Hepatitis B&C National. Training Program & Treatment Update. Family Practice Physicians Gastroenterologists Hepatologists

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Scripps Conference Services & CME www.scripps.org/conferenceservices Over 40 national CME conferences, in more than 15 specialty areas. 2010 National Hepatitis B&C Training Program & Treatment Update SAN DIEGO MAY 22 PHILADELPHIA JUNE 5 NEW ORLEANS JUNE 5 SAN FRANCISCO JUNE 12 CHICAGO JUNE 26 WASHINGTON DC JULY 10 NEW YORK JULY 24 IRVINE JULY 24 MIAMI AUGUST 28 LOS ANGELES SEPTEMBER 11 Family Practice Physicians Gastroenterologists Hepatologists TARGET AUDIENCE Internists Infectious Disease Specialists OB/GYN physicians Pediatricians Nurses Physician Assistants

Course Description and Highlights Up to 5.3 million people 2 percent of the U.S. population are living with chronic hepatitis B or hepatitis C. These diseases are more common than HIV/AIDS in the U.S. Yet, because hepatitis B and hepatitis C often present no symptoms, most people who have them are unaware until they develop liver cancer or liver disease many years later. A new IOM study entitled Hepatitis and Liver Cancer: A National Strategy for Prevention and Control of Hepatitis B and C finds that despite the prevalence of the diseases, they are not widely recognized as serious public health problems and states: An estimated 0.8 1.4 million people in the United States are chronically infected with hepatitis B virus (HBV) and 2.7 3.9 million people are chronically infected with hepatitis C virus (HCV). Lack of awareness about the prevalence of chronic viral hepatitis in the United States and about the proper methods and target populations for screening and medical management of chronic hepatitis B and hepatitis C contributes to continuing transmission; missing of opportunities for prevention, including vaccination; missing of opportunities for early diagnosis and medical care; and poor health outcomes in infected people. The Scripps National Hepatitis B & C Training Program and Treatment Update will contribute towards increasing the number of health care practitioners educated on the prevalence of chronic viral hepatitis, as well as those properly preventing, diagnosing, treating, and/or referring patients with chronic illness; therefore contributing towards prevention of new cases and improved management of already infected patients. Conference Highlights Updates on the latest clinical guidelines with patient-focused sessions addressing hepatitis C in the morning and hepatitis B in the afternoon. Local experts providing an interdisciplinary team approach to treatment with physician and midlevel provider faculty. Small classroom learning enviroment with attendance limited to approximately 50 practitioners per city. Interactive formats including practical case studies, small group discussion, and question and answer opportunities throughout. Receive up to 7.75 AMA PRA Category 1 Credits Convenient local venues and affordable registration fee. Educational Objectives After attending this course the participants will be able to: Discuss the prevalence and incidence of acute and chronic hepatitis B and hepatitis C both in the general US population and in at-risk populations. Review the history, epidemiology, demographics, natural history, histology, immunology and patho physiology of the viral infection. Discuss state-of-the-art diagnostic and treatment guidelines for both hepatitis B and C. Formulate and/or implement strategies for preventing, diagnosing, treating, and/or referring patients with HBV and/or HCV. Evaluate the multidisciplinary team approach to care of patients with hepatitis B and C. Establish a local network of practitioners for information sharing, referrals, etc. Improve the health of patients infected with the HBV and/or HCV virus.

