MaRS OVERVIEW2017. MaRS OVERVIEW / 1

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MaRS OVERVIEW2017 MaRS OVERVIEW / 1

MaRS OVERVIEW THE MaRS MISSION & CENTRE INNOVATION SUPPLY MaRS Ventures INNOVATION DEMAND Opening Markets and Driving Adoption TORONTO S UNIQUE POSITION Canada s Hub for Convergent Innovation MaRS OVERVIEW / 2

HISTORY OF DISCOVERY MaRS OVERVIEW / 3

DISCOVERY OF INSULIN MaRS OVERVIEW / 4

DISCOVERY OF STEM CELLS MaRS OVERVIEW / 5

#PLACEMatters MaRS OVERVIEW / 6

URBAN INNOVATION HUB 1.5 million sq ft Direct subway & streetcar access 150+ Total Tenants 80+ Startup Tenants Convening entrepreneurs with financial, academic & business communities MaRS OVERVIEW / 7

MORE THAN A BUILDING: AN INNOVATION HUB INNOVATION CENTRE INCUBATOR ACCELERATOR INNOVATION HUB INNOVATION DISTRICT Where? Building Space Place IP address Soft landings at other locations Multiple buildings in a geographic area Who? Varied tenants Startup ventures (general) Startup ventures (selected cohort) Startup and scaling ventures Incubators Corporate MNEs Investors Research labs and groups Convening of communities of interest Universities Hospitals Research Institutes Student startups Incubators Corporate MNEs What? Limited programming Venture services Venture services Capital Global examples Cambridge Innovation Centre JLABS * Have announced intention to pursue a Hub model. Y Combinator Venture services Capital Talent Systems (incl. policy) Corporate connections Global networks MaRS Grand Central Tech (NYC) The Crick Institute (London, 2016) Nesta (London, 2016) No centralized programming Biopolis* Mission Bay Kendall Square MaRS OVERVIEW / 8

THE GLOBAL GEOGRAPHY OF INNOVATION IS MOVING WHERE MaRS PLAYS: PLACE MATTERS IN THE NEW GEOGRAPHY OF INNOVATION Innovation is moving from suburban research parks to downtown innovation districts, as the global innovation economy is increasingly driven by a leading group of urban regions. These innovation hotspots have several common features: strong academic institutions exceptional (young) talent base a rich pool of startups and innovative global companies availability of risk capital government support and focus on innovation access to open, dynamic markets (at home and abroad) intense interactions and collaboration between science, startups, business, creative industries (convergence) Cities that are important nodes in the global economic system https://en.wikipedia.org/wiki/global_city MaRS OVERVIEW / 9

Kendall Square, Boston MaRS OVERVIEW / 10

Mission Bay, San Francisco MaRS OVERVIEW / 11

Crick Institute, London MaRS OVERVIEW / 12

Biopolis, Singapore MaRS OVERVIEW / 13

Karolinska Institute, Stockholm MaRS OVERVIEW / 14

Zhongguancun, Beijing MaRS OVERVIEW / 15

New York City MaRS OVERVIEW / 16

TORONTO: A HUB FOR CANADA S CONVERGENT INNOVATION Strongest Patenting and VC Investment in Canada Most Diversified Economy + Largest Industry Clusters Greatest Concentration of Canadian GDP Ottawa 4% Edmonton 5% Calgary 6% Toronto 19% Vancouver 7% Montreal 10% the job growth rate of Canada 2010-2015 2X 400,000 technology employees Sources: Stats Canada & Brookings Institute Global City GDP 2014; TechToronto / Statistics Canada; University of Toronto; OECD patent cooperation treat and Thomson Reuters MaRS OVERVIEW / 17

HOME TO: STARTUPS, SCALEUPS, RESEARCH, INVESTORS, CORPORATE HQs MaRS OVERVIEW / 18

SELECT MaRS CENTRE TENANTS BRINGING THE INNOVATION ECOSYSTEM TOGETHER STARTUPS CORPORATIONS, CAPITAL & SERVICE PROVIDERS ECOSYSTEM PARTNERS (PUBLIC) MaRS OVERVIEW / 19

LIFE @ MaRS TODAY * By 2017, when all contracted tenants are occupying space. 2,000+ Annual Events and Meetings 150,000 Annual Attendees 200 Annual International Delegations 6,000 People at Work MaRS OVERVIEW / 20

