(for example smithfebruary2017.doc) 50,000 or for periods longer than 24 months will not be reviewed.

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Research Grant Guidelines 1. Proposals must be submitted to the Executive Director at Histio UK 2. Proposals must be submitted in English language and follow the Research Proposal Format. a. Files must be uploaded as a compressed, single file PDF (maximum size of 4,000 KB). b. Proposals must use standard formatting requirements (11-point Arial font, ½ inch margins). c. The scientific section of the proposal may not exceed three (3) pages d. The application must include a completed Histio UK Project Grant Fund Application form e. Please name the file with the principal applicant s surname and grant year (for example smithfebruary2017.doc) 3. Applicants/investigators will receive email confirmation of receipt of their proposal. 4. Primary investigators may submit only one proposal for funding. 5. Research Grants are awarded for 12-24 months up to 50,000. Proposals in excess of 50,000 or for periods longer than 24 months will not be reviewed. 6. Funding may be for salaries of researchers directly engaged in the project or for consumable reagents 7. Funding is awarded to the Primary Investigator s institution only. It is the responsibility of that institution to disburse funding for joint projects. 8. The Histiocytosis UK does not fund indirect or overhead, principal investigator salaries. 9. Successful applicants will be required to present their work at the annual UK Clinician & Researchers Conference 10. A modest travel budget to attend the UK Clinician & Researchers Conference and Histiocytosis Association annual meeting is permitted to allow the applicant to present the research at the UK meeting and provided they have submitted an abstract to the annual HS meeting.

Research Grant Costing Guidelines CONDITIONALLY ACCEPTABLE COSTS TRANSACTION EXAMPLES Salaries for grant staff Researchers on fixed term contracts to work specifically funded project. This may include fellows, research assistants, data managers, students (except overseas student fees), technicians and nurses. Salary may be used to fund salary, the employer's national insurance contribution, and an employer's pension contribution which will not be higher than the rate used by the University Superannuation Scheme (USS) or NHS pension scheme. Laboratory expenses Laboratory chemicals and materials (e.g. reagents, isotopes, peptides, enzymes, antibodies, gases, proteins, cell/tissue/bacterial culture, plastic ware and glassware), as well as any associated charges for shipping, delivery and freight Please note that 'bench fees' will only be covered if they are for named researchers grant, and only if the Host Institution confirms that they do not include charges for unacceptable. Protective clothing Equipment purchase Gloves, lab coats Costs may include purchase, delivery, and installation of scientific equipment where that equipment is specific to the grant Personal computing Animal research Where justified, personal computing for named individuals engaged to work specifically grant (capped at 600 per person over the duration of the grant). Please note that standard per unit IT charges are not acceptable. Animal purchase and transportation, maintenance (including food) and experimentation. (Home Office Licences and animal handling training are not covered). Cell line authentication Costs to support the authentication of cell lines, for example, screening for contamination by mycoplasma, STR profiling for

Data sharing human cell lines or DNA fingerprinting for non-human cells. We will also cover purchase of cell lines from cell banks such as ATCC Archiving, repository fees, data storage and data management services. Data management and sharing must be reasonable and proportionate in the context of the overall grant. Data sharing do not include open access publication fees. Publication Page charges, of colour printing, reprints may be paid from grant underspend. Open Access should be charged to the Charities Open Access Fund (COAF). If the Host Institution does not have access to COAF, grant underspend may be used to fund open access. Subject and volunteer expenses PhD student expenses in the UK Recruitment (excluding participation fees), reasonable travel and refreshment for subjects and volunteers in population studies. Fees or honoraria for patients sitting on steering groups or advisory boards specifically relating to the funded research may be eligible, if consistent with Histio UK policy Please contact the office if you think this may be applicable to you. Please refer to Histio UK for SET FEES. Indexation Stipend Outside London 19,000 0 Inside London 21,000 0

TRANSACTION EXAMPLES ACCEPTABILITY UNACCEPTABILITY Recruitment Post advertising, relocation interviewee expenses If relating to recruiting patients/participants on a clinical trial If relating to recruitment of posts to a grant Travel & Subsistence, Conferences, Meetings Catering / Hospitality Training Postage / Courier Software in excess of 'personal Computing ' (see acceptable ) Telephone conference call Reasonable covered if: they come out of Underspend; and the person travelling is funded by the grant; and the purpose of travel relates to the grant If related to the science of the award e.g. scientific equipment If posting scientific materials, delivery If specialised Software specific to the funded research (e.g. specialised bioinformatics software) If in lieu of travel expenses for attending a meeting (NB infrastructure remain the responsibility of host institution) First class travel Meetings organised/hosted by Histio UK where attendee are reimbursed directly by Histio UK (these should not be charged to grants) May NOT come from grant underspend if for collaborative meetings relating to the grant and not excessive in cost If non science specific or general to HR eq. IT skills, personal development etc. General postage Generic office software All other cases Regulatory licences/fees Home office animal handling, Human Tissues Act Printing / Photocopying Usage Paper, pens, toner, All trials and Centres All trials and Centres GAL Only-acceptable if outlined

Stationery office postage Archiving All trials Mobile phone Promotional Material Pens, mugs, calendars, nurse uniforms, business cards. Research Nurse mobile on trials CTUs, Centres, ECMCs Not acceptable UNACCEPTABLE COSTS General estate Furniture Health and Safety Utilities Standard telephone and internet Standard IT charges Phone / computer accessories Fees to professional organisations Misc. Departmental support staff Central HR Costs Shared catering Key cutting, electrical point installations, waste disposal, cleaning services, removal etc. Chairs, desks, lab furniture, telephone handsets and conference call hubs First aid kit, hazard signs Electricity, gas, water Broadband, mobile line rental and calls Standard per unit IT Standard per unit IT Drives, cases, chargers, batteries Journal subscriptions, professional membership e.g. British Society of Cell Biology Paper wipes, laundry, reference books Secretarial support, librarians, general lab support staff Eye tests, CRB checks, redundancy, visas Coffee, milk, water, vending machines and maintenance Printing / Photocopying Insurance Gifts Insufficiently evidenced Rental of copiers Laptop, travel etc. Gift vouchers for trial participants No copy of invoice or receipt available