Our mission. University of Washington Evolving to Meet Faculty Needs. Universities Contribute to Building Wealthy Regions. Building Wealthy Regions

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Our mission University of Washington Evolving to Meet Faculty Needs To extend the impact of University of Washington research through the creation of partnerships that encourage investment in innovation Fiona Wills Director, Technology Licensing Tokyo Medical Dental University January 23, 9 Building Wealthy Regions Focus on "grow your own" strategies for technology development. entrepreneurial development deserves far more attention relative to marketing and recruiting-based strategies. The establishment of robust networking, mentoring, and startup capital programs, combined with improvements to infrastructure, education, and real estate offerings are key to enhancing the competitiveness of local firms. Find ways to link research institutions to the local economy. Research institutions play an important role in fostering and supporting technology-based development through the generation of commercially viable ideas, training sophisticated workers, and problem-solving for local companies. Spreading the Wealth: Building a Tech Economy in Small and Medium-Sized Regions Labor Markets, Technology, U.S. Economy, Cities, Community Development Deena Heg Paul Sommers The Brookings Institution October 3 Universities Contribute to Building Wealthy Regions Strong intellectual infrastructure Efficient mechanisms to transfer technology between people and institutions Excellent physical infrastructure Highly skilled technical workforce Good sources of capital Entrepreneurial culture Quality of life Many Parts of the Process to Master Success Rate for Technologies Investment Capital Proof of Concept Funding Opportunity Recognition Intellectual Property Protection Personnel Research Personnel Research Result R&D Funding Market Timing Facilities Research Time Delay Development Capital Technology Concept Innovation Infrastructure Zeal Support Concepts Local Business Climate Entrepreneurship Technology Solutions Market Access Market Size New or Existing Commercial Enterprise Research Result Technology Concept 1 Technology Solution 1 New or Existing Commercial Enterprise Cultural Motivation Random Factor 1

Goals and Interests of Fast Facts Aid Recruitment and Retention of Talent Contribute to Economic Development manages a total patent portfolio of over 2 issued and pending patents 244 companies have been started by UW students and faculty or with UW technology. Generate Financial Socially Responsible Broad Dissemination and Impact and of UW Technologies Promote Ties to Community/Industry In FY8, 571 researchers from 81 departments disclosed innovations to UW TechTransfer, increasing the number of departments worked with by 27 percent.. UW innovators earned $1 million from their successful technologies in FY8.. revenues contributed over $16 million in FY8 to UW s Royalty Research Fund, whose purpose is to advance new directions in research. Traditional metrics FY4-FY8 Non-commercial Dissemination 4 3 3 2 1 349 335 31 268 233 Disclosures 2 1 226 167 166 151 133 Patents filed 198 25 153 19 11 FY 4 FY 5 FY6 FY7 FY8 FY4 FY5 FY6 FY7 FY8 FY4 FY5 FY6 FY7 FY8 Research $ (1B/yr) Disclosures Licenses Licenses w/$ Revenue Start ups 4 th 1 th 3 rd 4 th 14 th 8 th $,, $45,, $4,, $35,, $3,, $25,, $2,, $15,, $1,, $5,, $ 2 1 Revenue Licenses Equity WRF FY4 FY5 FY6 FY7 FY8 ~ outgoing Material Transfer Agreements > 6, licenses were executed for academic no-charge software/content Top Ten Revenue Generating Technologies FY8 Revenue Disclosure Technology FY8 Date Polypeptides in Yeast $29,913,187 1982 Clotting Factor/Factor IX $6,22,87 1982 Hepatitis B Vaccine $2,16,413 1981 Tape Management Library for STK 44 Systems $931,975 1992 Metabolism-Based Drug Interaction Database $816,64 1999 Mass Spectrometry Fragmentation Patterns of Peptides $415,121 1994 Flow Cytometry Technologies $764,867 1995 High Intensity Focused Ultrasound for Intraoperative Ablation $374,731 1 Monoclonal Antibodies for Cancer Diagnostics $277,776 1985 Price Mining Software $258, 3 Technology Licensing Strategy Relationship based management Early relationships with investigators and business community to achieve superior commercialization results IP strategy designed with investigator needs and desires as focus One stop shopping for investigators, no way to get lost between groups Innovative IP and licensing strategies propagated across a broader range of projects, responsive to increasingly complex research environment Licensing terms responsive to current and emerging business models Best practices of both licensing groups maintained and fostered Domain specializations of copyright, patent, and trademark expertise Licensing Managers supported to facilitate excellence First class resources including LaunchPad and Informed Research Efficient IT support 2

