William F. Milton Fund - Harvard University

William F. Milton Fund - Harvard University MILTON FUND APPLICATION GUIDELINES INSTRUCTIONS 2012 The bequest of the William F. Milton Fund makes funds available to support research conducted by faculty members of Harvard University. An advisory inter-faculty Milton Fund Committee has been appointed to assist in the allocation of Milton Fund income. This Committee administers the funds to facilitate new approaches, initiate new projects, and in particular, assist junior faculty members in establishing their research programs. The amount allocated to any one program is comparatively small and the duration of support is limited to one year. ELIGIBILITY GUIDELINES The annual allocation of the William F. Milton Fund of Harvard University primarily supports investigations of a temporary nature, conducted within the University, that meet the following eligibility requirements: 1. Applicants must be voting members of Harvard University Faculty. Generally, this includes Assistant Professor or above, or Junior Fellows of the Harvard Society of Fellows. 2. The investigation must be of a: (1) medical; (2) geographical; (3) historical; or (4) scientific nature. 3. The investigation must: a. Be in the interests of or for promoting the physical and material welfare and prosperity of the human race (rather than its spiritual, intellectual or aesthetic welfare); b. Assist in the discovery and perfecting of any special means of alleviating or curing human disease; or c. Investigate and determine the value or importance of any discovery or invention. 4. Applicants having substantial active support ($200K or more not including applicant s salary and fringe benefits) which runs concurrently with the Milton Fund s award period will be assigned a very low priority rating for funding. 5. Ineligible: Instructors, post-doctoral fellows, residents, those with pending and/or anticipated promotions to voting academic status at the time of application submission, and anyone who has received a Milton Fund Grant within the previous five years are not eligible for funding. APPLICATION GUIDELINES DEADLINE: Applications must be received on or before October 21, 2011, 5pm Eastern (receipt date). Any application received after that time/date cannot be accepted for consideration. Funding up to $40,000 may be requested for a one year period beginning January AWARD: 1, 2012 APPLICATIONS: PLEASE NOTE: Must be submitted electronically to: miltonfund@hms.harvard.edu If applications are incomplete and/or missing appropriate signatures, they will be administratively denied and returned without review. http://www.hms.harvard.edu/spa/docs/forms/internalapps/milton_application_2012.doc Page 1 of 3

William F. Milton Fund - Harvard University GUIDELINES INSTRUCTIONS SUBMIT APPLICATIONS WITH CONTENTS IN THE FOLLOWING ORDER: 1. Application Face Page Complete all administration and research information. 2. Assurance of Compliance Location of Research: HMS applicants must complete this section according to standard HMS policy. Applicants whose research will be conducted at an HMS affiliate or other Harvard school must complete the section and obtain the signature of an authorizing official from that institution (usually the Sponsored Programs Office). Animal and Human Subjects: Applicants using either animals or humans in the proposed research must submit a copy of the current protocol and approval letter for our records. If approval is pending please insert pending instead of the protocol number on the form. The approval letter may be submitted to the Committee after the award is made. 3. Summary Statement, Narrative and References Summary Statement: Include a summary statement of the research proposal (not to exceed 200 words) in layman's terms. Narrative: Describe the proposed research in sufficient detail to enable the reviewing committee to appraise it. A level of detail typical of a Scientific American article is appropriate. Include a brief summary of preliminary work or other background material, objectives, and scope of work not to exceed 4 doublespaced pages with one-inch margins on all sides. Use a 12pt font. Insert pages on application, as necessary. References: Keep references on separate pages not to exceed 2 pages in length. 4. Budget and Justification Forms Applicant must provide a detailed budget and justification on the enclosed forms. The Budget Justification is a narrative of each line item explaining why it is essential to the proposed research project. Also, explain how the cost was calculated. The Committee will consider funding up to $40,000. Personnel: No individual above the level of post-doctoral fellow may receive salaries, stipends, or special remuneration from the Milton Fund. Personnel supported by Milton Funds may not conduct any course or instruction offered for academic credit. An occasional lecture, not regularly scheduled in a course of instruction, will not be regarded as a violation of this provision. Technicians and laboratory assistants may be paid to the extent that they work on Milton Fund supported investigations. Requests for payment of secretaries and other personnel usually considered office employees must be justified in terms of the proposed research. Fringe benefits must be calculated according to your institutional rate. Equipment: Only expenditures for the purposes of the proposed investigation are allowable for Milton Fund grants. Funds for large pieces of equipment planned to improve the general facilities of a laboratory are not usually approved. Funds for maintenance or service contracts are usually not allowable. Equipment becomes the property of Harvard University upon termination of the project. Travel: Travel to collect specimens or obtain data necessary to conduct the proposed research is allowable and must be explained thoroughly in the budget justification. Travel to scientific meetings is not an allowable budget item unless it can be related directly to the funded project. Supplies: All research related supplies are allowed. Overhead: No amount for indirect or administrative expenses may be included in a Milton Fund grant. http://www.hms.harvard.edu/spa/docs/forms/internalapps/milton_application_2012.doc Page 2 of 3

