EDCTP Report for the Regional Networks of Excellence

Transcription

1 Call Scheme Report type Report EDCTP Report for the Regional Networks of Excellence Submission of individual reports per site will no longer be accepted by EDCTP. Project Coordinators are requested to submit ONE consolidated report per Network Capacity-building Annual fourth Reporting period From [16 th May 2012] To [15 th May 2013] (ear 4) SECTION A: PROJECT PROFILE This information is used in the Project Profile published on the EDCTP website Project Coordinator Please provide a recent photograph for your profile Annex 1 Name: Prof. Pontiano Kaleebu Address: pontiano.kaleebu@mrcuganda.org EDCTP grant code Name of Network Grant title Coordinating Institution Country Total number of sites/institutions* Number of active sites contributing to this report CB EACCR The East African Consortium for Clinical Research: A capacity-building network of excellence, training and mentorship in the conduct of clinical trials in Africa Uganda Virus Research Institute (UVRI) P.O Box 49 Entebbe (Uganda) Nakiwogo Road Phone: Uganda 35 institutions 17 regional leading & 18 sister institutions continue to be active members Grant start and end date From 16 th May 2009 To 31 st December 2013 Value of EDCTP grant 3.46 million euros *only applies to sites with legal entity status EDCTP Reporting Template for the Regional Networks of Excellence Page 1 of 44

2 1.1 List of collaborators Please provide details of the work package leaders and other collaborators on the grant, indicating their role in the project (for example, project coordinator, PhD and MSc supervisor, site PI, work package leader, etc). Where collaborators have more than one role, please provide details. Site/Institution 1. Uganda Virus Research institute 2. MRC/UVRI Research Unit 3. Kilimanjaro Christian Medical Centre (KCMC) 4. MRC/UVRI Research Unit 5. Kenya Medical Research Institute- Kilifi 6. Uganda Virus Research Institute 7. Kenya Medical Reserach Institute 8. University of Oxford 9. Ifakara Health Research Institute- IHI 10. Armauer Hansen Reserach Institute (AHRI) Country Uganda Uganda Tanzania Uganda Kenya Uganda Kenya UK Tanzania Ethiopia Active (/N)* Name of collaborator Prof. Pontiano Kaleebu Prof. Heiner Grosskurth Prof. Gibson Kibiki Prof. Alison Elliott Prof. Kevin Marsh Dr. Edward Katongole Mbidde Dr. Nobert peshu Dr. Trudie Lang Dr. Abdulla Salim Dr. Abraham Aseffa Role in Network Overall Project Coordinator Former Director MRC/UVRI Unit & co-applicant Deputy Overall Project Coordinator Facilitator of capacity-building activities & coapplicant Co-applicant & Head of institution Chairman EACCR Steering committee & Director, UVRI Malaria node coordinator Member, EACCR Steering committee & training Member, EACCR Steering committee & Head of IHI Member, EACCR Steering committee & Head of site Area of expertise Gender Current HIV Male anda.org HIV Male com TB Male Immunology & Infectious Diseases Female Malaria Male HIV, Bioethics, oncology Male Malaria Male Malaria, clinical trials, Training (elearning) Female uk Malaria Male TB Male EDCTP Reporting Template for the Regional Networks of Excellence Page 2 of 44

3 Site/Institution 11. National Institute for Medical Research Mwanza 12. National Institute for Medical Research Mwanza 13. Armauer Hansen Reserach Institute (AHRI) 14. Muhimbili University of Health and Allied Sciences (MUHAS) 15. Institute of Endemic Diseases (IEND) 16. Muhimbili University of Health and Allied Sciences (MUHAS) 17. National Institute for Medical Research Dar es Salaam 18. National Institute for Medical Research Muhimbili 19. National Institute for Medical Research Muhimbili 20. Muhimbili University of Health and Allied Sciences(MUHAS) Country Tanzania Tanzania Canadian Tanzania Sudan Tanzania Tanzania Tanzania Tanzania Tanzania Active (/N)* Name of collaborator Dr. John Changalucha Mr. Mark Urassa Prof. Engers Howard Dr. Muhammed Bakari Prof. Maowia Mukhtar Dr. Patricia Jane Munseri Dr. Mwele Ntuli Malecela Dr. Sayoki Godfrey Mfinanga Dr. Beatrice K Mutayoba Prof. Japhet Killewo Role in Network Member, EACCR Steering committee & Head of site Facilitator, HIV activities Supervisor Training & coapplicant Mentoring & coapplicant Facilitator of EACCR capacitybuilding activities Facilitator of EACCR capacitybuilding activities Vice chair, Steering Committee & Director General NIMR TB node coordinator Facilitator of activities in the TB Node Area of expertise Gender Current Medical microbiology Male jchangalucha@yahoo.com HIV Male malloomark@yahoo.com Training Male engersh@ahriatlert.org/en gers_h@yahoo.com HIV, Training Male drbakari@yahoo.com/mba kari@muchs.ac.tz Malaria, Training Male mmukhtar@tropmedicine. org Training Female pmunsereri@yahoo.com Neglected infectious diseases TB, HIV and NCDs Female Male mmalecela@hotmail.com/ mmalecela@nimr.or.tz gsmfinanga@yahoo.com Scientist-TB Female bmutayoba@nimr.or.tz/be atricemutayoba@yahoo.co m Trainer Training Male jkillewo@muhas.ac.tz EDCTP Reporting Template for the Regional Networks of Excellence Page 3 of 44

4 Site/Institution 21. Muhimbili University of Health and Allied Sciences(MUHAS) 22. Uganda Virus Research Institute 23. KEMRI/CDC- Kisumu 24 Walter Reed Project/KEMRI Kisumu 25. University of Nairobi/Kenya AIDS Vaccine Initiative (KAVI) Country Tanzania Uganda Kenya Kenya Kenya 26. Maseno University Kenya 27. Ugandan Ministry of Health 28. St Rapheal Nsambya Hospital Uganda Uganda 29. NIMR-Tabora Tanzania N Active (/N)* Name of collaborator Prof. Eligius Lyamuya Dr. Jonathan Kayondo Mr. Steve Wandiga Dr. Berhards Ogutu Dr. Walter Godfrey Jaoko Prof.Ofulla Ayub V.O Dr. Asuman Lukwago Dr. Martin Nsubuga Dr. stafford Kibona Role in Network Member, steering committee & Trainer Member, implementation committee Trainer/facilitator of capacitybuilding activities & member steering committee Steering committee member Co-applicant & trainer Co-applicant, trainer Steering committee member, coapplicant Director of sister site, co-applicant, source of potential participants Director of sister site, co-applicant, source of potential participants Area of expertise Gender Current HIV, microbiology, immunology Male elyamuya@muhas.ac.tz HIV, malaria, molecular biology, bioinformatics Male jkayondo@gmail.com TB Male swandiga@kemricdc.org Malaria Male b6ogutu@gmail.com HIV, microbiology, training Malaria, training Internal medicine, policy Internal medicine Parasitology, Human African Trypanosomia sis Male Male Male Male Male wjaoko@kaviuon.org ofullavo@yahoo.com lukwagoman@yahoo.com Martin_nsubuga@yahoo.c o.uk/ martin.nsubuga.dr@gmail. com kibonastbr@yahoo.com EDCTP Reporting Template for the Regional Networks of Excellence Page 4 of 44

