Deadline: 12 noon Thursday 21 June 2018

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2018 Funding Round Saving 2000 lives a year in Yorkshire by 2025 Full Application Form Deadline: 12 noon Thursday 21 June 2018 Applications must be sent in Microsoft Word format to research@ycr.org.uk. PDFs will not be accepted. Please use the filename format [SURNAME] 2018 FULL APPLICATION. Please also submit 15 double-sided hard copies to arrive by the deadline above. PRIVACY AND USE OF PERSONAL DATA For full details on how we use your information please visit www.ycr.org.uk/information-for-applicants. BEFORE YOU BEGIN Check this box if you have sought advice from a relevant Clinical Studies Group. Check this box if have you consulted with NIHR Clinical Research Network Yorkshire and Humber about this proposal. Check this box to confirm that you have read the checklist at the end of this application. Check this box to confirm you have read the Information for Applicants, Award Conditions and Policies for Awards. SECTION 1 ABOUT YOU PRINCIPAL APPLICANT/s DETAILS Will your CURRENT employment extend beyond the end date of this project? If no, give the end date. phone number Contact Information Host Organisation / Department Postal address Town/City Postcode 1

PRINCIPAL APPLICANT/s DETAILS Principal 2 Surname Principal 2 Forename Principal 2 Title Click title Will your CURRENT employment extend beyond the end date of this project? If no, give the end date. phone number Contact Information Principal Applicant email address Host Organisation / Department Postal address Town/City Postcode Personal Assistant name Personal Assistant email Personal Assistant phone number Lay Representative PERSONAL ASSISTANT DETAILS (if applicable) LAY REPRESENTATIVE Email/phone number Check this box to confirm the lay representative has given permission for their contact details to be provided to us. Lay representative guidance can be found in the Information for Applicants document 2

SECTION 1 CO-APPLICANT DETAILS Will your CURRENT employment extend beyond the end date of this project? If not, give the end date. Will your CURRENT employment extend beyond the end date of this project? If not, give the end date. Will your CURRENT employment extend beyond the end date of this project? If not, give the end date. Will your CURRENT employment extend beyond the end date of this project? If not, give the end date. Will your CURRENT employment extend beyond the end date of this project? If not, give the end date. 3

SECTION 1 CO-APPLICANTS DETAILS Will your CURRENT employment extend beyond the end date of this project? If not, give the end date. Will your CURRENT employment extend beyond the end date of this project? If not, give the end date. Will your CURRENT employment extend beyond the end date of this project? If not, give the end date. Will your CURRENT employment extend beyond the end date of this project? If not, give the end date. Will your CURRENT employment extend beyond the end date of this project? If not, give the end date. 4

Project title Proposed start date (dd/mm/yyyy) Which funding priority does your Application address? (please tick one or more boxes) SECTION 2 ABOUT YOUR PROJECT Project length (months) 1. Early diagnosis of the most common cancers and increasing uptake of national cancer screening programmes 2. Cancer rehabilitation to reduce recurrence 3. Clinical trials in common cancers Total amount requested ( ) Amount must not be significantly different from that in the Preliminary Application Is your current research supported by other funding bodies? Are you currently applying elsewhere for support for work relating to this project? Is this application or any part of it currently being submitted elsewhere? Are you considering applying for NIHR portfolio status for your study? Will animals be used in this project? Click on the grey boxes below and choose from the drop down list Click on Yes/No Click on Yes/No Click on Yes/No Click on Yes/No Click on Yes/No If yes please give organisation details and award value. If yes please give organisation details and expected outcome date. If yes please give organisation details and expected outcome date. If yes give details on relevant discussions about portfolio adoption. Please note that pre-clinical work is unlikely to be in scope for the 2018 Funding Round. See Information for Applicants for further details. 5

SECTION 2 ABOUT YOUR PROJECT Project summary in lay terms for press releases or newsletters to the general public (100 words MAX) Word count Technical summary (100 words MAX) Word count NEED - What need does your project address? (150 words MAX) Word count 6

SECTION 2 ABOUT YOUR PROJECT IMPACT - What impact will your research have on cancer patients and/or cancer outcomes in Yorkshire? Please estimate to what extent this project will contribute to the goal of saving 2000 lives a year in Yorkshire by 2025? (150 words MAX) Word count PATIENT/PUBLIC INVOLVEMENT - Will this project involve members of the public, patient samples or use of patient data? If yes, please give the number of people and/or samples. PATIENT/PUBLIC BENEFIT DESCRIPTION - If this research is successful what is the timescale until patient/public benefit is realised and what are the key milestones towards achieving this benefit? (150 words MAX) Word count 7