William F. Milton Fund - Harvard University GUIDELINES INSTRUCTIONS Other Support: Provide active and pending support for the Principal Investigator in the format provided (see last page of application kit). No other format will be accepted. Other Support includes all financial resources, whether Federal, non-federal, commercial or institutional, available in direct support of an individual s research endeavors, including but not limited to research grants, cooperative agreements, contracts and/or institutional awards. Please do not include any "start-up" packages and/or tenure-transfer funding. Normally, only grants/gifts/subcontracts etc. with the applicant as Principal Investigator should be listed. Also include a short narrative (no more than one paragraph) which demonstrates the applicants need for funding. 5. Biographical Sketch Provide a bio-sketch for the applicant and any individual at the post-doctoral fellow level or above participating in the project. Four pages only. NIH format is acceptable. 6. Letter of Reference Required for Junior Fellows of the Harvard Society of Fellows only. Please include the letter of reference within the proposal. Do not mail directly to the Milton Fund Committee. 7. Proof of Appointment A copy of your current Harvard University Appointment form or proof of appointment is required. Proof appointment could be appointment letter (cover letter only), MARS appointment screen printout, letter from Chair confirming appointment. 8. Terms and Conditions (Completed and signed) Please read this document carefully as it contains important information regarding payment procedures and use of the Milton Funds. Once it is signed, you are agreeing to comply with the terms and conditions as they pertain to the Milton Fund. SUBMISSION INSTRUCTIONS Complete the application sections as described above and sign where required. 1. Print and collate all sections in the order described above. 2. Scan the application to PDF format. Review the PDF to ensure it is legible. 3. E-mail the PDF document to miltonfund@hms.harvard.edu. In Subject line of the e-mail include the PI s last name, first name, Milton 2011. (Ex: Jones, Sharon, Milton 2012). 4. E-mail must be received on or before Monday, October 21, 2011, 5pm Eastern time. Any application received after that time/date cannot be accepted. If you have any questions concerning this Application Kit, please contact a Milton Fund Coordinator: Deborah Good email: Deborah_good@hms.harvard.edu http://www.hms.harvard.edu/spa/docs/forms/internalapps/milton_application_2012.doc Page 3 of 3

Please refer to Milton Fund Application Instructions for help in completing this application. 1. APPLICATION FOR SUPPORT FACE PAGE RESEARCH INFORMATION Principal Investigator Academic Title Proposed Funding $ Project Period to Title of Project Type of Investigation Medical Geographic Historical Scientific Purpose of Proposed Study It is in the interest of, or for promoting the physical and material welfare and prosperity of the human race. It is to assist in the discovery and perfection of a special means of alleviating or curing human disease. It is to investigate and determine the value or importance of a discovery or invention. Other Support Total Active $ Total Pending $ Previous Milton Fund Support Previous Support $ Previous Period to ADMINISTRATIVE INFORMATION Principal Investigator Harvard Tub # Harvard Org # Harvard Root # Harvard ID Address School / Affiliate (only required if Harvard Root # is not known) Dept / Name Street Building / Room # City, State Zip Telephone Fax Email Financial Administrator (person with signature authority for accounts payable in your department) Name Title Address School / Affiliate Dept / Name Street Building / Room # City, State Zip Telephone Fax Email Page 1 of 11 Rev 09/11 [1-1]