5 Site/Institution 30. National Institute for Medical Research -Tanga Country Tanzania 31. NIMR-Mbeya Tanzania 32. University of Munich 33.. Karolinska Institute 34.Masaka Hospital 35. Centre for International Health, University of Bergen 36. KNCV Tuberculosis Foundation 37. Goteborg University 38. Infectious Disease Institute- Mulago 39. Radbourd University Medical center Nijmmegen (RUMCN) 40. National Institute for Medical Research Muhimbili Germany Sweden Uganda Norway Netherlands Sweden Uganda Netherlands Tanzania N N N N N Active (/N)* Name of collaborator Dr. Martha Lemnge Dr. Leonard Maboko Dr. Michael Hoelscher Prof. Eric Sandstrom Dr. Florence Tugumisirize Prof. Odd Morkve Dr. Van der Leth Prof. Ashton Michael Dr. Andrew Kambugu Prof. Van der Ven Dr. Bernard Ngowi Role in Network Director of sister site, co-applicant TB Male hoelsche@lrz.uinmuenchen.de Site Director, Steering committee member Steering committee member Steering committee member Director of sister site, source of potential participants Collaborator- Northern partner, co-applicant Advisor TB research Area of expertise Gender Current Malaria Female marthalemnge@yahoo.co m HIV Male lmaboko@mmrp.org HIV Male Eric.sandstrom@karolinsk a.se Paediatrics, epidemiology Female tugu2000flo@gmail.com TB Male Odd.morkve@cih.uib.no TB Male vanlethf@kncvtbc.nl Training Training Male Michael.ashton@gu.se Facilitator of capacity-building Collaborator- Northern partner, co-applicant Facilitation of TB node activities, Member, TB node secretariat HIV Male akambugu@idi.co.org Networking Male a.vanderven@aig.umcn.nl TB Male B_ngowi@yahoo.co.uk *Active: Sites involved with EDCTP-funded project activities during the current reporting period Please submit copies of CV s of any new collaborators as supporting annexes EDCTP Reporting Template for the Regional Networks of Excellence Page 5 of 44

6 1.2 Abstract (max 850 characters) Give a summary of the project and what was achieved, including the aims and objectives, research questions being addressed, study methods, results, findings and achievements of the project. Introduction: Since May 2009, an expandable East African Consortium for Clinical Research (EACCR) went into action with 35 regional institutions and 7 northern partners to promote health product innovation (drugs, devices and other solutions), capacity development and networking. It addresses challenges of fragmented/uncoordinated efforts, diminishing indigenous scientists, insufficient funds and inadequate infrastructure in Eastern Africa in partnership with the industry (both pharmaceutical and business) and policy makers. EACCR integrates scientists, health practitioners, academicians and policy makers from the region (including Ethiopia and Sudan) and Europe. It has networked actively with other research consortia and development partners in Africa and beyond. Methods: We conducted participatory appraisal (documented/reported observations, content analysis, teleconferencing and record abstraction) between May 2012-May 2013 on EACCR s work packages categorized into: governance, training, infrastructure, research and networking. Governance was structured regionally into 4 coordinating centers: Malaria (Kenya), TB (Tanzania), HIV (Uganda) and Training (Tanzania). Results and achievements: We maintained a consensus-governed and networked consortium also supporting other linked projects/activities of other funding streams. We secured 2 additional reports from Kenya and Tanzania for a regional social science study. We also registered 2 additional MSc research fellows from Ethiopia and Tanzania; recorded 11 graduated MSc fellows; completed 4 EDCTP senior fellowships and reached at least 100 scientists through 4 short-courses in GCLP, GCP, TB laboratory techniques, clinical monitoring and trial conduct. Five more laboratories of sister sites in Kenya, Sudan and Uganda were upgraded. EACCR contributed to 1 published peer-review article, at least 5 oral presentations at international meetings and to other several scientific presentations through other funding mechanisms. It has a regional reciprocal monitoring scheme of at least 10 experienced monitors, who have cumulatively conducted 27 site visits to 11 clinical trials and mentored at least 10 new monitors, including 2 from our new partner institution in Rwanda. 1.3 Description of the project The project description should cover background, objectives, results and outcomes, capacity building and networking (max: 5000 characters). Background EACCR is an Eastern African-led, EDCTP-enabled network established in May 2009 to contribute to: health research coordination; increased active mass of African scientists and research administrators; upgraded infrastructure; stronger networking and advocacy for conducting clinical trials or other research on HIV, Malaria, TB and other diseases of public health importance under best practices. It has 35 regional institutions from Kenya, Uganda, Tanzania, Ethiopia and Sudan in partnership with 7 northern partners. It coordinates & promotes health product innovation, capacity development and networking in Eastern Africa for improved health and social advancement of its population. Objectives To strengthen regional research coordination and infrastructure for multi-centre clinical trials plus other health research To enable less developed sites within EACCR to improve their capacity to participate in multi-centre clinical trials through mentorship and collaboration To plan and support training/mentoring of promising regional scientists and administrators through both short and long term courses To contribute to improved strategic quality management of research through an affordable reciprocal monitoring scheme To apply an interactive website for better communication, enhanced networking, advocacy, common databases and training To promote advocacy for: regionally-owned research and health agenda; research use in policy and programming and resource mobilization EDCTP Reporting Template for the Regional Networks of Excellence Page 6 of 44

