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Meeting The Joint Commission Standard for Antibiotic Stewardship: A Practical Approach Faculty: Zina Gugkaeva, PharmD, ID Pharmacist, Maury Regional Medical Center Christopher Evans, PharmD BCPS, Pharmacist Healthcare Associated Infections and Antimicrobial Resistance Program, TN Department of Health Brooke Stayer, PharmD BCPS, Antimicrobial Stewardship Coordinator, Holston Valley Medical Center Christopher Edwards, MD, Chief Medical Officer, Maury Regional Medical Center

CE Credit Information regarding continuing education credit

Conflict of Interest Disclosure The authors have no actual or potential conflict(s) of interest/relevant financial relationship(s) with any commercial interests in relation to this CE activity

Objectives 1. Secure leadership commitment for an antimicrobial stewardship team in the institutional setting 2. Develop a multidisciplinary antimicrobial stewardship team, focusing on engaging Infectious Disease physicians and other providers to promote stewardship practices 3. Demonstrate the value of antimicrobial stewardship programs to a leadership committee through the collection, analysis and reporting of antibiotic use data

Antimicrobial Stewardship Programs All hospitals should have an antimicrobial stewardship program (ASP) Hospitals don t all look the same, and neither should stewardship programs There must be flexibility in how programs are implemented Programs need to serve the needs of the patients in the hospital There are certain key elements that have been strongly associated with success

CDC Core Elements 1. Leadership Commitment 2. Accountability 3. Drug Expertise 4. Action 5. Tracking 6. Reporting 7. Education

Core Element Achievement Institutions Achieving 5 or more Core Elements https://healthwebaccess.tn.gov/idashboards/?guestuser=gue st&dashid=688&c=0

Core Element Achievement

2016 Core Element Achievement As of 12 April 2017, 105 ACH (95%) have completed the 2016 Annual Survey Hospitals Achieved 5 of more core elements 2014 58.6% 2015 70% 2016 100%* Hospitals Achieved all 7 core elements 2014 30.6% 2015 45.5% 2016 67%* *Of hospitals reporting as of 4/12/2017

Core Element Achievement Trends % of Institutions Achieving Specific Elements 100 90 80 70 60 50 40 30 20 10 0 TN - 2014 TN - 2015 TN - 2016* US - 2014 *Of hospitals reporting as of 4/12/2017

Acute Care Summary TN Acute Care Hospitals, 2015 HAI CLABSI CAUTI No. of Infections Standardized Infection Ratio (SIR) and 95% CI Distribution of Facility-specific SIRs No. of Facs with 1 Pred. Infection FACS WITH SIG. LOW SIR FACS WITH SIG. HIGH SIR No. of Unit/Type Facs Obs. Pred. SIR Lower Upper Adult/Pediatric ICUs 87 243 262.89 0.92 0.813 1.046 40 5 5 Adult/Pediatric Wards 106 192 239.05 0.80 0.695 0.923 47 7 1 Neonatal ICUs 25 57 62.31 0.91 0.699 1.177 12 0 0 Adult/Pediatric ICUs 87 416 400.75 1.04 0.942 1.141 50 3 5 Adult/Pediatric Wards 106 177 263.65 0.67 0.578 0.776 59 5 1 MRSA Acute Care Hospitals 109 319 258.23 1.24 1.105 1.377 44 0 6 CDI Acute Care Hospitals 109 2,449 2,555.7 0.96 0.921 0.997 85 11 8 Data reported as of January 24, 2017 Green highlighting indicates an SIR significantly LOWER than the 2015 national baseline Red highlighting indicates an SIR significantly HIGHER than the 2015 national baseline 13

CDI Reduction from AS Efforts Lancet ID 2017; 17: 411-21

New TJC Antimicrobial Stewardship Standard Listed as Medication Management Standard MM.09.01.01 Effective January 1, 2017 Affects hospitals, critical access hospitals, and nursing care centers Calls for antimicrobial stewardship program based on current scientific literature

TJC Standard Summary of Elements of Performance: Leadership support Education of patients and clinicians Multidisciplinary team Core Elements outlined by CDC Hospital protocols Collect, analyze, and report data Take action on improvement opportunities New Antimicrobial Stewardship Standard. Joint Commission Perspectives, July 2016, Vol 36(7) https://www.jointcommission.org/assets/1/6/hap- CAH_Antimicrobial_Prepub.pdf