ANIMAL AND HUMAN SUBJECTS WILLIAM F. MILTON FUND 2. ASSURANCE OF COMPLIANCE Does this research proposal involve the use of ANIMALS? YES NO If YES, have you submitted a protocol to the Animal Research Committee? YES NO IF YES, date of your latest approval Date Protocol # If NO, contact the Animal Experimentation/Human Studies Coordinator. Does this research proposal involve the use of HUMANS? YES NO If YES, is the protocol exempt from review according to PHS guidelines? YES NO If EXEMPT, exemption number Exemption # If NON-EXEMPT, has a protocol been sent to Human Studies Review Committee? YES NO If YES, date of your latest approval Date Protocol # If NO, call Human Studies Coordinator for assistance LOCATION OF RESEARCH Harvard University Name of School Affiliate of Harvard University Name of Affiliate Institution If research is conducted at a location other than Harvard Medical School, a research administration official must approve use of their facility by signing below. SIGNATURES OF APPROVAL Name & Title of Institutional Research Administration Official Signature: Research Admin Official Date (ONLY REQUIRED IF RESEARCH IS NOT AT HMS) Signature: Principal Investigator (REQUIRED OF ALL APPLICANTS) Date Typed Name of Department Chairperson Signature: Department Chairperson Date (REQUIRED OF ALL APPLICATNTS) Page 2 of 11 Rev 09/11 [2-1]

3a. SUMMARY STATEMENT Page 3 of 11 Rev 09/11 [3-2]

Please insert pages, as needed. WILLIAM F. MILTON FUND 3b. RESEARCH NARRATIVE Page 4 of 11 Rev 09/11 [4-4]

3c. REFERENCES Page 5 of 11 Rev 09/11 [5-6]

4a. DETAILED BUDGET Itemized Budget Project Period: January 1, 2012 through December 31, 2012 A. Personnel (Name & Role) No individual above the level of post-doctoral fellow may receive salaries, stipends, or special remuneration from the Milton Fund. Total Base Salary % Effort Project Salary Fringe Benefits Requested 1 $ x =$ +$ =$ $ x =$ +$ =$ $ x =$ +$ =$ $ x =$ +$ =$ $ x =$ +$ =$ A. Subtotal Personnel $ B. Other Research Expenses Price Quantity Total Requested Equipment 1 Travel 1 Supplies 1 Consultants 1 Miscellaneous (Detail) 1 B. Subtotal Other Research Expenses $ C. Total Requested (A +B) $ Page 6 of 11 Rev 09/11 [6-8]

4b. BUDGET NARRATIVE Page 7 of 11 Rev 09/11 [7-9]

5. OTHER SUPPORT Page 8 of 11 Rev 09/11 [8-11]

Insert as applicable: WILLIAM F. MILTON FUND 6. Letter of Reference required for Junior Fellows of the Harvard Society of Fellows only. All others are optional. 7. Proof of Appointment A copy of your current Harvard University Appointment form or proof of appointment is required. Proof appointment could be appointment letter (cover letter only), MARS appointment screen printout, or letter from Chair confirming appointment. Page 9 of 11 Rev 09/11 [9-13]