SECTION 2 PATIENT/PUBLIC BENEFIT DIAGRAM Provide a diagram of delivery of patient/public benefit. Please ensure you indicate whether this is anticipated during and/or beyond the timeframe of the propose project (indicating number of years, if relevant). 8

SECTION 2 PROJECT MILESTONE DIAGRAM Please provide a timeline e.g. Gantt chart of the project milestones. 9

SECTION 3 FULL PROJECT DESCRIPTION Projects 350k Projects > 350k Combined project background and detailed project plan MAX 2500 words plus up to 5 tables/figures Combined project background and detailed project plan MAX 15 pages including figures/tables Project background Please complete these sections in Calibri font size 10 with 1.5 line spacing 10

FULL PROJECT DESCRIPTION Detailed project plan Including: 1) milestones; 2) cost justifications; 3) if your work has statistical analyses, relevant power calculations; and 4) an estimate of lives saved by 2025 as a result of this work, including any assumptions made Word count (or page count for larger applications) 11

REFERENCES AND SUPPORTING LITERATURE Please list each reference in numerical order. 12

Why are you and your team well placed to deliver the objectives of this project? (100 words MAX) Word count SECTION 4 RESEARCH OUTPUTS AND INTELLECTUAL PROPERTY What plans are in place to protect or commercialise any research output(s) including intellectual property? (100 words MAX) Word count 13

SECTION 5 PROJECT COSTINGS PLEASE CONSULT INFORMATION FOR APPLICANTS BEFORE STARTING THIS SECTION SALARY COSTS REQUESTED ONLY include salaries of applicants when they are a directly incurred cost of this project (see Information for Applicants) Name and job title Grade and %FTE Staff costings (including NI and superannuation) Year 1 ( ) Year 2 ( ) Year 3 ( ) Year 4 ( ) Year 5 ( ) TOTAL ( ) TOTAL SALARY COSTS IF COSTINGS ARE NOT TOTALLED ACCURATELY YOUR APPLICATION MAY NOT BE CONSIDERED NON-SALARY PROJECT COSTS Please see Information for Applicants for our costing policy Individual costs of 3000 or over must be itemised and/or a quote provided Cost details Year 1 ( ) Year 2 ( ) Year 3 ( ) Year 4 ( ) Year 5 ( ) TOTAL ( ) TOTAL COSTS IF COSTINGS ARE NOT TOTALLED ACCURATELY YOUR APPLICATION MAY NOT BE CONSIDERED SUMMARY OF TOTAL COSTS Total salary costs PLEASE CONFIRM YOU HAVE CHECKED YOUR COSTINGS (E.G. Total non-salary project costs IN EXCEL) OVERALL TOTAL Yes/No (must match total provided in Section 2) IF COSTINGS ARE NOT TOTALLED ACCURATELY YOUR APPLICATION MAY NOT BE CONSIDERED 14

Surname SECTION 6 APPLICANT EXPERTISE PRINCIPAL APPLICANT Forename Relevant qualification Subject Grade Organisation Date Relevant posts held (include job title) Organisation Date Please describe your track record in delivering outcomes related to the proposed work (150 words MAX) Word count Please provide details of up to 5 of your recent publications (please include titles) Applicants for projects > 350k may supply all relevant publications 15

COPY THIS PAGE FOR ADDITIONAL CO-APPLICANTS AND RENUMBER CO-APPLICANT 1 Surname Forename Relevant qualification Subject Grade Organisation Date Relevant posts held (include job title) Organisation Date Please describe your track record in delivering outcomes related to the proposed work (150 words MAX) Word count Please provide details of up to 5 of your recent publications (please include titles) Co-Applicants for projects > 350k may supply all relevant publications 16

COPY THIS PAGE FOR ADDITIONAL STAFF MEMBERS AND RENUMBER ADDITIONAL STAFF 1 Surname Forename Relevant qualification Subject Grade Organisation Date Relevant posts held (include job title) Organisation Date Please describe your track record in delivering outcomes related to the proposed work (150 words MAX) Word count Please provide details of up to 5 of your recent publications (please include titles) Staff members for projects > 350k may supply all relevant publications 17

