Online Activity 1 hour May 25, 2015 May 24, 2016

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Format Time to Complete Released Expires Online Activity 1 hour May 25, 2015 May 24, 2016 Maximum Credits 1.0 / AMA PRA Category 1 Credit(s) TM Sponsored by: Commercial Supporter This activity is supported by an educational grant from Xoft, a subsidiary of icad, Inc.. Program Description Radiation therapy has been widely used to help reduce the recurrence of breast cancer and improve survival. Newer technologies such as electronic brachytherapy reduce the need for intraoperative shielding and improve safety for patients and providers. Intra-operative radiotherapy (IORT) as a treatment for breast cancer is a relatively new technique that is designed to be an adjunct or replacement for whole breast external beam radiotherapy (EBRT) in selected women suitable for breast-conserving therapy. Targeted intra-operative radiotherapy (IORT), which uses energy sources generated from a portable device within the operating room immediately after the breast tumor (and surrounding margin of healthy tissue) has been removed, greatly reduces the number of treatments required. Improvements in patient comfort and safety, as well as a potential reduction in costs, have been achieved. The delivery of single fraction radiotherapy directly to the tumor bed at the time of surgery, also allows the capability of adding EBRT at a later date. This CME accredited webinar series entitled, Radiotherapy for Breast Cancer: Advances and Options-A Case-Based CME Accredited Webinar Series, will focus on the latest data on effectiveness, appropriateness of IORT in the treatment of breast cancer as well as the technology and physics related to the procedure. Suggestions will be made for building an effective treatment team. An innovative tumor board format will be incorporated during the series to engender further thought and debate. A nationally-recognized faculty has been brought together, and will discuss IORT from the perspectives of the surgeon and the radiation oncologist. The potential advantages of IORT, as well as the latest data on its use, will be described. Newer methods of delivering high dose target

limited radiation therapy will be evaluated, and recommendations will be made for appropriate patient selection. Participants will have the opportunity to interact with the faculty in a Q&A session immediately following the live presentations. Attendees may register for any number of individual live interactive webinars. Each of the webinars will then be available online to give the widest group of learners access to this important series, as well as the ability to earn CME credit. Intended Audience Surgeons, Radiation Oncologists, Medical Oncologists, Radiation Therapists and other medical professionals involved in the treatment of breast cancer. Educational Objectives After taking part in this educational activity, participants should be better able to: Assess the appropriate usage of IORT in the treatment of breast cancer Identify the modalities available for IORT Identify potential improvements in patient comfort, safety and cost of various modalities of IORT Discuss the possible advantages of electronic brachytherapy Examine potential advances in the treatment of breast cancer Accreditor Disclosure of Conflicts of Interest The Institute for Medical Education (IME) adheres to all IMQ/CMA/ACCME Essential Areas, Standards and Policies. It is IME's policy that those who have influenced the content of a CME activity (e.g. planners, faculty, authors, reviewers and others) disclose all relevant financial relationships with commercial entities so that IME may identify and resolve any conflicts of interest prior to the activity. These disclosures will be provided in the activity materials along with disclosure of any commercial support received for the activity. Additionally, faculty members have been instructed to disclose any limitations of data and unlabeled or investigational uses of products during their presentations.

Planners and IME Staff Disclosure Edwin Jacobson, MD, PhD, has nothing to disclose Elizabeth Mittendorf, MD, PhD (Peer Reviewer), has nothing to disclose Claudine Hanna, MPH, has nothing to disclose Ella Scott, has nothing to disclose Credit(s) 1 Type AMA PRA Category 1 Credit(s) TM Accreditation Statement The Institute for Medical Education SM is accredited by the Institute for Medical Quality/California Medical Association (IMQ/CMA) to provide continuing medical education for physicians. The Institute for Medical Education SM takes responsibility for the content, quality and scientific integrity of this CME activity. Credit Designation Statement: The Institute for Medical Education SM designates this educational activity for a maximum of 1AMA PRA Category 1 Credit (s). Physicians should claim only the credit commensurate with the extent of their participation in the activity. This credit may also be applied to the CMA Certification in Continuing Medical Education. In accordance with the ACCME s revised Standards of Commercial Support, potential conflicts of interest are thoroughly vetted by the Executive Committee of IME. All conflicts are resolved prior to the beginning of the activity by the IME peer review process. The opinion expressed in this activity are those of the faculty and do not necessarily reflect those of IME.

Provider approved by the California Board of Registered Nursing, provider number 10672 for a maximum of 1 contact hour(s). Cultural and Linguistic Competency: California Assembly Bill 1195 requires continuing medical education activities with patient care components to include curriculum in the subjects of cultural and linguistic competency. The planners and speakers of this CME activity have been encouraged to address cultural issues relevant to their topic area. The Institute for Medical Education, Resources for Physicians also contains many useful cultural and linguistic competency tools including culture guides, language access information and pertinent state and federal laws. You are encouraged to visit the portal: http://www.ime-cme.com/forms/cultural_linguistic_competency_resources.pdf Disclosure of Unlabeled Use This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) does not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. Disclaimer Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer s product information, and comparison with recommendations of other authorities. Instructions In order to receive credit for this activity, the participant must complete the pre-test, complete the post-activity test with at least 70% correctness, and the activity evaluation. Method of Participation: There are no fees for participating in this CME activity. To receive credit during the period January 2014 to January 2015, participants must (1) read the learning objectives and disclosure statements, (2) study the educational activity, and (3) complete the post-test and activity

evaluation form, including the certificate information section. To obtain a certificate, participants must receive a score of 70% or better on the post-test. The post-test can be accessed at the end of the activity. If you have any questions relating to the accreditation of this activity, please contact The Institute for Medical Education at 310-209-2033 or contact@ime-cme.com. Privacy Policy IME protects the privacy of personal and other information regarding participants, educational partners, and joint sponsors. IME and our joint sponsors will not release personally identifiable information to a third party without the customer s consent, except such information as is required for reporting purposes to the appropriate accrediting agency. SYSTEM REQUIREMENTS Click the "Start Activity" button to indicate you have reviewed the CME/CE information for this activity.