End Stage Liver Disease

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End Stage Liver Disease Training Program and Treatment Update 2014 Target Audience: Gastroenterologists Hepatologists Oncologists Transplant Physicians Nurse Practitioners Physician Assistants Nurse Specialists Estancia La Jolla Hotel Scripps Conference Services & CME 858-652-5400 www.scripps.org/conferenceservices

Course Information Course Overview The number of patients with ESLD in the US is expected to continue to grow through 2020, largely due to the burden of chronic viral hepatitis and fatty liver disease which already exists in our population. As they age, a larger number of patients will develop decompensation events such as bleeding from esophageal varices, hepatic encephalopathy, hepatocellular carcinoma, ascites, hyponatremia and renal failure. The expected increase in number of ESLD patients will create more demand for health care providers who are able to care for the growing population, both in and out of the hospital. As such, this cutting edge, three quarter day course will teach diagnosis and management of common complications seen in patients with ESLD. After attending this educational program, the attendee will be able to recognize the treatable complications quickly and use the latest therapies in a reasonable fashion. Learning will concentrate on the areas which are evidence-based or literature-based; including portosystemic encephalopathy, ascites, hyponatremia, hepatocellular carcinoma screening and treatment, hepatorenal syndrome and bleeding due to portal hypertension. Conference Highlights Earn Category I CME and self-assessment credits toward Part 2 of the ABS MOC Program. Conference materials posted on web App; also allows for attendee and faculty networking. Updates on the latest clinical guidelines with strong patient-focused educational sessions. Interactive formats including practical case studies, small group discussion, and question and answer opportunities throughout. Receive up to 6.75 AMA PRA Category 1 Credits. Educational Objectives After attending this activity, participants should be able to: Summarize the causes of hepatic encephalopathy. Assess treatment options, including the use of rifaximin and lactulose therapies. Perform the appropriate and routine diagnostic tests required to ensure early diagnosis of HCC. Integrate newer treatment options for HCC including the use of tyrosine kinase inhibitors, drug eluting beads, and Y90 therapy. Identify the multiple causes for renal insufficiency in patients with ESLD including diuretic overuse, GI bleeding, systemic infection, hepatic decompensation, and hepatorenal syndromes type 1 and 2. Determine the risks for hyponatremia in the ESLD patient and the options for management including the use of vasopressin antagonists. Follow the guidelines for diagnosis and management of ascites in patients with ESLD including diuretics, therapeutic paracentesis, and transjugular intrahepatic portasystemic shunt (TIPS). Discuss safe and effective treatment of hepatitis C in the patient with cirrhosis Evaluate real-life cases which exemplify many of the complications of ESLD seen in a liver transplant center. Target Audience Gastroenterologists Hepatologists Oncologists Transplant Physicians Nurse Practitioners Physician Assistants Nurse Specialists

Conference Faculty Course Director Catherine Frenette, MD Medical Director, Liver Transplantation Medical Director, Hepatocellular Carcinoma Program Scripps Clinic, Center for Organ and Cell Transplantation La Jolla, California Faculty Sammy Saab, MD, MPH, AGAF Professor of Medicine and Surgery Head, Outcomes Research in Hepatology UCLA Ronald Reagan UCLA Medical Center Los Angeles, California Alexander Kuo, MD Associate Clinical Professor of Medicine Director of Hepatology Medical Director, Liver Transplantation UC San Diego Health System Faculty Disclosure In accordance with the ACCME Standards for Commercial Support, course directors, planning committees, faculty and all others in control of the educational content of the CME activity must disclose all relevant financial relationships with any commercial interest that they or their spouse/partner may have had within the past 12 months. If an individual refuses to disclose relevant financial relationships, they will be disqualified from being a part of the planning and implementation of this CME activity. Employees of a commercial interest with business lines or products relating to the content of the CME activity will not participate in the planning or any accredited portion of the conference. Disclosure will be made to all participants at the conference location, prior to the educational activity commencement.