7 Results and outcomes We secured 2 additional reports from Kenya and Tanzania for a regional social science study (annexes 1 and 2). EACCR contributed to 1 published peer-review article (annex 3) and to at least 5 oral presentations at international meetings (annexes 4-6). Other network-linked scientific presentations/publications through other funding streams are not included here. Capacity building We maintained a consensus-governed and networked consortium. We also registered 2 additional MSc research fellows from Ethiopia and Tanzania; recorded 11 graduated MSc fellows; completed 4 EDCTP senior fellowships and reached at least 100 scientists through 4 short-courses in GCLP, GCP, TB laboratory techniques, clinical monitoring and trial conduct. Five more laboratories of sister sites in Kenya, Sudan and Uganda were upgraded. It has a regional reciprocal monitoring scheme of at least 10 experienced monitors, who have cumulatively conducted 27 site visits to 11 clinical trials and mentored at least 10 new monitors, including 2 from our new partner institution in Rwanda. Networking Prepared a proposal to EDCTP for a joint planning meeting of stakeholders from EACCR and TESA (On-going by date of reporting) Submitted a research capacity building proposal to WHO/TDR (10 th May 2013) Distributed over 400 EACCR brochures during national & international meetings (On-going by date of reporting) Two EACCR members gave oral presentations at the 4 th annual East African Health and Science conference following successful peer-review of the submitted abstracts (annexes 7 & 8). This conference took place at Serena Hotel in Kigali, Rwanda. See report in annex 9. (26 th 29 th Mar 2013) Worked with the East Central & Southern Africa Health Community on an EDCTP capacity needs assessment for ethics committees of selected institutions in Uganda (Feb Mar 2013). Refer to annex 10. EACCR Scientific Liaison Officer attended a scientific meeting in Les Diablerets, Switzerland at the invitation of the TB Vaccine Initiative (TBVI) and the consortium on TB Vaccine Trials in Europe and Africa (TB-TEA), 26 th Jan 1 st Feb Refer to annex 11. Made Advocacy for EACCR in the Afrique one consortium meeting held in NDjamena (29 th Sep 6 th Oct 2012). Refer to annex 12. Submitted research & capacity building proposal to the Tropical Health & Education Trust, UK in partnership with University of Oxford (Sep 2012) Submitted a proposal for a outh Community HIV/AIDS (ocha) program to funders in Netherlands in collaboration with a South African partner (Aug 2012) Submitted a proposal on a point-of-care diagnostic for Malaria in collaboration with a Canadian industrial partner from Alberta to Grand Challenges- Canada (Jul 2012) 1.4 Relevance to EDCTP s objectives and mission Public health relevance to developing countries and alignment with the priorities of the EDCTP Joint Programme In line with EDCTP s principle of supporting networks of research centres involved in clinical trials, EACCR facilitates collaboration in Eastern Africa by uniting 35 diverse regional instutions with their distinctive strengths into a network for synergy and complementarity. Its members are learning and developing by doing EDCTP Reporting Template for the Regional Networks of Excellence Page 7 of 44

8 how to plan jointly (instead of silo planning), manage this initiative by consensus, share and pool limited resources equitably and jointly increase capacity to raise the quality of health research and practice for accelerating development of new or improved tools (vaccines, diagnostics, drugs, microbicides and interventions). This resonates well with the set mission of EDCTP. These expected outcomes are meant to improve the health and social advancement of the Eastern African population. The knock-on impact of EACCR will be feasible once adequate and sustainable capacity (of people, infrastructure, governance, finance, science and technology) has been built to conduct multi-centre clinical trials and other health research under best practices with adequate sample size requirements and networking. By networking in EACCR, meaningful partnerships (south-south, south-north and north-north) are created and strengthened in line with this ideal principle of EDCTP. This creates the enabling environment for handling many more multi-disease clinical trials, which are the heart of EDCTP s business. The objectives of EACCR mentioned above address the regional challenges of inadequate research infrastructure, limited critical mass of researchers and administrators, fragmentation and duplication of effort, competition for limited unshared resources and poor use of research evidence in policy formulation and programming. EACCR strives to collaborate with similar initiatives e.g through Wellcome Trust (THRiVE consortium, Makerere-UVRI Infection and Immunity program and Afriqueone) at institutional, country and regional level to avoid duplication of efforts, promote synergy and ensure sustainability. In addition, EACCR seeks partnership with national disease control programs, political goodwill and financial support regional governments and the East African Community to address mutual concerns collectively and jointly use research evidence for further interventions and higher-level advocacy. The onus is also upon the EACCR and its stakeholders to channel successful health products developed and evaluated through policy to large-scale implementation supported by strengthened health systems. SECTION B: PROJECT MANAGEMENT Overall summary of progress on the grant during this reporting period (max 300 words) 17 regional leading and 18 sister institutions continue to be active members. Some improvement in communication has been noted from Nsambya hospital, Sudan and Ethiopia. Several active research and capacity building calls were circulated regularly to node coordinators. We handled work plan and budget for revised contract to finalize pending activities after May Members held regular teleconferences and discussions of the EACCR implementation committee and node committees to discuss pertinent issues to the Network. EACCR s coordinator is now a member of the regional steering committee of the East African Community for the annual East African Health, Science & International Exhibition conference. In this conference, EACCR contributed to the review of scientific abstracts, developing the scientific program and to mobilizing conference participants and co-funders. Has there been any change to the management structure since submission of the last report to EDCTP? es -Malaria Node Assistant (Ms. Peninna Soipei Menza) from KEMRI-Kilifi in the organogram below, moved to new job. She was replaced by Ms. Esther Kivaya. EDCTP Reporting Template for the Regional Networks of Excellence Page 8 of 44

9 (12 members) & Secretariat UVRI, EBB, UG Committee (9 members) KCRI, Kilimanjaro, TZ (6 members) KEMRI-Kilifi, Kenya TB Node Committee (6 members) NIMR-Muhimbili, TZ DMS # V1 4 EACCR Governance Structure EACCR Steering Committee (13 members) Project Implementation Committee (12 members) Chair: PC or DPC HIV Node Committee (12 members) & Secretariat UVRI, EBB, UG Training Node Committee (9 members) KCRI, Kilimanjaro, TZ Malaria Node Committee (6 members) KEMRI-Kilifi, Kenya TB Node Committee (6 members) NIMR-Muhimbili, TZ 4 EDCTP Reporting Template for the Regional Networks of Excellence Page 9 of 44

