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1 Application form reference number: Expert Review Group: Reference number: Q1 Applicant Sponsor 1 (i.e. Head of Department or equivalent) Surname Forenames Title (Dr etc.) Sponsor 2 (i.e. Head of Department or equivalent) Q2 Title of project: Q3 Department name and address of administering organisation where different from applicant s address: Q4 Q5 Period for which support is sought (state in months): Proposed start date: Front page

2 Applicant Name Telephone numbers: Contact address Day Mobile Fax. Sponsor Name Contact address Telephone numbers: Day Mobile Fax. Contact details

3 Q6 CURRICULUM VITAE OF APPLICANT (a) Surname: Forenames: Nationality: Title of current post (If unemployed or in temporary employment, please give details of last appropriate post): Date of appointment/start date of last appropriate post: Expected date of termination/end date of last appropriate post: (c) With whom do you have your contract of employment? (d) Current/last appropriate salary details Basic salary: London Allowance: Salary enhancements: Currency: Please specify currency (If Other ): Date of last increment: Source of personal salary support (If Other, please specify): Please also be specific if salary is funded from more than one source. (e) Previous posts held: (most recent first) Date from Date to Position Department Organisation Curriculum Vitae of Applicant

4 (f) Education/training: Date (mm/yyyy) Qualification Subject Organisation (g) Please provide a summary of your scientific career to date, including key achievements and your aspirations in the long term. You should state why the aims of this fellowship would be beneficial to you at this stage of your career. (no more than 700 words) (h) What scientific considerations led you to choose this research environment? If you have already been based in this location for two years or more, please specify your reasons for remaining (no more than 400 words). (i) Career breaks Have you had any career breaks or periods of part-time work, for example parental or long-term sick leave? If yes, please provide details: Do you wish to undertake this award part time? Curriculum Vitae of Applicant

5 (j) Publications Please list all publications, including original research publications and other scholarly contributions. Publications should be in chronological order with the most recent first. Please give citation in full, including title of paper and all authors. Curriculum Vitae of Applicant

6 Q7 RESEARCH GRANTS FROM OTHER FUNDING AGENCIES Research grants held in the last five years and any key prior grants (list the most recent first). Please state the name of the awarding body, name(s) of grantholder(s) title of project, amounts awarded, your role in the project and start and end dates of support. For all active grants, indicate the number of hours per week that are spent on each project. Q8 (a) PREVIOUS APPLICATIONS TO THE ROYAL SOCIETY Is this the Applicant s first application to the Royal Society? Give details of all previous applications to the Royal Society over the last five years. Please include name of grantholder, grant number (if known), title of project and, if application was successful, the amount and period of award. Q9 (a) PREVIOUS APPLICATIONS TO THE WELLCOME TRUST Is this the Applicant s first application to the Wellcome Trust? Give details of all previous applications to the Wellcome Trust over the last five years. Please include name of grantholder, grant number (if known), title of project and, if application was successful, the amount and period of award. Q10 (a) RELATED APPLICATIONS (Please ensure that you read the guidance notes before completing this section, and that you comply with all the stated requirements while your Sir Henry Dale Fellowship is being considered.) Is this or a related application currently being submitted elsewhere? If yes, to which organisation? By what date is a decision expected? Has this, or a similar, application been submitted elsewhere over the past year? If yes, to which organisation? What was the result? (c) Is this application a resubmission or has it been previously considered under another Wellcome Trust or Royal Society scheme? If yes, by whom and when was it originally considered? Please give the reference number: Please state how this application differs from the original (no more than 500 words). Curriculum Vitae of Applicant

7 Curriculum Vitae of Applicant

8 Q11 DETAILS OF SPONSOR (i.e. Head of Department or equivalent) (a) Surname: Forenames Title of current post: Expected date of termination of current post: (c) With whom do you have your contract of employment? (d) Source of personal salary support (If Other, please specify): Please also be specific if salary is funded from more than one source. Details of sponsor

9 Q12 (a) RESEARCH QUESTION What is your research question? (no more than 100 words) Why is it important?(no more than 250 words) Q13 (a) SUMMARY OF PROPOSED RESEARCH INCLUDING KEY GOALS For scientifically qualified assessors: (no more than 200 words) For lay readers: (no more than 200 words) Science

