THE DOCTOR WILL SEE YOU NOW UNITED STATES ADVERTISING OPPORTUNITIES 2018

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THE DOCTOR WILL SEE YOU NOW UNITED STATES ADVERTISING OPPORTUNITIES 2018 Effective advertising opportunities BMJ is a leading healthcare knowledge provider. From internists, to neurologists and cardiologists, advertisers take advantage of BMJ's extensive reach into the healthcare market. Contact us For more information on advertising, and to discuss your campaign requirements, please contact: RON GORDON National Accounts Manager American Medical Communications (973) 214-4374 rgordon@americanmedicalcomm.com #1 in th e field of Rheuma tology Your link Neuro le to aders 2.5 milli on monthly impress ions

The BMJ one of the most respected general medical journals in the world keeps physicians, researchers and other health care professionals up-to-date on the latest medical advances around the world. The BMJ in print Available in three print editions, The BMJ is your link to internal medicine physicians in the United States and around the world. Contact your sales representative for the the latest circulation figures of each edition. The BMJ - Edition Clinical Research Edition 78k+ General Practice Edition 28k+ Academic Edition 900+ The BMJ online Global Print Circulation See page 3 for specs and pricing A digitally-responsive website provides an optimal viewing experience from any device. Online access can be purchased separately, or is free with a print subscription. The BMJ Established: 1840 Editor: Dr. Fiona Godlee Impact factor: 20.7* Primary audience: Internists and healthcare professionals who work in general and internal medicine Print Frequency: Varies by edition (weekly or monthly) Online frequency: New content daily Format: Responsive website provides an optimal viewing experience from any device. Individual and institutional subscriptions available; online access is free with a print subscription. Advertising options include: Leaderboard Mid-page unit Mobile Banner See page 4 for specs and pricing Why The BMJ online? A significant amount of U.S. traffic each month 1, accounting for 27% of all site visitors - 434 thousand+ monthly site visits from the U.S. 1-644 thousand+ monthly page views from the U.S. 1 High traffic volume each month - 1.5 million+ monthly site visits worldwide 1-2.7 million+ monthly page views worldwide 1 Reliable ad serving software ensures accurate delivery to your target audience. GEO-IP enables precise geographical targeting. Real Media and Open Adstream verifies delivery of advertisement inventory 1. Source: Google Analytics, Monthly average from January - June 2017 * 2016 Journal Citations Report, Clarivate Analytics, 2017 Your leaderboard here Your MPU here Mobile banner here U.S. Advertising Opportunities 2018 2

PRINT ADVERTISING Specialty journals -- Print statistics Journal Primary audience Global Circulation Frequency Annals of the Rheumatic Diseases Rheumatologists 12,350 Monthly Archives of Disease in Childhood Pediatricians 13,410 Monthly British Journal of Ophthalmology Ophthalmologists 800 Monthly British Journal of Sports Medicine Sports physicians 1,250 Bi-weekly Gut Gastroenterologists 2,900 Monthly Heart Cardiologists 1,450 Bi-weekly Journal of Investigative Medicine Biomedical researchers 830 8x per year Journal of ISAKOS Orthopedic surgeons 2,400 Bi-monthly Journal of NeuroInterventional Surgery Neurointerventional specialists 1,800 12 issues/year Journal of Neurology, Neuroscience and Psychiatry Neurologists 960 Monthly Thorax Pulmonologists 3,100 Monthly Please ask an advertising sales representative about statistics for any other Journal from BMJ. Print rates & specifications The BMJ Academic Edition Journals from BMJ Journal of NeuroInterventional Surgery Quarter page Color $ 4,000 Color $ 1,420 Color $ 2,200 Specifications Size - 3-1/2" (w) x 4-7/8" (h) B/W $ 2,135 B/W $ 915 B/W $ 840 Half page Color $ 5,345 Color $ 2,685 Color $ 2,160 B/W $ 4,000 B/W $ 1,340 B/W $ 1,225 Full page Color $ 6,945 Color $ 3,440 Color $ 3,165 B/W $ 5,345 B/W $ 1,945 B/W $ 1,785 Double-page spread Color $ 13,335 Color $ 6,880 Color $ 6,330 B/W $ 8,025 B/W $ 3,885 B/W $ 3,570 Horizontal - 7-3/8" (w) x 4-3/4" (h) Vertical - 3-1/2" (w) x 9-1/2" (h) Bleed - 8-1/4" (w) x 11-1/4" (h) Trim - 8-1/4" (w) x 11" (h) Live area - 7-3/8" (w) x 9-1/2" (h) Two single, full-page PDF files Left and right-hand page Allow 3/8" gutter bleed (3/16" on each side) Please note: Advertisements are accepted subject to availability and BMJ approval. U.S. Advertising Opportunities 2018 3

