National End Stage Liver Disease Training Program and Treatment Update 2013

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Target Audience: Gastroenterologists Hepatologists Oncologists Transplant Physicians Nurse Practitioners Physician Assistants Nurse Specialists Houston, TX San Diego, CA San Francisco, CA New York, NY August 10, 2013 September 7, 2013 September 7, 2013 September 21, 2013

Program 7:30 am Registration, Breakfast & View Exhibits 8 am : Epidemiology, Predicting Outcomes, Improving Survival 8:20 am Ascites, Hyponatremia, and Hepatorenal Syndrome 9 am Hepatic Encephalopathy 9:20 am In the Cirrhotic Patient: Variceal Bleeding and Ascites 9:40 am Break & View Exhibits 10 am Hepatocellular Carcinoma: Screening and Diagnosis 10:20 am Hepatocellular Carcinoma: Treatment Options 10:40 am Liver Transplantation: Indications and Contraindications, MELD Exceptions 11 am Case Presentations: ICU Management of Acute on Chronic Liver Failure Hepatitis C in the Patient with HCC: Down Staging into Transplant Criteria 12:30 pm Adjourn About Scripps SC Liver Research Consortium (SCLRC) is an organization of physicians specializing in hepatology and gastroenterology clinical research. SCLRC's mission is to team research sponsors and SCLRC's 71 research sites together to provide faster, higher-quality research results compared to the current "conventional" sponsor-site arrangement. This is accomplished by providing streamlined contract and budget negotiations, access to our scientific expertise in study design, efficient site selection, and ongoing site evaluation. For more information visit www.scliver.com Scripps Conference Services & CME, which offers nationally recognized annual conferences in various specialty areas, is committed to improving the quality of health care and advancing the practice of medicine by providing exceptional educational courses for physicians and other health care professionals. More information and conference brochure downloads are available at www. scripps.org/conferenceservices. Educational Objectives After attending this activity, participants should be able to: Summarize the causes of hepatic encephalopathy. Assess treatment options, including the use of rifaximin and lactulose therapies. Perform the appropriate and routine diagnostic tests required to ensure early diagnosis of HCC. Integrate newer treatment options for HCC including the use of tyrosine kinase inhibitors, drug eluting beads, and Y90 therapy. Identify the multiple causes for renal insufficiency in patients with ESLD including diuretic overuse, GI bleeding, systemic infection, hepatic decompensation, and hepatorenal syndromes type 1 and 2. Determine the risks for hyponatremia in the ESLD patient. Follow the guidelines for diagnosis and management of ascites in patients with ESLD including diuretics, therapeutic paracentesis, and transjugular intrahepatic portasystemic shunt (TIPS). Discuss safe and effective treatment of hepatitis C in the patient with cirrhosis Evaluate real-life cases which exemplify many of the complications of ESLD seen in a liver transplant center.