10 Q14 DETAILS OF RESEARCH PROJECT Detail (a) Aims of the project. Work which has led up to the project. (c) Experimental design and methods to be used in investigating this problem. Full details of the study design for experiments (humans & animals) must be provided. This should include power calculations, sample size justification and, where appropriate, case definition & inclusion/exclusion criteria. Please refer to guidelines. (d) Timetable. For clinical trials, please refer to guidelines. No more than 2,800 words should be used to describe the research project. Graphs, figures and supporting unpublished data should be attached as an appendix. These additional data must not exceed the equivalent of one A4 page in length. Science

11 Q15 REFERENCES (Research project) Please give citation in full, including title of paper and all authors. Science

12 Q16 DATA MANAGEMENT & DATA SHARING Will the proposed research generate data outputs that hold significant value as a resource for the wider research community? If yes, please provide a Data Management and Sharing Plan below (no more than 700 words) Q17 (a) PUBLIC ENGAGEMENT PLANS Do you have plans for engaging with the non-academic public about your work? If yes, do you wish to apply for a provision of funds for public engagement as part of your research proposal? Please refer to guidance for further information. QUESTIONS (c) AND (d): TO BE COMPLETED BY APPLICANTS WHO DO NOT WISH TO APPLY FOR A PROVISION FOR PUBLIC ENGAGEMENT (c) Please provide a brief outline of your public engagement plans (no more than 250 words) (d) Please note that the Funders provide support for researchers in the UK to engage with the non-academic public. Do you wish to receive information about training, funding and other public engagement opportunities? QUESTIONS (e) - (f): APPLICATION FOR A PROVISION FOR PUBLIC ENGAGEMENT (e) Please provide brief details of your proposal (No more than 700 words, please refer to guidance). (f) Total amount requested Science

13 Q18 RECOMMENDATION BY APPLICANT S PRESENT HEAD OF DEPARTMENT OR SUPERVISOR (no more than 500 words) Full name: Position: Q19 RECOMMENDATION BY SPONSOR (i.e. Head of Department or equivalent) (no more than 500 words) (a) If a suitable vacancy arose in a medical school, university establishment or elsewhere, would you be prepared to support the Fellow as a suitable applicant? During the tenure of the Fellowship, would you hope to be able to arrange for the creation of a suitable new post for the Fellow? Full name: Position: Recommendations

14 Q20 (a) WORK ABROAD THIS SECTION MUST BE COMPLETED BY APPLICANTS PROPOSING TO WORK ABROAD FOR PART OF THEIR FELLOWSHIP Name and address of host overseas organisation: Dates of travel and duration of trip(s) (c) Details of accompanying dependant(s) (d) Purpose of the visit(s) (no more than 100 words) (e) Recommendation by sponsor in host overseas organisation (no more than 300 words) Full name: Position: Recommendations

15 Q21 SUMMARY OF FINANCIAL SUPPORT REQUESTED Duration of grant (state in months): (a) (c) (d) (e) (f) (g) Salaries Materials and consumables Animals Equipment Miscellaneous Work abroad Provision for Public Engagement GRAND TOTAL TOTAL COST Financial details

16 Q22 (a) DETAILS OF FINANCIAL SUPPORT AND RESOURCES REQUESTED Salaries (including the applicant s salary) Post no. Name (if known) Staff category Salary Grade/ Scale Start date (dd/mm/yyyy) Period on project (months) % of full time Basic starting salary Total cost on grant Financial details

17 Q22 DETAILS OF FINANCIAL SUPPORT AND RESOURCES REQUESTED (cont.) Materials and consumables (description) Costs Financial details

18 Subtotal (c ) Animals Total purchase cost Total maintenance cost Total procedures cost Total associated cost Subtotal The table below should be duplicated for each different species. (i) (ii) (iii) (iv) (v) Animal species to be used, and strain if relevant Source of supply Purchase Purchase price per animal Total number of animals to be purchased Total purchase cost Maintenance Total number of animals to be maintained Total number of weeks maintenance required Cost per animal per week Total maintenance cost Experimental procedures Types of procedure(s) Cost per procedure(s) Total procedures cost Financial details

19 (vi) Associated costs Staff training costs Total staff training costs Animal environment, training and enrichment costs Total animal environment, training and enrichment costs Animal licence costs Total animal licence costs Total associated cost Financial details