MaRS ATTRACTS HUNDREDS OF GLOBAL VISITORS A YEAR Our 200 visiting delegations in FY2015 shows high interest in MaRS from China, Brazil, India, Western Europe and the US (shown by state). This understates the global interest in visiting MaRS from investors, corporates, partners and innovation tourists as we are forced to decline less strategic requests due to capacity constraints. MaRS OVERVIEW / 21

INVENTION + ADOPTION = INNOVATION MaRS OVERVIEW / 23

BRIDGING THE GAP BETWEEN INVENTION AND ADOPTION Health Systems Innovations Health Advanced Energy Centre Energy & Environment Corporate Engagement Program Centre for Impact Investing Data Catalyst Finance & Commerce Work & Learning Solutions Lab MaRS OVERVIEW / 24

ATTRACTING THE INNOVATORS WHO WILL CHANGE THE WORLD MaRS supports innovators who want to achieve strong business results and / or make a positive difference in the world - we identify them by these criteria: IMPACT They address big challenges facing Canada and the world MARKET DEMAND They have major global market opportunities, consumers not well served by current solutions DISRUPTION Exponential acceleration driven by science and technology, digitization and connectivity across converged sectors and disciplines ASSETS AND EXPERTISE Toronto, and Canada, are (or can be) centres of excellence Health Energy & Environment Finance & Commerce Work & Learning Biotech & Pharma Health & Wellness Digital Health Medical Devices & Diagnostics Energy Transportation Agritech Waste Mgmt. Adv. Materials Water Adv. Manufacturing AI, Data, & Analytics Alt. Finance Cybersecurity Insurance Tech Marketplaces Online & Mobile Retail Payments Retail Tech Business Intelligence Education & Training HR & Workforce Enterprise Software MaRS OVERVIEW / 25

LEVERAGING CONVERGENCE & EXPONENTIAL TECHNOLOGIES TO ACCELERATE INNOVATION MaRS OVERVIEW / 26

MaRS VENTURE SUPPORT PROGRAMS ARE SEGMENTED BY STAGE TO FOCUS ON HIGH-GROWTH HIGH-POTENTIAL VENTURES SCALE SERVICE MODEL VENTURE STAGE START 60% of Ventures $0-1M in revenue Pre-seed funding General (1:many & 1:few) Entrepreneurship education Experiential workshops Market Intelligence Insights Peer-to-peer online network GROWTH 35% of Ventures $1-5M in revenue Series A funding Specific (1:1) 1:1 Business & Technical advisory Talent, capital, Int l market and customer connections Marketing & PR support Functional training workshops Customized Market Intelligence Leverage expert network 5% of Ventures $5M+ in revenue Series B or more Customized (1:1) (Pilot Program) 1:1 Business & Technical advisory Talent, capital, Int l market and customer connections Marketing & PR support Functional training workshops Customized Market Intelligence Leverage expert network Connection to the Start venture ecosystem MaRS OVERVIEW / 27

MaRS VENTURES RAISED $867M in 2016 For reference, in 2016, CVCA recorded all VC funding to Canadian ventures as $3.2B, of which Ontario-based investments were $1.5B. $3.5 Billion raised since 2008 Source: all venture numbers as reported in the 2008-2016 venture client annual surveys. For details, see marsdd.com/survey-methodology. CVCA_2016 MarketOverview MaRS OVERVIEW / 28

MaRS VENTURES HAVE CONTINUED TO BUILD STRONG REVENUE TRACTION $483 $398 $146 $161 $201 $280 $1.8 Billion generated since 2008 (majority from exports) $70 $22 $38 2008 2009 2010 2011 2012 2013 2014 2015 2016 Source: all venture numbers as reported in the 2008-2016 venture client annual surveys. For details, see marsdd.com/survey-methodology. CVCA_2016 MarketOverview MaRS OVERVIEW / 29

EXPORTS ARE STRONG 52% of revenue (~$252M) is from undisclosed territory, and is excluded from these visuals. n = 79 TOTAL VENTURE REVENUES n = 98 Overall n = 331 n = 73 For details, see marsdd.com/survey-methodology. n = 78 MaRS OVERVIEW / 31

