HORIBA Core Technology

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HORIBA Core Tehnology HORIBA llotes its development resoures y fousing on speifi nlytil nd mesurement tehnologies, through the pplied development of these tehnologies, effiiently onduts produt development in 5 usiness segments with different mrkets. Gs Flow Control Infrred Mesurement Spetrosopi Anlysis Tehnology to mesure nd instntly ontrol the flow of gses Tehnology for rel-time nlysis of elements in gses Tehnology to mesure wvelength nd n intensity of the inident eletromgneti wve on sustnes EXFM-ONE Ultrsoni Exhust Flow Meter MICROPOLE System Residul Gs Anlyzer ENDA series Stk Gs Anlyzer PG-300 series Portle Gs Anlyzer MEXA-ONE series Motor Exhust Gs Anlyzer EMIA series Cron/Sulfur Anlyzer Yumizen H630 CRP Hemtology & CRP Anlyzer LRAM HR Evolution Lser Rmn Spetrosope CS-700 Chemil Solution Conentrtion Monitor Prtile-size Distriution Anlysis Tehnology to mesure prtile dimeter nd size distriution Eletrohemistry Tehnology to mesure potentil nd/or eletri urrent ompnied with interfil hemil retion Prti LA-960 Series Lser Sttering Prtile Size Distriution Anlyzer RP-1 Retile/Msk Prtile Remover H-1 series Industril Wter Qulity Anlyzer HF-960EM Hydrofluori Aid Sensor Antsense series Eletrode Type Blood Gluose Meter LAQUA series Benhtop ph/wter Qulity Anlyzer

HORIBA Join Yvon s world-leding spetrosopy tehnology A key omponent of spetrometers is the grting, whih diffrts inident rys into vrious wvelengths. Join Yvon hs een pioneer in the grting field out for 200 yers, nd joined HORIBA Group in 1997. The omintion of HORIBA nd Join Yvon s dvned tehnology ses hs led to utting-edge new devies. Why HORIBA Join Yvon is pioneer in the spetrosopy field HORIBA Join Yvon s dvned optil designs provide foundtion for tehnil innovtions ontining vriety of grtings. We rry out ll proesses in-house, from the design nd prodution of grtings to prodution of spetrometers ontining those grtings. Our tehnology reognized y NASA* In 2006, HORIBA Join Yvon won NASA JPL (Jet Propulsion Lortory) Awrd for three outstnding vrieties of OCO grtings*. (OCO grtings re superior due to their high preision, high diffrtion effiieny nd low sttering, enling mesurement of very wek spetrum under extreme onditions.) 2012 HORIBA Europe Reserh Center ws estlished in Sly, suur of Pris, Frne. This enter fouses on uilding oopertive frmework with industril, demi, governmentl nd edutionl institutions. 2016 A meters-lrge hologrphi grting ws developed nd produed t HORIBA Europe Reserh Center. 2016 NASA s JUNO proe entered Jupiter s orit. The proe ontins HORIBA grtings.

Three min ses in Jpn, Europe nd North Ameri HORIBA Sientifi hs three min reserh, development nd prodution ses, eh leding vendor for different type of optil nlysis tehnology. HORIBA Join Yvon HORIBA, Ltd. HORIBA Instruments In. Optil devies nd emission spetrometry X-ry, infrred, prtile size, gs nd wter qulity nlysis Fluoresene spetrosopy mesurement Min Produt - Rmn mirosopes - GD-OES - Spetrosopi ellipsometers - ICP-OES - Optil omponents Min Produt - Prtile size distriution nlyzers - X-Ry nlytil mirosopes - C/S/O/N/H nlyzers - ph/wter qulity nlyzers Min Produt - Fluoresene stedy stte spetrometers nd fluoresene lifetime spetrometers - Intrellulr imging - Spetrometers Mutul development nd jointly developed produts

