ABOUT THE REPORT. About the 3-Month Report

THE DIGEST OF BIOTECH JOB TRENDS IN MASSACHUSET TS QUARTERLY LIFE SCIENCES JOB MARKET REPORT: Q4 2017

ABOUT THE REPORT About the 3-Month Report MassBioEd produces a 3-Month Report on biopharmaceutical job trends each quarter of the year. The report compares job listings for the most current three-month period with job listings for the same three-month period of the previous year to determine underlying trends in job listings. About the MassBioEd Foundation MassBioEd s mission is to build a sustainable life sciences workforce in the region through educational programs that inspire and propel students, engage and excite teachers, and illuminate the pathway from classroom to careers. About The Digest of Biotech Jobs Trends in Massachusetts The Quarterly Report is a part of MassBioEd s ongoing Digest of Biotech Jobs Trends in Massachusetts, which also includes Briefs, a Medical Device Snapshot, and an annual Job Trends Forecast. The Briefs present basic data and analysis on particular aspects of biopharma industry job trends. The objectives in publishing the Briefs is to provide basic information about job listings trends, skills required of candidates, and prevalence of degree requirements for high trending occupations. The Annual Job Trends Forecast is intended to provide greater insight based on additional study in these areas. Acknowledgements The primary researcher and author of the 3-Month Report is Mark Bruso, Manager of Labor Market Research, under the direction of MassBioEd Foundation Executive Director, Peter Abair. Erica Dickinson, Product Support Manager at Burning Glass, provided able assistance to the MassBioEd research team in effectively using data from Burning Glass Technologies. MassBio, the industry council serving the biopharmaceutical community of the Massachusetts region, provided support for this series and MassBioEd s ongoing job trends initiative. For more MassBioEd job trends analysis, visit MassBioEd.org/Job_Trends. For inquiries, please email Mark Bruso, Manager of Labor Market Research, at Mark.Bruso@MassBio.Org. 2

TABLE OF CONTENTS Employment Overview 4 Monthly 5 Top Occupations 6 Regional Breakdown 7 Top Employers By Region 8 Data Tables 12 Appendix 24

Jan-11 Apr-11 Jul-11 Oct-11 Jan-12 Apr-12 Jul-12 Oct-12 Jan-13 Apr-13 Jul-13 Oct-13 Jan-14 Apr-14 Jul-14 Oct-14 Jan-15 Apr-15 Jul-15 Oct-15 Jan-16 Apr-16 Jul-16 Oct-16 Jan-17 Apr-17 Life Sciences Industry Employment MONTHLY EMPLOYMENT, MA LIFE SCIENCES INDUSTRY, Q1 2011 Q1 2017 71,519 56,730 First Time Crossing: 70,000 jobs May 2017 (19 months) 65,000 jobs Oct. 2015 (21 months) 60,000 jobs Jan. 2014 (70 months) 55,000 jobs March 2008 7% 6% 5% YEAR-OVER-YEAR EMPLOYMENT GROWTH 6.5% 6.4% 5.4% 4% 3% 2% 2.9% 1.7% 1% 0% 0.3% Life Sciences - MA MA - All US - All Linear (US - All) YEARLY GROWTH 2012: +0.8% 2013: +2.0% 2014: +4.8% 2015: +4.0% 2016: +5.1%

2,795 1,980 2,263 2,200 3,016 2,628 2,435 2,199 1,976 *Adjusted Job Totals controls for fluctuations within the entire universe of job listings in MA, i.e. it is the industry total divided by the state total of all sectors in a given month 2,380 1,964 2,298 1,966 2,296 2,337 2,258 2,486 1,997 2,360 1,792 2,250 1,655 1,878 1,655 Life Sciences Openings, Q4 2017 MONTHLY JOB LISTINGS, 2016 & 2017-568 -585-223 2016 2017 5,000 4,500 4,000 3,500 3,000 2,500 TOTAL + ADJUSTED* MONTHLY JOB LISTINGS 5.0% 4.5% 4.0% 3.5% 3.0% 2.5% In both raw totals and adjusted totals* of job openings (at left), the life sciences industry in MA has been decelerating at the about the same rate for the past two years. 2,000 1,500 1,000 500-2.0% 1.5% 1.0% 0.5% 0.0% In Q4, total job listings declined by -21.3%, while adjusted job listings declined by -10.7%, year-over-year.

Life Sciences Openings, Q4 2017 Top Occupations By Q4 2017 From Trend Medical Scientist 453-25% Researcher / Research Associate 187-38% Chemist 163-13% Administrative Manager 156-17% Office / Administrative Assistant 110-2% Chemical / Process Engineer 109-49% Marketing Manager 100 15% Healthcare Administrator 95-23% Biologist 91-38% Business Development / Sales Manager 87-21% Medical Director 79-11% Clinical Research Coordinator / Manager 79-12% Project Manager 73-21% Laboratory Technician 69-17% Quality Control Analyst 69-41% Sales Representative 68-28% Software Developer / Engineer 67-32% Program Manager 65-21% Biological Technician 62-17% Laboratory Technologist 59 5% Natural Science Research Manager 55 5% Compliance Manager 54-17% Human Resources / Labor Relations Specialist 53-4% Biostatistician 52-38% Operations Manager / Supervisor 48-1% for STEM openings in the life sciences industry in Massachusetts declined -26% year-over-year in Q4 2017. At left, many of the top occupations by listings in Q4 were STEM openings, which accounted for 54% of all listings in the quarter. They were measured against their preceding 12-month trend. STEM-related positions that grew much faster in Q4 than their quarterly average from the past year were Clinical Data Managers (+78%), Computer Scientists (+57%), Mechanical Engineers (+20%), Lab Technologists (+5%), Research Managers (+5%), and Biomedical Engineers (+2%). This was against a backdrop of widespread declines in job openings for most openings. At left, occupations with much lower or higher changes than average are highlighted. Red Much Lower Green Much Higher If you are from Industry, join our Skills Advisory Group! MassBioEd depends on input from industry experts in our Skills Advisory Group to interpret workforce data and provide guidance on skills needed for jobs in the industry. If you are from Higher Education, join our Higher Education Steering Council! MassBioEd requires feedback from our educational and training partners so that the reports we produce best reflect the information most vital to the alignment of their curricula and learning outcomes with workforce needs. For more information, please contact Mark Bruso at mark.bruso@massbio.org or 617.674.5131.

