Penn Medicine. Adult ECMO Symposium Friday-Saturday, March 31-April 1, 2017 A CME/ CNE- CERTIFIED COURSE

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Penn Medicine Adult ECMO Symposium 2017 Friday-Saturday, March 31-April 1, 2017 A CME/ CNE- CERTIFIED COURSE Smilow Center for Translational Research Perelman School of Medicine University of Pennsylvania 3400 Civic Center Boulevard Philadelphia, PA 19104 I N C O N J U N C T I O N W I T H Penn Medicine Nursing Endorsed by: COURSE DIRECTORS: Jacob T. Gutsche, MD J. Eduardo Rame, MD Joyce W. Wald, DO, FACC

Program Overview & Target Audience This symposium is designed as a two-day educational program with a series of lectures on adult extracorporeal membrane oxygenation (ECMO). The symposium will also offer the opportunity for hands-on training on extracorporeal life support technique to support cardiac and respiratory patients whose heart and lungs are unable to provide an adequate amount of gas exchange to sustain life. Subject experts will present insights into the technical aspects of the use of extracorporeal membrane oxygenation along with risks, benefits, and outcomes. Best practices in medical and nursing management of the ECMO patients along with how perfusion can empower nursing to manage ECMO patients in the critical care setting will be discussed. This activity has been designed for cardiovascular, pulmonary, critical care and anesthesia physicians, surgeons, perfusionists, nurse practitioners, physician assistants, respiratory therapists, nurses, fellows, residents and other healthcare professionals who want to enhance their extracorporeal membrane oxygenation knowledge. Learning Objectives Upon completion of this activity, participants should be able to: Discuss the appropriate care of adult ECMO patients with respiratory and/or cardiac compromise Review the risk/benefit and outcomes of ECMO technology in different clinical scenarios Describe best practices regarding the medical and nursing management of the ECMO-supported patient Define center-based interaction between perfusionists and nurses to improve management in ECMO-supported patients in the critical care setting Accreditation Physicians: The Perelman School of Medicine at the University of Pennsylvania is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Nurses: Penn Medicine Nursing is an approved provider of continuing nursing education by the Pennsylvania State Nurses Association, an accredited approver by the American Nurses Credentialing Center s Commission on Accreditation. Approval # 124-3-H-15 Perfusionists: The American Board of Cardiovascular Perfusion (ABCP) has approved this activity. Designation of Credit Physicians: The Perelman School of Medicine at the University of Pennsylvania designates this live activity for a maximum of 13.5 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Nurses: The program will award 13.58 contact hours. Perfusionists: This activity will award 15.6 Category 1 CEU s. Physician Assistants: AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit from organizations accredited by ACCME or a recognized state medical society. PAs may receive a maximum of 13.5 Category 1 credits for completing this activity.

Certificates and Transcripts: A few days prior to the symposium, pre-registered participants will receive an email containing directions and additional symposium information. After the symposium has concluded, all participants will receive a follow-up email containing a link to conference landing page with instructions to claim your credit. Once participants submit the request for credit, the credit can be viewed on a transcript or a certificate can be printed by logging onto www.penncmeonline.com. Disclosures The Perelman School of Medicine at the University of Pennsylvania, Office of Continuing Medical Education, adheres to the ACCME Standards for Commercial Support. Faculty disclosure information will be made available in the conference materials and syllabus. Faculty members are also expected to disclose to participants any discussions of off-label and/or investigational uses of pharmaceutical products within their presentations. Registration Fee The registration fees for Penn Medicine Adult ECMO Symposium 2017 are $500 for physicians and industry employees, $450 for STS Members, $300 for perfusionists, nurses, healthcare professionals, residents and fellows. Penn Medicine employees, faculty, staff and students will receive special course rates of $150 for physicians, $100 for perfusionists, nurses and healthcare professionals, residents, and fellows. A valid Penn Medicine ID is required to receive the special rate. Registration fees for the Simulation Training are $150 for physicians and industry employees, $100 for perfusionists, nurses, healthcare professionals, residents and fellows and $75 for Penn Medicine employees, faculty, staff and students. The registration fee includes attendance to the symposium, a course booklet and a link to view the presentations online, continental breakfasts, mid-morning and afternoon refreshments, lunch and post-symposium reception. If you are registering with a credit card, please register online at www.penncmeonline.com, then clicking on CME Activities/Live Events. To pay by check, complete the registration form and mail it in with your check. We cannot accept faxed or mailed registration forms with credit card information. Please see the top of the registration form for mailing information. All registrations will be confirmed in writing if your registration form and fee are received by March 17, 2017. Cancellation and Refund Policy In order to process refunds for course withdrawals, cancellations must be received in writing by March 17, 2017 (subject to a service charge of 10% of the registration fee but not less than $15.00). No refunds will be issued after March 17, 2017. The University reserves the right to cancel or postpone any course due to unforeseen circumstances. In the event of cancellation or postponement, the University will refund registration fees but is not responsible for related costs or expenses to participants, including cancellation fees assessed by hotels, airlines, and travel agencies. Meeting Location Penn Medicine Adult ECMO Symposium 2017 will be held Friday-Saturday, March 31- April 1, 2017 in the Arthur H. Rubenstein Auditorium at the Smilow Center for Translational Research, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, Pennsylvania, 19104.

