Breast Cancer Now CSO Project Grant Guidance Notes Remit:

Transcription

1 Breast Cancer Now CSO Project Grant Guidance Notes Remit: Breast Cancer Now and The Chief Scientist Office (CSO) will offer joint funding of up to 450,000 for Project Grants to be performed in a Scottish Research Institution, in a special initiative to fund translational biomedical research into breast cancer. Proposals must be translational in scope, where 'translational' is defined as having a clear pathway to patient benefit. Project grant applications will be invited from lead applicants with tenured posts at recognised Scottish Universities, NHS hospitals or research institutes. Awards are only available to researchers working in a Research Institution in Scotland. Co-applicants may be based elsewhere, but the project and its lead applicant must be based in a Scottish Research Institute in order to be eligible for funding. Collaborative applications from within Scotland are welcome, although the contracted grant (and associated funding arrangements) will be with the lead applicant's institution. Collaborations with industry (e.g. pharma/biotech/diagnostics) are welcome and are not restricted to Scottish-based companies. Named academic/clinical collaborators are permitted from outside Scotland (or from outside the rest of the UK), but the lead applicant must be a permanent salaried member of staff at a Scottish HEI or NHS Health Board. We will NOT accept the applications for the following: Applications from lead applicants without permanent, salaried positions Research into conditions other than breast cancer Psychosocial proposals/living with and managing breast cancer [Important note] we WILL accept these applications through our regular grant funding schemes. For more information, please visit our website here. The Scientific Advisory Board will not consider applications for equipment only. Under exceptional circumstances, funding for large pieces of equipment may be considered within a project grant application where there is overwhelming evidence that funding was required, the project could not proceed without it being in place, and that the equipment would be solely used for breast cancer research. Full justification for the equipment request is required and must be included in the research proposal. Breast Cancer Now-CSO will not consider applications from Principle Investigators based outside of Scotland. Breast Cancer Now-CSO will not consider an application from a commercial entity Breast Cancer Now-CSO will not consider applications for methods or service development research projects Breast Cancer Now-CSO will not consider applications from an individual who is NOT employed by an eligible institution i.e. a university, teaching hospital, or research institute. In order to be able to qualify for a Breast Cancer Now-CSO, the applicant must have an honorary contract with the university of which written evidence must be supplied along with the grant application form The Scientific Advisory Board will not consider applications for project grants, PhD studentships or scientific fellowships which request funding for consumables only. Project grant scheme: eligibility criteria

2 Joint Breast Cancer Now-CSO project grants are available to established researchers who have a strong track record in their field. Project grant awards can be from one to three years and can cover staff salary, research expenses and essential equipment. Applications should be made by the Principal Investigator whose position and salary will be guaranteed by the host institute. The applicant and project must be based within Scotland only, in a recognised academic or clinical institution. The Principal Investigator may apply for salaries for other staff, but they will not be permitted to apply for their own salary. Primary applicants must be a permanent salaried member of staff at a recognised clinical and/or academic institution. Applicants should have a strong academic track record in the field of breast cancer. If you are unsure about the eligibility and remit of your project, you must contact the Research Funding Team (grants_admin@breastcancercampaign.org) before you submit your application. Once the deadline has passed there will be no opportunity to debate individual circumstances and applications not meeting the requirements will be rejected without peer review. Making your application Applications are to be made using our online CC Grant Tracker system. You must fill out all sections of the application form (notes below) and yourself, any co-applicants, the Head of Department and the University/Institute Research Grants office (or finance office if not applicable) must complete the declarations online in order to submit your application. Co-applicants must confirm their involvement and provide a full CV online. Each collaborator must confirm their involvement in the project online, provide a brief description of their role and letter of support should be attached to the application form. The deadline for applications is 5pm on 1 July If you have any queries about filling in this application form, contact the Research Funding Team (grants_admin@breastcancercampaign.org, ). Proposals will be triaged by the Scientific Advisory Board (SAB) before external peer review to eliminate those with no realistic chance of success. Unsuccessful applicants will be informed of the outcome of their application at this point. Remaining applications will then be peer reviewed by at least two independent referees in accordance with AMRC guidelines. Final funding decisions will be made in December 2015 when our Board of Trustees meet to ratify recommendations for funding made by the Scientific Advisory Board. Applicants will be informed of the outcome by shortly afterwards. Please do not contact the Charity before this date it will not speed up the process. [Important Note - Grant funding must be taken up within nine months of award] Notes on the application form 1) Details section Title of the Project: The title of the project should be succinct and should accurately reflect the content of the research Please note that it is mandatory to complete this field to be allowed to navigate away from this section of the application form. Abstract of research This should be a maximum of 300 words and should provide a succinct summary of the proposal. The abstract will be used by potential reviewers to judge whether or not they should review the application. If your application is successful your abstract may be published on our website and other web based directories of research. Therefore commercially sensitive or confidential information should not be included in your abstract. If you believe your abstract should not be published as it is highly confidential