STEM Openings By Region, Q4 2017 50% Boston/Cambridge 1,660 1,122 2,782 Metrowest 329 435 764 North 316 270 586 Central 157 86 243 South & Cape 43 174 217 West 43 51 94 STEM Non-STEM Total Openings Year-Over-Year Job Growth, Non-STEM Occupations & STEM Occupations, Q4 2017 +87% Non-STEM Occupations STEM Occupations +23% +5% -34% -44% -11% -27% -10% -22% -20% -41% -19% Central North Boston/Cambridge Metrowest South & Cape West

Top Employers By STEM, Q4 2017 Complete list of employers, and map of regions begins on Page 12 In Boston/ Cambridge, Q4 STEM occupational job listings (60% of region s total) were dominated by a mix of large companies and research universities, and hospitals. TOP EMPLOYERS, 2017, ALL JOBS (by listings) Takeda (1,204) MGH (1,028) Biogen (919) Pfizer (810) Novartis (726) Sanofi Genzyme (572) Dana Farber (440) Partners Healthcare (344) Harvard U. (336) The South & Cape had, by a large margin, the lowest percentage of STEM listings (20%) out of total listings. Q4 had much fewer STEM openings than what has been documented in recent quarters. TOP EMPLOYERS, 2017, ALL JOBS (by listings) Merck (163) Cardinal Health (97) Life Technologies (63) C.C. Healthcare (37) Collegium (28) Upsher Smith Labs (22) Quest Diagnostics (21) Integra (19) Oxford Immunotec (17) 8

Top Employers By STEM, Q4 2017 Complete list of employers, and map of regions begins on Page 12 TOP EMPLOYERS, 2017, ALL JOBS (by listings) Pfizer (562) Merck (455) Life Technologies (173) Abbott Labs (103) Parexel (69) Charles River Labs (56) Lahey Health (42) EMD Serono (31) Cardinal Health (27) During Q4, approximately onehalf of all job listings for STEM-related positions were at four companies in the NE region Pfizer, Abbott Labs, Merck, and Life Technologies. Metrowest continues to be the the least concentrated region for STEM listings in Q4 2017. Shire listed the most openings within the region during that time, followed by AstraZeneca. TOP EMPLOYERS, 2017, ALL JOBS (by listings) Shire (405) Sanofi Genzyme (318) Alkermes (202) Sunovion (187) PerkinElmer (179) Life Technologies (166) Quest Diagnostics (158) Biogen (144) AstraZeneca (130) 9

Top Employers By STEM, Q4 2017 Complete list of employers, and map of regions begins on Page 12 TOP EMPLOYERS, 2017, ALL JOBS (by listings) B-M Squibb (200) Pfizer (181) AbbVie (134) UMass Medical (118) Sanofi Genzyme (105) Lab Corp. (76) Danaher Corp. (57) Charles River Labs (46) UMass Memorial (35) Nearly half of the total STEM listings in Central Mass. During Q4 2017 were at four organizations AbbVie, UMass Medical School, and Pfizer, and Bristol- Myers Squibb. The smallest region by size, Western MA saw their biotechrelated STEM openings occur primarily at local universities or hospitals. TOP EMPLOYERS, 2017, ALL JOBS (by listings) Baystate Health (79) UMass Amherst (55) Cardinal Health (16) Berkshire M.C. (15) Sisters of Prov. (13) Smith College (12) Abbott Labs (6) AstraZeneca (6) Lab Corp. (5) 10

Top Employers By STEM, Q4 2017 Complete list of employers, and map of regions begins on Page 12 At left are the leading companies in Q4 by their statewide job listings for all job types. Unsurprisingly, companies with large operations in Cambridge lead the way Takeda, Biogen, Sanofi Genzyme, and others. For STEM openings, generally the same organizations topped the list. Research hospitals and universities generally had a higher share of STEM openings than biotech companies MGH and Partners lead the way. 11