Today s Focus CDC Core Elements Joint Commission Standard 1. Leadership Commitment Medication Management Standard (MM).09.01.01 2. Accountability 3. Drug Expertise 4. Action 5. Tracking 6. Reporting 7. Education Antimicrobial stewardship program based on current scientific literature Elements of Performance: Leadership support Education of patients and clinicians Multidisciplinary team Core Elements outlined by CDC Hospital protocols Collect, analyze, and report data Take action on improvement opportunities New Antimicrobial Stewardship Standard. Joint Commission Perspectives, July 2016, Vol 36(7) https://www.jointcommission.org/assets/1/6/hap- CAH_Antimicrobial_Prepub.pdf

Leadership 1. Leaders establish antimicrobial stewardship as an organizational priority Examples of leadership commitment to an ASP include: Accountability documents Budget plans Infection prevention plans Performance improvement plans Strategic plans Dedicated salary support/specific time commitment for ASP leaders Using the electronic health record to collect AS data

Example Document

Leadership Open floor to discussion (5-10 min)

Accountability Who can be ASP leader? Physician Pharmacist Who provides drug expertise? Infectious Disease Pharmacist Infectious Disease Physician Pharmacist with training/experience in Antibiotic Stewardship

Multidisciplinary Team 4. The hospital has an antimicrobial stewardship multidisciplinary team that includes the following members, when available in the setting: Infectious disease physician Infection preventionist(s) Pharmacist(s) Practitioner Note 1: Part-time or consultant staff are acceptable as members of the antimicrobial stewardship multidisciplinary team Note 2: Telehealth staff are acceptable as members of the antimicrobial stewardship multidisciplinary team

Core Contributors Infection Preventionists Risk assessment & prevention planning skills Collect, analyze, and report antibiotic-related data Laboratory Input into specimen collection and proper use of relevant tests Review information flow of results to clinicians Create and interpret a facility antibiotic resistance report Nursing Review medications as part of their routine duties Could contribute through prompting discussions of antibiotic treatment, indication, and duration Clarify antibiotic allergies Information Technology (IT) Create ways to integrate guidelines and policies with decision support at point of care Track antibiotic use through medication administration records

Accountability and Multidisciplinary Team Open floor to discussion (5-10 min)

Tracking and Reporting 7. The hospital collects, analyzes, and reports data on its antimicrobial stewardship program. Examples: Utilization of antimicrobials within the facility (dispensing data, Days of Therapy, Defined Daily Doses) Cost of all antimicrobials within the facility Appropriateness of therapy Mean duration of antimicrobials over time (time to de-escalation, duration of therapy by specific infections) Prescribing habits Antimicrobial resistance trends within the facility Cost of dedicated time of ASP Team members Patient outcomes (readmission rates for specific infections, length of stay) Adherence to strategies recommended by ASP team

Stewardship Metrics Ready for Immediate Use and Tracking Clostridium difficile infection incidence Reported in NHSN Lab-ID Events MDRO incidence Days of therapy per admission or per patient days Redundant therapy events Useful but with Questionable Feasibility Readmissions related to ID Adverse drug events/toxicities Days of therapy per days present Total duration per admission or per antimicrobial admission Other process measures Clinical Infectious Diseases 2017;64(3):377 83

Reporting Leadership Clinical staff Individual provider feedback as needed

Tracking and Reporting Open floor to discussion (5-10 min)

Summary Identify your champions Integrate your team with key departments Monitor antimicrobial usage to identify your interventions (i.e. IV to PO conversion protocols, selected antimicrobial agents listed on a dosing card Track your progress Report your results to the leadership and clinical staff

Questions or Comments

For more information on the Tennessee Pharmacists Coalition and/or ACPE CE Contact Jackie Moreland at jmoreland@tha.com

Upcoming Webinars Antibiotic Stewardship: Meeting the Joint Commission Standards (Part Two) Wednesday, May 3rd at 12noon CT/1pm ET Presenters: Brad Crane, Pharm.D., BCPS Kelley Lee, Pharm.D. Ashley Tyler, Pharm.D., BCPS Register at: https://attendee.gotowebinar.com/register/3211098801818537218 *Application for one hour of ACPE CE has been submitted for this webinar