About Scripps and Accreditation Information About Scripps SC Liver Research Consortium (SCLRC) is an organization of physicians specializing in hepatology research, linking sponsors with our 47 sites to provide faster, higher-quality research results compared to conventional sponsor-site arrangements. SCLRC also educates clinicians throughout the US with CME training focusing on HBV and HCV. Scripps Conference Services & CME, which offers more than 40 nationally recognized annual conferences in over 15 specialty areas, is committed to providing exceptional educational courses for physicians and other health care professionals. More information and conference brochure downloads are available at www.scripps.org/conferenceservices. Disclosure It is the policy of Scripps Health to ensure balance, independence, objectivity, and scientific rigor in all sponsored educational activities. Course directors, planning committees, faculty and all others who are in a position to control the content of any educational activity sponsored by Scripps Health are required to disclose any real or apparent conflicts of interest related to the subject matter of the educational activity. Educational Grants This course is supported, in part, by educational grants from industry, in accordance with ACCME accreditation Standards for Commercial Support. Cultural and Linguistic Competency This activity is in compliance with California Assembly Bill 1195 which requires that all CME activities comprising a patient care element include curriculum addressing the topic of cultural and linguistic competency. The intent of this bill is to ensure that health care professionals are able to meet the cultural and linguistic concerns of a diverse patient population through effective and appropriate professional development. Cultural and linguistic competency was incorporated into the planning of this activity. Accreditation This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Scripps Health and Scripps Clinic Liver Research Consortium. Scripps Health is accredited by the ACCME to provide continuing medical education for physicians. Scripps Health designates this educational activity for a maximum number of 7.75 AMA PRA Category 1 Credit(s). Physicians should only claim credit commensurate with the extent of their participation in the activity. Documentation of awarded credit is provided for registered attendees in exchange for completed activity evaluation. Certificates of attendance are available, upon request, at the end of the course. Credit Breakdown Hepatitis C Morning Session = 4.0 credits Hepatitis B Afternoon Session = 3.75 credits The California State Board of Registered Nurses The California State Board of Registered Nurses (BRN) accepts AMA PRA Category 1 Credit(s) as meeting continuing education requirements for license renewal. Most state Boards of Registered Nurses accept AMA PRA Category 1 Credit(s) as meeting continuing education requirements for license renewal. Nurses should check with their state board regarding use of CME credit. The American College of Nurse Practitioners The American College of Nurse Practitioners (ACNP) accepts AMA PRA Category 1 Credit(s) from organizations accredited by the ACCME. This activity has been approved for a maximum of 7.75 AMA PRA Category 1 Credit(s). The American Academy of Physician Assistants AAPA accepts Category I credit from AMA Cateegory I CME organizations accredited by ACCME.

Program Morning Session: Hepatitis C 4 AMA PRA Category 1 Credits We will review the virology, genotypes, modes of infection of HCV and characteristics of the clinical illness caused by acute and chronic infections. Tests for HCV, including PCR assays and genotyping, interpretations and indications for liver biopsies and complications of cirrhosis will all be discussed. We will show how to initiate and monitor patients during treatment, manage of side effects of depression and hematologic complications of therapy and deal with various patient populations including African Americans, Latinos, and HIV-coinfected patients. Lastly, new drugs in development including protease inhibitors, polymerase inhibitors, new interferons, and other novel agents will be discussed. 7:30 a.m. Registration and Continental Breakfast 8 a.m. Review of Viral Hepatitis, Discovery of HCV and Natural History 8:20 a.m. Diagnostic Testing, Histology, Cirrhosis and Liver Biopsy 8:40 a.m. Treatment Guidelines: Who, What, When and How 9:25 a.m. Therapies in Development for HCV 9:45 a.m. Break 10 a.m. Case Presentations, Discussion and Q&A Management of Side Effects of Therapy Treatment of Relapsers and Non-Responders AA and Latino Populations When to Consider Deferring for New Therapies 12:15 p.m. Hep C Morning Session Adjournment Afternoon Session: Hepatitis B 3.75 AMA PRA Category 1 Credits We will summarize the history and discovery of HBV infection, discuss the modes of infection and prevalence of disease, and differentiate between acute and chronic infections. We will discuss protective antibodies, vaccination, complications of cirrhosis and hepatocellular carcinoma, tests for HBV, including PCR assays, genotyping and mutation analysis. Update the latest results of trials with nucleoside and nucleotide analogues for the treatment of chronic HBV including entecavir, tenofovir and pegylated interferons. We will include the latest AASLD guidelines for diagnosis, screening and treatment of chronic hepatitis B. 12:30 p.m. Registration and Box Lunch 1 p.m. Discovery of HBV, Natural History, Vaccination and Prevention 1:20 p.m. Diagnostic Testing, Liver Biopsy, Cirrhosis and Hepatocellular Carcinoma 1:40 p.m. Nucleoside/Nucleotide Analogues & Pegylated Interferons for HBV 2:30 p.m. Break 2:45 p.m. Case Discussions Management of Antiviral Resistance Treatment Algorithms and AASLD Guidelines HBeAg-Positive vs. HBeAg-Negative Patients Complications of Chronic Hepatitis B 5 p.m. Hep B Afternoon Session Adjournment