MaRS CHAMPIONS AN INCLUSIVE INNOVATION ECOSYSTEM MaRS VENTURES BOAST ONE OF THE HIGHEST RATES OF FEMALE TECH FOUNDERS GLOBALLY % of MaRS ventures with at least one female founder Startup Genome s 2015 Report ranks major global ecosystems by % of women founders 2016 28% Chicago #1 30% Boston #2 29% 2012 22% Silicon Valley #3 24% Paris #6 22% With 28% of MaRS ventures having female founders, MaRS matches globally leading gender-diverse tech ecosystems as reported by Startup Genome Source: all venture numbers as reported in the 2012-2016 venture client annual survey. For details, see marsdd.com/survey-methodology Tel Aviv #7 Toronto #9 Berlin #19 9% Note: Startup Genome used a smaller sample set for Toronto that included ventures from other incubators and accelerators as well as MaRS (i.e DMZ, CDL, OneEleven etc). Source: Start UP Genome Compass Report, 2015. MaRS numbers as reported through 2016 Venture Client Survey Results 19% 20% MaRS OVERVIEW / 32

MaRS CHAMPIONS AN INCLUSIVE INNOVATION ECOSYSTEM Founder demographics reflect the rich diversity of the city and experience; it continues to grow as the ecosystem matures Diversity % of MaRS ventures with at least one foreign-born founder Founders with previous startup experience % of MaRS ventures with 1+ founder having founded previous startup 2016 2015 56% 2016 2015 70% 2013 42% Source: all venture numbers as reported in the 2012-2016 venture client annual surveys. For details, see marsdd.com/survey-methodology. 2012 43% MaRS OVERVIEW / 33

MaRS IS MOBILIZING CAPITAL TO CLOSE IMPORTANT FUNDING GAPS $100M in capital mobilized by MaRS (as of the end of March 2016) has leveraged an additional $700M of capital in follow-on funding to help our companies compete globally. $700M In total leveraged funding Investment Accelerator Fund (IAF) Province of Ontario Capital ($48M) 150+ investments of $500k each Managed by MaRS MaRS Catalyst Fund $5M Impact Fund: Private Capital A MaRS Program ArcTern Ventures (MaRS Cleantech Fund) Cleantech: $45M Private Capital MaRS is an LP JOLT Accelerator Inc. Fully Invested in 2014 New for 2017: StandUp Ventures $5M funding from BDC for a Women s Entrepreneurship Fund, Managed by IAF MaRS OVERVIEW / 34

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World s 1 st Underwater-CAES Facility Toronto Island 2015 MaRS OVERVIEW / 41

Catalyzed and spun off by MaRS in 2009, MaRS Innovation was one of MaRS initial systems initiatives and continues to work closely with MaRS as part of an integrated commercialization and acceleration platform. MaRS Innovation Startups Single Commercialization Storefront for Academic Institutions Licensing & Industry Co-development Business Accelerator for Ontario s Emerging Companies Entrepreneurs from Across Ontario MaRS OVERVIEW / 42

ENTREPRENEURSHIP 101 (E101) After 10 years of in-person and online programming, we believe that reinventing E101 for an online audience represents a great opportunity to improve the way entrepreneurs in our community learn the process and methodology behind hypothesis-driven entrepreneurship. E101 launched with 1,860 enrolments in November 2016 and delivers a new version of the course each quarter. MaRS OVERVIEW / 43

ENTREPRENEUR S TOOLKIT COLLECTIONS marsdd.com/collections STARTUP FINANCE Find out how to deliver an effective pitch, understand a term sheet and raise money. WHAT ARE COLLECTIONS? Collections offer key library resources curated by topic. Find articles, videos and templates to help you launch and grow your startup. MaRS OVERVIEW / 44

In addition to direct support of 1200+ ventures, MaRS provides co-ordinated programming and support services to the Ontario Innovation Ecosystem via the ONE MaRS supports the technology innovation members of the ONE: 18 RICs across Ontario 50 Campus Linked Accelerators PROGRAMS MANAGED BY MaRS AND FUNDED BY MRIS THAT SUPPORT THE ONE INCLUDE: Investment Accelerator Fund (IAF) A seed-stage fund for early-stage growth capital of up to $500k ONE is funded by Ontario Government Business Acceleration Program (BAP) Provides support and mentoring services to early-stage ventures to accelerate their growth Data Catalyst Administers the ONE Innovation Data Partnership on behalf of the Province - tracking impact for ONE Innovation Members, and aggregating and sharing insights MaRS OVERVIEW / 45