3 please contact us. We will allow you provide us with a revised abstract that is publishable on our communications. The abstract should be laid out as follows: i) Background ii) Aims iii) Techniques and Methodology iv) Impact on breast cancer research Proposed duration This should be entered in months for a maximum three years (36 months) Proposed start date - Important note: Projects must start within nine months of the award letter being received. Award letters will be sent approximately one month after the Board of Trustees meeting in July Other Support Is this research supported by any other outside bodies? If yes indicate the organisations, degree and time scale of support. Please note that we will not consider part-funding of projects funded elsewhere. Submitted Elsewhere Is this application being submitted elsewhere? If yes give details of where the application has been submitted, and when a decision is expected. Type of application New application Follow on from a successful pilot grant Re-funding of a current grant Invited resubmission Uninvited resubmission If the application was rejected without any invitation to re-submit the application, a re-submission of the same application for the same award will not be considered. However, applications which are significantly different in terms of objectives and scope and that go beyond addressing the referee concerns of the previous application will be considered in competition with other applications. Applicants must submit a covering letter along with the application and must declare it as a revised application and detail the modifications which merit its re-consideration. If the application was rejected without any invitation to re-submit the application and the applicant plans to submit the research proposal for a different award i.e. Rejected fellowship to project grant, a covering letter must be submitted acknowledging the rejected grant, detailing the modifications which merit its reconsideration and the reasons for applying for a different award. If necessary, please contact the office for further clarification (grants_admin@breastcancercampaign.org). 2) Lead-Applicant The Lead Applicant must be the Principal Investigator who will lead the research and be responsible for delivering the project. Applicant s details and CV This section displays the Lead applicant s details and CV (contact address, qualifications, post held, current grant held) as entered by the Lead Applicant during the registration. These details can be updated at any time by visiting the Manage My Details section on the portal. Other Campaign applications under consideration

4 Where applicable, list grants by reference number (if known) and title, stating your role on the grant (e.g. lead applicant, co-applicant, etc.). Total number of publications Enter your total number of publications to date. Number of first author publications Enter the number of first author publications to date. Number of last author publications Enter the number of last author publications to date. Most relevant publications to date This will show your ten most important publications as entered in the Manage My Details section of the portal. To edit, go to the Manage My Details. 3) Co-Applicant(s) Co-applicants will have intellectual input into, and part ownership of the research if the application is successful; he/she is expected to be actively involved in the project. Adding Co-Applicant(s) To add a co-applicant, press Add a co-applicant, enter the surname, and press Find contact. If the co-applicant is found in our database (correct name, surname, institution and department), select it by clicking on the correct name and follow instructions If the co-applicant is not found in our database, click on Contact not found? Click to add and follow instructions Each co-applicant added to the grant will receive an asking them to confirm their involvement with this application, and to enter/update their CV. [Important note] - Each co-applicant must do the following before the submission deadline: Register with the Grants Online portal and update their CV by visiting the Manage My Details section Confirm participation as co-applicant for this application to be allowed to view the application Approve the application before the application can be submitted Co-applicants are able to view, but not edit, the application. 4) Collaborators Collaborators do not have access to grant funds. They will be expected to contribute to the overall intellectual direction of the research project or program of research and bring their own resources to the collaboration, but will not be involved in the day-to-day execution of the project. Adding Collaborators To add collaborator(s), press Add a collaborator, enter the surname, and press Find contact. If the collaborator is in our database (correct name, surname, institution and department), select it by clicking on the correct name and follow instructions If the collaborator is not in our database, click on Contact not found? Click to add and follow the instructions. A message will then appear asking you to confirm your selection and saving will generate an to each collaborator added to the grant will receive an asking them to confirm their participation and approve this application. [Important note] - Each collaborator must do the following before the submission deadline: Confirm participation as collaborator for this application to be allowed to view the application Approve the application

