Virus Structure and Assembly July 22-27, 2018 Steamboat Springs, CO Organizers: Colin Parrish, Ph.D. Cornell University Ithaca, NY Karen Maxwell, Ph.D. University of Toronto Toronto, Canada Vice Organizers: Susan Hafenstein, Ph.D. Penn State College of Medicine Hershey, PA Terje Dokland, Ph.D. University of Alabama at Birmingham BIrmingham, AL
Conference Program Sunday, July 22, 2018 4:00 pm - 9:00 pm Conference Registration 6:00 pm - 7:00 pm Welcome Reception 7:00 pm - 8:00 pm DINNER 8:00 pm - 9:30 pm Keynote Session Page 8:00 pm 8:15pm Welcome Karen Maxwell 8:15 pm - 8:50 pm Rebecca Dutch, University of Kentucky S-1 To assemble or not to assemble: spread of respiratory viruses 8:55 pm - 9:30 pm Ryland Young, Texas A&M S-2 Phage lysins: escaping the cell Monday, July 23, 2018 Morning Session 7:30 am - 8:45 am BREAKFAST 7:30 am - 1:00 pm Conference Registration 9:00 am - 12:00 pm Session 1: Virus Architecture - how the pieces fit 9:00 am 9:15 am Introduction to the FASEB Meeting Session chair Paulo Tavares, CNRS Alan Davidson, University of Toronto, Toronto, CA Phage head-tail joining Julie Thomas, Rochester Institute of Technology Studies of the assembly of the giant phage phikz 2
Brian Bothner, Montana State Bob Garcea, University of Colorado David Bhella, University of Glasgow Dynamic properties of viral particles and proteins Polyomavirus replication and assembly factories in cells Herpesvirus capsid and portal structure Monday, July 23, 2018 Afternoon 12:30 pm - 1:30 pm LUNCH and Meet the Experts Table 1: Two speakers Table 2: Two speakers 1:45 pm - 4:00 pm Special Session: Graduate Student Talks Kristin Parent, Michigan State University 4:00 pm - 6:00 pm Poster Session I 4:00 pm - 6:00 pm Conference Registration 6:00 pm - 7:15 pm DINNER Monday, July 23, 2018 Evening Session 7:30 pm - 9:45 pm Session 2: Viral Interactions with Host Components Session chair Tuli Mukhopadadhyay, Indiana University Hyeryun Choe, The Scripps Research Institute interacting with lipids (PC) Viral receptor interactions, and TIM proteins Petr Leiman, University of Texas Medical Branch Structure and function of the branched receptorbinding complex of bacteriophage CBA120 3
Craig Cameron, Penn State Distinct organelles for genome replication and virus assembly during poliovirus replication Tuli Mukhopadhyay, Indiana University Modulating Alphavirus assembly and spread Tuesday, July 24, 2018 Morning Session 7:30 am - 9:00 am BREAKFAST 7:30 am - 1:00 pm Conference Registration 9:00 am - 12:15 pm Session 3: Viral Protein Dynamics Felix Rey, Pasteur Institute Eric May, University of Connecticut Norovirus structure and conformational/phase transitions and mechanical and thermodynamic properties Bentley Fane, University of Arizona Felix Rey, Pasteur Institute Welkin Pope, University of Pittsburgh phix174 properties and assembly, and dynamics Viral glycoprotein structure, functions and dynamics Phage structure and assembly Tuesday, July 24, 2018 Afternoon 12:30 pm - 1:30 pm LUNCH and Meet the Experts Table 1: Two speakers Table 2: Two speakers 12:30 pm - 1:30 pm LUNCH and Virology Ed Round Table Rebecca Dutch, University of Kentucky Cara Pager, University at Albany, SUNY 4