10 SECTION C: RESEARCH ACTIVITIES Provide an update on the research activities that are supported by this grant. Copy and paste the table below should you wish to add additional trials, studies or sub-studies undertaken by the Network Research activity Includes all laboratory-based, epidemiology/proof-of- concept/demographic/observational, non-interventional studies and clinical trials Social science study on Health Seeking Behaviour of People on Anti-Retroviral Therapy for at least 3 years in Kenya, Tanzania and Uganda. 2 reports were received from Kenya and Tanzania during this reporting period. Investigators will now write a publication combining the findings from these 3 countries Disease area HIV Start and end dates June 2010 and May 2013 Study design Qualitative case study household evaluation Phase of Trial (if applicable) Not applicable Principal Investigator Prof. Janet Seeley (UVRI, Entebbe, Uganda) Co-Investigator 1 Mr. Ondeng e Ken (KEMRI-CDC, Kisumu, Kenya) Co-Investigator 2 Mr. Mark Urassa (NIMR, Mwanza, Tanzania Co-investigator 3 Ms. Mary Nyikuri (KEMRI-CDC, Kisumu, Kenya) Sponsor (if applicable) Aim of study To investigate and document the health seeking behavior, for all conditions, of people who have been accessing ART for at least three years to understand more about their adjustment to life with HIV as a chronic condition. This was to compare and contrast findings across the 3 countries with the view of informing the planning in the future. Main Objectives Not Applicable Primary Not Applicable Secondary Target population Sample size Adults on ART for at least 3 years and at least 2 household members they live with and have disclosed their HIV status (comparison group) Target gender: Equal number of males and females for ART patients 20 ART patients per country and 40 household members per country Age range: 18 years and above EDCTP Reporting Template for the Regional Networks of Excellence Page 10 of 44

11 Participating sites Site 1: UVRI, Entebbe, Uganda Site 4 Site 2: KEMRI-CDC, Kisumu, Kenya Site 5 Site 3: NIMR, Mwanza, Tanzania Site 6 Ethics and Regulatory Approval Name of committee approving the protocol: Uganda National Council for Science and Technology (Uganda), Kenya Medical Research Institute (Kenya) and National Institute for Medical Research (Tanzania) Protocol Informed Consent Informed consent Amendments to protocol (English) (Local language) Version [insert number here] [insert number here] [insert number here] [insert number here] Date of approval [DD/MM/] Trial Insurance Certificates Trial Master File Index [insert date here] [insert date here] [insert date here] [insert date here] Submit the latest version as supporting documents (if applicable) Not applicable Submit a copy of the checklist as supporting documents (if applicable) Not applicable Clinical Trial Registration Name of Registry (i.e Pan African Clinical Trials Registry/ Clinical Trials.Gov) Not applicable Trial Registration number [insert number here] Date of registration [insert date here] Product 1 Product 2 Product type Not applicable Not applicable Investigational Product (drugs/microbicides/etc) Product Name Not applicable Not applicable Pharmaceutical Not applicable Not applicable Manufacturer/Supplier GMP certificate [insert date here] [insert date here] Investigational Brochure [insert date and version here] [insert date and version here] on record Acquision of product [procured/drug donation] [procured/drug donation] Product Name Not applicable Manufacturer/Supplier Not applicable Controls GMP certificate [insert date here] Investigational Brochure [insert date and version here] on record Acquision of product [procured/drug donation] EDCTP Reporting Template for the Regional Networks of Excellence Page 11 of 44

12 Trial status Summary of progress made during the reporting period. Give details of changes in objectives, timelines, setbacks and challenges that have occurred and how these are being addressed Progress updates of clinical trial activities Monitoring plan Data Management Strategy Data sharing As per annexed reports 1 and 2. Completed field study activities. Data analysis and interpretation of country reports/data is on-going. Refer to annexes 1 and 2. Recruitment status Site 1 Site 2 Site 3 Site 4 Number of participants screened Number of participants enrolled Number of participants lost to follow up Number of study withdrawals Number of adverse events reported Number of serious adverse events Provide a brief summary of the serious adverse events reported (i.e types) Name of clinical trial monitor Not applicable Contact details of monitor Internal/External Type of Visits (i.e pre-trial, mid-trial, termination) Monitoring format i.e Number of CRF s assessed [10%, 50%, 100%] Number of visits Date of last monitoring visit Report available (es/no) [submit report as a supporting annex] As per annexed reports 1 and 2. EDCTP Reporting Template for the Regional Networks of Excellence Page 12 of 44

13 SECTION D: CAPACIT DEVELOPMENT Indicate how infrastructure upgrades and purchasing of capital equipment** has improved the capacity (under each section below), to conduct future research for each collaborating site. Annex 2 provides explanation on how levels are classed. Laboratories Name of site *Level at baseline Malaria laboratory equipment procured, installed and in use Siaya district 2 2 hospital, Kenya Malaria laboratory equipment procured, installed and in use BNNICD, El Gazera, 2 2 Sudan Clinical laboratory equipment procured, installed and in use UVRI clinic, Uganda 2 2 Malaria laboratory equipment procured, installed and in use Maseno University, Kenya 2 2 *Current level Clinical trial facilities Renovated building of health facility for a malaria node sister site Name of site Taveta district hospital, Kenya *Level at baseline 2 2 *Current level Information technology and information sharing facilities Purchased an ICT server for the malaria node sister site Name of site NIMR-Kilosa, Tanzania *Level at *Current level baseline 2 2 EDCTP Reporting Template for the Regional Networks of Excellence Page 13 of 44

14 Long-term training Please report on the progress made towards the training targets of all long-term trainees within this Network Type of training Target number of trainees Postdoctoral 2 Doctoral 2 Masters 26 *Others Not applicable *Others may include candidates completing Honors, Bachelors degrees or National Diplomas Candidate Name Surname Gender Nationality Project Title Post-Doctoral Student 1 Eugene Kinyanda M Ugandan Clinical trials in HIV/AIDS in Africa: Should they routinely control for mental health factors? (Uganda, ) Student 2 Jonathan Kayondo M Ugandan Evolution of HIV-1 ARV drug resistance mutations in the ART naïve during therapy; threshold frequency levels and linkage context associated with treatment failure in Uganda (Uganda, ) Doctoral Institution where registered London School of Hygiene and Tropical Medicine Health Protection Agency-UK and UVRI/MRC Supervisor Vikram P Kaleebu, D Pillay, JL Mbisa Date Registered Already communicat ed March 2010 Envisaged Date of completion Already communic ated March 2012 Student 1 William Worodria M Ugandan Short and long term clinical and immunological outcomes of patients with HIV/TB coinfections on ART (Uganda, ). University of Antwerp, Belgium and Makerere University Prof (s) uka Manabe;R.C olebunders; Luc Kestens Already communicat ed Already communic ated EDCTP Reporting Template for the Regional Networks of Excellence Page 14 of 44

