Mcubed. Revolutionary seed funding that de-risks institutional investment

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Mcubed Revolutionary seed funding that de-risks institutional investment Mark Burns TC Chang Professor of Engineering Executive Director of Mcubed and Research Innovation Office of the Vice President for Research University of Michigan Ann Arbor, MI

What is important in advancing university research? World-class faculty, students, and staff Cutting-edge research facilities Key partners in industry, foundations, and government Diversity of cultures and thought Available resources to initiate research

What is important in advancing university research? World-class faculty, students, and staff Cutting-edge research facilities Key partners in industry, foundations, and government Diversity of cultures and thought Available resources to initiate research >>>> How can we acquire and strategically distribute those resources to research teams?

NSF university research expenditure data 80,000 10-Year Increase in Expenditures (in $M) 70,000 60,000 50,000 40,000 30,000 20,000 10,000 0 All R&D Expenditures Fed Gov State/local Institution Business Other 2006 2016

10-year % increase NSF university research expenditure data 120% % Increase in expenditures, 2006-2016 100% 80% 60% ~$50 to ~$70B (2006-2016) 40% 20% 0% All R&D Expenditures Fed Gov State/local Institution Business Other

10-year % increase NSF university research expenditure data 120% % Increase in expenditures, 2006-2016 100% 80% 60% ~$50 to ~$70B (2006-2016) 40% 20% 0% All R&D Expenditures Fed Gov State/local Institution Business Other

10-year % increase NSF university research expenditure data 120% % Increase in expenditures, 2006-2016 100% 80% 60% ~$50 to ~$70B (2006-2016) 40% 20% 0% All R&D Expenditures Fed Gov State/local Institution Business Other

10-year % increase NSF university research expenditure data 120% % Increase in expenditures, 2006-2016 100% 80% 60% ~$50 to ~$70B (2006-2016) 40% 20% 0% All R&D Expenditures Fed Gov State/local Institution Business Other

All institutions Johns Hopkins U. U. Michigan, Ann Arbor U. Pennsylvania U. California, San Francisco U. Washington, Seattle U. Wisconsin-Madison U. California, San Diego Harvard U. Stanford U. Duke U. NSF university research expenditure data As percentage of total expenditures (~$1-$1.5B/institution) 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% Fed Gov State/local Gov Institution Business Nonprofit Other 0% 1 2 3 4 5 6 7 8 9 10

All institutions Johns Hopkins U. U. Michigan, Ann Arbor U. Pennsylvania U. California, San Francisco U. Washington, Seattle U. Wisconsin-Madison U. California, San Diego Harvard U. Stanford U. Duke U. NSF university research expenditure data As percentage of total expenditures (~$1-$1.5B/institution) 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% Fed Gov State/local Gov Institution Business Nonprofit Other 0% 1 2 3 4 5 6 7 8 9 10

All institutions Johns Hopkins U. U. Michigan, Ann Arbor U. Pennsylvania U. California, San Francisco U. Washington, Seattle U. Wisconsin-Madison U. California, San Diego Harvard U. Stanford U. Duke U. NSF university research expenditure data As percentage of total expenditures (~$1-$1.5B/institution) 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% Fed Gov State/local Gov Institution Business Nonprofit Other 0% 1 2 3 4 5 6 7 8 9 10

All institutions Johns Hopkins U. U. Michigan, Ann Arbor U. Pennsylvania U. California, San Francisco U. Washington, Seattle U. Wisconsin-Madison U. California, San Diego Harvard U. Stanford U. Duke U. NSF university research expenditure data As percentage of total expenditures (~$1-$1.5B/institution) 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% Fed Gov State/local Gov Institution Business Nonprofit Other 0% 1 2 3 4 5 6 7 8 9 10

Universities can strategically invest, but Traditional review can be biased against novel, interdisciplinary research Difficult for researchers to collectively advocate for central resources Major R1 universities are large; difficult to know who is doing what on campus

Mcubed Mcubed provides immediate seed funding without traditional review to multidisciplinary faculty and student research teams (cubes)

Timeline: traditional funding Idea generation Find collaborators Search for seed funding Apply for funding Day 1 Day 2 Day 3-30 Day 30-90 Wait for review Modify/ reapply Wait for approval/ account Begin research Day 90-150 Day 150-210 Day 210-270 ~1 year later