5 The lead applicant will fill in the reasons for collaboration (200 words max) and obtain a letter of collaboration (1 page max) from each collaborator to attach. Collaborators are able to view, but not edit, the application. Recommended/Excluded reviewers Please note: this section will not appear in the final pdf version of your application form or any document sent to reviewers. We may use this information to assist with the peer review process of your application. Recommended Reviewers Up to four reviewers may be recommended here. Do not include individuals who may present a conflict of interest with your application (e.g. same institution, close/recent collaborator, co-authorship in the last five years). To add recommended reviewers, click on Add Recommended Reviewers and follow instructions. Excluded Reviewers Up to four excluded reviewers may be listed. To add inappropriate reviewers, click on Add Excluded Reviewers and follow instructions. 5) Head of Department Before submission, the Head of Department must confirm the participation of the host institute. The Head of Department will receive an automated requesting confirmation of participation and approval of the application. Please note if adding a head of department as a co-applicant or collaborator, add the dean of the school as a head of department instead and ask them to sign off the application. Adding a Head of Department To add your Head of department, click on Add Head of Department, enter surname, and press Find contact. If the Head of Department is in our database (correct name, surname, institution and department), select it by clicking on the correct name and follow instructions If the Head of Department is not in our database, click on Contact not found? Click to add and follow instructions [Important note] - Before the submission deadline, the Head of Department must: Confirm participation as Head of Department for this application to be allowed to view the application Approve the application before the application can be submitted The Head of Department is able to view, but not edit, the application. 6) Finance Officer Before submission, the Finance Office must confirm participation. Adding a Finance officer To add a Finance Officer, click Add Finance Officer, enter as surname, and press Find contact If the Finance Officer is in our database (correct name, surname, institution and department), select it by clicking on the correct name and follow instructions If the Finance Officer is not in our database, click on Contact not found? Click to add and follow instructions The Finance officer added to the grant will receive an asking to confirm their participation.

6 [Important note] - The Finance Officer will act as the final signatory of the application Once the Lead Applicant has pressed submit, the Finance Officer will receive the request for final approval Before the submission deadline, the Finance Officer must: Confirm participation as the Finance Officer for this application to be allowed to view and edit the application. This step is required to validate the application form and submit the application for the final approval for from the Finance Officer. Approve the application. This step is the final approval required for the application to be fully submitted. The Finance Officer will receive a request for a final approval by once the applicant has pressed submit. The Finance Officer is able to view and edit the application. 7) Costs Allowed and disallowed costs The following list is not considered exhaustive. We may query and/or remove any costs that are deemed to be outside of our funding remit. For any queries, please us to grants_admin@breastcancercampaign.org Allowed costs include Salary for those member(s) of staff carrying out the research (Please note that we will not cover salary costs for tenured contracts or part thereof) Laboratory materials and consumables directly attributable to the project Microarray or sequencing costs Animal costs (purchase, housing, husbandry, animal licence costs etc.) Small pieces of equipment (including PC s) if essential for the project Computer software license (if required specifically for the project, for example image analysis) Access charges for shared equipment (for example hourly charge to use microscopy or mass spectrometry equipment) Pathology service costs Statistician advice/consultancy costs included in Other Expenses Costs associated with authentication/validation of cell lines Travel related to the research proposal (for example participant expenses to travel to focus group meetings/interviews/assessments) Home office licenses Disallowed costs include Salary recovery costs on tenured posts (Please note that we will not cover salary costs for tenured contracts or part thereof.) Full economic costs, including infrastructure costs (such as lighting, heating, telephones, use of library facilities, general laboratory equipment) General office expenses (photocopying, postage etc.). An exception may be made for secretarial assistance and printing costs for epidemiological/questionnaire based studies A proportion of central support staff salaries (e.g. secretarial support) A proportion of general technician salaries (for e.g. wash up, waste disposal etc.) A proportion of PI or CoI salary for supervision time Equipment maintenance and running costs Staff recruitment costs Publication or printing costs Purchase of books Attributing the cost of health and social care Research and Development (AcoRD) AcoRD came into effect in England, for research grant applications submitted after 1 October It is a mechanism for the Department of Health to meet some of the costs of charity-funded research in the NHS, for charities that are members of AMRC.

