CHAPTER ONE: EXECUTIVE SUMMARY Introduction Scope and Methodology Product Details End-Users Hospitals Home Health Nursing Homes Other Markets Issues

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1 CHAPTER ONE: EXECUTIVE SUMMARY Introduction Scope and Methodology Product Details End-Users Hospitals Home Health Nursing Homes Other Markets Issues and Trends Size and Growth of the Market Competitors CHAPTER TWO: INTRODUCTION Overview Aging of the Population Population Statistics Global Population Trends Global Population over 65 U.S. Population Trends U.S. Population over 65 Global Trends in Life Expectancy Barriers to Use of New Technologies in Patient Monitoring Emerging Trends Cloud-Based Mobile Healthcare Cloud Connectivity and Compatibility Healthcare Establishments Hospitals U.S. Hospital Segment Hospital Systems around the World Physicians Number of Physicians Nursing Homes International Trends in Nursing Facilities Home Health Proven Cost Effectiveness CHAPTER THREE: ADVANCED REMOTE PATIENT MONITORING PRODUCTS Overview New Technologies Wireless Technologies Smartphones in Healthcare Benefits of Healthcare Smartphones Challenges in the Implementation of Smartphones in Healthcare Settings Remote Monitoring Telemedicine Applications by Disease State

2 Global Cancer Incidence Global Cardiovascular Disease Rates Global Impact of Diabetes Global Obesity Rates by Population EMR (EHR) Data Transfer Applications and Equipment Technology Achievements Implantable Medical Devices Technology for Drug Adherence, Targeted Delivery, and Monitoring Mobile Medical Applications and Patient Monitoring Nanobots Product Segments with Advanced Technologies Vital Signs Monitoring Devices Blood Pressure Monitors Pulse Oximeters Temperature Diagnostic Monitoring ECG/EKG Spirometry Ultrasound Specialized Monitoring Anesthesia Monitoring Cardiovascular Disease Monitoring Cancer Treatment Monitors Diabetes Monitors Fetal Heart Monitors Osteoarthritis Prothrombin Time Monitors Respiratory Monitors Sleep Disorder Monitors Product Offerings Examples of Company Offerings Abbott American Medical Development (AMD) Telemedicine Products American TeleCare Bosch Healthcare Boston Scientific Cardiocom Carematix Covidien Cybernet Medical Corporation Draeger Medical GE Healthcare GlobalMed Honeywell HomMed Intel InTouch Health

3 InTechnology Johnson & Johnson LifeWatch Technologies Masimo Corporation MedApps Medtronic Mindray Nihon Kohden Omron Corporation OSI Systems Philips Medical Systems Roche Second Opinion Telehealth Solutions, Inc. St. Jude Medical Welch Allyn CHAPTER FOUR: COMPETITOR TRENDS AND MARKET SHARE ANALYSIS Overview Acquisitions and Agreements Abbott Laboratories Alere Covidien GE Healthcare GlobalMed Medtronic Philips Healthcare Welch Allyn Competitor Market Analysis Philips Healthcare Medtronic Covidien Roche St. Jude Medical GE Healthcare Johnson & Johnson Omron Draeger Boston Scientific Abbott Laboratories Nihon Kohden Masimo Corporation Mindray OSI Systems Other Companies CHAPTER FIVE: ISSUES AND TRENDS Introduction Issues and Trends Driving the Market

4 Aging of the Population Increasing Life Expectancy and the Demand for Advanced Healthcare Delivery Options Global Healthcare Trends General Economic Trends by Country U.S. Health Industry Trends U.S. Healthcare Challenges Economic Trends in the U.S. U.S. Health Expenditures by Type Health Information Technology and American Reinvestment and Recovery Act of 2009 (ARRA) Meaningful Use Criteria Stages of Meaningful Use Qualifying for Stage One Meaningful Use HIPAA Medicine-At-Work Healthcare Efficiency Electronic Medical Records Overview of EMRs EMR Adoption Are Electronic Healthcare Systems More Efficient? The EMR and Mobile Apps Hospital Communications Remote Monitoring Capacity Constraints Emphasis on Reducing Hospital Days Decreasing Healthcare Resources Nursing Shortage eicu eicu Case Study Opportunities in Telemedicine/Telemedicine Mental Health Assessment Through Telemedicine Post-Traumatic Stress Disorder (PTSD) Improving the U.S. Mental Care Environment Mental Disorder Statistics Suicide Growing Acceptance of Mobile Technologies North America Europe South America Asia-Pacific Internet Users and Growing Adoption of Technology Development of Patient Monitoring Technologies Audio and Video Algorithms to Sort Data or Trigger Alarms Alarm Fatigue Off-site Access to Data