Faculty & Location Information May 22 - San Diego, California Hilton San Diego Resort 1775 East Mission Bay Drive, San Diego, CA 92109 619-276-4010 Paul J. Pockros, MD, FACP Scripps Clinic Terek Hassenin, MD Southern California Liver Centers Jill Chang, PA-C Scripps Clinic Andrea Scherschel, NP Scripps Clinic June 5 - Philadelphia, Pennsylvania Loews Hotel Philadelphia 1200 Market Street, Philadelphia, PA 19107 215-627-1200 David Kaplan, MD University of Pennsylvania Santiago Munoz, MD Temple University Hospital Brenda Appolo, PA-C, MHA University of Pennsylvania June 5 - New Orleans, Louisiana Sheraton New Orleans Hotel 500 Canal Street, New Orleans, LA 70130 504-525-2500 Luis Balart, MD Tulane University Health Sciences Center Fred Regenstein, MD Tulane Abdominal Transplant Institute Cynthia Benz, MN, APRN Tulane Abdominal Transplant Institute June 12 - San Francisco, California Omni San Francisco Hotel 500 California Street, San Francisco, CA 94104 415-667-9494 June 26 - Chicago, Illinois Hilton Chicago 720 South Michigan Avenue, Chicago, IL 60605 312-922-4400 Donald Jensen, MD, FACP University of Chicago Medical Center Scott Cotler, MD University of Illinois at Chicago Amanda DeVoss, MMS, PA-C University of Chicago Medical Center July 10 - Washington, DC Sheraton Crystal City Hotel 1800 Jefferson Davis Highway, Arlington, VA 22202 703-486-1111 Zobair Younossi, MD Inova Fairfax Hospital Nila Rafiq, MD Inova Fairfax Hospital Brian Lam, PA Inova Health System July 24 - New York, New York Hilton Times Square 234 West 42nd Street, New York, NY 10036 212-840-8222 Douglas T. Dieterich, MD Mount Sinai School of Medicine David Bernstein, MD North Shore University Hospital Long Island Jewish Medical Center Elizabeth Kula, NP Mount Sinai School of Medicine Maly Tiev, ANP-BC, CCRC North Shore University Hospital Long Island Jewish Medical Center Lorenzo Rossaro, MD University of California Davis Health System Robert Gish, MD California Pacific Medical Center Donna Geiger, RN, MSN, FNP Petaluma Health Center

