Intramural Research Grant Program 2017 Application Form

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Centre for Innovation Overview Intramural Research Grant Program 2017 Application Form Applicants are advised to review the Canadian Blood Services Intramural Research Grant Program Guidelines to ensure alignment of their applications with the program objectives, research priorities and eligibility criteria. The complete application package must be delivered to Canadian Blood Services by 11:59 PM April 3 2017. Instructions It is the candidate s responsibility to ensure that all documents are delivered by the application deadline. No applications or additional material will be accepted after this deadline. Late or incomplete applications will not be considered. All documents must be delivered by email to centreforinnovation@blood.ca. The submitted application package must include the following documents: 1. Completed Application Form: Ensure that all fields are complete, including signatures, before submitting the application. Page/space and word count limitations must be adhered to. Sections of the application that exceed the identified limits will not be considered. 2. Supporting Documents i. Project Team Members CVs: A Canadian Common CV (https://ccv cvc.ca/) in the CIHR Academic format must be provided for the Principal Investigator and for each Co Investigator. CCVs should be appended to the application. ii. Letters of Collaboration: A letter of collaboration must be provided by each collaborator involved in the project. Letters of collaboration should be appended to the application. Intramural Research Grant Program Application Form

Section A: General Information PROJECT TITLE Principal Investigator: ENTER PRINCIPAL INVESTIGATOR NAME HERE PRINCIPAL INVESTIGATOR Family Name: Given Name(s): Institution: Phone: Email: CO INVESTIGATOR(S) Co Investigators are expected to contribute to the research program, and their expertise must be clearly required to address the project goals. Co Investigators are expected to require material budget items of some nature. Name (Last name, First name) Institution Insert rows as needed. COLLABORATOR(S) Collaborators are individuals whose role in the research project is to provide a specific service (e.g. access to equipment, provision of specific reagents, statistical analysis, etc.). Collaborators are not requesting a budget from Canadian Blood Services. Name (Last name, First name) Institution Insert rows as needed. Intramural Research Grant Program Application Form Page 1 of 14

AGREEMENT Principal Investigator: ENTER PRINCIPAL INVESTIGATOR NAME HERE The undersigned acknowledge that the enclosed application for research funding from Canadian Blood Services represents a study of which the Principal Invesigator was responsible for the proposal development. If funded, the Principal Investigator will assume primary responsibility for the implementation and performance of the proposed study. The undersigned agree that the general conditions governing the Intramural Research Grant Program, as set out in the Guidelines, are accepted by the Principal Investigator on behalf of the project team and the academic institution. Signatures: Principal Investigator Name: Date: Head of department at academic institution for Principal Investigators who are Canadian Blood Services Adjunct Scientists Name: Date: Intramural Research Grant Program Application Form Page 2 of 14

Section B: Project Team Principal Investigator: ENTER PRINCIPAL INVESTIGATOR NAME HERE PROJECT TEAM ROLES In the space provided below, outline the role of each of the Principal Investigator and Co Investigator(s) in the proposed study, specifically addressing the scientific and/or technical expertise each will bring to the proposed project, and the proposed division of scientific labour within the team. If applicable, elaborate on the contributions of collaborators. In a separate file, provide a full Canadian Common CV (https://ccv cvc.ca/) in the CIHR Academic format or equivalent for the Principal Investigator and all Co Investigators. If applicable, provide a letter of collaboration from each collaborator. Intramural Research Grant Program Application Form Page 3 of 14

Section C: Project Information Principal Investigator: ENTER PRINCIPAL INVESTIGATOR NAME HERE PROJECT ABSTRACT Provide a summary (200 words max.), in lay terms, of the proposed project, highlighting project objectives and deliverables and describing how the research is aligned with the Intramural Research Grant Program s objective, including identified Research Priorities. If the project is approved, this summary may be published on Canadian Blood Services website. Intramural Research Grant Program Application Form Page 4 of 14

RELEVANCY TO RESEARCH PRIORITY AREAS In the space provided, provide a description of how the proposal addresses one or more of the Research Priority Areas (RPA) identified for this competition. This justification should include how the research could assist Canadian Blood Services in reaching its overall goal of attaining excellence in the manufacturing and distribution of biological products and in the provision of clinical services, and how it fits into the Canadian Blood Services corporate strategy of improving patient outcomes and continually earning the right to serve the health care system. RPA 1: Promote Appropriate Utilization RPA 2: Ensure Adequate Supply RPA 3: Minimize Adverse Effects RPA 4: Optimize Quality RPA 5: New therapies or technologies Intramural Research Grant Program Application Form Page 5 of 14

SUMMARY OF PROGRESS In the space provided, provide a summary of progress in research activities related to the proposal and, for applications following a currently funded Intramural Research Grant, the progress attributable to the previous Intramural Research Grant. Intramural Research Grant Program Application Form Page 6 of 14