DATA TABLES Top Regional Employers By STEM, Q4 2017 Central Region AbbVie 25 UMass Medical School 19 Pfizer 10 Bristol-Myers Squibb 8 Danaher Corporation 8 UMass Memorial Healthcare 8 Charles River Company 6 IDEXX Laboratories 5 Sanofi Genzyme 4 Beth Israel Deaconess Medical Center 2 Drs Technologies Incorporated 2 Ipg Photonics Corporation 2 Sciex 2 Tufts University 2 Alexion Pharmaceuticals 1 Alpha Analytical 1 Astrazeneca 1 Baptist Health 1 Foremost Laboratories 1 Heywood Hospital 1 Iphotonics 1 Laboratory Corporation of America 1 Lakepharma, Inc 1 Leica Biosystems 1 Quest Diagnostics 1 South & Cape Region Cape Cod Healthcare 4 Cardinal Health 3 Corbus 3 Integra Life Sciences 3 Beth Israel Deaconess Medical Center 2 Collegium 2 Agfa Gevaert 1 Alpha Analytical 1 Astrazeneca 1 Cape Cod Hospital 1 Integer Holdings 1 Integrated Statistics 1 Life Technologies 1 Merck & Company 1 Organogenesis 1 Oxford 1 Pfizer 1 Qualitest 1 The Marine Biological Laboratory 1 Ul Llc 1 Underwriters Laboratories Incorporated 1 University of Massachusetts 1 UMass Medical School 1 Upsher Smith Laboratories 1 12

DATA TABLES Top Regional Employers By STEM, Q4 2017 Metrowest Region Shire 37 Astrazeneca 22 Cardinal Health 19 Sanofi Genzyme 18 Life Technologies 15 Parexel 11 Sunovion 10 Nova Biomedical 8 PerkinElmer 8 Biogen 7 Icon Clinical Research 7 Instrumentation Laboratory 6 Karyopharm Therapeutics 5 Lincoln Laboratory 5 Mclean Hospital 5 Merck & Company 5 Hologic 4 Amag Pharmaceuticals 3 Massachusetts General Hospital 3 Partners Healthcare 3 T2 Biosystems 3 Tetraphase Pharmaceuticals 3 Alkermes 2 Ascent 2 Astellas Pharma 2 Bentley University 2 Dana Farber Cancer Institute 2 Epharmasolutions 2 Hirelifescience, Llc 2 Lancaster Laboratories 2 Ocular Therapeutix 2 Pulmatrix Incorporated 2 Quest Diagnostics 2 A123 Systems 1 Acorda Therapeutics Incorporated 1 Angiodynamics 1 Anika Therapeutics 1 Ascent Life Sciences 1 Beth Israel Deaconess Medical Center 1 Biotie Therapies 1 Bioverativ 1 Boston Heart Diagnostics 1 Brandeis University 1 Bristol-Myers Squibb 1 Danaher Corporation 1 Doble Engineering Company 1 Dps Engineering 1 Hyde Engineering Consulting 1 Metrowest Region (continued) Kala Pharmaceuticals 1 Massachusetts Institute of Technology 1 Medtronic 1 Mettler Toledo 1 Newton Wellesley Hospital 1 Oak Ridge Institute for Science and Education 1 Pfizer 1 Research Triangle Institute 1 Selecta Biosciences 1 Syndax 1 Talent Retriever Llc 1 The Wirb Copernicus Group 1 Thermo Fisher Scientific 1 United Therapeutics Corporation 1 Wellesley College 1 West Region Baystate Health 11 UMass Amherst 10 Cardinal Health 4 Novartis 2 Smith College 2 Abbott Laboratories 1 Alfasigma USA 1 Avista Pharma 1 Berkshire Medical Center 1 Danaher Corporation 1 Mount Holyoke College 1 Teva Pharmaceuticals 1 13

DATA TABLES Top Regional Employers By STEM, Q4 2017 Boston/Cambridge Region Massachusetts General Hospital 255 Takeda 148 Partners Healthcare 147 Biogen 97 Pfizer 79 Sanofi Genzyme 56 Dana Farber Cancer Institute 53 Boston University 51 Harvard University 50 Merck & Company 48 Novartis 45 Alexion 28 Vertex 25 Celgene 23 Amgen 20 AbbVie 16 Beth Israel Deaconess Medical Center 15 Ironwood 13 Bluebird 12 Boston Children's Hospital 12 Icon Clinical Research 12 Thermo Fisher Scientific 10 Tufts Medical Center 10 Astrazeneca 9 Shc 9 Tufts University 9 Abbott Laboratories 8 Shire 8 Intellia Therapeutics 7 Life Technologies 7 Northeastern University 7 Semma Therapeutics 7 Draper Laboratory 7 UMass Medical School 7 Agios Pharmaceuticals 6 Akebia Therapeutics 6 Draper Laboratory 5 Massachusetts Institute of Technology 5 New England Herc 5 Hirelifescience, Llc 4 Hntb 4 Joslin Diabetes Center 4 Jounce Therapeutics 4 Benjamin Franklin Institute Of Technology 3 Blueprint Medicines Corporation 3 Boston Medical Center 3 Crispr Therapeutics Ag 3 Epm Scientific 3 Boston/Cambridge Region (continued) Parexel 3 Ra Pharmaceuticals 3 Sage Therapeutics 3 Teva Pharmaceuticals 3 Broad Institute 2 Cardinal Health 2 Charles River Analytics 2 Eli Lilly 2 Flexion Therapeutics 2 Foremost Laboratories 2 Glaxosmithkline 2 Hhmi 2 Human Services Research Institute 2 Integra Lifesciences 2 PerkinElmer 2 Pharmaceutical Calibrations & Instrumentation 2 Sarepta Therapeutics 2 Spectraforce 2 Suffolk University 2 Syros Pharmaceuticals 2 Abs Incorporated 1 Agilent Technologies 1 Akcea Therapeutics 1 Alexander Group 1 Alpha Net Consulting Llc 1 Als 1 Array Biopharma 1 Avrio Group 1 Axcella Health, Inc 1 Bmc Company 100 1 Boehringer Ingelheim 1 Boston Health Economics 1 Braskem 1 Bsg Team Ventures 1 Cambridge Health Alliance 1 Canon Virginia Incorporated 1 Caraco Pharmaceutical Laboratories 1 Charles Stark Draper Laboratory 1 Clinlinks 1 Covance Incorporated 1 Editas Medicine 1 Efron Consulting 1 Emerson College 1 Engineering 1 Erm Group 1 Exosome Diagnostics 1 Generations Family Health Center 1 Juniper Pharmaceuticals 1 14