DIGITAL ADVERTISING Specialty journals Website statistics Website Annals of the Rheumatic Diseases ard.bmj.com Archives of Disease in Childhood adc.bmj.com British Journal of Ophthalmology bjo.bmj.com British Journal of Sports Medicine bjsm.bmj.com Gut gut.bmj.com Heart heart.bmj.com Journal of Investigative Medicine jim.bmj.com Journal of ISAKOS jisakos.bmj.com Journal of NeuroInterventional Surgery jnis.bmj.com Journal of Neurology, Neuroscience and Psychiatry jnnp.bmj.com Thorax thorax.bmj.com Source: Google Analytics, Monthly average from January - June 2017 Primary audience U.S. visits per month: U.S. page impressions per month: Global visits per month: Rheumatologists 68,746 102,859 217,852 Pediatricians 52,417 78,226 78,226 Ophthalmologists 22,773 32,994 86,592 Sports physicians 105,567 159,158 362,680 Gastroenterologists 64,185 96,562 205,934 Cardiologists 43,543 63,230 148,627 Biomedical researchers 4,356 9,188 11,244 Orthopedic surgeons 1,768 2,633 4,950 Neurointerventional specialists 9,527 17,064 20,620 Neurologists 99,277 125,151 233,146 Pulmonologists 38,149 25,295 145,073 *Ad impression inventory may vary; ask a representative for the latest figures for these and any other BMJ journal. Digital rates & specifications includes The BMJ Format Pixels The BMJ and BMJ Journals CPM* Mobile banner 320 x 50 $70 $110 Leaderboard 728 x 90 $70 $110 Journal of NeuroInterventional Surgery Specifications File type GIFs (animated preferred) and Rich Media accepted, subject to production clearance MPU (Mid page unit) 300 x 250 $75 $110 Skyscraper 160 x 600 $70 $110 Super skyscraper 160 x 600 $70 $110 File size Deadline of receipt of material Up to 50kb 5 working days prior to publication Expandable skyscraper 160 x 600 $80 $110 x 240 Please note: Advertisements are accepted subject to availability and BMJ approval. * CPM is the abbreviation for cost per 1,000 impressions, which refers to the number of times your advertisement is seen or downloaded onto a specific page. U.S. Advertising Opportunities 2018 4

