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National Training Program and Treatment Update 2012 Gastroenterologists Hepatologists Oncologists Transplant Physicians Nurse Practitioners Physician Assistants Nurse Specialists San Diego, California Los Angeles, California New York, New York July 14, 2012 July 21, 2012 September 29, 2012

Program 7:30 am Registration, Continental Breakfast & View Exhibits 8 am Complications of ESLD: Hepatic Encephalopathy 8:30 am Complications of ESLD: Hyponatremia and Hepatorenal Syndrome 9 am New Treatment Options for Hepatocellular Carcinoma 9:30 am Complications of ESLD: Transjugular Intrahepatic Portosystemic Shunt (TIPS) for Variceal Bleeding 10 am Break & View Exhibits 10:15 am Case Presentations & Discussion on Treatment Guidelines Managing HCC in Different Settings Drugs for Hyponatremia Management of ESLD complications using Molecular Adsorbents Recirculating System (MARS) 12:30 pm Adjournment Educational Objectives After attending this activity, participants should be able to: Summarize the causes of hepatic encephalopathy. Assess treatment options, including the use of non-absorbable antibiotics and lactulose therapies. Perform the appropriate and routine diagnostic tests required to ensure early diagnosis of HCC. Integrate newer treatment options for HCC including the use of tyrosine kinase inhibitors. Identify the multiple causes for renal insufficiency in patients with ESLD including diuretic overuse, GI bleeding, systemic infection, hepatic decompensation, and hepatorenal syndromes type 1 and 2. Determine the risks for hyponatremia in the ESLD patient and the options for management including the use of vasopressin antagonists. Follow the guidelines for diagnosis and management of ascites in patients with ESLD including diuretics, therapeutic paracentesis, and transjugular intrahepatic portasystemic shunt (TIPS). Discuss the indications for MARS in the ESLD patient and when liver/kidney transplantation is considered an appropriate option for management. Evaluate real-life cases which exemplify many of the complications of ESLD seen in a liver transplant center. About Scripps SC Liver Research Consortium (SCLRC) is an organization of physicians specializing in hepatology and gastroenterology clinical research. SCLRC's mission is to team research sponsors and SCLRC's 71 research sites together to provide faster, higherquality research results compared to the current "conventional" sponsor-site arrangement. This is accomplished by providing streamlined contract and budget negotiations, access to our scientific expertise in study design, efficient site selection, and ongoing site evaluation. For more information visit www.scliver.com Scripps Conference Services & CME, which offers nationally recognized annual conferences in various specialty areas, is committed to improving the quality of health care and advancing the practice of medicine by providing exceptional educational courses for physicians and other health care professionals. More information and conference brochure downloads are available at www.scripps.org/conferenceservices.

Faculty & Location Information July 14, 2012 San Diego, California Hyatt Regency La Jolla 3777 La Jolla Village Drive San Diego, CA 92122 858-552-1234 Donald Hillebrand, MD Scripps Clinic Tarek Hassanein, MD Southern California Liver Centers Andrea Scherschel, NP Scripps Clinic July 21, 2012 Los Angeles, California Loews Hollywood Hotel 1755 North Highland Avenue Hollywood, California 90028 323-856-1200 Sammy Saab, MD University of California, Los Angeles Tse-Ling Fong, MD University Southern California Sherona Ngashea Bau, ACNP, MSN University of California, Los Angeles September 29, 2012 New York, New York New York Marriott Marquis 1535 Broadway New York, New York 10036 212-398-1900 Robert S. Brown, Jr., MD, MPH Columbia University Henry Bodenheimer, MD Beth Israel Medical Center Karen Weisz, NP Columbia University Three Easy Ways To Register Online www.scripps.org/conferenceservices Fax 858-652-5565 Mail Scripps Conference Services & CME ESLD Conference 11025 North Torrey Pines Road Suite 200, Maildrop: SCRC200 La Jolla, California 92037 Questions? Contact Scripps Conference Services & CME Phone 858-652-5400 Email med.edu@scrippshealth.org Exhibit Opportunities For information on exhibit and support opportunities during this and many other Scripps educational conferences, please contact: Scripps Conference Services & CME 858-652-5400 med.edu@scrippshealth.org www.scripps.org/conferenceservices Attendance Policies Registration Confirmation A confirmation letter will be e-mailed or mailed to you upon receipt of the conference registration form and payment. If you have not received it within two weeks, please contact the Scripps Conference Services & CME office. Attendee Cancellation, Substitution, Refund The course tuition is refundable, minus a $20 processing fee, if your cancellation is received in writing no later than one week prior to the course. Attendee substitutions are allowed, but notification must be made in writing no later than one week prior to the course. After this date, under no circumstances will refunds, credits, or substitutions be granted. No refunds or credits will be given to no shows. Guest Attendance Policy All conference activities (including educational sessions, meal functions, exhibit hall, etc.) are exclusively reserved for conference attendees. Non-registered guests (including children, family members, colleagues, etc.) are not allowed in the conference areas. Badges provided at registration are required for entrance into all functions and will be strictly enforced. Scripps Conference Modification or Cancellation Scripps reserves the right to modify the course s schedule or program as necessary. Scripps also reserves the right to cancel this conference, in which case a full refund of the registration fee will be provided. We are unable to refund any travel costs (flight, hotel, etc.) in the case of Scripps cancellation. Recording and Photography Clause Scripps reserves exclusive rights to record (audio and video) and/or photograph all conference proceedings for use in marketing materials, presentations and course content sales.