4:00 pm - 6:00 pm Poster session I continued 4:00 pm - 6:00 pm Conference Registration 6:00 pm - 7:15 pm DINNER Tuesday, July 24, 2018 Evening Session 7:30 pm - 9:45 pm Session 4: Viral Interactions with Host Defenses: innate responses, antibodies and CRISPR Cara Pager Brian Kelch, UMassMed CryoEM structure of a thermophilic phage capsid Blake Weidenheft, Montana State University Evolutionary outcomes of CRISPR-anti-CRISPR conflict James Crowe, Vanderbuilt University Cara Pager, University at Albany, SUNY lead the way Antibody expression and mechanisms of binding From the Methylome to the Epitranscriptome: RNA viruses Wednesday, July 25, 2018 Morning Session 7:30 am - 9:00 am BREAKFAST 7:30 am - 1:00 pm Conference Registration 9:00 am - 12:15 pm Session 5: Viruses as Tools Nichole Steinmetz, Case Western Reserve Lindsay Black, University of Maryland Viral nanoparticle-encapsidated enzyme and restructured DNA for cell delivery and gene expression 5
Nichole Steinmetz, Case Western Reserve NanoEngineering gone viral: plant virus-based contrast agents and therapeutics Alan Davidson Phoebe Stewart Rebecca DuBois Engineered tailocins CryoEM and cryoet studies of viral nanoparticles Structure-guided design of vaccines and therapeutics targeting childhood viruses Wednesday, July 25, 2018 Afternoon 12:30 pm - 1:30 pm LUNCH 1:00 pm - 4:00 pm Optional Group Activity - Strawberry Park Hot Springs 4:00 pm - 6:00 pm Poster session II 4:00 pm - 6:00 pm Conference Registration 6:00 pm - 7:15 pm DINNER Wednesday, July 25, 2018 Evening Session 7:30 pm - 9:45 pm Session 6: Viruses & Nucleic Acids Marc Morais Paula Traktman, University of South Carolina DNA packaging motors Olve Peerson, Colorado State University Structure, Mechanism, and Fidelity Modulation of Positive Strand RNA Virus Polymerase Paula Traktman, University of South Carolina Poxvirus replication and morphogenesis 6
Jose Penades Intra- and inter-generic transfer of pathogenicity island-encoded virulence genes by cos phages Thursday, July 26, 2018 Morning Session 7:30 am - 9:00 am BREAKFAST 7:30 am - 12:00 pm Conference Registration 9:00 am - 12:15 pm Session 7: Viruses & Nucleic Acids: cell infection and structural processes Susan Schroeder, University of Oklahoma Katya Heldwein, Tufts University Structural basis for membrane anchoring and fusion regulation of the Herpes Simplex Virus fusogen gb Andreas Kuhn, Hohenheim University, Stuttgart Assembly of bacteriophage M13 in the membrane of Escherichia coli Blair Szymczyna, Western Michigan University Capsid Protein Identification of the DNA Binding Surface on the SIRV Susan Schroeder, University of Oklahoma Structures of encapsidated satellite tobacco mosaic virus (STMV) RNA, the structures and energetics of prohead RNA (prna) Colin Parrish, Cornell University Host range control of Parvoviruses and capsid interactions with transferrin receptors and antibodies Thursday, July 26, 2018 Afternoon Session 12:30 pm - 1:30 pm LUNCH and Meet the Experts Table 1: Table 2: 7
1:30 pm - 3:15 pm Session 8: Virus-Host Protein Interactions: mechanisms and evolutionary co-selection Jun Liu Chad Petit, University of Alabama High-throughput cryo-electron tomography: Visualizing trans-envelope channel during viral infection Debbie Lindell, Technion University interactions Role of cyanophages in ecological processes - virus-host Chad Petit, University of Alabama at Birmingham Structural Basis for a novel interaction between the NS1 protein derived from the 1918 influenza virus and RIG-I Thursday, July 26, 2018 Evening 3:15 pm - 3:45 pm Business Meeting 4:00 pm - 6:00 pm Poster Session II continued 4:00 pm - 6:00 pm Conference Registration 6:00 pm - 7:30 pm DINNER 8:00 pm - Evening festivities @ The Cabin Bar 8