2018 NIH S10 Program:

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Camilla Blankenship
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1 2018 NIH S10 Program: -Shared Instrumentation Grant -Shared Instrumentation for Animal Research Grant -High End Instrumentation Grant Program Overview & Recent Changes

2 Overview and 2018 deadlines Shared Instrumentation Grant (SIG) Program: Budget range for the SIG: $50,000 - $600,000 High-End Instrumentation Grant (HEI) Program: Budget range for the HEI: $600,001 - $2,000,000 Shared Instrumentation for Animal Research (SIFAR) Grant Program: Budget range for the SIFAR: $50,000 - $750,000 Submit a VUMC proposal for matching funds consideration Announcement Posted: January 29, 2018 Internal Proposal Date: March 2, 2018 NIH Open Date: May 1, 2018 NIH Close Date: May 31, 2018

3 Which grant is right for me? Consider both price and purpose of instrumentation <$50,000 Not eligible. What is the price of the most expensive instrument in the application? $50,000-$600,000 Is the instrumentation specifically used to support animal research? >$600,000 HEI Grant Cluster Yes Is the system a cluster or single instrument? Single No SIG SIFAR Consider both SIFAR and SIG* *SIFAR considers requests for a single instrument only if the instrument is to be placed in a barrier facility

4 Shared Instrumentation Grant (SIG) The SIG program encourages applications from groups of NIHsupported investigators to purchase or upgrade a single item of expensive, specialized, commercially available instruments or integrated systems that cost at least $50,000. There is no maximum price requirement; however, the maximum award is $600,000. Types of instruments supported include, but are not limited to: X-ray diffractometers, mass and nuclear magnetic resonance (NMR) spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, cell sorters, and biomedical imagers.

5 Shared Instrumentation for Animal Research (SIFAR) Grant SIFAR was new in FY17. The SIFAR grant program supports requests for state-of-the art commercially available technologies needed for NIH-funded research using any vertebrate and invertebrate animal species. All SIFAR requests must be justified by how they ll advance animal research through novel workflows, improved rigor and reproducibility of experimental protocols, or streamlined procedures. Priority given to clusters of commercially available instruments configured as specialized integrated systems or as series of instruments to support a thematic workflow. An integrated instrument cluster will perform a function that no single component could provide. Series of instruments will enable experiments which require consecutive steps using different technologies. Requests for a single instrument will be considered only if the instrument is to be placed in a barrier facility. One item of instrumentation must cost at least $50,000. No instrument in a cluster can cost less than $20,000. The maximum award is $750,000.

6 High End Instrumentation (HEI) Grant The HEI grant program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of expensive, specialized, commercially available instruments or integrated systems that cost at least $600,001. The maximum award is $2,000,000. Types of instruments supported include, but are not limited to: X-ray diffraction systems, nuclear magnetic resonance (NMR) and mass spectrometers, DNA and protein sequencers, biosensors, electron and confocal microscopes, cell-sorters, and biomedical imagers.

7 Eligibility Overview

8 Eligibility Notes Multiple PIs not allowed for S10. However, Three Major Users with active NIH research awards must be included. Major Users supported by NIH grants should together require at least 35 percent of the Accessible User Time (AUT*). Projects supported by NIH research grants should together require at least 75 percent of the AUT. The 75% can include major and minor users who are not the primary 3 major users. Additionally, the use of any SIFAR instrument for animal research projects should be at least 75% of the AUT. Duplicate applications for the same or similar equipment not allowed or it must be stated by the institution that it is Not an unintended duplication. No re-submission prior to review of the former version. Single application requesting multiple types of instruments is not appropriate. *See next slide for AUT

9 Accessible User Time (AUT) Demonstrates need for a specific instrument. Defined as the number of annual hours the instrument can be used for any research purpose Need to justify AUT for proposed instrument based in individual situation at applicant institution. Applies to both SIG and HEI

10 Types of Support The program awards funds for purchase or upgrade of a single item (SIG, HEI) or cluster (SIFAR). Requested equipment must be commercially available. Requested equipment must be for research purposes only (and animal research purposes for SIFAR). Foreign-made equipment is eligible for purchase with S10 funds.