15 Student 2 Pauline Byakika F Ugandan Comparison of efficacy, safety and pharmacokinetics of intravenous artesunate and intravenous quinine followed by oral artemisinin combination therapy for severe malaria treatment in Uganda and evaluation of pharmacokinetic drug interactions of artesunate, quinine, lumefantrine and piperaquine with antiretroviral drugs (Uganda, ) University of Liverpool M Kamya, E Katabira, D Black, C Merry, S Khoo March 2011 March 2013 Masters Student 1 Thomas Mwinyiheri M Tanzanian Modelling TB transmissions in zoonotic areas of Arusha and Manyara regions. University of Dar es Salaam Student 2 Charles E. Makasi M Tanzanian To be communicated University of London International Programmes/Lond on Shool of Hygiene and Tropical Medicine/Stewart Dr N.Shaban, Bsc, PhD & Dr S. G. Mfinanga, MD, PhD & Dr. S. D. Hore- Musekwa, BSc, PhD Oct-10 Oct-10 Oct-12 Oct-13 EDCTP Reporting Template for the Regional Networks of Excellence Page 15 of 44

16 Others Student 3 Stella Zawedde Muyanja Student 4 Seith Chekata Inzaule F Ugandan Assessing the impact of Integration of HIV and TB services on TB Case finding and Treatment in rural health centers in Uganda M Tanzanian Combined antiretroviral treatment switch and discontinuation among HIV infected patients in new Nyanza general provincial hospital, western Kenya Student 5 Charles Kabugo M Ugandan Incidence and factors associated with TB iris is patients attending the HIV clinic in Masaka hospital. Student 6 Patrick Kazooba M Ugandan Predictors of virological failure among HIV-infected patients on first-line antiretroviral therapy in a rural cohort of South Western Uganda Student 7 Juma Magambo M Tanzanian Envelope Sequence Diversity and the Development of broadly neutralizing Antibodies in Chronically Human Immunodeficiency Virus Type 1 Infected Individuals from Rural Uganda Student 8 Shimma Ahmed M Sudanese Evaluation of new cloned MTB antigens and identification of immunodiagnostic markers of pulmonary TB Makerere College of Health Sciences Makerere College of Health Sciences Makerere College of Health Sciences LSHTM, UK and MRC Research Unit Makerere University University of Khartoum Ass Prof. David Guwatude Dr.Archilles Katamba Dr.Archilles Katamba Anne Tholen, Jonathan Levin Prof. George W. Lubega Prof. Mukhtar Maowia Student 9 Aman Elbadawi M Sudanese Molecular mapping of drug University of Dr. Osama Aug 2010 Aug 2013 Aug-10 Aug-10 Sep 2011 Aug-10 Oct-10 Oct-10 Aug-12 Aug-12 To be communic ated Aug-12 Oct-12 Oct-12 EDCTP Reporting Template for the Regional Networks of Excellence Page 16 of 44

17 Student 10 Student 11 Student 12 Student 13 Student 14 Student 15 Student 16 Student 17 resistance pattern of Mycobacterium TB 1 Gadaref state, eastern Sudan Khartoum sharief Daveline Nyakundi M Kenyan To be communicated LSHTM, UK To be communicat ed Oct-10 Oct-13 Pauline Akoo F Kenyan Immunization among Immunocompromised groups Philemon Tenu M Tanzanian Frank Magogo M Tanzanian Rajabu Rija M Tanzanian Tolbert Sonda M Tanzanian Jane Rogathi F Tanzanian Richard Kinyaha M Tanzanian Mathematical modeling of age-specific mortality rates to estimate HIV prevalence in adults using demographic surveillance data in Kisesa, Mwanza Evaluation of cheap and locally available attractants as baits in outdoor adult mosquito control devices. Factors associated with Anamia analysis of data on three different measurement tools in pregnant women and children under 5yrs. Morbidity and mortality trends in people living with HIV/AIDs attending Kilimanjaro Christian medical centre from Association between nutrition and childhood epilepsy in Hai District, Kilimanjaro Region, Tanzania. Retrospective cohort study on drug susceptibility test on second line anti tuberculosis Walden University Kilimanjaro Christian Medical University College (KCMU Co) Kilimanjaro Christian Medical University College (KCMU Co) Kilimanjaro Christian Medical University College (KCMU Co) Kilimanjaro Christian Medical University College (KCMU Co) Kilimanjaro Christian Medical University College (KCMU Co) Kilimanjaro Christian Medical University College To be communicat ed Aug-10 Aug 13 Jim Todd, MSc, PhD Oct-10 Oct-12 Dr. Robert Malima Oct-10 Oct-12 Jim Todd, MSc, PhD Oct-10 Oct-12 Jim Todd, MSc, PhD & Charles Mtabho, MD, MPH Oct-10 Oct-12 Jim Todd, MSc, PhD & Kathryn Burton, MD, MMED Oct-10 Oct-12 Prof. G. Kibiki, MD, MMED, PhD Oct-10 Oct-12 EDCTP Reporting Template for the Regional Networks of Excellence Page 17 of 44

18 Student 18 Student 19 Student 20 Student 21 Student 22 Student 23 Student 24 Elizabeth Kussaga F Tanzanian drugs for multi drug resistance tuberculosis patients treated cases. Assessment of factors influencing individuals participation in field based research. Lydia Nabacwa F Ugandan To be communicated Molecular assessment of Pfmdr 1 gene mutation after the introduction of Artemesin-based combination Petro Paulo M Tanzanian therapy in Tanzania Margaretha L. Sariko F Tanzanian Demissie To determine the rate of decline MTB bacillary load in the first 14 days of treatment in newly diagnosed TB patient on HRZE in Kilimanjaro region. Befekadu Debebe F Ethiopian To be communicated James Ngocho M Tanzanian To be communicated Moses Ngari M Kenyan Effect of Rickets on child survival in Kenya. (KCMU Co) Kilimanjaro Christian Medical University College (KCMU Co) & Dr. Stella Mpagama, MD, MSc. Dr. Hugh Reyburn, MMED(pead. ) PhD Oct-10 Oct-11 University of Liverpool, United Kingdom Dec-11 Sep-13 Kilimanjaro Christian Medical University College (KCMU Co) Kilimanjaro Christian Medical University College (KCMU Co) Kilimanjaro Christian Medical University College (KCMU Co) Kilimanjaro Christian Medical University College University of London Dr. R. Kavishe, PhD Oct-11 Oct-13 Prof. F. Mosha, PhD Oct-11 Oct-13 Prof. G. Kibiki, MD, MMED, PhD; Dr Bernard Ngowi (MD,PhD) September 2012 Sep-13 September 2012 Sep-13 Dr James Berkley & Greg Fegan (Kenya), Simon Collin (UK). Aug-11 Aug-13 EDCTP Reporting Template for the Regional Networks of Excellence Page 18 of 44

