Invitation to Apply for Partnering Forum 2007

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Invitation to Apply for Partnering Forum 2007 We are proud to announce that The International Life Science Partnering Forum KOBE/HYOGO 2007, which is an International Business Match Making Event for life science related companies, is now accepting applications for participants who are seeking business opportunities in the Japanese market. Through this program, participants will benefit by gaining access to executives or directors on business development from Kansai and Kobe-Hyogo area which is a center of Japan who are ready for partnerships and licensing opportunities in the U.S., Europe and Pacific-Asia. Date Venue Program Application Deadline September 18 th (Tue.),2007 9:30am-4:00pm Kobe Translational Research Informatics Center (TRI) (see the map at the end of this brochure) What s Partnering Forum? 1. Presentation of Business Plans (15min/company) 2. Individual Business Meetings (Pre-Arranged) 3. Welcome Reception August 10 th (Fri.),2007 The aim of the International Life Science Partnering Forum Kobe is in general to build bridges to international Life Science Regions with its biomedical clusters and companies. As a starting point we are interested in giving our companies the opportunity to introduce themselves to an international audience and also to inform about our development as a biomedical cluster in Japan. The proliferation of our mutual biomedical activities, will in the end benefit us all more in research & development and enrich our clusters with greater understanding and create more fruitful projects. Organized by Kobe City Government, Hyogo Prefectual Government, JETRO Kobe, Foundation for Biomedical Research and Innovation, Hyogo Economic Development Center

Programs (Draft) 8:30 9:30 Registration 9:30 9:35 Opening Remarks 9:35 9:50 Speech 9:50 12:00 I. Presentation and Partnering (11:30 12:00 Site Tour;Option) 12:00 13:00 Luncheon Seminar The presentation of Kobe At the Great Conference Room 1 13:00 15:00 II. Partnering 15:00 15:10 Summary and Closing Remarks 15:10 16:00 Reception How to Apply? Order Deadline : August 10 th, 2007 Free partnering & presentation to minimum costs Application Biotech Company Partnering Application and Application for Biotech Company & Life Science Cluster Exhibition - Partnering - Selected international biotechnology companies, interested in partnering with companies from the biomedical cluster of Kobe, are invited to participate at The International Life Science Partnering Forum Kobe On Tuesday, September 18th, 2007. - Selection of company - Your company can select the appropriate partnering company from Kobe (see also the list below), within a certain timeline (see also Dates: Deadline, Participants Directory & Cancellation) after: - Receiving your application for participation, Sending the Company Profile and, After receiving the Appointment Request Form from Kobe - Presentation - The International Life Science Partnering Forum Kobe features presentation opportunities for international biotech companies & Life Science Clusters. Presentation time will be prepared in the morning up to 9companies with audience from Kobe/Hyogo companies. Each company has 15 minutes for presentation. Principle is First come, first serve.

Contribution for Meals and Beverages Luncheon & Reception For providing our guests with meals and beverages during the Luncheon-seminar & at the final Reception, we chose a catering service to provide you with appropriate meals and beverages. Fee: Participants will be charged 1.000,- Yen for the Luncheon and 2.000,- for the meals and drinks at the Reception as 2 different service packages. Deadline for application Deadline for sending the application for participation Deadline for submission of application to participate: August 10 th 2007 Deadline for presentation PPT(Windows) data Deadline for submission of application to participate: August 10 th 2007 Deadline for sending the Company & Cluster Profile We ask that you send information regarding participating companies and/or clusters by August 10 th 2007 Directory of the Participants & Appointment Request Form The whole directory of the participants will be send out on the August 15 th 2007. Here the same day August 15 th 2007 the Appointment Request Form (International & Kobe companies) to all companies will also be sent out Deadline to submit Appointment Request Form The deadline to submit the Appointment Request Form is the August 22 nd 2007 Cancellation Policy Cancellations must be received in writing by August 31st, 2007, to the fax number +81-78-322-6072 att.: Mr. Kozo Mori, Manager, Medical Industry Development Project, New Corporate Development Department, Kobe City Government, Japan The International Life Science Partnering Forum September 18 th 2007 Application Form The application form for partnering, exhibition, site-tour and more are as follows:

Order Form Application Order Form Send to KOZO MORI, Kobe City Government Order Form Order Deadline: August 10th, 2007 Please fill in this order form and send it to The International Life Science Partnering Forum Kobe Managing Office listed below by fax: Company / Organization Name URL http:// Contact(s) (Agency/Person responsible for the order) Division NameTitle e-mailaddress TEL FAX Order Check ( ) Business partnering [ ] table(s) (1 table = 2 people) ( ) Presentation 15minutes incluging simultanious translator ( ) Site-Tour [ ] people ( ) Luncheon seminar [ ] people ( ) Reception [ ] people Partnering Participation & Site-Tour Fees - None Presentation Fee - None Luncheon & Reception Fees 1.000,- Yen for the Luncheon and 2.000,- for the meals and drinks at the Reception. Instructions 1) Order & Inquiry please fax to: Mr. Kozo Mori, Manager, Medical Industry Development Project, New Corporate Development Department, Kobe City Government 5-1 Kano-Cho 6-Chome, Chuo-Ku Kobe 650-8570, Japan Fax : +81-78-322-6072

Company Directory Sheet Company Directory Sheet and 2) please send your company/cluster-information by email also as electronic file to Mr. Mori with the attached excel-sheet. (This sheet can also be used for the clusters to be mentioned in the directory) Compan y Name Addre ss Contact Person Position TEL FAX Web Address E-mail Address Paid in Capital ( USD) No. of Employees Year of Establishment Company Overview (150 words max) Company Directory Sheet Specific Technologies to Partner/Phase Development(150 words max) Type of Deals Interested In (Check all that apply) Deal Details (target companies, target business areas, territorial rights, exclusivity, etc) (250 words max) Out-licensing In-licensing Joint Venture Research Agreement Distribution Other

Appointment Request Form and 3) please send your request to meet Japanese companies by email also as electronic file to Mr. Mori with the attached excel-sheet, making reference to candidate companies below, 105 companies list (see attached excel file) or participants company directory we will send later.

Candidate participants from Kobe/Hyogo Until now the following companies from Kobe has shown their interest to participate at the Partnering Forum Kobe on Tuesday the 18 th September 2007 for international company matchmaking: Cosmos Corporation - Interested in medical and healthcare devices manufacturing company HP: http://www.safetyweb.co.jp Trans Genic Inc. - Interested in Companies that have antibody-related technology - Companies that operate business on knockout mice HP: http://transgenic.co.jp Arblast - Interested in Bio/Pharmaceutical companies HP: http://www.arblast.jp/e/index.html CARNA BIOSCIENCE Inc - Interested in Pharmaceutical Company - Biotech Company - Biopharmaceutical Company HP: http://www.carnabio.com/english/index.html M&E Scientific - Interested in R&D department of companies related to pharmaceuticals, food, and cosmetics HP: http://www.mes-kibc.co.jp/ MCRI HP: http://www.mcri.co.jp/index1.htm

Senju Pharmaceutical Co Ltd HP: http://www.senju.co.jp/english/index.html ASPION - Interested in Pharmaceutical companies, cosmetic companies, healthy food companies, venture companies related to developing new drugs HP: http://www.aspion.co.jp/ Tissue Engineering and Cell Therapy Foundation for Biomedical research and Innovation (Dr. Kawamata Lab., FBRI) - Laboratory for Tissue Engineering and Cell Therapy FBRI focuses on regenerative medicine, drug discovery, and monitoring device. 105 medical-related companies in Kobe As well as candidate companies above, we have a network of 105 companies in Port Island 2 nd stage. Please refer to the attached excel file in order to fill out Appointment Request Form above.. The way to KOBE The way to Yokohama, BioJapan From Tokyo (Haneda, Narita); By air, 1-hour flight will take you to Kobe airport (operated every hour) By Shinkansen bullet train, 2.5-hour ride of Nozomi, super express from Tokyo station will take you to Shin-Kobe station. From Kansai International Airport (KIX), By ferry, only 29-minutes ride will take you to Kobe airport (every 45 min.). To Yokohama (venue of BioJapan 2007); We propose to take a flight from Kobe Airport to Haneda or Shinkansen bullet train from Shin-Kobe to Shin-Yokohama.