8. TERMS, CONDITIONS, & FINANCIAL ADMINITRATION GUIDELINES Awards from the William F. Milton Fund, a Harvard University Endowment Fund, must be administered through a Harvard 33 digit account string and thus are handled differently from sponsored awards administered directly through your own institution. There will be no subcontract or affiliate agreement issued. You should contact the administrator of your department to learn how to access your Milton funds. Below is a list of some general Harvard rules and procedures concerning the processing of Milton Fund expenditures follows for your information. The Milton Fund is similar to a sponsored research account in that you must adhere to the line item budget submitted. It is not to be used as a discretionary account (i.e., expenses incurred for other departmental purposes). Rebudgeting is permitted under limited conditions only. Changes between expense categories are allowable provided (1) the categories were approved on the original application budget; (2) the expenses are allowed according to general policy; (3) the total amount of the award is not exceeded; (4) the scope of the project is in no way modified. Requests for budgetary changes that DO NOT adhere to these conditions must be made in writing to the Milton Fund Committee. Invoices for expenditures are processed through the on-line WebVoucher system or paid through use of the HU PCard (Purchasing Card). Please do not submit invoices to the Milton Fund Coordinator. All invoices are processed via WebVoucher. Once entered and approved in the WebVoucher system all invoices need to have the WebVoucher number clearly indicated in the upper right hand corner of the invoice and should be sent directly to Harvard University Accounts Payable, 1033 Massachusetts Avenue, Cambridge, MA 02138. The Milton Fund awardee must not use personal funds to pay for services rendered by either companies or individuals. All invoices must be paid directly by Harvard University s accounts payable department. If the awardee does pay for expenditures, he/she must provide the original receipt(s) for the purchase. If original receipts are unavailable, a copy of the credit card bill and/or a copy of the front and back of the canceled check showing payment are required. It is your responsibility to manage this account. Harvard will not accept responsibility for cost over-runs. Milton Fund accounts are closed ninety (90) days after the expiration date of the grant period. Harvard will not accept responsibility for any invoices received past 90 days after the expiration date of the grant period. After 90 days any unexpended balance will be returned to the Milton Fund for future award cycles. Deficits must be cleared by ninety days after the expiration date of the grant period. An alternate Harvard account must be provided by your department in the event over-expenditures are not removed within this time period. If you have accounting related questions concerning your award, please contact the Harvard University General Accounting Office. No-cost extensions: Requests must be received, in writing, by the Committee at least thirty (30) days prior to the expiration date of your grant. No additional money will be made available to you; extensions are granted for a period of time ranging from three months to one year. Final Report: Upon completion of your research project please submit a (one page) report to the Milton Fund Committee. In addition, please acknowledge support from the Milton Fund in any publication. Correspondence (except invoices): should be directed to the Milton Fund Coordinator, by mail Sponsored Programs Administration, Harvard Medical School, 25 Shattuck Street, Gordon Hall, Suite 509, Boston, MA 02115, email deborah_good@hms.harvard.edu, telephone (617) 432-2911, or fax (617) 432-2651. Signature: Award Recipient Date Signature: Financial Administrator Date Name (please type) Name (please type) Email Email Page 10 of 11 Rev 09/11 [10-13]

Other Support Sample Format NAME OF INDIVIDUAL ACTIVE/PENDING Project Number (Principal Investigator) Dates of Approved/Proposed Project % Effort Source Annual Direct Costs Title of Project Amount for Applicants Salary & Fringe The major goals of this project are OVERLAP (summarized for each individual) NARRATIVE Samples ANDERSON, R.R. ACTIVE 2 R01 HL 00000-13 (Anderson) 3/1/97 2/28/00 30% NIH/NHLBI $186,529 Chloride and Sodium Transport in Airway Epithelial Cells $30,000 The major goals of this project are to define the biochemistry of chloride and sodium transport in airway epithelial cells and clone the gene(s) involved in transport. R000 (Anderson) 9/1/96 8/31/98 10% Cystic Fibrosis Foundation $43,123 Gene Transfer of CFTR to the Airway Epithelium $10,000 The major goals of this project are to identify and isolate airway epithelium progenitor cells and express human CFTR in airway epithelial cells. PENDING DCB 950000 (Anderson) 12/01/98 11/30/00 20% National Science Foundation $82,163 Liposome Membrane Composition and Function $20,000 The major goals of this project are to define biochemical properties of liposome membrane components and maximize liposome uptake into cells. OVERLAP There is scientific overlap between aim 2 of NSF DCB 950000 and aim 4 of the application under consideration. If both are funded, the budgets will be adjusted appropriately in conjunction with agency staff. NARRATIVE Page 1 of 11 Rev 09/11 [1-15]