Registration Conference Fees Included: course tuition, course materials, and breakfast. Not Included: travel costs, lodging and parking. Pre-Registration ends Tuesday prior to program date Onsite Registration begins Wednesday prior to program date $55 $70 Group Rate* $45 $60 *Register three (3) or more from your office and each of you will receive $10 off your registration. National Training Program and Treatment Update 2012 Please check one: San Diego, CA July 14, 2012 Los Angeles, CA July 21, 2012 New York, NY September 29, 2012 By completing this registration form and returning it to Scripps you are acknowledging compliance with all attendance policies. PLEASE PRINT CLEARLY. SHOULD WE HAVE ANY CONFERENCE COMMUNICATIONS, PLEASE PROVIDE YOUR DIRECT CONTACT INFORMATION. NAME (FIRST, MI, LAST) DEGREE (MD, DO, PHD, RN, ETC) BADGE NAME (IF DIFFERENT FROM ABOVE) AFFILIATION/HOSPITAL/COMPANY SPECIALTY DIRECT MAILING ADDRESS CITY STATE ZIP DIRECT PHONE FAX E-MAIL ASSISTANT NAME ASSISTANT DIRECT TELEPHONE ASSISTANT E-MAIL Please indicate any special needs (including dietary restrictions). Special requests will be considered and accommodated in full compliance with the Americans with Disabilities Act (ADA). Office use only: Date rec d Check no/approval CD Amount Confirmation Sent Initials PAYMENT METHOD Check Please make checks payable to Scripps (in US dollars only). Visa MasterCard Amex Discover If paying by credit card, please complete information below: CREDIT CARD NUMBER EXPIRATION DATE 3-DIGIT SECURITY CODE NAME ON CARD SIGNATURE BILLING ADDRESS (IF DIFFERENT FROM ABOVE)

Course Introduction Course Overview The number of patients with ESLD in the US is expected to continue to grow through 2020, largely due to the burden of chronic viral hepatitis which already exists in our population. As they age, a larger number of patients will develop decompensation events such as bleeding from esophageal varices, hepatic encephalopathy, hepatocellular carcinoma, hyponatremia and renal failure. The expected increase in number of ESLD patients will create more demand for health care providers who are able to care for the growing population, both in and out of the hospital. As such, this cutting edge, half-day course will teach diagnosis and management of common complications seen in patients with ESLD. After attending this educational program, the attendee will be able to recognize the treatable complications quickly and use the latest therapies in a reasonable fashion. Learning will concentrate on the areas which are evidence-based or literature-based; including portosystemic encephalopathy, hyponatremia, hepatocellular carcinoma, hepatorenal syndrome and bleeding due to portal hypertension. Conference Highlights Updates on the latest clinical guidelines with strong patient-focused educational sessions. Local experts providing an interdisciplinary team approach to treatment with physician and midlevel provider faculty. Small classroom learning environment Interactive formats including practical case studies, small group discussion, and question and answer opportunities throughout. Receive up to 4.25 AMA PRA Category 1 Credits. Convenient local venues and affordable registration fee. Accreditation Physicians (MD/DO) This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Scripps Health and Scripps Clinic Liver Research Consortium. Scripps Health is accredited by the ACCME to provide continuing medical education for physicians. Scripps Health designates this live activity for a maximum of 4.25 AMA PRA Category 1 Credit(s). Physicians should only claim credit commensurate with the extent of their participation in the activity. Documentation of awarded credit is provided for registered attendees in exchange for completed activity evaluation. Certificates of attendance are available, upon request, at the end of the course. Registered Nurses The California State Board of Registered Nursing (BRN) accepts AMA PRA Category 1 Credit(s) as meeting continuing education requirements for license renewal. Most state Boards of Registered Nursing accept AMA PRA Category 1 Credit(s) as meeting continuing education requirements for license renewal. Nurses should check with their state board regarding use of CME credit. Physician Assistants The American Academy of Physician Assistants accepts Category 1 credit from AMA Category 1 CME organizations accredited by the ACCME. Disclosure Commercial Support This course is supported, in part, by educational grants from industry, in accordance with ACCME accreditation Standards for Commercial Support. At the time of printing, a complete listing of commercial supporters was not available. Appropriate acknowledgement will be given to all supporters at the time of the educational activity. Cultural and Linguistic Competency This activity is in compliance with California Assembly Bill 1195 which requires that all CME activities comprising a patient care element include curriculum addressing the topic of cultural and linguistic competency. The intent of this bill is to ensure that health care professionals are able to meet the cultural and linguistic concerns of a diverse patient population through effective and appropriate professional development. Cultural and linguistic competency was incorporated into the planning of this activity. Faculty Disclosure In accordance with the ACCME Standards for Commercial Support, course directors, planning committees, faculty and all others in control of the educational content of the CME activity must disclose all relevant financial relationships with any commercial interest that they or their spouse/partner may have had within the past 12 months. If an individual refuses to disclose relevant financial relationships, they will be disqualified from being a part of the planning and implementation of this CME activity. Employees of a commercial interest with business lines or products relating to the content of the CME activity will not participate in the planning or any accredited portion of the conference. Disclosure will be made to all participants at the conference location, prior to the educational activity commencement.

Scripps Conference Services & CME 11025 N. Torrey Pines Rd. Suite 200, Maildrop: SCRC200 La Jolla, CA 92037 Nonprofit Org. U.S. Postage P A I D Permit No. 1981 San Diego, CA 92138 National Training Program and Treatment 2012 June September 2012 3 cities across the US Scripps Conference Services & CME 858-652-5400 www.scripps.org/conferenceservices San Diego, CA July 14 Los Angeles, CA July 21 National Training Program and Treatment Update 2012 New York, NY September 29 Gastroenterologists Hepatologists Oncologists Transplant Physicians Target Audience: Nurse Practitioners Physician Assistants Nurse Specialists