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Renal-Electrolyte & Hypertension Division at Penn Medicine Presents BLOOD PRESSURE 2018: BP Guidelines: Same Game with Different Rules? and Secondary Hypertension: An Update with Cases A C M E / C N E - A C C R E D I T E D C O N F E R E N C E Friday, October 12, 2018 Smilow Center for Translational Research Perelman School of Medicine at the University of Pennsylvania 3400 Civic Center Blvd 19104 www.penncmeonline.com Delaware Valley Chapter

Program Overview & Target Audience Hypertension is a common public health problem and affects approximately 30-40% of all adults in the US. The guidelines for BP goals have been evolving and the most recent guidelines from the AHA/ACC target a lower BP goal then previously recommended. There are many controversies about these new guidelines and what the appropriate BP goal is in the different populations including patients with low cardiovascular risk, patients with chronic kidney disease, diabetes and the elderly. There are also many nuances in the treatment of secondary hypertension and the program will discuss approaches to the diagnosis and management of patients with Pheochromocytoma, primary aldosteronism and renovascular disease. We will also discuss other more unique areas of hypertension including the treatment of neurogenic hypotension and the use of novel therapies for the treatment of hypertension specifically renal denervation. This activity is designed for nephrologists, cardiologists, physician assistants, advanced practice nurses, healthcare professionals, residents and fellows. Learning Objectives: Upon successful completion of this activity, participants should be able to: Examine the new BP guidelines that physicians and health care providers should adhere to Explain the rationale for the new BP guidelines Define BP goals in specific populations including DM and CKD Describe the diagnosis and management of pheochromocytoma Discuss the diagnosis and management of primary aldosteronism Discuss the diagnosis and management of renovascular hypertension Construct novel therapies of treatment of hypertension specifically the role of renal denervation Hosting Department This conference is hosted by the Department of Medicine, Renal-Electrolyte & Hypertension Division at Penn Medicine. Disclosures Penn Medicine, Office of Continuing Medical and Interprofessional Education, adheres to the ACCME Standards for Commercial Support. Faculty and planners disclosure information will be made available in the conference materials and syllabi. Faculty members are also expected to disclose to participants any discussions of off-label and/or investigational uses of pharmaceutical products within their presentations.

Accreditation In support of improving patient care, Penn Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. Designation of Credit Physicians: Penn Medicine designates this live activity for a maximum of 4.5 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses: This activity is approved for 4.5 contact hours. Physician Assistants: AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit from organizations accredited by ACCME or a recognized state medical society. PAs may receive a maximum of 4.5 Category 1 credits for completing this activity. Certificates and Transcripts: After the conference has concluded, all participants will receive a follow-up email with instructions and a link. Once participants submit the request for credit, the earned credits will be available for viewing on a transcript and certificates will be available for printing at www.penncmeonline.com. Please note that the individual certificate will not be mailed. Registration Fees The registration fee for Blood Pressure 2018: Raising the Bar on Measurement and Management is $50 for all attendees. All University of Pennsylvania, Drexel/Hahnemann University faculty, staff, fellows, residents and students may attend at no charge. Jefferson University residents, fellows and students may also register at no charge. The registration fee includes admission to the conference, a course booklet, and link to view the presentations online, and a credit certificate. The fee also includes continental breakfast and mid-morning break. You may register online for the course by visiting www.penncmeonline.com then clicking on CME/CNE activities/live events and scrolling down to this conference on the list. You may also mail your completed registration form. We cannot accept faxed registration forms. Please see the top of the registration form for mailing information. All registrations will be confirmed in writing if your registration form and fee are received by September 28, 2018. Services for the Disabled If special arrangements are required for an individual with a disability to attend this meeting, please contact the Office of Continuing Medical Education no later than September 28, 2018 at 215-898-8005.

Cancellation and Refund Policy In order to process refunds for course withdrawals, cancellations must be received in writing by September 28, 2018 (subject to a service charge of $15.00). No refunds will be issued thereafter. The University reserves the right to cancel or postpone any course due to unforeseen circumstances. In the event of cancellation or postponement, the University will refund registration fees, but is not responsible for related costs or expenses to participants, including cancellation fees assessed by hotels, airlines, and travel agencies. Meeting Location Blood Pressure 2018: BP Guidelines: Same Game with Different Rules? and Secondary Hypertension: An Update with Cases will be held Friday, October 12, 2018 at the Smilow Center for Translational Research, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania, 19104. Directions & Parking: The Arthur H. Rubenstein Auditorium is located on the 1st Floor level of the Smilow Center for Translational Research. Smilow CTR is connected to the Perelman Center for Advanced Medicine and is located at 3400 Civic Center Blvd,. We strongly recommend you use GPS or an online driving directions site (such as mapquest.com, drivingdirections.com or googlemaps.com) for exact directions to and from your starting point or if you prefer to take public transportation to and from campus, please visit http://www.upenn.edu/services/transportation for options. The 3600 Civic Center Blvd Parking Garage is open for public parking. This garage is accessible from Civic Center Blvd and is located at Civic Center Blvd and West Service Drive (next to the Colket Research Center). The Smilow TRC is about a 5 minute walk from the parking garage. Parking is $20 per day and parking fees are not paid for or reimbursed by the conference. Nondiscrimination Statement The University of Pennsylvania values diversity and seeks talented students, faculty, and staff from diverse backgrounds. The University of Pennsylvania does not discriminate on the basis of race, sex, sexual orientation, gender identity, religion, color, national or ethnic origin, age, disability, or status as a Vietnam Era Veteran or disabled veteran in the administration of educational policies, programs or activities; admissions policies; scholarship and loan awards; athletic, or other University administered programs or employment. Questions or complaints regarding this policy should be directed to Executive Director, Office of Affirmative Action and Equal Opportunity Programs, 3600 Chestnut Street, Sansom Place East Suite 228, Philadelphia PA 19104-6106 or 215-898-6993 (Voice) or 215-898-7803 (TDD). www.upenn.edu/affirm-action