Directions & Parking The Arthur H. Rubenstein Auditorium is located on the 1st Floor level of the Smilow Translational Research Center. Smilow TRC is connected to the Perelman Center for Advanced Medicine and is located at 3400 Civic Center Blvd, Philadelphia, PA. We strongly recommend you GPS or use an online driving directions site (such as mapquest.com, drivingdirections.com or googlemaps.com) for exact directions to and from your starting point or if you prefer, to take public transportation to and from campus, please visit http://www.upenn.edu/services/transportation for options. On Friday, March 31st, the 3600 Civic Center Blvd Parking Garage is open for public parking. This garage is accessible from Civic Center Blvd and is located at Civic Center Blvd and West Service Drive (next to the Colket Research Center). Smilow TRC is about a 5 minute walk from this parking garage. Parking is $20 per day. This garage is only open Monday-Friday. It is closed on weekends. On Saturday, April 1st, the Perelman Center for Advanced Medicine garage (3400 Civic Center Blvd) is open to those attending the ECMO Symposium. Parking is $13-$20 per day, depending on your length of stay. Parking fees are not paid for, validated or reimbursed by the symposium. Overnight Accommodation Options There are no special room rates for course participants. Please contact the following hotels directly if you are interested in overnight room reservations (rooms subject to availability): Homewood Suites by Hilton 4109 Walnut Street Philadelphia, PA, 19104 215-382-1111 www.homewoodunivcity.com *Homewood Suites offers a complimentary shuttle service The Inn at Penn 3600 Sansom Street, Philadelphia, PA 19104 215-222-0200 www.theinnatpenn.com Sheraton University City Hotel 3600 Chestnut Street Philadelphia, PA 19104 215-387-8000 www.sheraton.com/universitycity Services for the Disabled If special arrangements are required for an individual with a disability to attend this meeting, please contact the Office of Continuing Medical Education no later than March 17, 2017, at 215-898-6400. Nondiscrimination Statement The University of Pennsylvania values diversity and seeks talented students, faculty, and staff from diverse backgrounds. The University of Pennsylvania does not discriminate on the basis of race, sex, sexual orientation, gender identity, religion, color, national or ethnic origin, age, disability, or status as a Vietnam Era Veteran or disabled veteran in the administration of educational policies, programs or activities; admissions policies; scholarship and loan awards; athletic, or other University administered programs or employment. Questions or complaints regarding this policy should be directed to Executive Director, Office of Affirmative Action and Equal Opportunity Programs, 3600 Chestnut Street, Sansom Place East Suite 228, Philadelphia, PA 19104-6106 or 215-898-6993 (Voice) or 215-898-7803 (TDD). www.upenn.edu/affirm-action.