5 Full-service Outsourcing Converged Wireless Networks Data Management and the Electronic Medical Record Turnkey Systems Disease Management Kits FCC Rules for Medical Wireless Communication System Compatibility CHAPTER SIX: GLOBAL MARKET SIZE AND FORECAST Overview Total Global Market Size and Forecast Global Markets by Product Type Vital Sign Monitoring Diagnostic Monitoring Specialized or Disease-Specific Monitoring End-User Markets The Global Telemedicine Market Global Hospital and Acute Care Patient Monitoring Market Global Markets by Region Market Drivers and Inhibitors Growth Drivers Growth Inhibitors Emerging Trends CHAPTER SEVEN: U.S. MARKET SIZE AND FORECAST Overview Total U.S. Market Size and Forecast Markets by Product Type Vital Sign Monitoring Diagnostic Monitoring Specialized or Disease-Specific Monitoring Markets by Major Disease Asthma Cancer COPD Diabetes Heart Conditions Other End-User Markets Hospitals/Acute Care Centers Home Health/Telemedicine CHAPTER EIGHT: CASE STUDIES Overview Examples of Implemented Technologies Honeywell's LifeStream View St. Alexius Medical Center (SAMC) Telemedicine Project Ottawa Hospital--Ottawa, Ontario Philips ICU Telemedicine Program

6 Southeast Alabama Medical Center--Dothan, Alabama Meridian Health New Jersey Mount Sinai Hospital and the University Health Network (UHN) New York, New York Sentara Healthcare Norfolk, Virginia Provena Health--Mokena, Illinois The Whole Child Pediatrics P.S.C. Florence, Kentucky Remote Monitoring with Honeywell HomMed Rural Wireless Healthcare: 3G Mobile Medicine CHAPTER NINE: CORPORATE PROFILES Introduction Profiles Abbott Laboratories Aerotel Medical Systems Alere AMD Global Telemedicine American TeleCare AuthentiDate Relevant B. Braun Baxter Bosch

7 Boston Scientific C.R.Bard Cardiocom Carematix Compumedics Covidein Criticare Systems Cybernet Medical Dräger Medical GE Healthcare Getinge Group GlobalMed Group Hoana Medical Honeywell HomMed

8 Infinium Medical InTechnology Intel Corporation InTouch Health Johnson & Johnson Masimo Mindray Nihon Kohden Omron Healthcare OSI Systems

9 Proteus Digital Health Roche Second Opinion Telehealth Schiller Smiths Medical St. Jude Medical Welch Allyn APPENDIX A: REGULATORY AUTHORITIES AND ORGANIZATIONS..375 APPENDIX B: LIST OF COMPANIES LIST OF EXHIBITS EXECUTIVE SUMMARY Table 1-1 The U.S. Market for Advanced Remote Patient Monitoring Systems Figure 1-1 The Global Market for Advanced Remote Patient Monitoring Systems Figure 1-2 Advanced Remote Patient Monitoring Systems Market Share by Company INTRODUCTION Table 2-1 The Global Population, Figure 2-1 The Global Population, Table 2-2 Global Population Trends Age 65+, Figure 2-2 Global Population Trends Age 65+, Table 2-3 The U.S. Population, Figure 2-3 The U.S. Population, Table 2-4