SECTION 7 PREVIOUS YORKSHIRE CANCER RESEARCH AWARDS THIS SECTION IS ONLY FOR CURRENT OR PREVIOUS YORKSHIRE CANCER RESEARCH AWARD HOLDERS PLEASE COPY THIS PAGE FOR ANY ADDITIONAL AWARDS Please complete if any applicant on this project has been a Principal Applicant on a Yorkshire Cancer Research award with a start date within the past five years. Project title and award reference Project start date (DD/MM/YYYY) Project end date (DD/MM/YYYY) Award holder(s) Brief summary of project impact including advancement of knowledge, contribution to clinical practice, commercial exploitation and career development Peer reviewed research papers directly resulting from this award (full academic citation) Page number where Yorkshire Cancer Research is acknowledged Please indicate whether research papers have been submitted to disclosure@ycr.org.uk and/or press@ycr.org.uk. Please provide Yorkshire Cancer Research disclosure reference number(s) or any IP opinions from Yorkshire Cancer Research with relevant dates (where applicable). Have either of the following been provided to Yorkshire Cancer Research? If so, please give relevant dates. 1) Annual Reports 2) KPI reports 18

SECTION 8 PREFERRED REVIEWERS Applicants must name AT LEAST 2 and up to 4 preferred reviewers from OUTSIDE YORKSHIRE. Those who have co-published with ANY applicant within the past 3 years are not eligible. Reviewer 1 Name Email Tel Organisation Expertise Reviewer 2 Name Email Tel Organisation Expertise Reviewer 3 Name Email Tel Organisation Expertise Reviewer 4 Name Email Tel Organisation Expertise Name Organisation SECTION 8 EXCLUDED REVIEWERS Applicants may name up to 2 EXCLUDED reviewers from OUTSIDE YORKSHIRE Excluded reviewer 1 Email Name Organisation Excluded reviewer 2 Email 19

SECTION 9 ACCEPTANCE OF AWARD CONDITIONS AND POLICIES FOR AWARDS I/We shall be actively engaged in, and in day-to-day control of, the project. I/We have read the Charity s current Award Conditions and Policies for Awards. If my/our application is successful I/we agree to abide by them. of Principal Applicant(s) Date This application MUST be submitted via the Principal Applicant s Line Manager or Head of Department AND the officer responsible for the administration of any award granted. Each should sign the following declaration: I confirm I have read the application and that, if awarded, the work will be accommodated and administered in the Organisation/Department in accordance with the Award Conditions and Policies for Awards. The staff gradings and salaries quoted are correct and in accordance with the normal practice of this Organisation. HEAD OF DEPARTMENT/LINE MANAGER Title click title Name Job title Organisation Address line 1 Address line 2 Town/City Postcode Phone number Postal Address Email Date (dd/mm/yyyy) ADMINISTRATIVE AUTHORITY Title click title Name Job title Organisation Address line 1 Address line 2 Town/City Postcode Phone number Postal Address Email Date (dd/mm/yyyy) 20

CHECKLIST FOR APPLICANTS PLEASE COMPLETE BEFORE SUBMITTING YOUR APPLICATION Have you read the Information for Applicants, Award Conditions and Policies for Awards? Have you consulted with a relevant Clinical Studies Group? Have you consulted the NIHR Clinical Research Network Yorkshire and Humber team to discuss NIHR portfolio adoption and potential CRN support for your study? Have you completed all sections of the application form? Have all the applicants signed Section 1? Have applicants provided employment end dates if they fall before the end of the project? Have you had a Patient or Lay Representative read and comment on the application and particularly the project lay summary? Do you have permission to provide their contact details to Yorkshire Cancer Research? Have you checked that all amounts in Section 5 have been added up correctly? We recommend using Excel to ensure totals are correct. Are only direct project costs included? Have you provided a breakdown for any costs over 3000? Applications with costings that do not add up correctly may not be considered Has the form been signed by the Head of Department/Line Manager and the appropriate Organisation Administrative Authority in Section 9? Have you ensured that you have not altered the format of the original application form? Note that applications must conform to the word count and formatting rules where indicated. The only additions allowed to the application are notices of ethical approval, letters signifying collaboration and quotations for costings which you can include at the end of the application or send as attachments in PDF format. Manuscripts and papers may be sent to accompany the application as PDF attachments if they have been accepted for publication and they are not available in the public domain. Please also send 15 hard copies of any supplemental material. Please note if your application passes the Strategic Fit Assessment you will be asked to provide further hard copies of the supplementary material. Have you printed and signed the original application form? (electronic signatures are accepted). In addition to this have you sent a total of 15 double-sided photocopies to Jacob Smith House, 7 Grove Park Court, Harrogate, HG1 4DP? Hard copies must also be received by the application deadline. Have you emailed a copy in Microsoft Word format to research@ycr.org.uk? Application forms in PDF formats will not be accepted. Please name the file in the following format [SURNAME] - 2018 FULL APPLICATION. Please do not submit an application if you answer no to any of the above questions. If you do not receive an acknowledgement within 7 days of submitting your application please contact research@ycr.org.uk or phone 01423 501269. 21