7 Breast Cancer Now are members of the AMRC and therefore, if your application involves clinical research in a NHS Trust, there are some research costs which we will not be expected to pay (such as data collection or preparing for regulatory approval), where these activities are being carried out by staff employed by the NHS/NIHR Clinical Research Network. The full list of exempted costs is: Local study trial co-ordination and management. Data collection needed to answer the questions that the research study is addressing (including collecting data for and completing the report). Regulatory preparation and compliance including obtaining ethical approval and complying with the Medicine for Human Use (Clinical Trials) Regulations The time taken by chief and principal investigators (CI and PI) to explain the study to professional colleagues, and to understand, the research elements of a study. For example the time taken to explain the criteria for patient eligibility or to explain the randomisation protocol. Sponsorship fees such as MHRA fees, and CTA annual renewal fees. Overheads Project grants will be funded on the understanding that the host institution meets the overhead and infrastructure costs. Infrastructure costs include items such as lighting, heating, telephones, use of library facilities, general laboratory equipment, general office expenses, core laboratory services (wash up and waste disposal), maintenance and running costs of laboratory equipment, estates costs. Breast Cancer Now-CSO will not pay for central support staff e.g. secretarial support nor photocopying, printing or postage costs etc., (except in cases where the volume of paperwork and mailings are considerable for example epidemiological or psychosocial studies). Breast Cancer Now-CSO will only fund directly incurred costs and not the full economic costs of research (fecs) or a proportion of these. Personnel costs We will cover the salary of the person who will directly work on the research proposed. A proportion of PI or CoI salary for supervision/consultancy time is not allowed. Please note that Breast Cancer Now-CSO will not cover salary costs for tenured contracts or part thereof. At least one personnel cost must be added for project grant. Breast Cancer Now-CSO will not accept project grant applications for consumables and equipment only. Adding Personnel costs To add personnel costs, click on Add Personnel Costs and complete the table: Staff member details Enter the details of each staff member, including a brief description of their job title Qualification - Please note here the highest qualification achieved by the researcher Role Please detail the role that the named researcher will have in the project Grade and Scale point The grade and scale point at which appointment is expected should be noted here. A copy of the grade/scale system used must be uploaded with the application Basic salary Enter staff costs at the full time rate per annum (100% WTE). Applications should include any salary increases expected to take place during the period of the grant, including annual increments based on the host institution s salary scale and potential inflationary increases. Salaries should be included from

8 the proposed start date of the project not the date of the application. Contact your finance department for advice on potential salary increases % WTE Enter what percentage of full time working time equivalent the researcher will spend on the project. Justification Please provide a brief justification of the personnel costs applied for. Salary The salary will be calculated automatically from the basic salary and %WTE values entered. Employer s on costs These costs are superannuation/graduated pension and NI contributions and should be included in the salary for all staff Materials and consumables A detailed breakdown and justification for of all minor equipment and materials and consumables is requested. Microarray/sequencing and animal costs are to be listed separately. Minor equipment We assume a basic level of equipment provision by the host institution. The items requested here must be required specifically for the research proposed. New requests for equipment will not be considered once the project has started. [Important Note] We will not fund a large piece of equipment, unless the project cannot proceed without it being in place. Full justification for the equipment request is required and must be included in the research proposal. Maintenance costs should be included under Other Expenses. Animal costs If the Project involves the use of animals, you must detail the number and species of animal to be used; why an animal model is necessary and why this specific model was chosen. Detail the animal costs required for this research, including purchase, housing and husbandry. Further questions including regarding the species, number, justification and procedures used and how these have been refined to adhere to the 3R s in animal research will be required in the Additional Details section of the form. Other expenses Any other costs not listed above should be included here Conference travel costs Breast Cancer Now-CSO will cover costs for travel to conferences where Breast Cancer Now-CSO are being presented. Conference travel costs must be added in the application form in order to validate the form and submit. We will provide 1000 for the costs of travel, registration and accommodation for one international conference and 300 per year for the costs of travel, registration and accommodation for national conferences. We will pay costs only on receipt of invoice, and will require a short report on the outcomes of the conference. Travel related to the research proposal (for example participant expenses to travel to focus group meetings/interviews/assessments or travel between collaborating centres) is permissible if fully justified. This must be added in the Other Expenses section.

9 8) Research Proposal The core text of your research proposal must address the points listed below. Failure to do so will result in your application being removed from consideration. Research Proposal (2000 words) Aims and purpose of proposed investigation Outline the objectives of the research proposal, the significance of any results that may be obtained, and their relevance to breast cancer. Background to the project Briefly outline the background to this project, as well as the need for the current proposal. Plan of investigation and methodology Detail the experimental methods, techniques and analyses that will be used to test the proposed hypotheses. Potential problems Outline any potential problems or challenges you anticipate with your proposed investigation, as well as how you plan to address these. Timescale Outline the planned timescale for this investigation, including project milestones. Integration with ongoing research (150 words) Please describe how the proposal fits into the on-going work of the laboratory where the project is place. taking Expected value (150 words) Outline the expected value of this research to both the academic community and breast cancer patients. This should include expectations for both long and short term objectives for the results of the project. Figures An additional two page document (doc, docx, pdf) containing figures (including legends) and/or a Gantt chart (or similar) may be uploaded here. References An additional or two page document containing references for your proposal (including any relevant publication from your group) may be uploaded here. [Important note If you have used Endnote to format the references, please remove the formatting and convert it to pdf prior to uploading it to the application form] Abstracts of unpublished papers An additional one page document (doc, docx, pdf) containing abstracts of unpublished papers only may be uploaded here. Note: If you wish to include confidential unpublished data in your application which you do not wish to be seen by external referees, this should be submitted by to grants_admin@breastcancercampaign.org in a separate document to the application form. This information will be treated as confidential; it will be held in the office and will only be seen by two members of the Scientific Advisory Board. 9) Preliminary Data (500 words) Please describe any preliminary data that is relevant to your application (500 words max) A one-page document (.doc, docx, pdf) containing figures and legend for your preliminary data may be uploaded here. 10) Additional Details (500 words) Intellectual property body Please provide the name of your host institutions IP body. Breast Cancer Now-CSO s aim is to exploit the outcome of its research so that the understanding, diagnosis and treatment of breast cancer and related diseases are maximised. Neither the host institute nor Breast