Timeline: Mcubed Idea generation Find collaborators Search for seed funding Apply for funding Day 1 Day 2 Day 3-30 Day 30-90 Wait for review Modify/ reapply Wait for approval/ account Begin research Day 90-150 Day 150-210 Day 210-270 ~1 year later ~2 days later

How Mcubed works Faculty get virtual token, based on unit-defined eligibility Faculty post project ideas on Mcubed website (mcubed.umich.edu) 3 faculty, 2 different units = $60k interdisciplinary cube for 1 year Money used to fund undergraduate and graduate students, postdocs No formal review! Cubes must present at symposium (oral or poster)

Mcubed website

Mcubed website

Mcubed Symposia: Single Deliverable Keynote Speakers 2013: Tony Fadell 2014: Mark Schlissel 2017: Francis Collins

Mcubed unique peer-to-peer review Peer review #1 Faculty must post projects on Mcubed website (Public accountability) Peer review #2 Each faculty member can only join one cube each three-year cycle (Strategic commitment) No proposal is required or reviewed Faculty have the freedom to work on the problem that they think is the most impactful

Mcubed has attracted national attention Other Mcubed-inspired (token-based) programs: Michigan State: WaterCube University of Virginia: 3 Cavaliers Texas A&M University: T3

Study: Proposal review process may not distinguish great from good Simulated NIH study section Reviewed proposals funded first time or were eventually be funded (i.e., after revision) Results: Pier, EL, et al., Low agreement among reviewers evaluating the same NIH grant applications, PNAS, 115(12), 2952-2957 (2018).

Study: Proposal review process may not distinguish great from good Simulated NIH study section Reviewed proposals funded first time or were eventually be funded (i.e., after revision) Results: No correlation between funded and not funded No correlation between reviewers Lottery was suggested as a replacement! Pier, EL, et al., Low agreement among reviewers evaluating the same NIH grant applications, PNAS, 115(12), 2952-2957 (2018).

Study: Researchers are more efficient if given more freedom Looked at countries in Europe Evaluated increase in productivity (i.e., publications) as a function of increased funding Results: Mallaopaty S, Scientists get more bang for their buck if given more freedom, Nature, May 23 (2018). Sandstrom U and den Besselaar PV, Funding, evaluation, and the performance of national research systems, J. Informetrics, 12, 365-384 (2018).

Study: Researchers are more efficient if given more freedom Looked at countries in Europe Evaluated increase in productivity (i.e., publications) as a function of increased funding Results: More reviewed, prescriptive countries (heavily reviewed, research area prescribed) were less efficient Mallaopaty S, Scientists get more bang for their buck if given more freedom, Nature, May 23 (2018). Sandstrom U and den Besselaar PV, Funding, evaluation, and the performance of national research systems, J. Informetrics, 12, 365-384 (2018).

Mcubed process is less risky More efficient than traditional review Researchers vote with their feet and are more knowledgeable than study section members Relatively low level of support to ~250 teams per cycle means risk is diversified Mcubed: $4.5M central support to over 700 faculty Other: $4.5M would reach ~10-20 faculty Distributed resources bring buy-in, return on investment

$20K per faculty token (Classic Cube) Central $6,667 Unit $ $13,333 Faculty $

Impact per cycle $4.5M $60M external funding Units $4.5M Central Admin $4.5M Faculty ~250 Cubes 300 publications, presentations, patents, etc. 1000 trainees 700 faculty

Mcubed stimulates university-wide collaborations

Mcubed Diamond Program supports external partnerships ($2.3M raised to date)

How Mcubed Diamond Works You post your project idea Faculty suggest approaches to tackle problem You help select the project owner Project then cubes same as internal cycle Funding is immediately made available to the team to begin the research

Donors, Corporations, Foundations

Summary New non-traditional review (no formal review) Process matches fast-paced exchange of information in today s research environment External partners brought in through Diamond including industry, foundations, alumni Investigators explore new solutions to today s most important societal problems Mcubed de-risks institutional investment with significant impact and return on investment

mcubed.umich.edu mcubedinfo@umich.edu Add photo of cube: commemorative cubes at reception