20 Q22 DETAILS OF FINANCIAL SUPPORT AND RESOURCES REQUESTED (cont.) (d) Equipment (i) Equipment purchase Type of equipment Equipment specification Preferred manufacturer/ supplier (if known) Maintenance contract duration (months) Cost of maintenance contract Number of items Cost per item Total cost Contribution from other sources Amount requested Financial details

21 Total: Financial details

22 Q22 DETAILS OF FINANCIAL SUPPORT AND RESOURCES REQUESTED (cont.) (d) Equipment (cont.) (ii) Request for equipment maintenance. Maintenance of existing Wellcome Trust-funded equipment The Funders will only consider providing maintenance funds for equipment more than five years old if the applicant can demonstrate it is cost-effective to do so. Details of equipment/facility Wellcome Trust grant reference number of original award Award start date Award end date Date of purchase Start/end dates of any current maintenance contract & length Total cost of maintenance contract % time of use for this project Total cost for project Total (iii) Request for access charges Access Charges Details of equipment/facility Original source of funding Wellcome Trust grant reference number, if applicable Expiry date(s) of any Wellcome Trust-funded maintenance contract(s) Standard access charge per unit Specify unit (e.g. per hour, per day, per sample ) No. of units to be used for project Total cost for project Financial details

23 Total Financial details

24 Q22 DETAILS OF FINANCIAL SUPPORT AND RESOURCES REQUESTED (cont.) (e) Miscellaneous (description) Costs Subtotal (f) Work abroad (i) Airfare(s) of Applicant and any accompanying partner/spouse (ii) Airfare(s) of any accompany dependent children (iii) Subsistence/overseas allowances (detail below) Financial details

25 Subtotal Financial details

26 Q23 (a) (i) (ii) ACCESS TO RADIATION SOURCES Synchrotron Radiation Sources Will the proposed research require access to a synchrotron radiation source? Please specify to which source(s) you will be applying (i) (ii) (iii) Neutron Sources Will the proposed research require access to a neutron source? Are you requesting costs on this application? If yes, complete table below (anticipated usage must be specified in whole days) and Q23 (d)(iii) Access Charges, detailing the costs required. Details of neutron source Total number of days Number of days per annum Year 1 Year 2 Year 3 Year 4 Year 5 Total (iv) Please justify your proposed access to the neutron source, including the number of days requested (no more than 500 words). Financial details

27 Q24 (a) REASONS FOR SUPPORT REQUESTED In this section, justify: Staff requested specifying their roles, responsibilities and location, if appropriate, with respect to the proposed project (no more than 700 words) Materials and consumables (no more than 500 words) (c) Animal (numbers and species) (no more than 300 words) (d) Equipment, equipment maintenance and access charges (no more than 700 words). For access charges, please show how they have been calculated on a cost-recovery basis. This can include (i) a maintenance or service contract providing a basic level of service; (ii) running costs; (iii) materials and consumables; and (iv) staff time. Please also state the percentage of time/number of hours the equipment/facility will be used for the project. (e) Miscellaneous costs (no more than 500 words) (f) Work abroad (no more than 300 words) Justification of costs requested

28 Q25 CURRICULUM VITAE OF NAMED RESEARCH ASSISTANT (a) Surname: Forenames: Date of birth: Degrees, diplomas etc. (subject, class, university and dates): (c) Current post (if not currently in employment, please give details of most recent post): Position and grade: Department: Organisation: Funding body: Termination date of support: Current basic salary: Basic salary must be shown separately from any salary enhancements or other allowances. Incremental date: If currently funded by a Wellcome Trust or Royal Society grant, please give grant reference number: (d) Previous posts (with dates): (e) Most recent publications: (no more than five; please give citation in full, including title of paper and all authors) Curriculum Vitae of research assistant

29 Q26 FULL ECONOMIC COSTING (UK applicants only) The Funders would like to monitor the full economic cost of research proposals. If your organisation is calculating the full economic costs of this proposal, the table below should be completed. Please note that a contribution will be made by the Royal Society to indirect and estate costs. The Wellcome Trust does not fund the full economic cost of research This information is being gathered for monitoring purposes only and will have no bearing on the peer review and decision-making process for your application. (a) Does the Host Organisation use TRAC or an alternative methodology validated by the UK Research Councils to calculate full economic costs? If yes, please complete the following table: Directly Incurred Costs Staff Travel and subsistence Other costs Equipment Subtotal Directly Allocated Costs Principal Applicant salary costs Coapplicant salary costs Estates costs Other Directly Allocated Costs Subtotal Indirect Costs TOTAL Full Economic Cost ( ) Administration