Risks in Early-Stage Innovations Innovation is embryonic Doesn t work outside the lab Can t make robust enough Doesn t scale Cost to manufacture Efficacy regulatory hurdles Long development timeline Uncertainty of market Competition Acceptance not developed to meet a need, reimbursement Equals Significant financial risk Gap Funding from technology to product, from grants to sales. Commercialization Grants TGIF (WRF & UW) - new match! Life Sciences Discovery Fund Coulter Foundation Funds / Endowment Grants Research Bench Development Pilot Seed Investment WSIB Funded Bridge Fund UW Angels Alliance Industry Investment Production Scale Up Translational Research Programs W. H. Coulter Foundation Translational Research Partnership Program Coulter Research Awards with Bioengineer and Clinician Business Plan Fellowships Institute of Translational Health Sciences IND Support Project Funding Awards Business Plan Fellowships WRF Gifting Program Gifts to promising projects needing small amounts of seed funding ($5, - $,) Life Sciences Discovery Fund $35 million/year for 1 years Goals promote health make the life sciences industry more competitive strengthen Washington's economy Two funding competitions per year Innovative Programs to Advance Health Research Beneficial Applications of Technology for Health Care Quality and Cost Effectiveness Technology Gap Innovation Fund TGIF Licensing Successes Up to 2 grants per year of $, each Designed to enhance the commercial value of UW discoveries Royalty Research Fund and WRF provided funds External review panel assess based upon: Increased ability to license discovery or to start a company Commercial potential Reasonable Milestones $2.4 million in Technology Gap Innovation Funds (TGIF) have been awarded to 49 projects since the program was introduced in 4. Rose Ann Cattolico of Biology will optimize the industrial-scale culture of a high lipidcontaining strain of algae that produces biofuel. James Preston Van Hooser of the Comparative Medicine Department, will construct, test, and evaluate a novel hands-free workstation to decontaminate animal cages in specific pathogenfree environments. Vikram Jandhyala, Electrical Engineering, for enhancements to a unique suite of simulation software for designing micro- and nanoelectronics. David Koelle of Medicine will create and test a second generation vaccine for Herpes Simplex- 2 (HSV-2), the virus that causes genital herpes. Shaoyi Jiang of Chemical Engineering will develop and test a marine coating paint made with highly effective antimicrobial compounds that are non-toxic to the environment, unlike metalbased paints currently used to coat marine vessels. 3

LaunchPad Partnering to catalyze business formation LaunchPad EIR Program People UW Researchers VCs Entrepreneurs Business Leaders Innovation Manage IP Assets Aggregate IP Rights Mentoring Networking Strategic Planning Market Focus LaunchPad Teams Plan Mentor Analyze Entrepreneur-in-Residence Program Serial entrepreneurs invited to pursue their next opportunity via UWTT Minimal stipend to cover necessary incidental expenses - EIRs accept because of good will and opportunity Mentoring faculty and students Building team, business case, early investment, and market development Broader and deeper VC relationships Guide UW Business UW Law Competitive Analysis Legal Technology Development Funds Available to Companies UWTT Strategic Initiatives: Informed Research Washington Technology Center Research & Technology Development Granting Program ($, - $3,) SBIR/STTR Federal granting programs Seed VC Funding Industry and investment advisors early in the innovation cycle Use industry information to put research in context: choices, details, directions, needs Industry connections may foster more industrially sponsored research UWTT Strategic Initiatives: Research Commons Create significant research communities with UW at the hub Found an expanding community of use around UW research data set Metrics for our new mission Prospective faculty/grad students meeting with UWTT Researcher participation in guided invention sessions Researchers (new/veteran) working with LaunchPad UW-originating startups Venture investment in UW startups over time/years out Private equity: held/realized proceeds Venture capital firms backing UW startups UWTT speculative investment in IP (patent budget) % of innovations and patents that are licensed over 5 year period from speculative investment 4

Thank you Fiona Wills, Ph.D. Director, Technology Licensing University of Washington 4311 11th Avenue NE, Suite Seattle, WA 9815 Voice: 26-543-397 Email: fwills@u.washinton.edu Additional information can be found on the UWTT website at: www.depts.washington.edu/techtran 5