RESPONSE TO PREVIOUS REVIEWS Two (2) pages maximum If this application is a resubmission of a previously unsuccessful grant application, use this space to respond to previous reviewers comments. The response should stand alone and should not require reference to any other document, because reviewers will not have access to previous application information. As such, briefly describe the weaknesses identified by previous reviewers in order to respond to them. Intramural Research Grant Program Application Form Page 7 of 14

RESEARCH PROPOSAL In eleven (11) pages maximum (not including appendices): (a) Describe the proposed research (central hypothesis, research question, specific objectives); (b) Describe the proposed research methodology and/or assays and outline any preliminary data; (c) Describe the relevance of the proposal to the Intramural Research Grant Program s objectives and identified Research Priorities; (d) Describe how the proposed research could be translated into changes in transfusion service or transfusion medicine practice; and (e) Identify any potential pitfalls and outline how the project goals will be achieved if pitfalls are encountered (work plan, timelines, analysis and interpretation of results). References, tables, charts, figures and photographs may be included in addition to the eleven (11) page limit. Legends must be succinct. Detailed descriptions of methods and discussion of results should be included in the body of the proposal, not in the legends or in an appendix. Intramural Research Grant Program Application Form Page 8 of 14

RELEVANT PUBLICATIONS A maximum of three (3) published or submitted articles relating to progress, plus a maximum of two (2) published articles substantiating the subject matter expertise of the Principal Investigator and Co Investigators may be appended to the application. Submitted articles must be accompanied by proof of submission to a journal. List all appended articles in the space below. HEALTH AND SAFETY CERTIFICATION Indicate if the proposal involves the following. Note that this information is used for administrative purposes to ensure that research ethics approvals are in place prior to the release of funds to successful applicants. This information is not used to evaluate the merit of the application. Biohazards Pathogenic agents Yes No Containment level required: 1 2 3 4 none Recombinant genetics Yes No Containment level required: 1 2 3 4 none Radioisotopes Yes No Human Experimentation Containment level required: 1 2 3 4 none Has ethics approval been applied for or obtained? Yes No Not applicable Animal Experimentation Has ethics approval been applied for or obtained? Yes No Not applicable SEX AND GENDER Note that this information is used for administrative purposes and is not used to evaluate the merit of the application. Are sex (biological) considerations taken into account in this proposal? Are gender (socio cultural) considerations taken into account in this proposal? Yes No Yes No Describe how sex and/or gender considerations will be considered in your research proposal: Intramural Research Grant Program Application Form Page 9 of 14

Section D: Budget Principal Investigator: ENTER PRINCIPAL INVESTIGATOR NAME HERE The requested maximum budget for the two year period of the grant is $400,000, with a maximum budget of $200,000 per year. Review the Use of Grant Funds section in the Intramural Research Grant Program Guidelines to become familiar with the eligible and non eligible expenses under this program. Outline the budget requested for each year of the research proposal (maximum two years). For part time and/or shared resources, indicate fractions to represent the time commitment to the project (e.g. 0.5). Budget Overview TOTAL TWO YEAR BUDGET REQUESTED: $ Investigator Name Year 1 Budget Year 2 Budget Insert rows as needed. $ $ $ $ $ $ Intramural Research Grant Program Application Form Page 10 of 14

Budget Year 1 Research staff (excluding trainees) Research assistants Technicians Other personnel Research trainees Postdoctoral fellows Graduate students Summer students Materials, Supplies, and Service Animals* Expendables Services Other Travel (maximum $3000 per year) No. Salary Benefits Funds Requested No. Stipend Benefits Funds Requested Funds Requested Funds Requested Equipment (maximum $8500 per grant) TOTAL * Funding for animal studies is dependent upon an approved animal protocol. If animal studies are contracted out, include this budget allocation under Services. Intramural Research Grant Program Application Form Page 11 of 14

Budget Year 2 Research staff (excluding trainees) Research assistants Technicians Other personnel Research trainees Postdoctoral fellows Graduate students Summer students Materials, Supplies, and Service Animals* Expendables Services Other Travel (maximum $3000 per year) No. Salary Benefits Funds Requested No. Stipend Benefits Funds Requested Funds Requested Funds Requested Equipment (maximum $8500 per grant) TOTAL * Funding for animal studies is dependent upon an approved animal protocol. If animal studies are contracted out, include this budget allocation under Services. Intramural Research Grant Program Application Form Page 12 of 14

BUDGET DESCRIPTION In seven (7) pages maximum, provide a detailed justification for all budget items requested. In addition, outline how funds will be allocated between the Principal Investigator and Co Investigator(s). In kind contributions to the project and other sources of funding for the project must be identified. Intramural Research Grant Program Application Form Page 13 of 14

REAL OR PERCEIVED BUDGETARY OVERLAP In the space provided below, supply details of any overlap with extisting or proposed funding. Use this space to dispel any uncertainties that could arise in the minds of reviewers as to whether you are already funded, in whole or in part, for the proposed work, as they review the list of funded and submitted grants in your CCV. Source: Amount: Comment as to overlap/lack of overlap: Source: Amount: Comment as to overlap/lack of overlap: Insert rows as needed. Intramural Research Grant Program Application Form Page 14 of 14