Course Agenda 7:30 a.m. Registration, Breakfast & View Exhibits Key Concepts in Cirrhosis Management of Underlying Diseases 8 a.m. Natural History of Compensated Cirrhosis 8:30 a.m. Treatment Strategies in Autoimmune Liver Diseases with Cirrhosis 9 a.m. Treating Hepatitis C Before or After Liver Transplantation 9:40 a.m. Break & View Exhibits New Concepts in the Treatment of Cirrhosis Complications 10 a.m. Hepatic Encephalopathy 10:30 a.m. Ascites, Hyponatremia, and Renal Failure 11 a.m. Cardiopulmonary Complications: Hepatopulmonary Syndrome and Portopulmonary Hypertension 11:30 a.m Hepatocellular Carcinoma: Making the Diagnosis and Choosing the Best Treatment 12:30 p.m. Lunch and View Exhibits Update in Liver Transplantation 1 p.m. Liver Transplantation: How do I get my Patient a liver? 1:30 p.m. Immunosuppression: What s new and how we do it 2:15 p.m. Long Term Care of the Liver Transplant Patient 3 p.m. Questions and Panel Discussion 3:30 p.m. Adjournment

Accreditation, Disclosure & About Scripps Accreditation Physicians (MD/DO) This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Scripps Health and SC Liver Research Consortium. Scripps Health is accredited by the ACCME to provide continuing medical education for physicians. Scripps Health designates this live activity for a maximum of 6.75 AMA PRA Category 1 Credit(s). Physicians should only claim credit commensurate with the extent of their participation in the activity. Surgical Credits This activity provides Category I CME and selfassessment credits toward Part 2 of the ABS MOC Program. Registered Nurses For the purpose of recertification, the American Nurses Credentialing Center accepts AMA PRA Category 1 Credits issued by organizations accredited by the ACCME. For the purpose of relicensure, the California Board of Registered Nursing accepts AMA PRA Category 1 Credits. Most states Board of Registered Nursing accept AMA PRA Category 1 Credit(s) as meeting continuing education requirements for license renewal. Nurses should check with their state board regarding use of CME credit. Physician Assistants The American Academy of Physician Assistants accepts Category 1 credit from AMA Category 1 CME organizations accredited by the ACCME. Exhibit Opportunities For information on exhibit and support opportunities during this and many other Scripps educational conferences, please contact: Scripps Conference Services & CME 858-652-5400 med.edu@scrippshealth.org www.scripps.org/conferenceservices Disclosure Commercial Support This course is supported, in part, by educational grants from industry, in accordance with ACCME accreditation Standards for Commercial Support. At the time of printing, a complete listing of commercial supporters was not available. Appropriate acknowledgement will be given to all supporters at the time of the educational activity. Cultural and Linguistic Competency This activity is in compliance with California Assembly Bill 1195 which requires that all CME activities comprising a patient care element include curriculum addressing the topic of cultural and linguistic competency. The intent of this bill is to ensure that health care professionals are able to meet the cultural and linguistic concerns of a diverse patient population through effective and appropriate professional development. Cultural and linguistic competency was incorporated into the planning of this activity. About Scripps SC Liver Research Consortium (SCLRC) is an organization of physicians specializing in hepatology and gastroenterology clinical research. SCLRC s mission is to team research sponsors and SCLRC s 81 research sites together to provide faster, higherquality research results compared to the current conventional sponsor-site arrangement. This is accomplished by providing streamlined contract and budget negotiations, access to our scientific expertise in study design, efficient site selection, and ongoing site evaluation. For more information visit www.scliver.com Scripps Health, a nonprofit health care system based in, includes more than 2,600 affiliated physicians and over 13,000 employees at five acute-care hospital campuses, home health care services and a network of clinics, physician offices and outpatient centers. Scripps is committed to contributing to the future of medicine through its clinical research trials, graduate medical education and continuing medical education programs. More information can be found at www.scripps.org. Follow Us! www.facebook.com/scrippscme www.twitter.com/scrippshealth www.youtube.com/scrippshealth Subscribe to our Scripps Conference Services & CME newsletter at www.scripps.org/cmeemails