DATA TABLES Top Regional Employers By STEM, Q4 2017 Boston/Cambridge Region (continued) Kalvista Pharmaceuticals 1 Lexicon Pharmaceuticals 1 Lilly 1 Longford & Company 1 Maxisit 1 Mcphs University 1 Medimmune 1 Medpace Incorporated 1 Memorial Sloan-Kettering Cancer Center 1 Mersana Therapeutics 1 Nimbus Therapeutics 1 Novocure 1 Nuprobe 1 Orchard Therapeutics 1 Oxford International 1 Parkwood International 1 Physical Sciences Incorporated 1 Planet Pharma 1 Quintiles 1 Raytheon 1 Regeneron 1 S&R Resources 1 Sequence 1 Softworld 1 Sun Pharmaceutical Industries 1 The Kemtah Group 1 Ul Llc 1 Ultragenyx Pharmaceutical 1 UMass Boston 1 Va Boston Health Care System 1 Valeant Pharmaceuticals 1 Vida International 1 Vindy 1 Wsit 1 North Region Pfizer 46 Abbott Laboratories 44 Merck & Company 41 Life Technologies 23 Lahey Clinic 15 Lahey Health 10 Amgen 6 Charles River Company 6 Danaher Corporation 6 Cardinal Health 4 EMD Serono 4 Integrated Project Services 4 Parexel 4 Sun Pharmaceuticals 4 HNTB 3 Integra Lifesciences 3 Lantheus Medical Imaging 3 Thermo Fisher Scientific 3 Abiomed 2 Amec 2 Hire Life Science 2 Integrated Resources 2 Merrimack College 2 North Shore Medical Center 2 PerkinElmer 2 Sarepta Therapeutics 2 Aequor Healthcare Services 1 Cambridge Isotope Laboratories 1 Charm Sciences 1 Cutis Pharma 1 Dps 1 Epm Scientific 1 Flexion Therapeutics 1 Highres Biosolutions 1 Insulet Corporation 1 Ipura Consulting Group, Llc 1 Lancaster Laboratories 1 Leica Biosystems 1 Massachusetts General Hospital 1 Meridian Bioscience Incorporated 1 Mettler Toledo 1 Nantero 1 Pci Synthesis 1 Shire 1 Skyworks 1 UMass Lowell 1 15

DATA TABLES Top Statewide Employers By Total, Q4 2017 Organization Takeda 289 Massachusetts General Hospital 286 Pfizer 233 Biogen 200 Merck & Company 198 Partners Healthcare 188 Sanofi Genzyme 169 Life Technologies 133 Dana Farber Cancer Institute 124 Shire 113 Cardinal Health 87 Alexion 85 Novartis 82 Abbott Laboratories 67 Boston University 60 Harvard University 56 Parexel 55 AbbVie 54 Vertex 46 PerkinElmer 45 Astrazeneca 41 Amgen 41 Ironwood 34 Lincoln Laboratory 34 Lahey Clinic 32 Beth Israel Deaconess Medical Center 31 UMass Medical School 30 Sunovion 29 Celgene 28 Icon Clinical Research 27 Charles River Company 27 Thermo Fisher Scientific 22 Baystate Health 19 Boston Children's Hospital 19 Raytheon 18 Quest Diagnostics 18 Collegium 17 Instrumentation Laboratory 17 Danaher Corporation 16 The Charles Stark Draper Laboratory 15 Bluebird 15 UMass Amherst 15 Karyopharm Therapeutics 14 Tufts Medical Center 13 Bristol-Myers Squibb 13 Lahey Health 13 Tufts University 13 New England Herc 12 Organization Shc 12 Integra Life Sciences 11 UMass Memorial Healthcare 11 Alliance Healthcare Services 10 Cape Cod Healthcare 10 North Shore Medical Center 10 Northeastern University 10 Semma Therapeutics 10 Massachusetts Institute of Technology 9 Mclean Hospital 9 Laboratory Corporation of America 9 Alkermes Incorporated 9 Boehringer Ingelheim 9 Bruker Company 9 Nova Biomedical 9 Baptist Health 9 The Marine Biological Laboratory 8 Agios Pharmaceuticals 8 Akebia Therapeutics 8 Hire Life Science 8 Intellia Therapeutics 8 Sun Pharmaceuticals 8 Sarepta Therapeutics 8 Draper Laboratory 8 Broad Institute 7 Bioverativ 7 Hntb 7 Lancaster Laboratories 7 Hologic Incorporated 7 Epm Scientific 7 Newton Wellesley Hospital 6 Astellas Pharma 6 Flexion Therapeutics 6 IDEXX Laboratories 6 Jounce Therapeutics 6 Syros Pharmaceuticals 6 S&R Resources 6 Sage Therapeutics 6 Joslin Diabetes Center 5 EMD Serono 5 Amag Pharmaceuticals 5 Corbus 5 Quintiles 5 Epharmasolutions 5 Blueprint Medicines Corporation 5 Union Of Concerned Scientists 5 Covance Incorporated 4 Integrated Project Services 4 16