Faculty & Location Information August 10, 2013 Houston, Texas Houston Marriott West Loop by The Galleria 1750 West Loop South Houston, TX, 77027 713-960-0111 Howard P. Monsour, Jr., MD The Methodist Hospital Norman Sussman, MD Baylor College of Medicine Debbie Calaris, MS, PA-C Baylor College of Medicine September 7, 2013 San Diego, California San Diego Marriott La Jolla 4240 La Jolla Village Drive La Jolla, CA 92037 858-587-1414 Catherine Frenette MD Scripps Clinic Tarek Hassanein,MD Scripps Clinic and Southern California Liver Center Andrea Scherschel, NP Scripps Clinic September 7, 2013 San Francisco, California Omni San Francisco Hotel 500 California Street San Francisco, CA 94104 415-677-9494 Bilal Hameed, MD University of California, San Francisco R. Todd Frederick, MD California Pacific Medical Center Jessica Stark PA-C, MPH SutterHealth September 21, 2013 New York, New York Hilton Times Square 234 West 42nd Street New York, NY 10036 212-840-8222 Robert S. Brown, Jr., MD, MPH Columbia University Paul J. Gaglio, MD Montefiore Medical Center Albert Einstein College of Medicine Margie Fernandez- Sloves, DNP Columbia University Three Easy Ways To Register Online www.scripps.org/conferenceservices Fax 858-652-5565 Mail Scripps Conference Services & CME Conference 11025 North Torrey Pines Road Suite 200, Maildrop: SCRC200 La Jolla, California 92037 Questions? Contact Scripps Conference Services & CME Phone 858-652-5400 Email med.edu@scrippshealth.org Exhibit Opportunities For information on exhibit and support opportunities during this and many other Scripps educational conferences, please contact: Scripps Conference Services & CME 858-652-5400 med.edu@scrippshealth.org www.scripps.org/conferenceservices Attendance Policies Registration Confirmation A confirmation letter will be e-mailed or mailed to you upon receipt of the conference registration form and payment. If you have not received it within two weeks, please contact the Scripps Conference Services & CME office. Attendee Cancellation, Substitution, Refund The course tuition is refundable, minus a $20 processing fee, if your cancellation is received in writing no later than one week prior to the course. Attendee substitutions are allowed, but notification must be made in writing no later than one week prior to the course. After this date, under no circumstances will refunds, credits, or substitutions be granted. No refunds or credits will be given to no shows. Guest Attendance Policy All conference activities (including educational sessions, meal functions, exhibit hall, etc.) are exclusively reserved for conference attendees. Non-registered guests (including children, family members, colleagues, etc.) are not allowed in the conference areas. Badges provided at registration are required for entrance into all functions and will be strictly enforced. Scripps Conference Modification or Cancellation Scripps reserves the right to modify the course s schedule or program as necessary. Scripps also reserves the right to cancel this conference, in which case a full refund of the registration fee will be provided. We are unable to refund any travel costs (flight, hotel, etc.) in the case of Scripps cancellation. Recording and Photography Clause Scripps reserves exclusive rights to record (audio and video) and/or photograph all conference proceedings for use in marketing materials, presentations and course content sales.

Registration Conference Fees Included: course tuition, course materials, and breakfast. Not Included: travel costs, lodging and parking. Pre-Registration ends Tuesday prior to program date Onsite Registration begins Wednesday prior to program date $55 $70 Group Rate* $45 $60 *Register three (3) or more from your office and each of you will receive $10 off your registration. Please check one: Houston, TX August 10, 2013 San Diego, CA September 7, 2013 San Franicsco, CA September 7, 2013 New York, NY September 21, 2013 By completing this registration form and returning it to Scripps you are acknowledging compliance with all attendance policies. Would you like to receive the Scripps Conference Services & CME Email Newsletter? Yes No PLEASE PRINT CLEARLY. SHOULD WE HAVE ANY CONFERENCE COMMUNICATIONS, PLEASE PROVIDE YOUR DIRECT CONTACT INFORMATION. NAME (FIRST, MI, LAST) DEGREE (MD, DO, PHD, RN, ETC) BADGE NAME (IF DIFFERENT FROM ABOVE) AFFILIATION/HOSPITAL/COMPANY SPECIALTY DIRECT MAILING ADDRESS CITY STATE ZIP DIRECT PHONE FAX E-MAIL (This is required and will be your user name when accessing your online account.) Please indicate any special needs (including dietary restrictions). Special requests will be considered and accommodated in full compliance with the Americans with Disabilities Act (ADA). Office use only: Date rec d Check no/approval CD Amount Confirmation Sent Initials PAYMENT METHOD Check Please make checks payable to Scripps (in US dollars only). Visa MasterCard AMEX Discover If paying by credit card, please complete information below: CREDIT CARD NUMBER EXPIRATION DATE 3-DIGIT SECURITY CODE NAME ON CARD SIGNATURE BILLING ADDRESS (IF DIFFERENT FROM ABOVE)