19 Student 25 Ravelyne Opar F Kenyan None Student 26 Regulatory affairs with Deborah Mogaka F Kenyan biomedical devices (MSc) University of Liverpool, U.K None Oct-2011 Jun-2013 North Eastern University, Boston Prof Brad (USA) Hossack Apr-2011 Sept.2012 Please insert additional rows as required EDCTP Reporting Template for the Regional Networks of Excellence Page 19 of 44

20 Long-term trainees: Retention of Built Capacity For those candidates who have completed or are approaching completion of their respective long-term training, please state their future plans (i.e plans to integrate into current Network, further studies, application for Senior Fellowship, will be leaving the NoE, seeking employment etc) Candidate Name Surname Training (i.e. MSc, PhD) Plans once degree has been completed Student 1 Thomas Mwinyiheri MSc. Employed permanently by the NIMR-Muhimbili Student 4 Seith Chekata Inzaule MSc. To be communicated Student 5 Charles Kabugo MSc. To be communicated Student 8 Shimma Ahmed MSc. Employed by IEND Sudan Student 9 Aman Elbadawi MSc. Employed by IEND Sudan Completed in June Now working with a contract research organization (PPD) Student 10 Daveline Nyakundi MSc. as a clinical research Associate Student 11 Pauline Aoko MPH Hopes to proceed to PhD program if funding becomes available Student 12 Philemon Tenu MSc. Back to employer (NIMR), Continued to PhD programme Student 13 Frank Magogo MSc. Integrated into current Network Student 14 Rajabu Rija MSc. Integrated into current Network Student 15 Tolbert Sonda MSc. Back to employer (KCRI), continued to PhD programme Student 17 Jane Rogathi Student 18 Richard Kinyaha Student 19 Elizabeth Kussaga MSc. MSc. MSc. Integrated into current Network Integrated into current Network Employed by KCRI EDCTP Reporting Template for the Regional Networks of Excellence Page 20 of 44

21 Student 21 Petro Paulo MSc. Integrated into current Network Student 22 Margaretha L. Sariko MSc. Integrated into current Network Student 24 Moses Ngari MSc statistics Hopes to proceed to PhD program if funding is available Student 25 Ravelyn Opar MPH. To be communicated Student 26 Deborah Mogaka MSc in regulatory affairs with biomedical devices Please insert additional rows as required No additional funds to support her position. She is in the process of leaving KEMRI- Kilifi to look for other job openings elsewhere EDCTP Reporting Template for the Regional Networks of Excellence Page 21 of 44

22 Short-term training [eg Short courses in GCP, HSRP, GCLP, IATA etc] Name of training Dates of training Venue Agency providing training Duration of training Number of participants Reciprocal Scheme follow-up workshop on Clinical Trial Monitoring 30th - 31st May 2012 Lenana conference centre, Nairobi Global Health Network in partnership with World-Wide Antimalarial Resistance Network 2 days 22 pooled regional monitors Name of Trainee Surname Gender Nationality Position held WANZE KOHI Institutional Affiliation (site name) M TANZANIAN Clinical trial monitor NIMR, Muhimbili BEATRICE MUTAOBA F TANZANIAN Clinical trial monitor NIMR, Muhimbili GODFATHER KIMARO M TANZANIAN Clinical trial monitor NIMR, Muhimbili JEREMIAH KIDOLA M TANZANIAN Clinical trial monitor NIMR, Mwanza GEORGE PRAGON M TANZANIAN Clinical trial monitor NIMR, Mwanza ELIZABETH AUO F KENAN Clinical trial monitor KEMRI-CDC PENINNA SOIPEI F KENAN Clinical trial monitor KEMRI-KILIFI JOHNSTONE THITIRI M KENAN Clinical trial monitor KEMRI-KILIFI STACE GONDI M KENAN Clinical trial monitor KEMRI-WRP JACQUELINE NANGE F KENAN Clinical trial monitor KAVI JENIFFER KIGERA F KENAN Clinical trial monitor KAVI PHILIP NALUANDE M UGANDAN Clinical trial monitor UVRI, Uganda ANNET NANVUBA F UGANDAN Clinical trial monitor UVRI, Uganda NAMPIJJA PROSS F UGANDAN Clinical trial monitor UVRI, Uganda MIRRIAM AKELLO F UGANDAN Clinical trial monitor UVRI/MRC, Uganda SARAH NANZIGU F UGANDAN Clinical trial monitor Makerere University EDCTP Reporting Template for the Regional Networks of Excellence Page 22 of 44

23 NAKUA MARGARET F UGANDAN Clinical trial monitor Makerere University ZEWDU HURISA DADI M ETHIOPIAN Clinical trial monitor AHRI DAVELINE NAKUNDI F KENAN Clinical trial monitor PPD MUZAMIL MAHDI F SUDANESE Clinical trial monitor Qassr Univ, Khartoum VICTORINE OWIRA F KENAN Clinical trial monitor KEMRI/WRP HRINE MATHEKA F KENAN Clinical trial monitor KEMRI-CDC Please provide a few examples of how this training has enhanced capacity within this network This follow-up training strengthened sharing of best practices and tools in monitoring clinical trials in Eastern Africa while enabling on-going mentoring of junior/new monitors in cross-site/cross-study monitoring plus south-south and south-north networking among colleagues. There will be cost-saving instead of always depending on hired clinical research organizations while improving quality of trials/studies conducted and gradually increasing on the number of clinical monitors in the region over time. Refer to details of this workshop in annex 13. Workshops [i.e Data Management; Grant writing, Laboratory techniques, Project Management] Name of workshop GCP and GCLP Date of training 27 th to 31 st August 2012 Venue NIMR CEEMI Conference hall Kenya AIDS Vaccine Initiative (KAVI)/University of Nairobi in Collaboration with NIMR Muhimbili for EACCR, Name of agency conducting workshop TAMOVAC, NIH Project and REMSTART trial network. Duration of training 5 days Number of participants 33 (Refer to group photograph in annex 14) Name of Trainee Surname Gender Nationality Position held Principal Investigator, TAMOVAC Mohamed Bakari M Tanzanian Trial Mohamed Janabi M Tanzanian Study Investigator TAMOVAC Trial Eric Aris M Tanzanian Study Investigator TAMOVAC Trial Mary Ngatolwa F Tanzanian TAMOVAC Trial Staff Dorothea Niima F Tanzanian TAMOVAC Trial Staff Institutional Affiliation (site name) Muhimbili University of Health and Allied Sciences (MUHAS) MUHAS MUHAS MUHAS MUHAS EDCTP Reporting Template for the Regional Networks of Excellence Page 23 of 44