10 Cancer Now-CSO (nor its agents) shall be under any obligation to protect intellectual property and materials where, in the party s reasonable opinion, this is not deemed the optimal method of achieving Breast Cancer Now-CSO s aim. It is the responsibility of the appropriate authority in the host institute and/or the grant holder to regularly review any results produced from or arising during the course of Breast Cancer Now-CSO funded research and identify and without unnecessary delay, inform Breast Cancer Now-CSO (or its agent) of any rights in those results, including any patents, design rights, copyright and other industrial and intellectual property rights, whether register-able or not and all scientifically useful or commercially exploitable material, know-how and data relating to any invention arising from Breast Cancer Now-CSO funded research ( Intellectual Property Rights ) which might be suitable for commercial exploitation. Publication or any other form of public presentation of the results should not occur until after that review and all necessary steps to protect any Intellectual Property Rights have been taken. However, there should be no unnecessary delay before publication. The host institute shall allow Breast Cancer Now-CSO (or its agent) to visit, meet and discuss with Breast Cancer Now-CSO grantees the results of their research and any potential for protection of such Intellectual Property Rights and for the commercial exploitation of their research. If, in the opinion of Breast Cancer Now- CSO (or its agent), any results of Breast Cancer Now-CSO funded research are protectable or have a potential for commercial exploitation then Breast Cancer Now-CSO (or its agent) will inform the host institute. The host institute shall have the first option to take all necessary steps to protect any Intellectual Property Rights, as may from time to time be identified by the host institute and /or Breast Cancer Now-CSO (or its agent) and notified by each of them to the other. If the host institute decides not to protect any Intellectual Property Rights, Breast Cancer Now-CSO (either itself or through its agent) may elect, but is not obliged, to take the necessary steps required to protect those Intellectual Property Rights. In this case, the host institute shall co-operate fully with Breast Cancer Now-CSO (or its agent) and ensure that their employees, contractors and agents do the same and will, upon Breast Cancer Now-CSO s (or its agent s) request, assign to Breast Cancer Now-CSO (or its agent), at no cost (but without prejudice to paragraph 5), their respective whole right, title and interest in and to the results of any Intellectual Property Rights relating to those results. All revenues generated through the commercial exploitation of the Intellectual Property Rights arising from research funded by Breast Cancer Now-CSO, shall following reimbursement of costs directly incurred in protecting the Intellectual Property Rights and in carrying out the exploitation be divided equally between the host institute on the one hand and Breast Cancer Now-CSO (or its agent) on the other regardless of which undertook the commercial exploitation. In the event that parties other than those funded by Breast Cancer Now-CSO contribute to the generation of Intellectual Property Rights, the parties shall meet to agree who should assume responsibility for such action and a revenue share which reflects the relative contributions of all parties. Successful applicants must therefore advise Breast Cancer Now-CSO of all other financial assistance to their projects. The host institute shall be solely responsible for rewarding the inventors and department in which the researchers are situated out of its share of the revenue net of the aforementioned costs. The host institution shall not enter any agreement to commercially exploit, or that grants any third party the right to commercially exploit, the research results and/or Intellectual Property Rights without first sending such agreement to be reviewed by the Breast Cancer Now-CSO (or its agent) and obtaining the written consent of the Breast Cancer Now-CSO (or its agent). Breakthrough Breast Cancer and Breast Cancer Campaign -CSO (or its agent) reserves the right to refuse such consent or to grant consent subject to such terms and conditions as Breast Cancer Now-CSO (or its agent) may decide. For the avoidance of doubt, Breast Cancer Now-CSO reserves the right to vary its policy from time to time regarding ownership and exploitation of the Intellectual Property Rights and to change these Conditions accordingly. Commercial significance Please outline if the results of this research are likely to have commercial potential. Please provide further detail if there has previously been any patent filed or commercial interest expressed in the research related to this application.