DATA TABLES Top Statewide Employers By STEM, Q4 2017 Organization Massachusetts General Hospital 259 Partners Healthcare 150 Takeda 148 Pfizer 137 Biogen 104 Merck & Company 95 Sanofi Genzyme 78 Dana Farber Cancer Institute 55 Abbott Laboratories 53 Boston University 51 Harvard University 50 Novartis 47 Life Technologies 46 Shire 46 AbbVie 41 Astrazeneca 33 Cardinal Health 32 Alexion 29 Amgen 26 Vertex 25 Celgene 23 Beth Israel Deaconess Medical Center 20 Icon Clinical Research 19 UMass Medical School 19 Parexel 18 Danaher Corporation 16 Lahey Clinic 15 Thermo Fisher Scientific 14 Ironwood 13 Bluebird 12 Boston Children's Hospital 12 Charles River Company 12 PerkinElmer 12 Baystate Health 11 Tufts University 11 Lahey Health 10 Sunovion 10 Tufts Medical Center 10 UMass Amherst 10 Bristol-Myers Squibb 9 Shc 9 Hire Life Science 8 Integra Life Sciences 8 Nova Biomedical 8 UMass Memorial Healthcare 8 UMass Medical School 8 Hntb 7 Organization Intellia Therapeutics 7 Northeastern University 7 Semma Therapeutics 7 The Charles Stark Draper Laboratory 7 Agios Pharmaceuticals 6 Akebia Therapeutics 6 Instrumentation Laboratory 6 Massachusetts Institute of Technology 6 Draper Laboratory 5 IDEXX Laboratories 5 Karyopharm Therapeutics 5 Lincoln Laboratory 5 Mclean Hospital 5 New England Herc 5 Sun Pharmaceuticals 5 Cape Cod Healthcare 4 EMD Serono 4 Epm Scientific 4 Hologic Incorporated 4 Integrated Project Services 4 Joslin Diabetes Center 4 Jounce Therapeutics 4 Sarepta Therapeutics 4 Teva Pharmaceuticals 4 Amag Pharmaceuticals 3 Benjamin Franklin Institute Of Technology 3 Blueprint Medicines Corporation 3 Boston Medical Center 3 Corbus 3 Crispr Therapeutics 3 Flexion Therapeutics 3 Foremost Laboratories 3 Lancaster Laboratories 3 Lantheus Medical Imaging 3 Quest Diagnostics 3 Ra Pharmaceuticals, Inc 3 Sage Therapeutics 3 T2 Biosystems 3 Tetraphase Pharmaceuticals 3 Abiomed 2 Alkermes 2 Alpha Analytical 2 Amec 2 Ascent 2 Astellas Pharma 2 Bentley University 2 Broad Institute 2 17

DATA TABLES Top Occupations, Q4 2017 Occupations Q4 2017 Change vs. Trend Q4 2016 Q1 2017 Q2 2017 Q3 2017 AVG Medical Scientist 453-24% 562 625 567 637 598 Researcher / Research Associate 187-39% 346 299 308 278 308 Chemist 163-15% 186 189 196 193 191 Administrative Manager 156-17% 216 213 155 166 188 Office / Administrative Assistant 110-1% 103 109 93 140 111 Chemical / Process Engineer 109-49% 250 235 151 218 214 Marketing Manager 100 17% 97 82 80 81 85 Healthcare Administrator 95-23% 125 122 106 142 124 Biologist 91-39% 154 152 164 123 148 Business Development / Sales Manager 87-21% 101 120 107 114 110 Medical Director 79-11% 91 85 77 104 89 Clinical Research Coordinator / Manager 79-16% 99 82 100 95 94 Project Manager 73-21% 89 93 97 91 93 Laboratory Technician 69-16% 96 74 96 62 82 Quality Control Analyst 69-41% 110 121 122 112 116 Sales Representative 68-31% 79 101 132 86 100 Software Developer / Engineer 67-13% 59 79 76 95 77 Program Manager 65-25% 82 103 77 84 87 Biological Technician 62-17% 88 68 64 79 75 Laboratory Technologist 59 13% 51 56 62 40 52 Natural Science Research Manager 55 3% 62 59 29 63 53 Compliance Manager 54-23% 62 82 53 85 71 Human Resources / Labor Relations Specialist 53-4% 56 58 54 51 55 Biostatistician 52-40% 88 102 78 78 87 Operations Manager / Supervisor 48-5% 69 76 10 49 51 Systems Analyst 46 12% 42 54 34 34 41 Quality Control Systems Managers 46-29% 68 66 53 70 64 Mechanical Engineer 45 34% 33 36 31 34 34 Product Manager 43-28% 67 58 60 55 60 Regulatory Affairs Specialist 43-5% 43 39 38 61 45 Financial Manager 40-17% 46 55 55 38 49 Technical Writer 40-31% 39 60 89 43 58 Attorney 35-15% 39 55 27 40 40 Customer Service Representative 34-17% 32 52 37 43 41 Account Manager / Representative 34 6% 35 31 34 28 32 Quality Inspector / Technician 34-38% 52 48 67 52 55 Business / Management Analyst 34-28% 37 49 56 45 47 Production Worker 34-7% 31 36 30 48 36 Executive Assistant 33-22% 34 45 43 45 42 Accountant 32-26% 36 46 40 51 43 Data / Data Mining Analyst 30-11% 23 36 44 32 34 Medical Assistant 30-6% 36 22 37 31 31 Financial Analyst 28 15% 24 22 25 25 24 Communications / Public Relations Manager 27 9% 29 26 17 28 25 Chief Executive Officer 27 67% 28 11 11 14 16 18

