for the welfare of the patient by performing all necessary aspects of the medication-use system. R1.4.1: Display initiative in preventing, identifying, and resolving pharmacy-related patient-care problems. R1.5: Provide concise, applicable, comprehensive, and timely responses to requests for drug information from patients and health care providers. R1.5.1: Discriminate between the requesters' statement of need and the actual drug information need by asking for appropriate additional information. R1.5.2: Formulate a systematic, efficient, and thorough procedure for retrieving drug information. R1.5.3: Determine from all retrieved biomedical literature the appropriate information to evaluate. R1.5.4: Evaluate the usefulness of biomedical literature gathered. R1.5.5: Formulate responses to drug information requests based on analysis of the literature. R1.5.6: Provide appropriate responses to drug information questions that require the pharmacist to draw upon his or her knowledge base. R1.5.7: Assess the effectiveness of drug information recommendations. R2.1: As appropriate, establish collaborative professional relationships with members of the health care team. R2.1.1: Implement a strategy that effectively establishes cooperative, collaborative, and communicative working relationships with members of interdisciplinary health care teams. R2.2: Place practice priority on the delivery of patient-centered care to patients. R2.2.1: Choose and manage daily activities so that they reflect a priority on the delivery of appropriate patient-centered care to each patient. R2.4: Collect and analyze patient information. R2.4.1: Collect and organize all patient-specific information needed by the pharmacist to prevent, detect, and resolve medication-related problems and to make appropriate evidence-based, patient-centered medication therapy recommendations as part of the interdisciplinary team. R2.4.2: Determine the presence of any of the following medication therapy problems in a patient's current medication therapy: (1) Medication used with no medical indication; (2) Patient has medical conditions for which there is no medication prescribed; (3) Medication prescribed inappropriately for a particular medical condition; (4) Immunization regimen is incomplete; (5) Current medication therapy regimen contains something inappropriate (dose, dosage form, duration, schedule, route of administration, method of administration); (6) There is therapeutic duplication; (7) Medication to which the patient is allergic has been prescribed; (8) There are adverse drug or device-related events or potential for such events; (9) There are clinically significant drug-drug, drug-disease, drug-nutrient, or drug-laboratory test interactions or potential for such interactions; (10) Medical therapy has been interfered with by social, recreational, nonprescription, or nontraditional drug use by the patient or others; (11) Patient not receiving full benefit of prescribed medication therapy; (12) There are problems arising from the financial impact of medication therapy on the patient; (13) Patient lacks understanding of medication therapy; (14) Patient not adhering to medication regimen. R2.4.3: Using an organized collection of patient-specific information, summarize patients health care needs. R2.6: Design evidence-based therapeutic regimens. R2.6.1: Specify therapeutic goals for a patient incorporating the principles of evidence-based medicine that integrate patient-specific data, disease and medication-specific information, ethics, and quality-of-life considerations. R2.7: Design evidence-based monitoring plans. R2.7.1: Design a patient-centered, evidence-based monitoring plan for a therapeutic regimen that effectively evaluates achievement of the patient-specific goals. R2.8: Recommend or communicate regimens and monitoring plans. R2.8.1: Recommend or communicate a patient-centered, evidence-based therapeutic regimen and corresponding monitoring plan to other members of the interdisciplinary team and patients in a way that is systematic, logical, accurate, timely, and secures consensus from the team and patient. R2.9: Implement regimens and monitoring plans. R2.9.1: When appropriate, initiate the patient-centered, evidence-based therapeutic regimen and monitoring plan for a patient according to the organization's policies and procedures. R2.9.2: Use effective patient education techniques to provide counseling to patients and caregivers, including information on medication therapy, adverse effects, compliance, appropriate use, handling, and
4 medication administration. R2.10: Evaluate patients progress and redesign regimens and monitoring plans. R2.10.1: Accurately assess the patient s progress toward the therapeutic goal(s). R2.10.2: Redesign a patient-centered, evidence-based therapeutic plan as necessary based on evaluation of monitoring data and therapeutic outcomes. R2.11: Communicate ongoing patient information. R2.11.1: When given a patient who is transitioning from one health care setting to another, communicate pertinent pharmacotherapeutic information to the receiving health care professionals. R2.11.2: Ensure that accurate and timely medication-specific information regarding a specific patient reaches those who need it at the appropriate time. R2.12: Document direct patient care activities appropriately. R2.12.1: Appropriately select direct patient-care activities for documentation. R2.12.2: Use effective communication practices when documenting a direct patient-care activity. R2.12.3: Explain the characteristics of exemplary documentation systems that may be used in the organization s environment. Activities: Review all patients histories upon consultation to the Pediatric Infectious Diseases Team. Particular attention is paid to