Anthem Blue Cross and Blue Shield Commercial Professional Reimbursement Policy

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Subject: Injection and Infusion Administration and Related Services & Supplies IN, KY, MO, OH, WI Policy: 0015 Effective: 05/01/2017 Coverage is subject to the terms, conditions, and limitations of an individual member s programs or products and policy criteria listed below This reimbursement policy also applies to Employer Group Retiree Medicare Advantage programs Description This policy addresses reimbursement and reporting requirements for injection and infusion administration and related services and supplies submitted by a provider on a Form CMS-1500 This policy applies to procedures included in the code ranges of 96360-96361 for hydration; 96365-96371 for therapeutic, prophylactic, or diagnostic infusion; 96372-96379 for injection; 96401-96549 for administration of chemotherapy and other highly complex drugs or biological agents; and, 99601-99602 for home infusion/specialty drug administration Policy I Place of Service: The Health Plan follows Current Procedural Terminology (CPT ) coding guidelines for the appropriate place of service reporting of hydration, injection and infusion codes Per CPT, These codes are not intended to be reported by the physician in the facility setting Therefore, the Health Plan s claims editing system will deny reimbursement for procedures in the code ranges stated above (excluding 96405-96406, 96440, 96446, 96450, and 96542) when reported as performed by a physician in a facility setting Some examples of facility settings include but are not limited to: hospital inpatient/outpatient and emergency departments, ambulatory surgery centers, surgical suites, birthing centers, skilled nursing facilities, and residential treatment facilities 99601-99602 are used to report infusion/specialty drug administration services provided to the patient located in a home setting and are only eligible for reimbursement when reported with a place of service that indicates the patient s residence (eg, private residence (12), assisted living facility (13)) II Reporting Multiple Infusions: The Health Plan requires that correct coding be followed when reporting the administration of multiple infusions, injections, or a combination of both, whether performed concurrently or sequentially The following examples are some, but not all, CPT coding guidelines that should be followed: IN, KY, MO, OH, WI 0015 Injection and Infusion Administration and Related Services and Supplies Page 1 of 5 Anthem Blue Cross and Blue Shield is the trade name of Anthem Insurance Companies, Inc Independent licensee of the Blue Cross and Blue Shield policies; and Compcare and BCBSWi collectively, which underwrite or administer the POS policies Independent licensees of the Blue Cross and Blue Shield Association ANTHEM is a registered trademark of Anthem Insurance Companies, Inc The Blue Cross and Blue Shield names and symbols are registered

Only one initial service code should be reported unless two separate IV sites are used The initial code is one that best describes the primary reason for the encounter even if performed subsequent to another infusion If an injection or infusion is of a secondary nature (eg, not the primary reason for the encounter), but was administered first, the appropriate subsequent or concurrent code should be reported** **Example: If hydration is administered prior to the chemotherapy infusion, chemotherapy is the primary reason for the patient encounter and is reported as the initial service (96413) The hydration infusion is reported as 96361 (each additional hour listed separately in addition to the primary procedure) even though chronologically it was administered first IN, KY, MO, OH, WI 0015 Injection and Infusion Administration and Related Services and Supplies Page 2 of 5 Anthem Blue Cross and Blue Shield is the trade name of Anthem Insurance Companies, Inc Independent licensee of the Blue Cross and Blue Shield policies; and Compcare and BCBSWi collectively, which underwrite or administer the POS policies Independent licensees of the Blue Cross and Blue Shield Association ANTHEM is a registered trademark of Anthem Insurance Companies, Inc The Blue Cross and Blue Shield names and symbols are registered In addition, the Health Plan has implemented frequency restrictions for certain infusion procedures when the description of the code may be reflective of the total number of times it is clinically possible or clinically reasonable to perform a given procedure on a single date of service For example: 96416 which describes prolonged (more than eight hours) IV Chemotherapy administration has a frequency restriction of one time per date of service 96367 which describes additional sequential IV infusion up to one hour (in addition to the code for the primary procedure) has a frequency restriction of six times per date of service For comprehensive guidelines on the reporting of initial and sequential injection and infusion codes, please refer to the guidelines outlined in the CPT manual in the section titled Hydration, Therapeutic, Prophylactic, Diagnostic Injections and Infusions, and Chemotherapy and Other Highly Complex Drug or Highly Complex Biologic Agent Administration III Reporting an Evaluation and Management (E/M) Service in Addition to Injection and/or Infusion administration: Based on CPT guidance, the Health Plan requires that correct coding be followed when reporting an E/M service provided on the same day as injection and/or infusion administration services When a substantial diagnostic or therapeutic procedure is performed, or a major or even minor surgical/therapeutic procedure is rendered, there is an inherent E/M service component included in the reimbursement for these procedures; therefore, the E/M service is not separately reimbursed If, however, the patient s presenting condition or symptoms required a significant, separately identifiable E/M service above and beyond the other service provided, then modifier 25 should be appended to the E/M service code to be eligible for separate reimbursement IV Reporting Injections and Infusions with Nuclear Medicine Studies: The February 2012 publication of cpt Assistant states the injection or administration of a radiopharmaceutical or nuclear medicine related drug is considered part of patient management in the course of providing nuclear medicine studies and considered inherent to the studies Therefore, the Health Plan considers CPT codes

