MORE THAN PATIENT MONITORING. Keith Errey, CEO

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MORE THAN PATIENT MONITORING Keith Errey, CEO Keith.errey@isansys.com

The Challenge: UK Patient Safety & NHS shortages In-hospital deterioration Nearly 10% of patients In-patient adverse events 850,000 Avoidable In-hospital deaths 12,000 Deaths from sepsis 37,000 Unnecessary bed days Total patient safety costs 1.6 Billion 5 billion (at least!) 2

The Solution: Patient Status Engine Measure Model Predict Continuous, Real-time Patient Digitization Vital signs & biomarkers Heart Rate Temperature Respiration Rate SpO2 Blood Pressure Heart Rate Variability Early warning scores Create patient history Progress Measures Continuously Updated Electronic Patient Record Alerts Patient Status Actions Real time notifications = Early Intervention Patient The Clinical Healthcare Cloud Clinician / Carer 3

Transforming Healthcare Delivery Reduce In-hospital patient deterioration and ICU readmission Reduce readmission in first month of discharge Facilitate early transition of care from hospital to home Digitising the patient analytics and big data 4

New Generation Healthcare Medical Devices Clinical Sensors Vital signs Continuous, in real time Clinical Services Early warnings & predictive analytics Service removes complications for providers Price per patient / no upfront costs Healthcare IT/ Big Data Trends Apps & algorithms New clinical understanding 5

New Generation Healthcare Our Business INNOVATION at the intersection Large scale global opportunities Clinical Services Medical Devices Healthcare providers can reduce expenditure improve efficiencies AND Improve patient outcomes Healthcare IT/ Big Data Data & Information Business 5

Isansys Lifecare Limited Enhanced by SBRI Contracts Established April 2010, Offices in Oxfordshire UK and Bangalore India Founded by experienced Digital Health professionals in response to clinical customers 16 strong team includes a world-class engineers, manufacturing, regulatory and global marketing professionals. Up from 8 prior to SBRI. CE marked, IP protected medical device technology, fully audited and regulated to ISO13485 and MDD Delivery contracts with NHS trusts to provide Vitals as a Service for early detection of patient deterioration 6

The Patient Status Engine Platform Innovation In Hospital Digitised Patients Wearable sensors Low power Wireless Connections Wi-Fi Hospital Secure Wi-Fi Network Isansys Server and Data Base (Runs behind hospital firewall) Lifetouch Heart Rate Respiration Rate Heart Rate Variability Lifetemp Temperature New Pulse Oximeter Oxygen Saturation Blood Pressure Low power Wireless Connections Gateways One per bed Real time vital signs Patient charts Device association Relay to Isansys Server Patient data on any authorised device Nurses Station Dashboard API Hospital Server Electronic Health Record Other Patient Data?? Supplied by Hospital or IT Partner 7

The Patient Status Engine Platform At Home Patient @ Home Digitised Patients Wearable connected sensors & mobile app Low power Wireless Connections Wi-Fi/ 3G Secure Wi- Fi/3G/4G Network Isansys Server and Data Base (Runs behind hospital firewall) Lifetouch Heart Rate Respiration Rate Heart Rate Variability Lifetemp Temperature Gateway Mobile device Patient App Collection of vital sign data and analysis (sepsis detection) Relay to Isansys Server Immediate feedback/message/ visit to patient Nurses Station / clinical call center Dashboard API Hospital Server Patient data on any authorised device Electronic Health Record Other Patient Data?? 7

SBRI Phase 1 Contracts Awarded Every Patient Monitored: An expansion of Isansys Patient Status Engine (PSE) to enable a scalable, low cost multiple vital sign patient-data acquisition and analysis platform, for rapid early detection of deterioration and avoidance of adverse events Patient safety category Early Detection of Sepsis in the Community: A repurposing and extension of the Isansys Patient Status Engine (PSE) for early detection of sepsis to avoid hospital admission through primary care interventions for cancer patients undergoing chemotherapy Cancer category 10

SBRI Benefits for Isansys MANY! 100% funded technical and clinical development programmes The customer - the NHS - is the focus. Contracts with Papworth NHS Trust Speed up of key technology that can be used in many applications of our platform Significant increased in the size and quality of our team opened up 8 new positions Increased awareness of the company and our products, leading to a great deal of interest from other technology suppliers and system integrators who would like to partner with us increased interest and credibility with future investors Exposure and increased credibility with prospective customers, particularly NHS 11

Isansys Experiences of SBRI Straightforward, transparent and easy to follow application process The SBRI team are interested, accessible and helpful - and we know who they are! 100% funding is very nice! Light touch project monitoring. Project reporting requirements are appropriate for the size of the projects and the company s management resources ( i.e. not overly onerous or bureaucratic Focus is on getting new products and technology into the NHS to improve care and reduce inefficiency Far and away the best funding mechanism I have ever seen! 12