Hotel & Location Information Estancia La Jolla Hotel & Spa 9700 N. Torrey Pines Road La Jolla, CA 92037 Hotel Direct 858-550-1000 Reservations 877-437-8262 Rates and Reservations Please book your own sleeping room and request the Scripps Health Corporate Rate of $199/night. This rate does not include the nightly resort fee of $17. Daily and overnight valet parking is $10. Download the Scripps CME app for your smart phone or tablet! All conference information including a detailed agenda, faculty listing, faculty disclosures, industry support, attendee list, and course materials can be found on the free Scripps CME conference app for iphone, ipad, Android, and BlackBerry. To download the app on your smart phone or other device visit the appropriate app store and search ScrippsCME (must be one word) or scan the appropriate QR code below. The app is free of charge and will be continuously updated during and after the course. iphone Android Blackberry Storm and Torch To access the site using your cell phone or computer s web browser: http://www.grupio.com/scrippscme

End Stage Liver Disease 2014 Conference Fees Included: Course tuition, access to conference materials (via mobile app and conference website) internet in meeting space, breakfast, break and lunch. Not Included: Travel costs, lodging, parking, and dinner. Registration Fees F IRST NAME, MI, LAST NAME AFFILIATION/HOSPITAL/COMPANY STREET ADDRESS CITY/STATE/PROVINCE/ZIP CODE/COUNTRY PHONE FAX DEGREE (MD, DO, PHD, RN, ETC.) SPECIALTY EMAIL (THIS IS REQUIRED AND WILL BE YOUR USER NAME WHEN ACCESSING YOUR ONLINE ACCOUNT.) Office Use Only: Date Received Amount Check No. / Approval CD Confirmation Sent Initials PAYMENT METHOD Please make Checks payable to Scripps. Visa MasterCard Amex Discover If paying by credit card, please complete the information below. CREDIT CARD NUMBER EXPIRATION DATE SECURITY CODE NAME ON CARD BILLING ADDRESS IF DIFFERENT FROM ABOVE AUTHORIZED SIGNATURE Thru Aug 18 On-site after Aug 18 Fee $75 $100 Please print clearly. Should we have any conference communications or updates please provide your direct contact information. Please indicate any special needs (including dietary restrictions). Special requests will be considered and accommodated in full compliance with the Americans with Disabilities Act (ADA). Estancia La Jolla Hotel How to Register Online: www.scripps.org/conferenceservices Fax: 858-652-5565 Mail: Scripps Conference Services & CME End Stage Liver Disease 11025 North Torrey Pines Road Suite 200, Maildrop: SCRC200 La Jolla, California 92037 Attendance Policies Registration Confirmation A confirmation letter will be e-mailed or mailed to you upon receipt of the conference registration form and payment. If you have not received it within two weeks, please contact the Scripps Conference Services & CME office. Attendee Cancellation, Substitution, Refund The course tuition is refundable, minus a $20 processing fee, if your cancellation is received in writing no later than August 18. Attendee substitutions are allowed, but notification must be made in writing no later than one week prior to the course. After this date, under no circumstances will refunds, credits, or substitutions be granted. No refunds or credits will be given to no shows. Guest Attendance Policy All conference activities (including educational sessions, meal functions, exhibit hall, etc.) are exclusively reserved for conference attendees. Non-registered guests (including children, family members, colleagues, etc.) are not allowed in the conference areas. Badges provided at registration are required for entrance into all functions and will be strictly enforced. Scripps Conference Modification or Cancellation Scripps reserves the right to modify the course s schedule or program as necessary. Scripps also reserves the right to cancel this conference, in which case a full refund of the registration fee will be provided. We are unable to refund any travel costs (flight, hotel, etc.) in the case of Scripps cancellation. Recording and Photography Clause Scripps reserves exclusive rights to record (audio and video) and/or photograph all conference proceedings for use in marketing materials, presentations and course content sales.

Scripps Conference Services & CME 11025 N. Torrey Pines Road Suite 200, Maildrop: SCRC 200 La Jolla, California 92037 End Stage Liver Disease Training Program and Treatment Update 2014 Estancia La Jolla Hotel End Stage Liver Disease Training Program and Treatment Update 2014 Estancia La Jolla Hotel Target Audience: Gastroenterologists Hepatologists Oncologists Transplant Physicians Nurse Practitioners Physician Assistants Nurse Specialists Scripps Conference Services & CME 858-652-5400 www.scripps.org/conferenceservices