INVENTION + ADOPTION = INNOVATION MaRS OVERVIEW / 46

MaRS unique innovation model goes beyond direct venture support to OPENING MARKETS AND DRIVING ADOPTION Innovation only happens when new products and Health Systems Innovations Advanced Energy Centre services reach their target customers and markets. This is often the hardest part of the innovation lifecycle, especially in highly regulated markets like health, energy and finance. MaRS works with partners to help open these markets, address regulatory barriers that have slowed the adoption of new technologies and increase the innovation capacity in these systems. Corporate Engagement Program Centre for Impact Investing Data Catalyst Solutions Lab MaRS OVERVIEW / 47

CORPORATE INNOVATION PARTNERS MaRS WORKS TO ACCELERATE THE ADOPTION OF TECHNOLOGY BY A DIVERSE RANGE OF CORPORATE PARTNERS MaRS OVERVIEW / 48

Demand-side systems initiatives evolved in response to recognized barriers to technology adoption ADVANCED ENERGY CENTRE 2011 (CII) Challenge: Limited awareness about the opportunity of impact investment in Canada. 2011 Excellence in Clinical Innovation and Technology Evaluation (EXCITE) Challenge: Ontario medtech innovation and healthcare investment were disconnected. Ontario startups did not have a pathway to adoption and patients did not have access to the best made-in Ontario technologies. 2012 Green Button Challenge: Smart Grid and energy management solutions need to access data from utilities and smart meters to scale, but there is no consistent and secure way for them to connect, globally. 2013 MyHealth Challenge: The health system is slow to adopt digital health solutions for clinicians and consumers have not consistent and secure way to access the provincial ehealth data infrastructure. 2013 Challenge: Need for modernization of government regulation and lack of cross-sector collaboration in removing barriers to innovation. 2014 (AEC) Challenge: Despite being a leader in energy policy (smart meters, coal closures, solar and wind, etc), Ontario did not experience the expected follow on economic development because the system itself does not adopt innovation well. Procurement by Co-Design: 2016 Challenge: Publicly funded health delivery organizations in Ontario were using price (commodity purchasing) instead of value to procure new health technologies, effectively shutting out innovative technologies developed by smaller firms. MaRS OVERVIEW / 49

and keep MaRS and Ontario at the forefront of global thought leadership on emerging approaches for building innovation economies and solving complex barriers ADVANCED ENERGY CENTRE G7 Social Impact Investment Taskforce SVX partnerships in California and Mexico Partnership with Social Finance US and UK on pay-for-success projects Launched Canada s first national Social Impact Bond (SIB) Introduced B Corps to Canada BresoDx, first EXCITE graduate, now being adopted by Ontario health system Pioneered global best practice in harmonizing pre- and post-market health tech assessment EXCITE International spun out in 2016 with network of >45 players in US, UK, EU and Asia/Pacific. Partnered with US White House and NIST to develop Green Button Founding member of Global Entrepreneurship Research Network (GERN) with World Bank, NESTA, Endeavour, Kauffman Fdn Solutions Lab considered global leader in field of public and social innovation labs Hosted global labs summit (2014) Invitations to speak at international events >5 year Worked with international funders like Rockefeller Fdn Work is seen as global best practice (e.g. by OECD, WEF) International partners include Eneco (Netherlands), Celsia (Colombia), EEPA (Chile), EDC (Canada) Partnered with RMI (Rocky Mountain Institute) to deliver Newtonian Shift in US with New York Power Authority, California ISO MOUs with JITRI (China); Tech Mahindra & Himachal Pradesh State Electricity Board (India); Jalisco (Mexico) MaRS OVERVIEW / 50