COURSE DIRECTOR Debbie Cohen, MD Professor of Medicine Director, Hypertension Co-director, Neuroendocrine Tumor Program Perelman School of Medicine at the University of Pennsylvania SPEAKERS Italo Biaggioni, MD Professor of Medicine and Pharmacology David Robertson Professor in Autonomic Disorders Vanderbilt University Nashville, TN Mehrdad Hamrahian, MD Associate Professor of Medicine Division of Nephrology Director of Jefferson Hypertension Center Thomas Jefferson University Christopher B. McFadden, MD Associate Professor of Medicine Cooper Medical Center Camden, NJ Robin Neubauer, BSN Clinical Research Nurse Practitioner Hospital of the University of Pennsylvania Michael Rudnick, MD Associate Professor of Medicine Perelman School of Medicine at the University of Pennsylvania Chief, Section of Nephrology and Hypertension Penn Presbyterian Medical Center Penn Medicine Allan B. Schwartz, MD Professor of Medicine Division of Nephrology & Hypertension Drexel University College of Medicine Raymond Townsend, MD Professor of Medicine Renal Electrolyte and Hypertension Division Perelman School of Medicine at the University of Pennsylvania

AGENDA Friday, October 12, 2018 7:30 8:00 AM Registration and Continental Breakfast 8:00 8:10 AM Introduction and Welcome Debbie Cohen, MD 8:10 8:40 AM AHA/ACC Guidelines Expounded Raymond Townsend, MD 8:40 9:00 AM BP Goals in Diabetes and Hypertension Allan Schwartz, MD 9:00 9:20 AM BP Goals in CKD Mehrdad Hamrahian, MD 9:20 9:40 AM Aldosterone Excess or Primary Aldosteronism Debbie Cohen, MD 9:40 10:00 AM Blood Pressure Extremes in Parkinson Disease and Related Autonomic Disorders Italo Biaggioni, MD 10:00 10:20 AM Break 10:20 10:50 AM Pheochromcytoma: A Genetic Disease? Debbie Cohen, MD 10:50 11:20 AM Renovascular Disease (FMD vs ARAS) Michael Rudnick, MD 11:20 11:50 AM Update on Renal Denervation Raymond Townsend, MD 11:50 AM 12:20 PM Debate: How Low Should Your BP Go: Does it Matter? Yes it Matters: Raymond Townsend, MD No it Doesn t Matter: Christopher McFadden, MD 12:20 12:40 PM Panel Discussion With All Participants Moderated by Raymond Townsend, MD and Robin Neubauer, BSN 12:45 PM Adjourn 1:00 2:00 PM Board Meeting with Lunch* *Sign-up required

BLOOD PRESSURE 2018: BP Guidelines: Same Game with Different Rules? and Secondary Hypertension: An Update with Cases Friday, October 12, 2018 If you are registering using your credit card, please register online at: www.penncmeonline.com and click on CME/CNE Activities/Live Events. Questions? Contact us at: Phone: 215-898-6400 or 215-898-8005 penncme@mail.med.upenn.edu Please note we are unable to accept faxed registration forms. Please print or type Name (First) (Last) Academic Degree Medical Specialty Affiliation (Hospital, Office, or Company) Address ( Affiliation or Home) City State Zip Phone Fax E-mail Registration Fee (pre-payment is required to be officially registered) $50.00 for Practicing Physicians and Industry Representatives Nurses, Healthcare Professionals, Residents and Fellows Free for University of Pennsylvania, Drexel/Hahnemann University and Jefferson University Fellows, Residents and Students Free for University of Pennsylvania, Drexel/Hahnemann University Faculty and Staff I will Attend the Board Meeting with Lunch Payment Method If you are paying by credit card, please register online at www.penncmeonline.com and click on CME/CNE Activities/Live Events. If you are paying by check, you may mail your completed registration form and check made payable to The Trustees of the University of Pennsylvania/CME to: Conference Coordinator, Penn Medicine, Office of Continuing Medical and Interprofessional Education, 150 Anatomy/Chemistry Building 3620 Hamilton Walk, 19104-6061 Do not include any credit card information on the registration form or email any credit card information Please Note: Walk-in registrants must bring payment to the program. Seating may be limited for walk-in registrants..

150 Anatomy/Chemistry Building 3620 Hamilton Walk 19104-6061 BLOOD PRESSURE 2018: BP Guidelines: Same Game with Different Rules? and Secondary Hypertension: An Update with Cases A CME/CNE-ACCREDITED CONFERENCE Friday, October 12, 2018 Smilow Center for Translational Research Perelman School of Medicine at the University of Pennsylvania 3400 Civic Center Blvd. 19104 Delaware Valley Chapter Non-Profit Org. U.S. Postage P A I D Permit No. 2563 Phila., PA 19104