11 Research involving animals Applicants are expected where possible to adopt procedures and techniques which avoid the use of animals, and where this is not possible, to use the minimum number of animals considered necessary to achieving a valid result in any experiment (this may involve the use of animals of higher quality). Grant holders are asked to ensure that any new procedure which reduces the number of live animals required for research or testing is communicated through the usual media so that it becomes known to all who might make use of it. If the Project studentship involves the use of animals, you must detail and justify the number and species of animal to be used; whether the animals will be genetically modified (and, if so, Will these animals express, or be bred to express, harmful mutations?); why an animal model is necessary and why this specific model was chosen. Please also describe how the project plan has been refined to adhere to the 3Rs by using the minimum number of animals possible and causing the least suffering (please refer to for further details). We require this information to ensure that all necessary approvals are/will be in place and to collect data for the Association of Medical Research Charities (AMRC) on the use of animals within our grant portfolio. If the appropriate approvals are already in place, please provide the Home Office Number and upload the licence in the corresponding section within the form (MS Word or PDF only). Please provide the following Justification for the use of the animals proposed as against any available alternative models Full details and justification for the numbers of animals to be used Details and justification for the species to be used Description of the procedures to be used and action proposed to refine the techniques and whether they are described as MILD/MODERATE/SEVERE Please give a brief justification on why alternatives cannot be used Please upload a copy of the relevant pages of the animal licence including details of the licence holder and number. Where the work is subject to regulation by the Animals (Scientific Procedures) Act 1986, the provision of that act must be observed. Our support for a particular project does not absolve the applicant from personal responsibility in this regard; application for all licenses and certificates required under the Act must be made to the Home Office direct through the host establishment s normal channels. We do not insist that Home Office approval of any particular project be sought in advance of the application for funding, but any award made in response to such an application will be on the absolute condition that no work which is fees controlled by the Act will begin until the necessary licenses and certificates have been obtained. Any levied under the Act are the responsibility of the host establishment and cannot be provided under the grant. Finally, please also indicate whether the research will involve the use of stem cells, providing further justification if embryonic stem cells are to be used. Ethical considerations Policy on patient involvement in medical research We require that patients be treated according to the World Medical Association Declaration of Helsinki and the Guidelines for Good Clinical Practice. If this project requires Ethical Committee approval, please indicate here and upload the relevant Ethical Approval letter with the application. If ethical approval is pending, or to be sought once funding is confirmed please indicate here. Research involving tissue samples and/or cell lines If human tissue samples are being used give details of where they will be obtained from. [Important Note - You may apply for samples from our Tissue Bank] Please visit for more information on the Tissue Access Policy and browse what samples are available.

12 If you intend to access samples from our Tissue Bank, please check that the Tissue Bank has the samples you require. If your grant application is successful, then you may apply to the Tissue Bank for the materials you require. This will not include a repeat of the peer review already undertaken on your grant application, but will involve our Tissue Access Committee checking the material you require is suitable for you aims. Please do not request funding to cover the costs of the materials, we will cover these costs for you upon application to the Tissue Bank. If you require more information or wish to speak to us about what is available from the Tissue Bank then please contact grants_admin@breastcancercampaign.org Consider if you need expert input from a pathologist. If this is the case, a named pathologist is required as a collaborator. The Breast Cancer Tissue Bank may be able to provide pathology support on a collaborative basis, please indicate if you will be asking for this if you will be apply to the Tissue Bank for material. If cell lines are being used quantitative information on the material to be used and its source(s) is required. If new cell lines are to be obtained externally give details of where they will be sourced from and how they will be authenticated on receipt. Details on what procedures will be undertaken to validate/authenticate the cell lines, to ensure they are free from cross contamination, microbial contamination and phenotypic drift must be given. Plans to validate cell lines at the start of the project and throughout the research must be given. Power calculations Where relevant (for example if formal statistical inference will be performed) details about sample sizes and power calculations should be given, including as appropriate: The outcome measure on which the power calculations are based The size of the difference that the study is powered to detect, and justification of positing that size For population studies further details should be given, including as appropriate: The outcome measure on which the power calculations are based The likely prevalence of the exposures of interest The justification for the choice of the type I error rate The justification for the effect size that the study is powered to detect Details on how assumptions made about the completeness of follow-up and covariate data have been taken into account A one-page document (doc, docx, pdf) including details about power calculations only may be uploaded here. 11) Campaign Grants Held Please provide details of a current or most recent Campaign funded grant either as Lead Applicant or Co- Applicant. 12) Lay Overview In order to promote a better understanding of the research Breakthrough Breast Cancer and Breast Cancer Campaign-CSO funds, we require you to supply a lay summary which will be used to describe this grant to relevant stakeholders, including our Trustees and supporters. The information may also be used for fundraising purposes to ensure we can fund your research should your application be recommended for funding. Should the grant be awarded the information may be used in lay publications and the audience may include existing and potential donors to the charity. It is essential that all parities understand why and how their money is being spent.