30 Q27 (a) (c) (d) (i) RESEARCH INVOLVING HUMAN PARTICIPANTS, BIOLOGICAL SAMPLES AND PERSONAL DATA RELATING TO LIVING OR DEAD PERSONS Does your project involve human participants? If yes, refer to notes. Will personal data be used? Will your project involve use of biological samples? Please state: By whom and when the ethics of the project has been reviewed, and specify any other regulatory approvals that have been obtained. (ii) And/or: By whom and when the ethics of the project will be reviewed, and specify any other regulatory approvals that will be sought. (e) (i) (ii) (iii) In the course of your project: Do you propose to use facilities within the National Health Service (NHS)? Does your research involve patients being cared for by the NHS? If the answer is yes to (i) or (ii) above, please indicate which organisation has agreed to be the sponsor for the project under the Research Governance Framework for Health and Social Care, published by the Department of Health in England or the corresponding departments in Northern Ireland, Scotland or Wales. Please note that the Funders cannot act as sponsor. (f) (g) (i) (ii) Does your project involve a clinical trial? If yes, refer to notes and submit the requested information. If your project involves a clinical trial: Please state whether it is covered by The Medicines for Human Use (Clinical Trials) Regulations. Please indicate which organisation has agreed to be the sponsor for the project. Please note that the Funders cannot act as sponsor. (iii) Please confirm that (1) an independent Trial Steering Committee (TSC) will be established and its membership discussed with the Trust (If any other type of independent monitor is to be implemented, please indicate and provide any relevant details) (2) approval will be obtained for the trial protocol, typically by the TSC, prior to commencement of the trial (3) the trial will be registered on the International Standard Randomised Controlled Trial Number Register (ISRCTN), ClinicalTrials.gov, or on another register listed on the WHO International Clinical Trials Registry Platform (ICTRP) Administration

31 (h) Please upload your completed 'Clinical trialists form' here. Q28 (a) (c) (d) (e) (f) (g) EXPERIMENTS ON ANIMALS Do your proposals involve the use of animals? Do your proposals involve the use of animal tissue? Do your proposals include procedures to be carried out on animals in the UK which require a Home Office licence? If yes, refer to notes. Does the organisation where the animal work is to be carried out hold a certificate of designation under the Animals (Scientific Procedures) Act 1986? Do your proposals involve the use of animals or animal tissue outside the UK? If yes, refer to notes. If your project does involve the use of animals, what would be the severity of the procedures? Please provide details of any procedures of substantial or moderate severity (no more than 250 words). (h) Why is animal use necessary: are there any other possible approaches? (no more than 250 words) (i) Will any of the following species to be used? Primate Cat Dog Equidae Genetically Altered Animals Other animals (j) Why is the species to be used the most appropriate? (no more than 250 words) Specific questions for experiments involving non-human primates (k) (i) Non-human primates Do you expect facilities and practices, and the proposed research will comply with the principles set out in the 'National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) Guidelines: Primate accommodation, care and use' (http://www.nc3rs.org.uk/downloaddoc.asp?id=418)? If not, please explain why. Administration

32 (ii) Will it be necessary to transport the non-human primates (i.e. from breeding facility and within the host organisation environment)? If so, indicate approximate journey times and the measures that will be taken to minimise the potential stress during transport. (iii) Will single housing of the non-human primates be necessary at any time? If so, please provide details in terms of the justification for single housing, its duration, and what additional resources will be provided to the animals to minimise the impact on animal welfare. (iv) Describe the experimental procedures involved and how any pain, suffering, distress and/or lasting harm will be minimised. Have the procedures been recently reviewed by the Named Veterinary Surgeon (NVS), Named Animal Care and Welfare Officer (NACWO) and ethical review process (ERP)? (v) Will any of the experimental procedures involve food and/or water restriction? If so, justify why this is necessary and outline what alternatives have been considered. (vi) Will any of the experimental procedures involve restraint? What alternatives have been considered? Describe the nature of the restraint, its duration and frequency, and what will be done to avoid distress? (vii) What prior experience and training in non-human primate use, care and welfare have the staff named in the application had? What provision is made for continuing professional development in these areas? (viii) Will any of the staff involved require specific training for any of the procedures concerned? Please provide details of the training needed and where it will be undertaken. Specific questions for experiments involving Cats and Dogs Administration