DATA TABLES Top Occupations Q4 2017 Occupations Q4 2017 Change vs. Trend Q4 2016 Q1 2017 Q2 2017 Q3 2017 AVG Validation Engineer 25-7% 36 23 25 24 27 General Manager 25-56% 45 56 76 48 56 Contract Administrator 23 33% 22 14 16 18 18 Chemical Technician 23-19% 24 31 16 42 28 Nursing Assistant 23 14% 16 15 23 26 20 Production Supervisor 22-16% 18 28 34 26 27 Office Manager 22 28% 12 22 14 19 17 Human Resources Manager 22 11% 26 13 19 21 20 Recruiter 22 11% 17 20 17 24 20 Engineering Manager 21-12% 25 22 16 32 24 Registrar / Patient Service Representative 21 44% 13 11 12 21 14 Procurement / Sourcing Manager 19 21% 17 9 21 17 16 Bookkeeper / Accounting Clerk 19 0% 17 29 14 17 19 Electrical Engineer 19 62% 7 11 16 13 12 College Professor / Instructor 18-37% 43 27 19 26 29 Computer Scientist 18 60% 7 5 21 12 11 Computer Systems Engineer / Architect 18-10% 14 16 25 25 20 Computer Programmer 18-44% 28 34 23 44 32 Training and Development Specialist 18 44% 11 12 18 8 12 Production Plant Manager 17-25% 25 25 28 12 22 Medical Secretary 16 4% 11 18 15 19 16 Clinical Data Systems Specialist / Manager 16 73% 5 9 11 12 9 IT Project Manager 16-17% 29 18 17 13 19 Industrial Engineer 15-35% 17 29 23 24 23 College / University Administrator 15-33% 22 26 14 25 22 Sterile Processing Technician 14-6% 17 16 14 12 15 Training and Development Manager 14 62% 9 5 13 7 9 Public Relations / Communications Specialist 13-3% 14 19 12 11 14 Treasurer / Controller 13 31% 8 12 7 12 10 Phlebotomist 13-50% 26 17 27 34 26 Computer Support Specialist 13-38% 22 29 20 14 21 General / Electrical Engineering Technician 12 30% 8 16 6 7 9 Biomedical Engineer 12 2% 18 8 6 15 12 Civil Engineer 12 2% 15 6 17 9 12 Manufacturing / Production Technician 12-40% 21 20 27 12 20 Biochemist 12-42% 30 23 11 19 21 Statistician 12-70% 42 37 51 32 41 Manufacturing Machine Operator 12-9% 15 13 8 15 13 Buyer / Purchasing Agent 11-7% 7 13 19 11 12 Database Administrator 11-14% 10 13 16 12 13 Microbiologist 11-56% 26 12 31 32 25 Mental Health / Behavioral Counselor 11 12% 7 9 10 13 10 Fundraising Manager 11-25% 12 14 16 16 15 Marketing Specialist 10 10% 11 12 10 3 9 Market Research Analyst 10-36% 11 15 17 19 15 19

DATA TABLES Top Occupations, Q4 2017 Occupations Q4 2017 Change vs. Trend Q4 2016 Q1 2017 Q2 2017 Q3 2017 AVG Safety Manager 9 22% 7 6 6 11 8 Retail Store Manager / Supervisor 9-46% 15 16 27 12 17 Auditor 9-34% 6 19 19 13 14 Cyber / Information Security Engineer / Analyst 9 0% 4 11 5 16 9 Health Technician / Technologist (Other) 9-27% 5 14 17 13 12 Manufacturing Engineer 9-32% 16 14 15 8 13 Network Engineer / Architect 9-48% 19 13 22 15 17 Physician 9-63% 15 21 38 23 24 Maintenance Technician 9-49% 19 16 19 15 17 Security Officer 9-3% 6 7 7 16 9 Restaurant / Food Service Supervisor 9-13% 8 12 10 9 10 Laborer / Warehouse Worker 8-25% 12 10 16 7 11 Compliance Officer / Analyst 8-49% 23 13 23 8 17 Scheduler / Operations Coordinator 8-22% 10 11 12 10 11 Surveillance Officer / Investigator 8-21% 13 12 5 10 10 Sales Supervisor 8 49% 5 4 4 9 5 Supply Chain / Logistics Manager 7-34% 12 16 12 6 11 Retail Sales Associate 7 38% 4 2 13 3 5 Epidemiologist 7 17% 9 7 5 3 6 Medical / Pharmaceutical Sales Representative 7 180% 3 0 0 7 3 Pet Care Workers / Managers 7 44% 7 3 3 7 5 Janitor / Cleaner 7 36% 2 3 5 9 5 Compensation and Benefits Manager 7-21% 10 5 11 8 8 Field Service Technician 7-29% 8 6 11 12 9 Graphic Designer / Desktop Publisher 7 80% 4 2 2 7 4 Inventory Specialist 7 172% 1 1 3 4 2 Payroll Specialist 6-3% 11 8 2 5 6 Operations Analyst 6-11% 4 12 4 7 7 Economist 6-8% 3 10 9 4 7 Cytogenetic Technologist / Cytotechnologist 6-52% 10 13 14 13 13 Network / Systems Administrator 6-43% 12 11 11 8 11 Data Scientist 6-56% 17 16 12 10 14 Logistics / Supply Chain Analyst 6 17% 1 7 8 4 5 Repair / Service Technician 6 6% 8 1 4 9 5 Coach 6 13% 5 4 4 8 5 Interpreter / Translator 6 51% 3 4 3 5 4 Billing Clerk / Specialist 5 15% 7 5 2 4 5 Food Service Team Member 5 8% 5 6 4 4 5 Shipping / Receiving Clerk 5 106% 1 1 2 5 2 Claims Specialist / Adjuster / Examiner 5 109% 0 2 0 8 2 Cardiovascular Technician / Technologist 5 100% 4 2 3 1 3 CIO/ Director of Information Technology 5-69% 10 14 23 18 16 Receptionist 5-6% 5 4 6 5 5 Writer 5-11% 5 10 3 5 5 20