MaRS CENTRE FOR IMPACT INVESTING The Centre unlocks the power of private capital to tackle persistent social challenges. CAPITAL ADVISORY SERVICES Advise on the creation and execution of social finance and impact investing strategies and tools. VENTURE SERVICES Support promising social enterprises and connect them with impact investors. RESEARCH & POLICY Advocate for the policy and regulatory changes necessary to encourage growth of the impact investing market. CATALYST FUND Invest in early stage companies that have an environmental or social mission. $91 million capital mobilized to date Launched the SVX investment platform Launched $4m social impact bond in health Virgin as lead $5m impact fund investor MaRS OVERVIEW / 51

MaRS HEALTH SYSTEM INNOVATION DISRUPTING SYSTEM ENABLERS & PROCESSES TO INCREASE THE HEALTH SYSTEM S INNOVATION CAPACITY PROGRAM AREAS INNOVATION ADOPTION & PROCUREMENT APPLICATION OF HEALTH DATA CAPITAL & BUSINESS MODEL INNOVATION INNOVATION MINDSETS Social Impact Bond INNOVATION MEET-UP PROJECTS MaRS OVERVIEW / 52

EXCITE EXCITE (Excellence in Clinical Innovation and Technology Evaluation) expedites health system adoption of impactful technologies through pre-adoption, evidencebased assessment via early collaboration between industry, academia, regulators, payers, government and the broader health system. INNOVATORS ENABLING FASTER MARKET ACCESS OF DISRUPTIVE TECHNOLOGIES FOR IMPROVED HEALTH SYSTEM OUTCOMES MaRS OVERVIEW / 53

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INNOVATION PROCUREMENT ENHANCING CAPACITY TO DEVELOP & PROCURE INNOVATIVE SOLUTIONS Supported by MaRS Solutions Lab Using design-based approaches, Solutions Lab is a public, social innovation lab that brings about positive, large-scale systems change by working closely with diverse partners across society. MaRS OVERVIEW / 55

DATA-DRIVEN INNOVATION CONNECTING INNOVATORS & DATA TO ENHANCE HEALTH SERVICE DELIVERY & EMPOWER PATIENTS Supported by MaRS Data Catalyst Data Catalyst is focused on building the data layer for the innovation economy and creating new markets through smarter data access. MaRS OVERVIEW / 56

OUTCOMES-BASED MODELS DESIGNING NEW BUSINESS MODELS FOCUSED ON MEASURING AND PAYING FOR OUTCOMES $4m social impact bond in health Supported by MaRS Centre for Impact Investing The Centre unlocks the power of private capital to tackle persistent health and social challenges. MaRS OVERVIEW / 57

MaRS DATA CATALYST OPENING MARKETS THROUGH ACCESS TO DATA Enabling secure access to health records to scale digital health solutions for clinicians and consumers Creating new models for digital population health surveillance with public health agencies across North America TRACKING THE INNOVATION ECONOMY Enabling the ecosystem to scale startups by tracking companies, investors, talent, and markets over time, sector and location SOCIAL & ECONOMIC IMPACT EVALUATION Operationalizing the social and economic impact framework for MaRS and setting the bar for global innovation hubs Enabling secure access to energy data (Green Button) to scale energy management services and global export opportunities In development: Access to complete smart home and building data and a financial services sandbox MaRS OVERVIEW / 58

MaRS SOLUTIONS LAB MaRS Solutions Lab convenes changemakers around today s most complex and important challenges so all Canadians can flourish tomorrow Work & Energy & Learning Innovation Adoption Environment Resilient Society Finance & Commerce Keystone Transitions Health MaRS OVERVIEW / 59

MaRS ADVANCED ENERGY CENTRE FOSTER the adoption of innovative energy technologies in Ontario and Canada LEVERAGE those successes and experiences into international energy markets PROGRAM AREAS UTILITY TRANSFORMATION COMMUNITY ENERGY & BUILDING ENERGY EFFICIENCY INTERNATIONAL ENERGY DATA ACCESS Have helped almost 400 energy leaders strategize for the future of the energy sector Zibi project: JV between the local utility and developer, creating zero carbon development in Ottawa More than 80 international company connections made Ontario Green Button pilot with London Hydro The Advanced Energy Centre (AEC), founded in February 2014, is a partnership between MaRS Discovery District, the Ontario Ministry of Energy and the private sector, with Siemens and Capgemini as founding partners. ACHIEVEMENTS MaRS OVERVIEW / 60

MaRS OVERVIEW Thank you MaRS OVERVIEW / 61