24 Arafa Khamis F Tanzanian TAMOVAC Trial Staff MUHAS Dilly Hassan F Tanzanian TAMOVAC Trial Staff MUHAS Magdalena Lyimo F Tanzanian TAMOVAC Trial Staff MUHAS Sabrina Mugusi F Tanzanian TAMOVAC Trial Staff MUHAS Emmanuel Kapesa M Tanzanian TAMOVAC Trial Staff MUHAS Triphonia Tesha F Tanzanian TAMOVAC Trial Staff MUHAS Grace Mbura F Tanzanian TAMOVAC Trial Staff MUHAS Grace Maghembe F Tanzanian TAMOVAC Trial Staff MUHAS Abdallah Ally M Tanzanian TAMOVAC Trial Staff MUHAS Maijo Biseko M Tanzanian REMSTART Trial Staff NIMR Muhimbili Edwin Chitaje M Tanzanian REMSTART Trial Staff NIMR Muhimbili Mbaazi Senkoro M Tanzanian REMSTART Trial Staff NIMR Muhimbili Bernard Poyo M Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Desderia Nyakunga F Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Onolina Msisi F Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Paulina Lumao F Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Flora Changamke F Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Joachim Mgimba M Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Fred Mhalu M Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Zena Babu F Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Fenella Msangi F Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Muhidin Salehe M Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Monica Matovu F Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Geneveva Lualilo F Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Jengela Peter M Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Paul Mjelwa M Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Peter Muhanga M Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital Daudi Mtuya M Tanzanian TB Staff NIH Iringa Study Iringa Regional Hospital EDCTP Reporting Template for the Regional Networks of Excellence Page 24 of 44

25 Please provide a few examples of how this training has enhanced capacity within this network This training improved the skills of the participants to conduct a GCP and GCLP compliant trials since most of the participants are from different trials going on in Tanzania Name of training Dates of training Venue Agency providing training Duration of training Number of participants Skill-sharing workshop on best practices for conducting regional clinical trials in a resource-limited setting 14th February 2013 Sanctum Hotel, Entebbe, Uganda Global Health Network in partnership with UVRI 1 day 51 Participants First name Surname Gender Nationality Position held Refer to annexes 15 and 16 with list of participants and group photograph Institutional Affiliation (site name) Please provide a few examples of how this training has enhanced capacity within this network Shared lessons learned and recommended skills/approaches for promoting and supporting conduct of clinical trials in resource-limited settings. See annex 17 for detailed report. EDCTP Reporting Template for the Regional Networks of Excellence Page 25 of 44

26 Network-linked Senior Fellowship Projects Does this network have links or host recipients of EDCTP-funded Senior Fellowship Training Award scheme? If yes, please provide further details Candidate Name and title Dr. Eugene Surname Gender Nationality EDCTP project code Kinyanda Male Ugandan To be communicated Research Study or clinical trial See info already given above Dr. Jonathan Kayondo Male Ugandan T See info already given above Dr. Pauline Dr. William Byakika- Kibwika Female Ugandan TA See info already given above Worodria Male Ugandan To be communicated See info already given above How is the Senior Fellowship project linked with NOE? Through research attachment; patient management; subject recruitment at the MRC/UVRI Unit; academic attachment at Makerere University (EACCR leading institutions) Through laboratory research attachment; subject recruitment at the MRC/UVRI Unit and UVRI; academic attachment at Makerere University (EACCR leading institutions) Through mentoring; patient management; subject recruitment; personal academic attachment at IDI/Makerere University (EACCR leading institution) Through research attachment; patient management; subject recruitment; academic attachment at Makerere University (EACCR leading institutions) Contribution of Senior Fellow to NoE activities/objectives Mental health and HIV research publications; quality mental health service offered to patients; mentoring junior colleagues; providing expected research leadership HIV basic research publications; establishment of molecular laboratory and bioinformatics; mentoring junior colleagues; providing expected research leadership; contributions to EACCR implementation committee Malaria research publications; quality health service offered to patients; mentoring junior colleagues; providing expected research leadership TB research publications; quality medical care services offered to patients; mentoring junior colleagues; providing expected research leadership EDCTP Reporting Template for the Regional Networks of Excellence Page 26 of 44

27 For the senior fellows above, please state plans to integrate them into the Network of Excellence with the aim of retaining built capacity ie. Lead research teams, formation of new research teams/units, supervision of longterm trainees etc. Name of Senior Fellow Dr. Eugene Kinyanda Dr. Jonathan Kayondo Dr. Pauline Byakika-Kibwika Dr.William Worodria Future plans within Network of Excellence (as part of staff retention strategy) Has already secured a new MRC African Research Leadership award of 5 years for leading a research program, overseeing its execution to completion and mentoring junior colleagues within EACCR Has already secured another research grant for strengthening capabilities in genome-wide association studies, molecular biology and bio-informatics through H3 Africa. He is also mentoring junior colleagues at Makerere University and UVRI. Has been promoted to a position of associate professor at Makerere College of Health Sciences where she will continue to build a research team, mentor junior colleagues, conduct more research and provide high quality medical care to both patients and research volunteers Has taken on more TB research at Makerere College of Health Sciences where he will continue to build a research team, mentor junior colleagues, provide better health care to patients and is now eligible to pursuit a post-doctoral research program Research Staff, training and capacity development Summary of numbers of staff employed on the grant Staff category Senior staff: Senior Fellows/Professors/Senior Clinicians or equivalent Mid-career staff: Intermediate level fellows (> years postdoctoral experience)/clinicians/ lecturers or equivalent Site 1-UVRI Site 2-KCMC/KCRI Full-time Part-time Full-time Part-time Male Female Male Female Male Female Male Female Doctoral and Masters students Graduate researchers Laboratory (Managers, technicians, assistants) Nurses and Fieldworkers EDCTP Reporting Template for the Regional Networks of Excellence Page 27 of 44