July 24 - Irvine, California Westin South Coast Plaza 686 Anton Boulevard Costa Mesa, CA 92626 714-540-2500 Timothy Morgan, MD VA Long Beach Healthcare Systems John Hoefs, MD University of California, Irvine Cynthia Corkern, RN Private Practice August 28 - Miami, Florida Hyatt Regency Miami 400 SE Second Avenue, Miami, FL 33131 305-358-1234 Lennox J. Jeffers, MD Miami VA Medical Center Nikolas Pyrsopoulos, MD, PhD, MBA Florida Hospital Carla Molliner, PA-C, MHS University of Miami Center for Liver Disease Kay Sornmayura, MSN, ARNP-BC, DNP Candidate University of Miami Center for Liver Disease September 11 - Los Angeles, California Hilton Los Angeles/San Gabriel 225 West Valley Blvd. San Gabriel, CA 91776 626-270-2700 Sammy Saab, MD University of California, Los Angeles Tse-Ling Fong, MD University of Southern California Mary Peralta Sr., LVN University of California, Los Angeles Four Ways To Register Online www.scripps.org/conferenceservices Fax 858-652-5565 Phone 858-652-5400 Mail Scripps Conference Services & CME Hepatitis B&C Program 11025 North Torrey Pines Road Suite 200, Maildrop: SCRC200 La Jolla, California 92037 Questions? Contact Scripps Conference Services & CME Phone 858-652-5400 Email med.edu@scrippshealth.org Registration Confirmation A confirmation letter will be e-mailed or mailed to you upon receipt of the conference registration form and payment. If you have not received it within two weeks, please contact the Scripps Conference Services & CME office. Attendee Cancellation, Substitution, Refund The course tuition is refundable, minus a $20 processing fee, if your cancellation is received in writing no later than one week prior to the conference. Attendee substitutions are allowed, but notification must be made in writing one week prior to the conference. After this date, under no circumstances will refunds, credits, or substitutions be granted. No refunds or credits will be given to no shows. Scripps Conference Modification or Cancellation Scripps reserves the right to modify the course s schedule or program as necessary. Scripps also reserves the right to cancel this conference, in which case a full refund of the registration fee will be provided. We are unable to refund any travel costs (flight, hotel, etc.) in the case of Scripps cancellation. Policy on Guest Attendance All conference activities (including educational sessions, meal functions, etc.) are exclusively reserved for conference attendees. Badges provided at registration are required for entrance into all functions and will be strictly enforced. Recording and Photography Clause Scripps reserves exclusive rights to record (audio and video) and/or photograph all conference proceedings for use in marketing materials, presentations and course content sales.

Registration Registration fee includes course tuition, breakfast for morning session, lunch for afternoon session and relevant course materials. Pre-Registration Fees Onsite Registration Fees Hepatitis C Morning Session $45 $55 Hepatitis B Afternoon Session $45 $55 Hepatitis C and B $75 $90 Hepatitis C and B Group Rate* $65 $80 *Register three (3) or more from your office and each of you will receive $10 off your registration. Offer applies to full conference registrations only. Please check one: San Diego May 22 Philadelphia June 5 New Orleans June 5 San Francisco June 12 Chicago June 26 Washington DC July 10 New York July 24 Irvine July 24 Miami August 28 Los Angeles September 11 Are you a physician/midlevel provider in? Family Practice/General Practice/Internal Medicine Gastroenterology/Hepatology/Infectious Disease Please print clearly. Your badge will read as follows: n a m e ( F i r s t, M I, L a s t ) D E G R E E ( M D, D O, P h D, R N, e t c ) A f f i l i a t i o n / H o s p i t a l / C O M P A N Y S P E C I A L T Y M A I L I N G a d d r e s s C i t y S t a t e z i p p h o n e f a x E - M A I L Please indicate any special needs (including dietary restrictions). Special requests will be considered and accommodated in full compliance with the Americans with Disabilities Act (ADA). Office use only: Date rec d Check no/approval CD Amount Confirmation Sent Initials PAYMENT METHOD Check Please make checks payable to Scripps (in US dollars only). Visa MasterCard Amex Discover If paying by credit card, please complete information below C R E D I T c a r d N U M B E R E X P I R A T I O N D A T E N A M E O N C A R D s i g n a t u r e b i l l i n g a d d r e s s ( i f d i f f e r e n t f r o m a b o v e )

Scripps Conference Services & CME 11025 N. Torrey Pines Rd. Suite 200, Maildrop: SCRC200 La Jolla, CA 92037 Nonprofit Org. U.S. Postage P A I D Permit No. 1981 San Diego, CA 92138 2010 National Hepatitis B&C Training Program & Treatment Update Register three (3) or more health care professionals from your office and receive $10 off your registration fee. 2010 National Hepatitis B&C Training Program & Treatment Update Register three (3) or more health care professionals from your office and receive $10 off your registration fee. Conference Highlights Updates on the latest clinical guidelines with patient-focused sessions addressing hepatitis C in the morning and hepatitis B in the afternoon. Local experts providing an interdisciplinary team approach to treatment with physician and midlevel provider faculty. Small classroom learning environment with attendance limited to approximately 50 practitioners per city. Interactive formats including practical case studies, small group discussion, and question and answer opportunities throughout. Receive up to 7.75 AMA PRA Category 1 Credits Convenient local venues and affordable registration fee.