Comprehensive cardiology research, reviews, education, debate and commentary to enhance your medical knowledge Heart Asia is an online only journal that conveys the best cardiology research and practice from developing regions to an international audience. The journal seeks to publish work from around the world, with the Asia Pacific being a region of particular focus. The essential resource in cardiology Heart is an international peer reviewed journal that keeps cardiologists up to date with advances in the diagnosis and treatment of cardiovascular disease. The Open Access companion to Heart Open Heart is a PubMed indexed journal, publishing high quality Open Access research with all the scientific rigour of its companion journal Heart. With stringent peer review, we ensure maximum transparency and maximum impact on research progress and patient care. Comprehensive neurology research to enhance your PN is the essential read for busy clinical neurologists who want practical and evidence-based information to keep up to speed and safe in managing patients. JNIS is dedicated to providing dedicated and specialist scientific literature pertaining to neurointerventional surgery and is the leading peer review journal in it s field. SVN is a fully Open Access journal dedicated to Stroke and Vascular Neurology and is the official journal of the Chinese Stroke Association. Access multidisciplinary content As a subscriber / member of JNNP, you will also have access to PN and JNIS. Access is provided to all members of the Association of British Neurologists (ABN). Individual subscriptions are also available. JNNP is a leader in the field - publishing ground-breaking research on neurological sciences from around the world. Comprehensive nursing research, reviews, and education to enhance your Encouraging best practice in nursing Evidence-Based Nursing (EBN) is designed to alert practising nurses to important and clinically relevant advances in treatment, diagnosis, aetiology, and prognosis. EBN surveys a wide range of international medical and nursing journals, applying strict criteria for the quality and validity of research, in order to identify the most important studies. End of Life Journal is a free, peer-reviewed journal for nurses and others working in health and social care for dying people and their family and friends at home, in hospital and in care homes. An inclusive view of supportive and palliative care research Connecting disciplines and specialties throughout the world, BMJ Supportive & Palliative Care provides high quality, clinicallyrelevant research on all conditions requiring supportive or palliative care. Ideal reading for all healthcare workers and researchers across medical and surgical specialties. Improving sexual and reproductive health worldwide Journal of Family Planning and Reproductive Health Care (JFPRHC) keeps you informed with the latest research, reviews, commentary and discussion in the field of sexual and reproductive health. bmj.co/nursing Comprehensive paediatric research to enhance your Showcasing the best in paediatric medicine Official journal of the Royal College of Paediatrics and Child Health, Archives of Disease in Childhood (ADC), brings you the latest advances in childhood disease diagnostics and treatment, inclusive of the perinatal period through to adolescence. Keeping your paediatric practice up-to-date Published six times a year, ADC Education and Practice assists paediatricians at all levels with ongoing professional development, fully supported by the Royal College of Paediatrics and Child Health. Focused, high-quality neonatal and perinatal medicine Your essential, bimonthly resource, ADC Fetal and Neonatal edition brings you the latest, high-quality research focused on neonatal and perinatal medicine. Stay one step ahead with the latest Open Access paediatric research and reviews BMJ Paediatrics Open is a peer-reviewed Open Access journal dedicated to publishing original research, clinical reviews and protocols on any aspect of child health from all healthcare professionals. Comprehensive pharmacy research, reviews, and education to enhance your Independent and reliable advice on drug treatment and management of disease Drug and Therapeutics Bulletin (DTB) provides rigorous and independent evaluations of, and practical advice on, individual treatments and the overall management of disease for doctors, pharmacists and other healthcare professionals Saving you time and improving your practice Evidence-Based Medicine provides time-saving, distilled research for the busy professional in all medical specialties Publishing practical and innovative research As the official journal of the European Association of Hospital Pharmacists, the European Journal of Hospital Pharmacy advances the science, practice and profession of hospital pharmacy and aims to improve the standard of patient care in hospitals and related institutions worldwide bmj.co/pharmacy Providing high-quality content for healthcare professionals, clinicians and researchers across the globe, our diverse public health portfolio includes some of the most influential specialty journals in their field Comprehensive rheumatology research to enhance your Number 1 journal in the Rheumatology category medical knowledge and improve patient care The Open Access companion to Annals of the Rheumatic Diseases EULAR Textbooks EULAR textbooks are designed to help you with your continuous medical education in rheumatology and complement the EULAR on-line courses. The world s first Open Access lupus journal Comprehensive sports medicine research to enhance your medical knowledge and improve patient care The Open Access companion to BJSM BMJ Open Sport & Exercise Medicine covers all aspects of the field from physiology to return to play. The journal publishes original articles considered by peer reviewers to be coherent and technically sound, ensuring that the latest research is disseminated rapidly to a global audience. Keep up to date with the latest advances in sports and exercise medicine British Journal of Sports Medicine (BJSM) is a multimedia portal offering authoritative original research, systematic reviews, consensus statements and timely debate in sport and exercise medicine, as well as clinical education and implementation success stories. Our web, print, video and audio material, combined with active social media, serves the international community of clinicians who treat active people. Essential Cardiology from BMJ Essential Neurology from BMJ Essential Nursing Resources Essential Paediatrics from BMJ Essential Pharmacy Resources Essential Public Health from BMJ Essential Rheumatology Essential Sports Medicine Resource ADDITIONAL TITLES Additional advertising opportunities! Maximize your visibility and investment through these creative ad placements. etoc alert advertising: Available for each BMJ journal. etoc recipients have opted-in to receive an email with the table of contents for each new issue. e-newsletter advertising: Quarterly and monthly content marketing emails are sent to specialty-specific U.S. physicians. 30% average open and 40% average click through rate. Controlled print circulation: Sponsor sending an entire journal issue to U.S. health care professionals. Print cover wraps: Ensure your message is seen by print journal recipients on a cover wrap or belly band. Other opportunities available. Please contact us today to discuss these highly targeted options! Additional titles include: Cardiology Heart Asia Open Heart Endocrinology BMJ Open Diabetes Research & Care Evidence-Based BMJ Evidence-Based Medicine Evidence Based Mental Health Evidence-Based Nursing Gastroenterology Frontline Gastroenterology BMJ Open Gastroenterology General Medicine BMJ Case Reports BMJ Open Journal of Medical Ethics Medical Humanities Postgraduate Medical Journal Neurology Practical Neurology Stroke and Vascular Neurology Nursing Evidence-Based Nursing End of Life Journal BMJ Supportive & Palliative Care Journal of Family Planning & Reproductive Health Care Pediatrics ADC Education & Practice Edition ADC Fetal & Neonatal Edition BMJ Paediatrics Open Pharmacy European Journal of Hospital Pharmacy BMJ Evidence-Based Medicine Drug and Therapeutics Bulletin Public Health BMJ Global Health Emergency Medicine Journal Injury Prevention Journal of Epidemiology & Community Health Occupational & Environmental Medicine Sexually Transmitted Infections Tobacco Control Quality & Safety BMJ Quality & Safety Respiratory BMJ Open Respiratory Research Rheumatology Eular Textbooks RMD Open: Rheumatic & Musculoskeletal Diseases Lupus Science & Medicine Specialty Acupuncture in Medicine BMJ Supportive & Palliative Care Journal of Clinical Pathology Journal of Family Planning and Reproductive Health Care Journal of Medical Genetics Sports Medicine BMJ Open Sport & Exercise Medicine Veterinary In Practice Veterinary Record Veterinary Record Open Veterinary Record Case Reports U.S. Advertising Opportunities 2018 5

Advancing the practice of healthcare worldwide Contact us For more information on advertising, and to discuss your campaign requirements, please contact: RON GORDON National Accounts Manager American Medical Communications (973) 214-4374 rgordon@americanmedicalcomm.com BMJ, Two Hudson Place, Hoboken, NJ 07030 U.S. Advertising Opportunities 2018 6