33 (l) Cats and Dogs (i) From where will the animals be sourced? (ii) Will it be necessary to transport the animals? If so, indicate approximate journey times and the measures that will be taken to minimise the potential stress during transport. (iii) Are animals to be imported? Where animals are to be imported, what journey times have been agreed with the Home Office? Describe the conditions for the animals at the breeding establishment and how the potential stress during transport will be minimised. (iv) Please provide details of the housing for the animals, e.g. enclosure size, environmental enrichment. (v) Will single housing of the animals be necessary at any time? If so, please provide details in terms of the justification for single housing, its duration, and what additional resources will be provided to the animals to minimise the impact of the single housing. (vi) Describe the experimental procedures involved and how any pain, suffering, distress and/or lasting harm will be minimised. Have the procedures been recently reviewed by the Named Veterinary Surgeon (NVS), Named Animal Care and Welfare Officer (NACWO) and ethical review process (ERP)? (vii) Will any of the experimental procedures involve restraint? What alternatives have been considered? Describe the nature of the restraint, its duration and frequency, and what will be done to avoid distress? (viii) What prior experience and training in animal use, care and welfare will be required of the staff named in the application? What provision is made for continuing professional development in these areas? (ix) Will any of the staff involved require specific training for any of the procedures concerned? Administration

34 Please provide details of the training needed and where it will be undertaken. Q29 (a) RISKS OF RESEARCH MISUSE It is the responsibility of organisations in receipt of Wellcome Trust funding to ensure that any risks that research could be misused for harmful purposes are managed in an appropriate manner. Please confirm that you have considered whether your proposed research could generate outcomes that could be misused for harmful purposes. Have you identified any tangible risks of this type? (c) If yes, please briefly describe these risks and the steps that you and your organisation will take to manage them (no more than 250 words). Q30 (a) LOCATION OF RESEARCH Will the research project be undertaken in a Wellcome Trust Clinical Research Facility? If yes, please specify: Will the research project be undertaken in the Wellcome Trust Sanger Institute or a Wellcome Trust Centre? If yes, please specify: Please provide a letter of support from the Director of the Centre/Clinical Research Facility specified. Q31 CONSULTANCIES, EQUITIES AND DIRECTORSHIPS Do any of the applicants have consultancies or any equity holdings in, or directorships of, companies or other organisations that might have an interest in the results of the proposed research? If yes, give brief details (no more than 200 words). Q32 (a) INTELLECTUAL PROPERTY Will the proposed research use technology, materials or other invention that, as far as you are aware, are subject to any patents or other form of intellectual property protection? If yes, give brief details (no more than 200 words). Is the proposed research, in whole or in part, subject to any agreements with commercial, academic or other organisations? If yes, give brief details (no more than 200 words). (c) Is the proposed research likely to lead to any patentable or commercially exploitable results? Administration

35 If yes, give brief details (no more than 200 words). (d) If any potentially commercially exploitable results may be based upon tissues or samples derived from human participants, please confirm that there has been appropriate informed consent for such use. Administration

36 COLLABORATION ON GRANT Collaborators, i.e. scientific/medical/academic colleagues, who are associated with a research proposal and named in the body of the application, but are not coapplicants, are asked to complete this form. Name of collaborator: Full address: Extent and nature of collaboration: Detail the role and contribution of the collaborator, with an indication of the time the collaborator will spend on the project (no more than 200 words). For biomedical research projects only: detail any reagents the collaborator will provide. Please indicate if there are any Intellectual Property issues or restrictions arising from Material Transfer Agreements (no more than 200 words). Collaboration form

37 ADDITIONAL INFORMATION Additional information you wish to communicate regarding this application. For example, please state if you are sending additional material, such as collaborators forms, under separate cover. Suggested reviewers should be listed in a covering letter, which can be accessed via your homepage. Additional information

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