Helpful Links City of Kobe: http://www.city.kobe.jp/cityoffice/27/kigyoyuchi/iryokannrenn/eng/index.html http://www.city.kobe.jp/index-e.html http://feel-kobe.jp/english/index.html Transport: http://www.kansai-airport.or.jp/english/ http://jr-central.co.jp/english.nsf/doc/timetable http://www.mkgroup.co.jp/english/shuttle/index.html http://www.city.kobe.jp/cityoffice/39/030/ Hotels: http://www.portopia.co.jp/en/index.html http://kobe.okura.com/ http://www.kobe-orientalhotel.co.jp/ http://www.orientalhotel.co.jp/en/eng_top.html http://www.sheraton-kobe.co.jp/index_pc.html BioJapan2007: http://expo.nikkeibp.co.jp/biojapan/eng/index. html

Kobe Cluster in brief The biomedical cluster of Kobe Our Mission: We, city of Kobe and the Foundation for Biomedical Research and Innovation, are currently working on the Kobe Medical Industry Development Project (MID) with the aims of establishing a research and development center for leading-edge medical technology and for a world wide life science cluster. The MIDs core facility is the Institute for Biomedical Research and Innovation (IBRI), where translational research bridges the gap between basic research and clinical applications. Other key facilities include the Translational Research and Informatics Center (TRI), an information center for clinical research, and the Business Support Center for Biomedical Research Activities (BMA), which offers support services for bio-venture businesses. In addition to these facilities, we have completed the Kobe Medical Device Development Center (MEDDEC), which is a public rental facility and primarily focuses on facilitating the evaluation and improvement of cutting-edge medical devices and technologies. With these core facilities, we are working in close cooperation with the RIKEN Center for Developmental Biology (CDB) on the practical application of regenerative medicine. And we are also working on providing business support services through establishing venture business funds and supporting foreign affiliated companies as well as Japanese medical-related companies. Our supports are: Various kinds of support to promote the creation of new businesses, and support clinical research for pharmaceutical and medical products (Clinical Research Coordination Center), and others. We have been organizing the Pro-cluster Kobe, where mentors advise private companies on Japanese FDG, about the Japanese market and also about other crucial topics related to the Life Science situation in Japan. Technology: Gene/Cell Therapy, Imaging, Developmental Biology, Molecular Imaging & Development of Medical Devices Highlights: We can provide a lot of facilities, such as dry labs, wet labs, animal laboratories, CPC, Radio isotope laboratory. And we arrange as well business partnering between researchers and medical related companies in and outside Kobe. Establishment of 105 biomedical companies: We have already clustered many biomedical companies and arrange as well business meetings among them. In

addition to that have Kobe companies organized a corporate sector with the name MedCollab KOBE, which supports the network of the companies inside the cluster. Kobe Medical Device Development Center (MEDDEC). MEDDEC is a rental facility, which is established with the focal point on R&D functions for advanced medical technologies and cutting-edge medical devices. Anticipated Highlights: The Molecular Imaging Project: Kobe is ready and aiming to provide the Pharmaceutical Industry with a promising Platform of the Molecular Imaging Research, with this the RIKEN Molecular Imaging R&D Center was established October 2006. Further the Kobe Healthcare Industry Development Center (HI-DEC) was established November 2006. Both centers are placed very near our core institute IBRI. It is to mention that HI-DEC is a rental facility for R&D and business incubation for healthcare technologies and this will additionally supplement our activities on Medical Devices inclusive the center MEDDEC. From here the Kobe Airport, with domestic flights e.g. to Tokyo, is reachable in 5 minutes by the Portliner Mono-rail. The biomedical cluster of Kobe in brief: - The City of Kobe, with clustering biomedical venture companies, has been progressing at an accelerated pace on the basis of the city s Medical Industry Development Project. - 105 biotech core-companies inside the biomedical cluster of Kobe. - The City of Kobe is exerting to promote research and development of state-of-the-art medical technologies and help create new businesses, by promoting collaboration among domestic and foreign medical-related companies, universities and research institutions on Port Island 2nd Stage as the main project site. - The project s core facility is the Institute of Biomedical Research and Innovation (IBRI), which can name in principal three research themes: 1. Research and development of medical equipment 2. Support for clinical research into pharmaceutical products 3. Clinical application of regenerative medicine - The latest progress The Medical Device Development Center (MEDDEC) was opened on the 10th February 2006 in Kobe and will stands for a public lease facility to promote the evaluation and improvement of medical device and technology with catheter, stent, endoscopes plus the minimum invasive product for promoting the creation of new business in the related field of medical treatment. - The Kobe-Airport opened on the 16th of February 2006 in Kobe - Expansion of the medical-related industry (including welfare) 38 trillion yen (1996) => 91 trillion yen (2010) based on the cabinet meeting decision in 1997 - The National Government decided March 2007 the placement of the Supercomputer at the Kobe-Cluster Site for the year 2012, which will also have an important impact on our Life Science Cluster activities.