HORIBA s mnufturing with long-term stility nd reliility To rete highly relile nlyzers, HORIBA tkes the utmost re with every step of the proess, from mteril prodution to ssemly nd ging. When produing the sensor setion t the ore of the devie, every step from the polishing nd qulity hek of the prts to ssemly is rried out in-house to uild solid foundtion of qulity. Gs hrging of detetor Aging of light soure Optil filter Aging of detetor Polishing of detetor Mnufturing of optil filter Shving of detetor Assemling of detetor Min prts of Non-Dispersive Infrred (NDIR) nlyzer used to mesure CO nd CO2 The flgship ftory HORIBA BIWAKO E-HARBOR (Jpn) E= Engineering Enhnement Enggement Environment Energy System Building re 7,125 m2 Totl floor re 28,177 m2 Numer of employees (s of 2016) Aout 600 (inl. prt-time employees nd ffilite ompnies)

Rmn Spetrosopy Applition Ctegories Cron Mterils - Cron nnotue - Dimeter, hirlity, doping, et. - Grphene - Lyers, defets, et. - Others - sp 2 nd sp 3 struture - DLC oting properties - Dimond qulity nd provenne Semiondutors - Stress/strin nlysis - Doping/Defet - Contmintions - Superlttie struture - Crystl form nlysis - Photoluminesene (PL) - Miro-nlysis Phrmeutils - Cosmetis - Chemil identifition ontent uniformity - API quntifition - High-throughput sreening - Polymorphs, rystl-form trnsformtion nd therml stility nlysis - Drug ounterfeiting nd dditive detetion - Drug-ell intertion - Rel-time retion monitoring nd terminl produt detetion Life Sienes - Bio-mromoleule (lipids, proteins, rohydrtes, DNA, et.) - Bteri lotion, identifition nd lssifition - Cell nlysis (ell imging) - Drug distriution in ells/tissues - Diseses & erly dignosis, onology - Lel-free in-vivo nd in-vitro nlysis - Nnotoxiology Geology - Minerls/rystl forms - Fluid inlusion - Phse trnsformtion - In-situ high/low temperture retion - Therml oxidtion of orgni mterils - Fluoresene miro-nlysis Jewelry - Museum - Forensis - Gemstones/jde - Metlwre orrosion - Cellulose/Textiles/Fiers - Hndwriting uthentition - Explosives/ullet remnnts - Printing inks/pigments - Drugs Cron Mterils Mesuring dimeter of CNT Applition 2: Bteri Identifition Semiondutors Crystlline evlution of outermost surfe of semiondutor mteril Applition 2: Bteri Identifition Life Sienes Bteri identifition Films In-line nlysis of film thikness nd omposition in Roll to Roll prodution proess Low wvenumer region Surfe (~ Severl hundred nm) Bulk Bulk nlysis XRD (X-ry) Not only the outermost surfe Visile Lser Rmn (543 nm) 2 m Only the outermost surfe UV Lser Rmn (325 nm) Comprison of penetrtion length of X-ry nd lser 0.2 m Intensity(.u.) UV Lser Visile Lser Rmn shift (m - 1 ) Visile nd ultrviolet lser Rmn spetr mesured t the sme lotion Disriminnt funtion 2 0.3 0.2 0.1 0-0.1-0.2-0.3-0.4-0.5-0.8-0.6-0.4-0.2 0 0.2 0.4.60 Disriminnt funtion 1 Sensor unit of Rmn Sensor unit of Ellipsometer Rmn Spetrum of SWCNT (Single Wll Cron Nno Tue) CNT dimeter n e evluted y nlyzing RBM. The RBM is mode in whih SWCNT strethes in the dimetril diretion. It hs orreltion with the dimeter of SWCNT t the pek etween 100-300 m -1. LRAM HR Evolution The differenes in rystlline n e deteted y using ultrviolet lser mirosope Rmn spetrosopy for the differene in rystlline of the smple's outermost surfe, whih ould not e onventionlly distinguished y XRD or visile lser mirosopy Rmn spetrosopy. XploRA PLUS Rmn imging gives distriution nd hemil informtion. Rmn dt nlyzed y multivrite nlysis shows us good disrimintion of the teri speies. The teri speies ould e identified y the omintion of Rmn nd multivrite nlysis. XploRA INV Al 2O 3 film on PET Sustrte In the Roll to Roll film prodution proess, the film is pulled t the other side during oting nd wounded on the opposite side. At this time, the vrition in oting film thikness nd omposition hnge ffets the yield. By instlling sensors of Rmn nd ellipsometer in the Roll to Roll prodution equipment, the vrition in oting film thikness nd omposition hnge n e monitored in line, during the prodution proess.