DATA TABLES Historical Employment By Sector, 2011-2013 Month Industry Sector 3254 54171 54138 3345 6113 622 6215 Totals Jan-11 8,383 32,213 273 1,635 2,025 8,805 3,396 56,730 Feb-11 8,377 32,118 269 1,655 2,183 8,810 3,426 56,839 Mar-11 8,411 32,126 269 1,646 2,190 8,828 3,440 56,910 Apr-11 8,394 32,424 276 1,643 2,206 8,807 3,442 57,192 May-11 8,436 32,467 280 1,642 2,159 8,807 3,466 57,257 Jun-11 8,676 32,754 283 1,658 1,993 8,883 3,476 57,722 Jul-11 8,667 32,986 289 1,691 1,981 8,914 3,492 58,019 Aug-11 8,694 32,900 288 1,688 1,960 8,901 3,528 57,959 Sep-11 8,577 32,648 285 1,678 2,164 8,867 3,535 57,754 Oct-11 8,540 32,595 284 1,674 2,227 8,838 3,573 57,730 Nov-11 8,586 32,662 281 1,682 2,247 8,862 3,582 57,902 Dec-11 8,707 32,842 274 1,688 2,208 8,862 3,595 58,177 Jan-12 8,764 32,246 274 1,664 2,049 8,872 3,487 57,356 Feb-12 8,798 32,181 272 1,667 2,219 8,861 3,483 57,481 Mar-12 8,852 32,323 275 1,680 2,242 8,871 3,504 57,748 Apr-12 8,919 32,366 278 1,682 2,231 8,862 3,520 57,858 May-12 8,941 32,371 280 1,680 2,191 8,861 3,528 57,853 Jun-12 9,122 32,811 285 1,715 2,047 8,939 3,566 58,484 Jul-12 9,108 32,689 285 1,723 1,996 8,932 3,560 58,294 Aug-12 9,095 32,695 284 1,715 1,977 8,917 3,556 58,239 Sep-12 8,950 32,371 282 1,706 2,192 8,881 3,557 57,939 Oct-12 8,913 32,314 283 1,710 2,264 8,843 3,558 57,886 Nov-12 8,982 32,382 282 1,718 2,281 8,869 3,594 58,109 Dec-12 9,103 32,558 286 1,724 2,251 8,873 3,632 58,426 Jan-13 9,246 32,612 278 1,936 2,097 8,819 3,785 58,773 Feb-13 9,310 32,709 275 1,918 2,312 8,798 3,821 59,143 Mar-13 9,350 32,736 276 1,923 2,322 8,812 3,807 59,227 Apr-13 9,345 32,337 286 1,925 2,341 8,810 3,778 58,822 May-13 9,336 32,419 292 1,937 2,282 8,832 3,781 58,880 Jun-13 9,505 32,849 296 1,966 2,084 8,903 3,832 59,434 Jul-13 9,486 32,937 304 1,979 2,001 8,929 3,814 59,450 Aug-13 9,484 32,879 306 1,963 1,997 8,924 3,806 59,360 Sep-13 9,393 32,556 301 1,943 2,196 8,891 3,787 59,067 Oct-13 9,192 32,595 293 1,945 2,280 8,831 3,821 58,957 Nov-13 9,103 32,713 294 1,958 2,305 8,889 3,864 59,126 Dec-13 9,122 32,794 296 1,966 2,276 8,901 3,886 59,241 INDUSTRY SECTORS: NAICS 3254: Pharmaceutical MFG, including Biologics (100%) NAICS 541711: Research and Development in Biotechnology (100%) NAICS 541712: R&D in Physical, Engineering, and Life Sciences (except biotech) (22%) NAICS 334516: Analytical Laboratory Instrument MFG (30%) NAICS 54138: Testing Laboratories (9%) NAICS 622: Hospitals (4.5%) NAICS 61131: Universities (1.9%) NAICS 621511: Medical Testing Laboratories (100%) 21