13 This lay overview section will not be reviewed as part of the funding decision, and will be used for data gathering and monitoring purposes only. The section must be completed to validate the online application for and submit. Below are some guidelines to help you write a lay summary for your research proposal. To pitch the lay summary at the appropriate level it might help to imagine yourself talking to a friend or a relative about your work. In general, when writing a lay summary, try to avoid using jargon or technical terms if you must use such terms, define what it means in non-specialised language first. Lay Summary To write this section, it might help you to think of it as an abstract for a non-scientific audience; do not use your scientific summary. For example: On diagnosis of breast cancer a patient may be offered several forms of treatment including radiotherapy; in fact the majority of breast cancer patients receive this form of treatment and is used to destroy any breast cancer cells left behind after surgery. This work aims to reduce the side effects experienced by those who receive the treatment. Need for project Outline why there is a need to support this particular avenue of research (particularly for patient benefit) what is the problem that this research proposal trying to solve? For example: Radiotherapy is a very effective treatment for breast cancer but a small minority of patients develop unpleasant side effects. At the end of treatment some women develop marked redness and peeling of the skin, which usually rapidly heals. A few later develop unsightly red blood vessels or thickening beneath the skin, often associated with chronic pain. These late effects are life-long. At present it is impossible to identify which patients are susceptible to the side effects before they receive treatment. Aim of the project Outline what the project aims to achieve. Testing of project Outline the methodological approach to be taken. Try to avoid technical terms describing methods, and instead focus on what the methods aim to achieve. Patient benefit Indicate what the relevance of the outcome of the research is to patients with breast cancer or those who are at risk. Give the reader a reason to engage with what you do by explaining how your work will help people affected by the breast cancer, even if this is a long way off. Confidentiality issues surrounding IP State here if there are any IP, confidentiality or patient recruitment issues that would be compromised as a result of external communication of your research to our stakeholders (consider details included in your proposal as well as in this lay summary). 13) Data sharing plan We are interested in finding out how researchers are sharing their research data, in addition to publishing in peer review journals and presenting at conferences. Please complete this section with details of your data sharing plans. This data sharing plan will not be reviewed as part of the funding decision, and will be used for data gathering and monitoring purposes only. We are interested in finding out how researchers are sharing their research data, in addition to publishing in peer review journals and presenting at conferences. Please complete this section with details of your data sharing plans. This data sharing plan will not be reviewed as part of the funding decision, and will be used for data gathering and monitoring purposes only.

14 Completing the data sharing plan In some disciplines, for example bioinformatics and proteomics it is common practice to make large data sets available in public access databases. If your project will generate large data sets please describe how these will be shared. Descriptions may include: Data quality and standards data should be released in a format that conforms to agreed community standards, especially where this allows interoperability with other relevant datasets Methods for data sharing - for example through deposition in existing public databases or on request, including access mechanisms where appropriate Standards and metadata - the standards and methodologies that will be adopted for data collection and management Relationship to other data available in public repositories Further intended and/or foreseeable research uses for the completed dataset(s) Proprietary data - any restrictions on data sharing due to the need to protect proprietary or patentable data Timeframes for public release of data We are keen to encourage data sharing in all scientific disciplines (in addition to those detailed above). So applications in other areas should describe here any mechanisms or databases currently used to share data, or indicate any issues and barriers that exist to hinder data sharing. Our position statement on data sharing As a member of the National Cancer Research Institute (NCRI), we endorse the NCRI data sharing policy and asks that researchers share the data generated from publicly funded research, in order to maximise value to the research community and ultimately for patient benefit. We have contributed to the costs of the NCRI Informatics Initiative, which supports the development of data standards and promotes a culture of data sharing. We encourage applicants to detail their data sharing plans in their application form. Applicants who do not currently share their data will be encouraged to indicate what issues and barriers exist that hinder them from making their data available to the wider research community Open Access Policy From 1st October 2014, we will provide funds to support the payment of article processing charges (APCs). Please read our policy on Open Access here. Please note that you do not need to add these costs into your application. We are working in partnership with a number of medical research charities to provide funds for Open Access, by forming the Charity Open Access Fund (COAF). This fund will enable a greater number of our supported publications to be made immediately available at the point of publication. COAF will be available to 36 UK institutions and authors at these institutions should apply to their host institutions to access this fund. Find out more by visiting Researchers that are not based at an institution which receives support from the COAF may contact us directly to organise payment of APCs. 14) Research category Please select from the research categories outlined the one category that your research proposal falls within. The research categories we use mirror the Common Scientific Outline (CSO) codes used by the National Cancer Research Institute (NCRI). Further information on these categories can be found on the ICRP website Categorising your application will assist us to monitor the types of applications received and funded. This information is for monitoring purposes only and the information you provide will have no bearing on the referees selected to review your proposal, or on the decision of whether to award the grant.