10 Percent U.S. Population Over Age 65 by Year, Figure 2-4 United States Population Trend Age 65+, Table 2-5 Average Life Expectancy in Years by Country 1980 and 2012 Figure 2-5 Average Life Expectancy in Years by Country 1980 and 2012 Figure 2-6 Most Significant Barriers to Implementing IT, 2011 vs Table 2-6 U.S. Registered Hospitals by Type, 2011 Figure 2-7 Distribution of U.S. Registered Hospitals by Type, 2011 Figure 2-8 Number of Hospitals in the US, , Estimated 2015 Table 2-7 Leading For-Profit U.S. Hospital Chains, 2008 and 2010 Table 2-8 Registered Hospitals and Acute Care Centers by Country Figure 2-9 Registered Hospitals and Acute Care Centers by Country Figure 2-10 Number of Physician Offices, Table 2-9 Medical Doctors per 1,000 Population by Country Figure 2-11 Number of Nursing Homes (United States), Table 2-10 US Nursing Homes, Beds and Residents Table 2-11 Estimated Nursing Service Establishments and Care Centers by Country Figure 2-12 Growth in Hosptice Programs Figure 2-13 Patrons Served in Hospice, Table 2-12 Percentage Hospice Admissions by Diagnosis, ADVANCED REMOTE PATIENT MONITORING PRODUCTS Table 3-1 U.S. Prevalence of Selected Medical Conditions Figure 3-1 U.S. Prevalence of Selected Medical Conditions Table 3-2 Total Cancer Incidence by Sex and Country Figure 3-2 Total Cancer Incidence by Sex and Country

11 Table 3-3 Obesity Rates by Country 2000 and 2010 Figure 3-3 Obesity Rates by Country 2000 and 2010 Table 3-4 Categories for Blood Pressure Levels in Adults Table 3-5 Oxygen Saturation Levels and Normal Heart Rates by Age Table 3-6 Select Patient Monitoring Systems February 2013 CHAPTER FOUR: COMPETITOR TRENDS AND MARKET SHARE ANALYSIS Table 4-1 Competitor Analysis, Global Advanced Remote Patient Monitoring Equipment and Devices, 2012 CHAPTER FIVE: ISSUES AND TRENDS Table 5-1 Total Healthcare Expenditures as a Percent of GDP by Country 1990, 2000 and 2010 Figure 5-1 Total Healthcare Expenditures as a Percent of GDP by Country 1990, 2000 and 2009 Table 5-2 Average Annual Growth of GDP by Country Table 5-3 National Healthcare Expenditures in the United States Figure 5-2 Healthcare Spending as a Percent of GDP in the United States, Table 5-4 National Health Expenditure Amounts, by Type of Expenditure: Calendar Years Table 5-5 Stages of Meaningful Use Figure 5-3 Percent of Organizations that Expect to Qualify for Stage One Meaningful Use Figure 5-4 Percent of U.S. Hospitals Reporting Security Breach of IT System, 2011 and 2012 Figure 5-5 Top Concerns -- Security of Computerized Medical Information, 2011 and 2012 Table 5-6 Percent of Office-based Physicians Using EMRs, * Figure 5-6 Percent of Office-based Physicians Using EMRs, by Level of EMR System, Table 5-7 State Data: Percent of Office-based Physicians Using EMRs, Preliminary 2010 Figure 5-7 Percent of U.S. Hospitals Reporting ED Capacity Issues by Type of Hospital, Current Survey March 2010 Figure 5-8

12 Percent of U.S. Hospitals Reporting ED Diversion in Last 12 Months by Type of Hospital, Current Survey March 2010 Figure 5-9 Percent of U.S. Hospitals Citing Factor as Number One Reasons for ED Diversion, Current Survey March 2010 Table 5-8 U.S. Hospital Length of Stay, Average by Age Group Figure 5-10 U.S. Hospital Length of Stay, Average by Age Group Table 5-9 Average International Length of Stay, by Country 2010 Figure 5-11 Average International Length of Stay, by Country 2010 Table 5-10 Mental Disorder Statistics in the U.S. Figure 5-12 Mental Disorders by Type in the U.S. Figure 5-13 Suicides Rates by Sex and Country, 2008 Table 5-11 Cellular Phone Subscribers by Country Figure 5-14 Internet Users per 100 Inhabitants, 2010 Figure 5-15 Access to On-Line Patient Information from Remote Location, 2011 and 2012 CHAPTER SIX: GLOBAL MARKET SIZE AND FORECAST Table 6-1 The Global Market for Advanced Remote Patient Monitoring Systems Figure 6-1 The Global Market for Advanced Remote Patient Monitoring Systems Table 6-2 The Global Market for Advanced Vital Sign Monitoring Systems Figure 6-2 The Global Market for Advanced Vital Sign Monitoring Systems Figure 6-3 Distribution of Sales for Global Advanced Vital Sign Monitoring Systems, 2012 Table 6-3 The Global Market for Advanced Diagnostic Monitoring Systems Figure 6-4 The Global Market for Advanced Diagnostic Monitoring Systems Figure 6-5 Distribution of Sales for Global Advanced Diagnostic Monitoring Systems, 2012 Table 6-4 The Global Market for Advanced Specialized/Disease Specific Monitoring Systems Figure 6-6