11 Not funded by the S10 program: An instrument with a base cost of less than $50K for SIG or SIFAR, or less than $600K for HEI. Multiple instruments bundled together, or a series of complementary related instruments. Clusters are allowed & encouraged for SIFAR Software, unless it is integral to operation of a piece of equipment. Instruments used for clinical (billable) care or instruction. General purpose equipment. Proposals to advance design of existing technology or to develop new instrumentation.

12 Special Use Instrument (SUI) Applies to High End Instrumentation program only. Used if institution cannot justify sole use of high-end instrument for NIH-supported and other biomedical research. The instrument s Biomedical Research Time must be at least 50% of the AUT. Remainder of the AUT (max 50%) can be used for non-biomedical research activities, e.g. research in other fields, curricular instructions, and billable clinical care. The institution must contribute portion of the purchase cost commensurate with proposed non-biomedical research use. Contact VUMC Office of Research before considering application for SUI.

13 Required Administrative Elements Annual Advisory Committee meetings and reports Definition and justification of Accessible User Time (AUT) Inventory of other similar instruments, including justification/documentation for why these are not available to the PI and user group 5 year financial plan Institutional support for backup of the financial plan for 5 years from installation of the instrument or for its effective lifetime Annual instrument reports for 5 years after award

14 If an existing award 2013 or later: PI Check List Coordinate with core facility to organize annual instrument advisory committee meetings if not already occurring. Collect information for use in Final Progress and Annual Usage s, including annual report from the instrument advisory committee. Coordinate with Office of Research on publications data. Submit annual reports to NIH as instructed by the program office. If planning a new S10 proposal: Review the RFA : SIG: SIFAR: HEI: Submit an internal proposal online by March 2: Seriously consider collaboration with a core facility Obtain a written statement of support from PI (or core) department or center, committing to provide backup of the equipment financial plan for 5 years from installation of the instrument or for its effective lifetime. Contact the Office of Research with any questions about eligibility, institutional commitments, reporting, Special Use Instrument option.

15 Questions? Contact us with any questions about the S10 program. VUMC Amy Martinez Office of Research VU Liane Moneta-Koehler Office of the Vice Provost for Research Find general program information HERE Find FAQs on the NIH site HERE.

16 Post-Award ing

17 ing: Instrument Performance Each year, VU & VUMC must submit tables including the following for all S10 awards from previous 5 years: Current instrument status Actual usage time Status of maintenance agreement Number of publications citing the S10 award Explanation for any instrument that is non-functional OOR collects this via annual survey effort Reminder: Encourage users to acknowledge your S10!

18 Instrument Performance Example

19 ing: Final Progress At the end of Funding Year 1, the PI must submit a Final Progress, including the following: List of users, their funding and hours of use List of publications Narrative describing impact from Advisory Committee

20 ing: Annual Instrument Usage At the end of Year 2, the PI must submit a Usage, similar to the Final Progress and including the Advisory Committee. The NIH Scientific Research/Contact staff will provide specific instructions to grantees prior to the due date for report. First awards to require this new report were made in 2014.

if needed PI submits at end of Year 2 PI submits at end of Year 3 PI submits at end of Year 4 PI submits at end of Year 5

21 Summary: S10 ing Requirements Submitted to NIH: Instrument Performance Final Progress Annual Usage Annual Usage Annual Usage Annual Usage Vanderbilt submits every year PI submits at expiration of grant, at end of Year 1 PI requests nocost extension, if needed PI submits at end of Year 2 PI submits at end of Year 3 PI submits at end of Year 4 PI submits at end of Year 5 Annual Advisory Committee Annual Advisory Committee Annual Advisory Committee Annual Advisory Committee Annual Advisory Committee

Workshop: NIH Large Instrumentation Programs (S10)

Workshop: NIH Large Instrumentation Programs (S10) 2017 Funding Opportunity Announcements (FOAs): PAR-17-074: Shared Instrumentation Grant (SIG) Program & PAR-17-076: High-End Instrumentation (HEI) Grant