15 15) Declaration I understand that Breast Cancer Now- CSO will not attach any additional information once the application is submitted. Failure to provide all required information may result in the application being rejected from consideration. I understand that submission of an application indicates full acceptance of the terms and conditions of award as detailed in the terms and conditions document (Appendix 1). Please tick this box to confirm that you have read and agree to the above declaration. 16) Attachments This section will list all the documents uploaded with your application. 17) Validation Validating your online application form This section will list all the sections and fields that still require completing or correcting in order to validate your application form and submit. If none of the application form sections are listed, this means your application form has passed all the validation checks and can be submitted for the Final Approval. Submitting your Application Please follow the next steps to assist you in completing the application process: 1 Press Save & Close Once your application form has passed the validation stage (including approvals from Co-applicant(s) and Head of Department and Collaborator(s)), click Save and Close. You will be taken to the details page of your application. The submit application button on the right hand side of the page should be available. 2 Click Submit At this stage, an automated will be sent to your Finance Office to Approve your application. This is only upon your Finance Department final approval that the application is fully submitted. This must be completed before the deadline for submission. 3 Submission notification All the participants will receive a confirmation that the application has been fully submitted once the final approval from the Finance Officer has been obtained. Hard copies of your grant application It is not required to send hard copies of your grant application at this stage. One hand-signed hard copy will be requested if your application has been deemed suitable by our SAB and sent for external peer review. You will be notified in due course. If you have any queries regarding this application please contact the Research Funding Team (grants_admin@breastcancercampaign.org, ) Appendix 1 Breast Cancer Now-CSO Terms and Conditions of award Finances

16 Payment of grant Grants will be paid quarterly in arrears, on the receipt of an invoice accompanied by a completed Expenditure Breakdown form from the Finance Officer. Breast Cancer Now-CSO are not liable as employer of any persons to whom support may have been given. Final invoices must be received by us within 12 months of the award finish date. Invoice payments will not be made against any grant which has failed to return a signed start date form. Grant amounts agreed will not be increased or extended other than in exceptional circumstances and where funds are available. Applications should include expected cost of salary rises over the period. Our grants are awarded in pounds sterling. Any fluctuations in the exchange rate must currently be met by the grant holder. Travel to conferences Upon presentation of invoice, and corresponding Expenditure Breakdown Form, Breast Cancer Now-CSO will fund up to 1,000 of the costs of travel, registration and accommodation for one international conference throughout the duration of the Breast Cancer Now-CSO funded project. In order to qualify for this, the grant holder must present work funded by Breast Cancer Now-CSO, whether it is in the form of a poster or an oral presentation. We would prefer that the researcher conducted the presentations; this of course depends on his/her experience or the form that the conference takes. We will also require a short report of the outcomes of the conference. Upon presentation of invoice, and corresponding Expenditure Breakdown Form, Breast Cancer Now-CSO will fund up to 300 of the costs of travel, registration and accommodation of one national conference per year, with the same conditions as described above. It is the policy of Breast Cancer Now to encourage the researcher (who may not necessarily be the grant holder) to present at the conference. Breast Cancer Now- CSO will pay costs only on receipt of invoice, and will require a short report on the outcomes of the conference. The travel budget will be available for use for up to 12 months after the award finish date. Grant extensions General Under exceptional circumstances Breast Cancer Now-CSO will consider extensions of current grants for up to 12 months. Extensions will also be considered if it can be demonstrated that the additional time will be beneficial to the project in terms of further results for publication. As a general guideline, a one-month extension for each year of a project funded can be approved. All grant amendment requests must come from the grant holder only. Cost extensions will not be considered for pilot grants. For extensions of up to three months, please contact us for a grant extension request form, which should be submitted at least three months before the extension would start. Applications for extensions of up to three months with costs will be considered by the original Scientific Advisory Board sponsors while extensions of up to three months without costs will be considered by our Research Grants Manager. Cost extensions of between three to 12 months must be put to the Scientific Advisory Board. The request should be put to the office three to six months before the extension would start and at least two months before the next Scientific Advisory Board meeting. A full application from the grant holder should be considered and reviewed by the Scientific Advisory Board at either the May or November Board meeting. Maternity leave We will agree to put the grant into a period of abeyance while the researcher is on maternity leave. The length of time for maternity leave and the conditions on which the researcher will return must be discussed with us in advance of the researcher going on leave. As we do not employ the researcher, we are not responsible for covering maternity leave; the University is expected to assume full responsibility for this. Researcher resignation If a researcher employed on a Breast Cancer Now-CSO funded grant leaves, we will agree to put the grant into abeyance for a period of up to 12 months. If the position is not filled within this time funding may be