Course Introduction Course Overview The number of patients with ESLD in the US is expected to continue to grow through 2020, largely due to the burden of chronic viral hepatitis and fatty liver disease which already exists in our population. As they age, a larger number of patients will develop decompensation events such as bleeding from esophageal varices, hepatic encephalopathy, hepatocellular carcinoma, ascites, hyponatremia and renal failure. The expected increase in number of ESLD patients will create more demand for health care providers who are able to care for the growing population, both in and out of the hospital. To meet this growing demand, this cutting edge, half-day course will teach diagnosis and management of common complications seen in patients with ESLD. After attending this educational program, the attendee will be able to recognize the treatable complications quickly and use the latest therapies in a reasonable fashion. Learning will concentrate on the areas which are evidence-based or literature-based; including portosystemic encephalopathy, ascites, hyponatremia, hepatocellular carcinoma screening and treatment, hepatorenal syndrome and bleeding due to portal hypertension. Conference Highlights NEW! Earn Category I CME and self-assessment credits toward Part 2 of the ABS MOC Program. Updates on the latest clinical guidelines with strong patient-focused educational sessions. Local experts providing an interdisciplinary team approach to treatment with physician and midlevel provider faculty. Interactive formats including practical case studies, small group discussion, and question and answer opportunities throughout. Receive up to 4.25 AMA PRA Category 1 Credits. Convenient local venues and affordable registration fee. Accreditation Physicians (MD/DO) This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Scripps Health and Scripps Clinic Liver Research Consortium. Scripps Health is accredited by the ACCME to provide continuing medical education for physicians. Scripps Health designates this live activity for a maximum of 4.25 AMA PRA Category 1 Credit(s). Physicians should only claim credit commensurate with the extent of their participation in the activity. Documentation of awarded credit is provided for registered attendees in exchange for completed activity evaluation. Certificates of attendance are available, upon request, at the end of the course. Surgical Credits This activity provides Category I CME and self-assessment credits toward Part 2 of the ABS MOC Program. Registered Nurses The California State Board of Registered Nursing (BRN) accepts AMA PRA Category 1 Credit(s) as meeting continuing education requirements for license renewal. Most state Boards of Registered Nursing accept AMA PRA Category 1 Credit(s) as meeting continuing education requirements for license renewal. Nurses should check with their state board regarding use of CME credit. Physician Assistants The American Academy of Physician Assistants accepts Category 1 credit from AMA Category 1 CME organizations accredited by the ACCME. Disclosure Commercial Support This course is supported, in part, by educational grants from industry, in accordance with ACCME accreditation Standards for Commercial Support. At the time of printing, a complete listing of commercial supporters was not available. Appropriate acknowledgement will be given to all supporters at the time of the educational activity. Cultural and Linguistic Competency This activity is in compliance with California Assembly Bill 1195 which requires that all CME activities comprising a patient care element include curriculum addressing the topic of cultural and linguistic competency. The intent of this bill is to ensure that health care professionals are able to meet the cultural and linguistic concerns of a diverse patient population through effective and appropriate professional development. Cultural and linguistic competency was incorporated into the planning of this activity. Faculty Disclosure In accordance with the ACCME Standards for Commercial Support, course directors, planning committees, faculty and all others in control of the educational content of the CME activity must disclose all relevant financial relationships with any commercial interest that they or their spouse/partner may have had within the past 12 months. If an individual refuses to disclose relevant financial relationships, they will be disqualified from being a part of the planning and implementation of this CME activity. Employees of a commercial interest with business lines or products relating to the content of the CME activity will not participate in the planning or any accredited portion of the conference. Disclosure will be made to all participants at the conference location, prior to the educational activity commencement.

Scripps Conference Services & CME 11025 N. Torrey Pines Rd. Suite 200, Maildrop: SCRC200 La Jolla, CA 92037 NONPROFIT ORG. U.S. POSTAGE PAID PERMIT NO. 1981 SAN DIEGO, CA Scripps Conference Services & CME 858-652-5400 www.scripps.org/conferenceservices Follow Us! Target Audience: Gastroenterologists Hepatologists Oncologists Transplant Physicians Nurse Practitioners Physician Assistants Nurse Specialists www.facebook.com/scrippscme www.twitter.com/scrippshealth www.youtube.com/scrippshealth Subscribe to our Scripps Conference Services & CME newsletter at www.scripps.org/cmeemails