96365, 96369, 96372, 96373, 96374, and 96379 to be incidental to nuclear medicine studies, CPT codes 78012 79999, and not eligible for separate reimbursement Modifiers will not override these edits The Health Plan s allowance for nuclear medicine studies does not include the cost of radiopharmaceuticals or nuclear medicine related drugs The provider may report these drugs separately with the proper Healthcare Common Procedure Coding System (HCPCS Level II) A, J, Q, or S codes which are eligible for separate reimbursement V Reporting Injection and Infusion Services with Procedural Services that Include Injections or Infusions as Part of the Service: Hydration, therapeutic, prophylactic, and diagnostic injections and infusions are used for the administration of fluids and medications and the Health Plan considers these injection and infusion services to be an integral component to the performance of procedural services that require the use of injection or infusion services to complete the procedure Therefore, when CPT codes 96360-96361, 96365-96368, and 96372-96375 are reported with procedures that inherently include injection or infusion services to complete the procedure the injection and infusion service will not be eligible for separate reimbursement (eg, 96372 (therapeutic, prophylactic, or diagnostic injection (specify substance or drug); subcutaneous or intramuscular ) is not eligible for separate reimbursement when reported with 92242 (fluorescein angiography and indocyaninegreen angiography) VI Reporting an Agent for Infusion: CPT advises that both the specific substance(s) and/or drug(s) provided be reported along with the administration service rendered Therefore, therapeutic fluids and medications administered by the physician are reported separately using the appropriate CPT/HCPCS code(s) and if covered, are eligible for separate reimbursement The diagnosis for the infused/injected drug must be reported at the claim line level If fluids are used to administer the therapeutic agent or drug, this administration is an integral component of the drug administration; it is not reported separately, and is not eligible for separate reimbursement Therapeutic IV hydration infusion administered separately over a prescribed time and rate is separately reported and is eligible for separate reimbursement Please refer to the multiple reporting methodologies described in section II Reporting Multiple Infusions VII Inclusive Services and Supplies: Services related to intravenous infusion such as local anesthesia, IV start or access to a catheter or port, and flushing procedures should not be reported separately, and are not eligible for separate reimbursement IN, KY, MO, OH, WI 0015 Injection and Infusion Administration and Related Services and Supplies Page 3 of 5 Anthem Blue Cross and Blue Shield is the trade name of Anthem Insurance Companies, Inc Independent licensee of the Blue Cross and Blue Shield policies; and Compcare and BCBSWi collectively, which underwrite or administer the POS policies Independent licensees of the Blue Cross and Blue Shield Association ANTHEM is a registered trademark of Anthem Insurance Companies, Inc The Blue Cross and Blue Shield names and symbols are registered

In addition, the Health Plan follows CPT coding guidelines for CPT code 96523 (irrigation of implanted venous access device for drug delivery systems) which state that the code should not be reported in conjunction with any other service Therefore, CPT code 96523 is not eligible for separate reimbursement when billed with any other service Materials and supplies used during the course of the administration of intravenous infusion, or for injections, are considered to be an integral component of the reimbursement for the services provided and are not eligible for separate reimbursement Examples of specific HCPCS codes may be found in the coding section These supplies include but are not limited to: needles and syringes needle free injection devices sterile water, saline, heparin, and/or dextrose diluent/flush refill kits disinfectant wipes and agents such as alcohol, peroxide, iodine, Betadine, and phisohex, tape, gauze, gloves, trays, etc, and/or any other miscellaneous supplies or items related to the administration of an injection or IV infusion ambulatory infusion pumps, IV poles Coding The following table identifies by code some of the materials and supplies that are described in the policy section The inclusion or exclusion of a specific code does not indicate eligibility for coverage under all circumstances This table is provided as an informational tool only, to help identify some of the procedures described above The Health Plan has implemented a customized edit, if none already existed, in the standard claim editing software package that denies reimbursement for the codes found in this table when billed with the associated injection/infusion administration codes described in the Description section of this policy Modifiers will not override the edits A4206 A4213 A4223 A4305 A4649 A6217 E0776 S1016 A4207 A4215 A4244 A4306 A4657 A6218 E0779 A4208 A4216 A4245 A4450 A4927 A6219 E0780 A4209 A4220 A4246 A4452 A4928 A6220 E1399 A4210 A4221 A4247 A4455 A4930 A6221 J1642 A4212 A4222 A4248 A4550 A6216 A6257 S1015 IN, KY, MO, OH, WI 0015 Injection and Infusion Administration and Related Services and Supplies Page 4 of 5 Anthem Blue Cross and Blue Shield is the trade name of Anthem Insurance Companies, Inc Independent licensee of the Blue Cross and Blue Shield policies; and Compcare and BCBSWi collectively, which underwrite or administer the POS policies Independent licensees of the Blue Cross and Blue Shield Association ANTHEM is a registered trademark of Anthem Insurance Companies, Inc The Blue Cross and Blue Shield names and symbols are registered

CPT is a registered trade mark of the American Medical Association Use of Reimbursement Policy: This policy is subject to federal and state laws, to the extent applicable, as well as the terms, conditions, and limitations of a member s benefits on the date of service Reimbursement Policy is constantly evolving and we reserve the right to review and update these policies periodically No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, or otherwise, without permission from Anthem Blue Cross and Blue Shield 2017 Anthem Blue Cross and Blue Shield IN, KY, MO, OH, WI 0015 Injection and Infusion Administration and Related Services and Supplies Page 5 of 5 Anthem Blue Cross and Blue Shield is the trade name of Anthem Insurance Companies, Inc Independent licensee of the Blue Cross and Blue Shield policies; and Compcare and BCBSWi collectively, which underwrite or administer the POS policies Independent licensees of the Blue Cross and Blue Shield Association ANTHEM is a registered trademark of Anthem Insurance Companies, Inc The Blue Cross and Blue Shield names and symbols are registered