28 Pharmacists Data (Managers, IT officers and assistants) Administrative staff 1 Quality Control (Managers, officers) 1 1 Finance staff 1 1 Others (ancillary i.e drivers, general assistants etc) Total Staff category Senior staff: Senior Fellows/Professors/Senior Clinicians or equivalent Mid-career staff: Intermediate level fellows (> years postdoctoral experience)/clinicians/ lecturers or equivalent Site 3-KEMRI WT Site 4-NIMR Dar es saalam Full-time Part-time Full-time Part-time Male Female Male Female Male Female Male Female Doctoral and Masters students Graduate researchers Laboratory (Managers, technicians, assistants) Nurses and Fieldworkers Pharmacists Data (Managers, IT officers and assistants) Administrative staff EDCTP Reporting Template for the Regional Networks of Excellence Page 28 of 44

29 Quality Control (Managers, officers) Finance staff 2 1 Others (ancillary i.e drivers, general assistants etc) Total Please add columns for additional sites How has the grant contributed to the professional development of ALL staff employed on the project? Highlight any individuals who have progressed in their careers or have been promoted. Several short courses in grant writing, grant management and financial management have been conducted in partnership with EDCTP, other funders and regional collaborators for both scientists and research administrators as part of their continuing professional development in order to improve personal growth plus efficiency and effectiveness during implementation of existing and new grants. The acquired knowledge has been applied through learning by doing. Opportunities have been opened for consultation of colleagues within and across institutions plus countries and sharing best practices. Similarly, training in GCP and GCLP courses, clinical trial monitoring, scientific writing, epidemiology and data management was conducted for the project staff as per reports provided. The same has been done for disease-specific and laboratory training.one of success stories is the promotion of Dr. Pauline Byakika- Kibwika to the position of associate professor at Makerere University. Ms. Esther Kivaya, who is assistant coordinator of the malaria node, also progressed to become a lead trial monitor at KEMRI-Kilifi after gaining massive experience in monitoring, training in GCP and monitoring. EDCTP Reporting Template for the Regional Networks of Excellence Page 29 of 44

30 SECTION E: RESEARCH OUTPUT Please list the research outputs from this research grant during the current reporting period. ou may include in press or published material How many accepted (in press or published) peer-reviewed publications (research papers or books) have been produced during this reporting period as a result of this grant? Detail each publication in the following order: Author(s); Article Title; Journal Name; ear; Volume; Issue Number; Page Numbers, and confirm that EDCTP funding has been acknowledged in all publications. Please include copies of research papers as supporting annexes. Several publications have been generated from EACCR through other co-funding mechanisms closely linked to it although such information is yet to be collated comprehensively in such a short time. Some selected publications are outlined below: 1. Byakika-Kibwika, P., Lamorde, M., Mayito, J., Nabukeera, L., Namakula, R., Mayanja-Kizza, H. et al. (2012a). Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults.. J Antimicrob Chemother, 67(9), Byakika-Kibwika, P., Lamorde, M., Mayito, J., Nabukeera, L., Mayanja-Kizza, H., Katabira, E. et al. (2012b). Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults.. Malar J., 11(132). 3. Lamorde, M., Byakika-Kibwika, P., Tamale, W., Kiweewa, F., Ryan, M., Amara, A. et al. (2012). Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults.. AIDS Res Treat., 2012(105980). 4. Lamorde, M., Byakika-Kibwika, P. & Merry, C. (2012). Pharmacokinetic interactions between antiretroviral drugs and herbal medicines. Br J Hosp Med (Lond), 73(3), Davis Kibirige *, Richard Ssekitoleko, Edrisa Mutebi and William Worodria. Overt diabetes mellitus among newly diagnosed Ugandan tuberculosis patients: a cross sectional study. BMC Infectious Diseases 2013, 13: Davis Kibirige, Edrisa Mutebi, Richard Ssekitoleko, William Worodria, and Harriet Mayanja-Kizza. Vitamin D deficiency among adult patients with tuberculosis: a cross sectional study from a national referral hospital in Uganda. BMC Res Notes. 2013; 6: Catherine Abbo, Eugene Kinyanda, Ruth B Kizza, Jonathan Levin, Sheilla Ndyanabangi, Dan J Stein. Prevalence, comorbidity and predictors of anxiety disorders in children and adolescents in rural north-eastern Uganda. Child and Adolescent Psychiatry and Mental Health 07/2013; 7(1): Eugene Kinyanda et al. Prevalence and risk factors of depression in childhood and adolescence as seen in 4 districts of north-eastern Uganda BMC Int Health Hum Rights 13: E Kinyanda. Psychiatric disorders and psychosocial correlates of high HIV risk sexual behaviour in war-affected Eastern Uganda. AIDS Care 24: Deogratius Ssemwanga, Anne Kapaata, Frederick Lyagoba, Brian Magambo, Maria Nanyonjo, Billy N. Mayanja, Chris M. Parry, and Pontiano Kaleebu. AIDS Research and Human Retroviruses. December 2012, 28(12): doi: /aid Seeley, Janet PhD *,, ; Nakiyingi-Miiro, Jessica PhD *, ; Kamali, Anatoli MSc *, ; Mpendo, Juliet MPH ; Asiki, Gershim MSc * ; Abaasa, Andrew MSc * ; De Bont, Jan PhD ; Nielsen, Leslie RN ; Kaleebu, Pontiano PhD *,, High HIV Incidence and Socio-Behavioral Risk Patterns in Fishing Communities on the Shores of Lake Victoria, Uganda. Sexually Transmitted Diseases: June Volume 39 - Issue 6 - p doi: /OLQ.0b013e d 12. David Cooper; Fiona Ewings; Sarah Fidler; Martin Fisher; John Frater; Michelle Gabriel; Pontiano Kaleebu; Steve Kaye; Anthony Kelleher; Sabine Kinloch; Myra McClure; Jose M Miro; Rodney Phillips; Kholoud Porter; Gita Ramjee; Helen Rees; Mauro Schechter; Giuseppe Tambussi; Jonathan Weber; Abdel Babiker. Short-course antiretroviral therapy in primary HIV infection. The New England journal of medicine 2013;368(3): George M Miiro; Francine Ntoumi; Alexander Pym; Maerangis Rahmani; Ousmane Sarr; Odile Ouwe Missi Oukem-Boyer; Keertan Dheda; Souleymane MBoup; Pontiano Kaleebu. EDCTP regional networks of excellence: initial merits for planned clinical trials in Africa. BMC public health 2013;13():258. Refer to annex 3. EDCTP Reporting Template for the Regional Networks of Excellence Page 30 of 44