13 The Global Market for Advanced Specialized/Disease Specific Monitoring Systems Figure 6-7 Distribution of Sales for Global Advanced Specialized/Disease Specific Monitoring Systems, 2012 Table 6-8 The Global Market for Advanced Remote Patient Monitoring Systems, by End User (Hospitals/Acute Care and Home Health/Mobile Care) 2012 Table 6-5 The Global Telemedicine Market Figure 6-9 Growth in Global Telemedicine Market Table 6-6 The Global Hospital and Acute Care Monitoring Market Figure 6-10 Growth in Global Hospital and Acute Care Monitoring Market Table 6-7 Global Market for Advanced Remote Patient Monitoring, 2012 Figure 6-11 Global Market for Advanced Remote Patient Monitoring, 2012 CHAPTER SEVEN: U.S. MARKET SIZE AND FORECAST Table 7-1 The U.S. Market for Advanced Remote Patient Monitoring Systems Figure 7-1 The U.S. Market for Advanced Remote Patient Monitoring Systems Table 7-2 U.S. Advanced Remote Patient Monitoring Market by Product Type 2012 Figure 7-2 The U.S. Market for Advanced Remote Patient Monitoring Systems, by Technology Type, 2012 Table 7-3 U.S. Advanced Remote Patient Monitoring Market by Disease Type 2012 Figure 7-3 The U.S. Market for Advanced Remote Patient Monitoring Systems, by Disease, 2012 Table 7-4 U.S. Advanced Remote Patient Monitoring Market Forecast by Disease Type 2017 Figure 7-4 The U.S. Market Forecast for Advanced Remote Patient Monitoring Systems, by Disease, 2017 Table 7-5 The U.S. Market for Advanced Remote Patient Monitoring Systems, by End User (Hospitals/Acute Care and Telemedicine) Figure 7-5 The U.S. Market for Advanced Remote Patient Monitoring Systems, by End User (Hospitals/Acute Care and Telemedicine) Table 7-6

14 The U.S. Market for Advanced Remote Patient Monitoring Systems, by End User (Hospitals/Acute Care and Telemedicine) 2012 Table 7-7 The U.S. Market for Advanced Remote Patient Monitoring Systems, by End User (Hospitals/Acute Care and Telemedicine) 2017 CHAPTER EIGHT: CASE STUDIES Table 8-1 Results of St. Alexius Medical Center Telemedicine Project CHAPTER NINE: CORPORATE PROFILES Figure 9-1 United States Utility by Country of Origin Figure 9-2 Abbott's Financial Performance, Figure 9-3 Alere's Financial Performance, Figure 9-4 AuthentiDate's Financial Performance, Figure 9-5 B Braun's Financial Performance, Figure 9-6 Baxter's Financial Performance, Figure 9-7 Bosch's Financial Performance, Figure 9-8 Boston Scientific's Financial Performance, Figure 9-9 C.R. Bard's Financial Performance, Figure 9-10 Compumedics' Financial Performance, Figure 9-11 Covidien's Financial Performance, Figure 9-12 Dräger's Financial Performance, Figure 9-13 General Electric's Financial Performance, Figure 9-14 Getinge's Financial Performance, Figure 9-15 Honeywell's Financial Performance, Figure 9-16 InTechnology's Financial Performance, Figure 9-17 Intel's Financial Performance, Figure 9-18 Johnson & Johnson's Financial Performance, Figure 9-19

15 LifeWatch's Financial Performance, Figure 9-20 Masimo's Financial Performance, Figure 9-21 Medtronic's Financial Performance, Figure 9-22 Mindray's Financial Performance, Figure 9-23 Nihon Kohden's Financial Performance, Figure 9-24 Omron's Financial Performance, Figure 9-25 OSI System's Financial Performance, Figure 9-26 Royal Philips Electronics' Financial Performance, Figure 9-27 Roche's Financial Performance, Figure 9-28 Smiths Group's Financial Performance, Figure 9-29 St. Jude's Financial Performance,

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