DATA TABLES Historical Employment By Sector, 2014-2016 Month Industry Sector 3254 54171 54138 3345 6113 622 6215 Totals Jan-14 9,809 34,030 295 1,949 2,167 8,906 3,885 61,041 Feb-14 9,840 34,023 294 1,943 2,305 8,882 3,899 61,184 Mar-14 9,900 34,138 296 1,946 2,321 8,912 3,890 61,403 Apr-14 9,904 34,100 299 1,956 2,332 8,900 3,938 61,429 May-14 9,996 34,228 303 1,964 2,238 8,928 3,978 61,635 Jun-14 10,055 34,683 308 1,987 2,017 8,994 4,009 62,052 Jul-14 10,069 34,817 312 2,006 2,075 9,112 4,068 62,459 Aug-14 10,053 34,726 311 1,982 2,051 9,108 4,071 62,302 Sep-14 9,985 34,464 308 1,965 2,242 9,055 4,059 62,078 Oct-14 10,379 34,170 309 1,987 2,339 9,045 4,128 62,357 Nov-14 10,411 34,338 309 2,002 2,371 9,086 4,129 62,647 Dec-14 10,500 34,656 307 2,021 2,352 9,107 4,127 63,070 Jan-15 10,903 34,686 310 2,063 2,129 9,036 4,057 63,184 Feb-15 10,890 34,500 306 2,067 2,321 9,012 4,038 63,133 Mar-15 10,908 34,885 309 2,070 2,359 9,040 4,073 63,645 Apr-15 10,865 35,143 313 2,095 2,375 9,058 4,069 63,917 May-15 10,789 35,465 315 2,099 2,288 9,080 4,133 64,169 Jun-15 10,760 36,067 319 2,108 2,139 9,158 4,177 64,729 Jul-15 10,675 36,193 316 2,105 2,113 9,197 4,153 64,752 Aug-15 10,583 36,424 320 2,095 2,073 9,177 4,171 64,843 Sep-15 10,468 36,230 317 2,068 2,258 9,132 4,168 64,641 Oct-15 10,421 36,819 319 2,093 2,356 9,104 4,218 65,330 Nov-15 10,273 37,069 317 2,105 2,375 9,143 4,155 65,438 Dec-15 10,300 37,327 319 2,118 2,364 9,163 4,122 65,714 Jan-16 10,094 37,319 321 2,140 2,157 9,095 4,413 65,539 Feb-16 10,140 37,477 320 2,139 2,346 9,080 4,441 65,944 Mar-16 10,169 37,733 324 2,147 2,364 9,107 4,480 66,324 Apr-16 10,188 38,063 335 2,159 2,377 9,120 4,517 66,759 May-16 10,269 38,269 334 2,156 2,324 9,147 4,526 67,025 Jun-16 10,507 38,954 339 2,185 2,109 9,241 4,526 67,860 Jul-16 10,450 39,792 338 2,206 2,124 9,329 4,495 68,733 Aug-16 10,437 39,720 337 2,204 2,097 9,316 4,488 68,600 Sep-16 10,460 39,220 332 2,182 2,296 9,297 4,467 68,253 Oct-16 10,054 40,155 331 2,199 2,357 9,288 4,485 68,868 Nov-16 10,113 40,364 331 2,199 2,357 9,288 4,465 69,117 Dec-16 10,192 41,084 331 2,199 2,357 9,288 4,491 69,942 INDUSTRY SECTORS: NAICS 3254: Pharmaceutical MFG, including Biologics (100%) NAICS 541711: Research and Development in Biotechnology (100%) NAICS 541712: R&D in Physical, Engineering, and Life Sciences (except biotech) (22%) NAICS 334516: Analytical Laboratory Instrument MFG (30%) NAICS 54138: Testing Laboratories (9%) NAICS 622: Hospitals (4.5%) NAICS 61131: Universities (1.9%) NAICS 621511: Medical Testing Laboratories (100%) 22

DATA TABLES Historical Employment By Sector, 2017 - Present Month Industry Sector 3254 54171 54138 3345 6113 622 6215 Totals Jan-17 9,930 40,204 330 2,210 2,191 9,355 4,539 68,758 Feb-17 9,852 40,559 329 2,205 2,356 9,320 4,524 69,146 Mar-17 9,987 40,777 329 2,210 2,360 9,328 4,491 69,482 Apr-17 9,951 40,979 336 2,211 2,381 9,314 4,633 69,804 May-17 9,967 41,300 335 2,202 2,317 9,321 4,617 70,059 Jun-17 10,217 42,449 339 2,235 2,205 9,430 4,645 71,519 INDUSTRY SECTORS: NAICS 3254: Pharmaceutical MFG, including Biologics (100%) NAICS 541711: Research and Development in Biotechnology (100%) NAICS 541712: R&D in Physical, Engineering, and Life Sciences (except biotech) (22%) NAICS 334516: Analytical Laboratory Instrument MFG (30%) NAICS 54138: Testing Laboratories (9%) NAICS 622: Hospitals (4.5%) NAICS 61131: Universities (1.9%) NAICS 621511: Medical Testing Laboratories (100%) 23

APPENDIX MassBioEd utilizes Burning Glass Labor Insight for the bulk of its real-time online job listing data. Per the description on Burning Glass website, their Labor Insight software collects millions of online job postings [everyday] from close to 40,000 sources and applies [their] patented technology to mine and code detailed data from each posting, describing the specific skills, education, experience, and work activities required for the job going well beyond the occupation and industry codes offered in other sources. All job listings data is sourced from Burning Glass Labor Insight, unless otherwise noted. Employment numbers were derived from the Department of Labor, Bureau of Labor Statistics Quarterly Census of Employment and Wages (QCEW), a survey of employers that covers 98 percent of all workers in the country. Staffing patterns, or the count of individual occupations by industry in the state, were found by using Department of Labor, Bureau of Labor Statistics Occupation Employment Statistics (OES) Research Estimates. These are derived from sample surveys and thus are approximations subject to sampling error, as well as nonsampling errors by respondents filling out the surveys. 24