Funding Opportunity: Postdoctoral Fellowship Grant Awards

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Arkansas Children s Research Institute Funding Opportunity: Postdoctoral Fellowship Grant Awards Program Overview Program Purpose Eligibility Requirements This grant mechanism will support investigator initiated, hypothesis driven (goal directed) research directed by trainees conducting pediatric research on the ACH campus. Eligible candidates include those with MD, PhD, MD/PhD, PharmD or PharmD/PhD degree in their second year of postdoctoral training. All trainees must apply with a faculty mentor. Each application must include a detailed mentoring plan and mentor statement. Mentors will assume responsibility for scientific integrity and conclusion of work proposed. Mentors must practice on the ACH campus. Key Dates Letter of Intent Due Date Application Due Date Award Date March 20 each year May 15 each year June 15 each year Award Information Funds Available and Anticipated Number of Awards Award Budget Award Project Period Arkansas Children s Research Institute (ACRI) sets aside up to $60,000 annually in support of this program. Final funding decisions are contingent upon the institutional availability of funds. $15,000 Total 24 months Application and Submission Information Application Characteristics Describe original, investigator-initiated clinical/translational research that is hypothesis driven and has specific aims that can be successfully executed in a 24-month period. The proposed scope of work must be appropriate for time available to the trainee to enable completion of the project. Personnel costs for UAMS faculty cannot be included in the final budget. Support for data analysis distributed by UAMS faculty or staff cannot exceed 20% of the total budget. With approval of the ACRI President, a single, 6 month no-cost-extension is allowed for work not completed at the end of the 24 month period. No preliminary data is required, but may be included if available. The Research Plan will follow the NIH R03 format and should not exceed 6 pages. This format includes a detailed timeline for project conduct, completion, analysis and eventual publication. The proposed project must be of sufficient scientific rigor to support development of a peer-reviewed scientific / professional publication. Letter of Intent A LOI is due no later than 5 p.m. on March 20 of each year. The LOI should be submitted to Amy Stalls (stallsar@archildrens.org) via email.

The LOI should be no longer than one page in length and include the following components: 1. Principal Investigator: Name/Title/Contact Information 2. Faculty Mentor: Name/Title/Organization 3. Project Title; and 4. A brief description of the research conducted. Upon receiving the LOI, the information will be reviewed. Upon approval by the ACRI President, applicants will be contacted and invited to apply with a full submission. Application Package Grant application forms may be downloaded from the ACRI website: http://www.archildrens.org/research/resources-for-researchers/achri-forms. Please see Attachment 2 for a complete listing of the required forms and instructions for preparing the Research Strategy. Application Review and Selection Process Grants will be reviewed by a Special Emphasis Panel (SEP) using current NIH criteria. This SEP will be constituted by the ACRI President who will have oversight responsibility for the grant program. All proposals will be scored by the SEP and prioritized for funding by the ACRI President with final funding decisions made by the ACRI Board. Reporting Requirements A final progress report is due upon completion of the award. Failure to submit a final report may jeopardize future funding. Application Submission Contact Information Amy Stalls, ACRI Research Grants Specialist Telephone: 501-364-3627 Email: stallsamyr@uams.edu.

Attachment 1 Application Materials & Research Strategy Requirements On or before 5 p.m. on the deadline date, an applicant must email a PDF copy of his or application to the ACRI Research Grants Specialist. Application Materials The final application should include the following items: 1. ACRI Intramural Funding Application Form 2. ACRI Intramural Research & Related Budget Form 3. ACRI Intramural Budget Justification Form 4. Study Summary Form (for applicants whose proposals include human subjects clinical trials) 5. NIH Biographical Sketch 6. Specific Aims (1 page) 7. Research Strategy (6 pages or less, not to include reference citations) 8. Detailed Mentoring Plan and Mentor Statement 9. Relevant institutional resources necessary to support the research (for example, letters of support from collaborators) Research Strategy Requirements The research strategy should not exceed 6 pages (not including reference pages). Use at least one-half inch margins (top, bottom, left, and right) for all pages. For font, use an Ariel typeface, a black font color, and a fond size of 11 points or larger. The research strategy should include the following sections: a. Significance Explain the importance of the problem or critical barrier to progress in the field that the proposed project addresses. Explain how the proposed project will improve scientific knowledge, technical capacity, and/or clinical practice in one or more broad fields. Describe how the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field will be changed in the proposed aims are achieved. b. Innovation Explain how the application challenges and seeks to shift current research or clinical practice paradigms. Describe any novel theoretical concepts, approaches or methodologies, instrumentation or interventions to be developed or used, and any advantage over existing methodologies, instrumentation, or interventions. Explain any refinements, improvements, or new applications of theoretical concepts, approaches or methodologies, instrumentation, or interventions. c. Approach Describe the overall strategy, methodology, and analyses to be used to accomplish the specific aims of the project. Include how data will be collected, analyzed, and interpreted as well as any resource sharing plans as appropriate. Discuss potential problems, alternative strategies, and benchmarks for success anticipated to achieve the aims. If the project is in the early stages of development, describe any strategy to establish feasibility, and address the management of any high risk aspects of the proposed work. Point out any procedures, situations, or materials that may be hazardous to personnel and precautions to be exercised. If research on Human Embryonic Stem Cells (hescs) is proposed but an approved cell line from the NIH hesc Registry cannot be identified, provide a strong justification for why an appropriate cell line cannot be chosen from the Registry at this time.

If an applicant has multiple Specific Aims, then the applicant may address Significance, Innovation and Approach for each Specific Aim individually, or may address Significance, Innovation and Approach for all of the Specific Aims collectively.

Attachment 2 Approved and Not Approved Expenses This attachment provides guidance regarding expenses that this program may or may not cover. The list is not all inclusive; please contact Amy Stalls (stallsamyr@uams.edu) with any questions. Approved Expenses Biostatical Support/Data Analysis no more than 20% of the total budget Computer/Software (with clear justification they are needed for the proposed research) Equipment Office Supplies (research related only) Publication Costs of Publishers Salary/Fringe of research personnel (coordinators, assistants) Supplies for Research Project (actual research costs) Travel (exceeding no more than $1,000 for presentation of research at a national meeting) Not Approved Expenses Any Expense Not Directly Related to Research Activity Any Personal Professional Fee Board Exam Fees Board Review Courses DEA # Lab Coats Medical Licenses Membership Dues to Societies and Professional Organizations Personnel Costs for UAMS Faculty Periodicals Professional Liability Insurance Subscriptions Telephone and Pager