the medication/allergy history. If indicated, the resident interviews the patient (or parents) concerning medication and/or allergy history. Identify and prioritize significant current and past medical history. Distinguish which of the problems identified require drug therapy. Current medications and dosing regimens. History of past drug allergies or adverse drug reactions. Past medications used to treat condition. Pertinent normal and abnormal laboratory values. Complete P-CARE section for CC-HPI-PMH (chief complaint, history of present illness, and past medical history) for each patient admission. Evaluate initial medication therapy regimen for appropriateness. Focus is paid, but not limited to antimicrobial therapy. Know the pharmacology of each drug used. Know the indication for each drug used Assess drug selection given the patient s medical problem list, gestational age, contraindications, and drug interactions. Evaluate dose given the patient s organ function, age, gestational age, weight, and potential drug interactions. Determine if route and method of administration is optimal for patient s needs. Evaluate regimen for therapeutic duplications or omissions Develop an antimicrobial drug therapy-monitoring plan. Determine parameters (objective and subjective) to monitor for efficacy and/or toxicity. Determine how often each monitoring parameter should be reviewed. Define acceptable endpoints for therapy. Evaluate the outcomes of implementing the pharmacotherapeutic regimen and modify as needed based on continuous evaluation of data. Gather data as called for in the monitoring plan Compare values of each parameter to the desired values Modify the pharmacotherapeutic regimen as necessary based on evaluation of data Document outcomes of implementing the pharmacotherapeutic regimens and modifications to the regimen Pharmacokinetic consultation on any medications monitored by serum levels. Aminoglycosides, Vancomycin, azoles, etc. Documentation Review all infectious disease/antimicrobial monitors for patients being followed by the Pediatric Infectious Disease Service. Goals/ Objective: R2.4 R2.4 R2.6 R2.7 R2.4 R2.10 R2.6 R2.7 R2.12
5 Document all of the above activities in P-Care Document all therapeutic interventions in P-Care Document all patient progress notes in P-Care Document clinical activities in the Electronic Medical Record per Hospital Policy Attend Pediatric Infectious Diseases consultation service rounds daily. Contribute to drug therapy decisions, bring forth medication-related issues, provide drug information, and provide informal medication education as the need arises or is requested. Research therapeutic issues as requested by the Pediatric Infectious Disease staff, nurses, or preceptors. Attend Friday Morning Pediatric Grand Rounds. R1.4 R1.5 R2.2 R2.8 R1.5 Preceptor Interaction: Meet regularly (4-5 days per week) with preceptor to review Pediatric Infectious Diseases patients. Review past medical history, history present illnesses, and pertinent laboratory data as it relates to disease state and therapeutic drug monitoring, evaluate initial drug therapy, identify potential medication related issues, develop and report on monitoring plans for medication therapy, discuss potential modification of therapy base on results of monitoring, identify medication therapeutic endpoints and patient progress towards reaching those endpoints. Participate in disease state or drug specific topic discussions as outlined in rotation objectives with preceptor. Present at least one Pediatric ID related 30 minute in-service to the pharmacy staff or Pediatric Infectious Diseases Service. As an alternative, may develop a specific pharmacy/medication project that pertains to the Pediatric Infectious Diseases Service and their patients. Meet with the preceptor at the midpoint of the rotation for a verbal evaluation and near the end of the rotation for a written evaluation, using Resitrak. Evaluation Strategy ResiTrak will be used for documentation of formal evaluations. For evaluations, resident and preceptor will complete the evaluations separately. The preceptor and the resident will meet to discuss the evaluations. This discussion will provide feedback for both the resident and preceptor on their performance. What type of evaluation Verbal Summative Summative Selfevaluation Preceptor andlearning Experience Evaluations Required Readings: Who Preceptor, Preceptor, When Mid-Rotation End of learning experience End of learning experience End of learning experience Practice Guidelines for the Management of Bacterial Meningitis Clinical Infectious Diseases 2004;39: Diagnosis and management of acute otitis media. Pediatrics 2004;113(5): Aspiration pneumonitis and aspiration pneumonia. NEJM 2001;344(9): Guidelines for the management of intravascular catheter-related infections. CID 2001;32: Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus Aureus Infections in Adults and Children. CID 2011;52(1):1-38 Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: Circulation Jun 14;111(23):e Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med
6 (3) VRE infections. NEJM 2000;342(10): Practice guidelines for the treatment of candidiasis. CID 2000;30: Recommended Immunization Schedules for Persons Aged 0 Through 18 Years - United States, MMWR (51&52)1-4 Resources Available: Pediatric Dosage Handbook, Lexi-comp, 17 th edition , Takemoto CK, Hodding JH, Kraus DM. Pharmacotherapy: A Pathophysiologic Approach, 7 th Edition, Dipiro JT et al. Red Book: 2009 Report of the Committee on Infectious Disease, 28 th Edition, Pickering LK, et al. Goodman and Gilman s the Pharmacological Basis of Therapeutics, 10 th Edition, Hardman JG et al. Mayo Clinic Rochester Antibiogram
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