AFM-Rmn HORIBA Sientifi nd AIST-NT, mnufturer of dvned SPM systems designed speifilly for integrtion with optil spetrosopy, provide n innovtive solution tht ddresses the hllenges of NnoRmn imging. Co-lolized Rmn-AFM Conventionl Miro-Rmn provides diffrtion limited su-miron sptil resolution. Co-lolized mesurement is ll out overlpping Rmn mp with n AFM mp (topogrphy, phse, pitne, et.). TERS: Tip Enhned Rmn Spetrosopy TERS rings you the hemil speifiity of Rmn spetrosopy with imging t sptil resolution typilly down to 10 nm. This tehnique n e demonstrted on vrious smples rnging from 1D, 2D nnomterils, orgni moleules nd polymers, to life sienes smples. Composite Rmn imge of grphene flke AFM Cpitne imge of the sme grphene flke D-nd TERS mp of grphene oxide flke TERS mpping of single ron nnotue showing n optil sptil resolution down to 8 nm onfirmed from the setion nlysis of the intensity of the TERS nds. XploRA Nno LRAM HR Evolution Nno LRAM HR Evolution nd XploRA PLUS/INV integrted with Snning Proe Mirosopes (SPM) n provide nno imging spetrosopy of Rmn nd SPM simultneously. Compt, fully utomted nd esy-to-use Nno Rmn systems for high speed TERS imging t nno sle. ComiSope XploRA ComiSope XploRA is fully integrted ompt AFM-Rmn system dedited to trnsprent smples (Life sienes). For Detils of HORIBA Rmn Lineup: www.hori.om/sientifi/produts/rmn-spetrosopy/

Rmn Mirosope XploRA series Rmn Mirosope Fully utomted nd fully onfol Rmn mirosopes llow fst non-destrutive hemil miro-nlysis nd Rmn hemil imging. XploRA PLUS For reserh nd nlytil ls [Exittion] 532 or 785 nm (XploRA One) 532, 638, 785 nm, others on request (XploRA PLUS/INV) XploRA INV For iologil pplitions XploRA One For industril nd routine nlysis [Confol imging] 1 μm XY (XploRA One), 0.5 μm XY (XploRA PLUS/INV) LRAM HR Evolution Ultimte Rmn Spetrosopy High spetrl nd sptil resolution nlytil Rmn mirosope idelly suited to oth miro nd mro mesurements, with dvned onfol imging pilities in 2D nd 3D. [Spetrl rnge] UV-NIR (200-2,100 nm) [Cutoff] >50 m -1 (Stndrd), >5 m -1 (Option) [Detetors] Up to three detetors Modulr nd Fier Coupled Rmn A rnge of spetrometers nd detetors for integrting into your own Rmn experiment, with performne to suit ll requirements. Modulr Rmn Trnsmission Rmn Provides ost effetive ess to tehnique idelly suited to ulk hemil nlysis of opque smples, inluding powders nd tlets. Trnsmission Rmn Mro Rmn Benhtop nd portle Rmn systems designed for portility nd high qulity Rmn mesurements: MroRAM Affordle Benhtop Rmn Spetrometer Triple Rmn SEM Rmn Proess Rmn The Triple grting Rmn spetrometer offers the ultimte in spetrosopi performne. For fundmentl reserh nd dvned pplition of hemil nlysis using Rmn spetrosopy. T64000 Triple Rmn System Verstile with possiility to mesure Rmn, Photoluminesene nd Cthodoluminesene. For identifition of ompounds moleulr indings, phses nd polymorphism of its smple under vuum, eventully t low temperture using old smple stge. R-CLUE SEM-Rmn High effiieny dedited proess Rmn nlyzer for rugged nd roust Rmn monitoring. Proess Rmn