The following Course Directors & Faculty hold academic and/or clinical appointments from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine, Philadelphia, PA COURSE DIRECTORS Associate Professor of Cardiothoracic Surgery Surgical Director, Lung Transplantation and ECMO Director, Thoracic Transplantation Jacob T. Gutsche, MD Assistant Professor of Anesthesiology and Critical Care Co-Medical Director Penn Lung Rescue Program System Director for Cardiovascular Critical Care and Postoperative Care, UPHS J. Eduardo Rame, MD Assistant Professor of Medicine Medical Director, Mechanical Circulatory Support Joyce W. Wald, DO, FACC Associate Professor of Clinical Medicine Associate Director, Mechanical Circulatory Support Program Director, Practice Development FACULTY Michael Acker, MD William Maul Measey Professor of Surgery Chief, Division of Cardiothoracic Surgery Director, Heart & Vascular Center Vice Chair, Department of Surgery Director, Thoracic Residency Program Joseph Adler, PT, DPT, CCS Physical Therapist Acute Care Team Leader, Pulmonary Rehabilitation and Conditioning Hospital of the University of Pennsylvania Good Shepherd Penn Partners Edward Cantu, III, MD Assistant Professor of Surgery Associate Surgical Director Lung Transplantation Director, Ex Vivo Lung Perfusion Center Kathryn Gray, CCP, MHA Director, Perfusion Services Hospital of the University of Pennsylvania John C. Haddle, CCP, LP, MBA Director, Perfusion Services Penn Presbyterian Medical Center Pennsylvania Hospital Kelly Hoenisch, BSN, RN Nurse Manager, Heart &Vascular ICU Jiri Horak, MD Assistant Professor of Clinical Anesthesiology and Critical Care Anesthesia Chief, Adult Congenital Heart Program Director, Cardiothoracic Intensive Care Unit Medical Director, Long-Term Acute Care Medical Director, Intermediate Cardiac Surgery Unit Sameer Khandhar, MD Clinical Assistant Professor of Medicine Cardiovascular Division Penn Presbyterian Medical Center Mark E. Mikkelsen, MD, MSCE Assistant Professor of Medicine Director, Medical Intensive Care Unit Associate Scholar, Center for Clinical Epidemiology and Biostatistics Director, Medical Critical Care Transition Program Chief, Section of Medical Critical Care, Pulmonary, Allergy, and Critical Care Division Nuala J. Meyer, MD, MS Assistant Professor of Medicine Emily Moyer, MSN, CRNP Nurse Practitioner, Cardiothoracic Surgical ICU Mary Frances Quinn, BSN, RN, CCRN Clinical Nurse IV, Distinguished Nurse Clinician ECMO Educator Heart & Vascular ICU Hospital of the University of Pennsylvania Prashanth Vallabhajosyula, MD, MS Assistant Professor of Surgery Division of Cardiovascular Surgery William J. Vernick, MD Associate Professor of Clinical Anesthesiology and Critical Care Director, Cardiac Anesthesia Penn-Presbyterian Medical Center Co-Medical Director, Penn Lung Rescue Matthew L. Williams, MD Assistant Professor of Surgery Penn Presbyterian Medical Center GUEST SPEAKERS Ayyaz Ali, MB ChB, PhD Consultant Surgeon Department of Cardiothoracic Surgery Papworth Hospital Cambridge, United Kingdom Michael Anselmi BS,CCP, LP Procirca Regional Director UPMC Procirca Pittsburgh, PA Peter Arlia, MBA, CCP, LP Perfusion Director University of Pittsburgh Medical Center Pittsburgh, PA Matthew D. Bacchetta, MD Surgical Director, Adult Extracorporeal Membrane Oxygenation Program Director, Pulmonary Thromboendarterectomy Program Surgical Director, Pulmonary Hypertension Comprehensive Care Center New York Presbyterian Columbia University College of Physicians & Surgeons New York, NY David Baran, MD Director, Heart Failure and Transplant Research Newark Beth Israel Medical Center Rutgers New Jersey Medical School Newark, NJ Daniel Brodie, MD Associate Professor of Medicine Director, Medical Intensive Care Units and Medical Critical Care Service Director, Medical ECMO Program Co-Director, Center for Acute Respiratory Failure New York Presbyterian Columbia University College of Physicians & Surgeons New York, NY Aly El Banayosy, MD Executive Director, Acute Circulatory Support and Advanced Critical Care Integris Baptist Medical Center Oklahoma City, OK Melissa Grayson, BS, CCP, LP ECMO Coordinator UPMC Procirca Pittsburgh, PA Bartley P. Griffith, MD Professor of Surgery Thomas E. and Alice Marie Hales Distinguished Professorship in Transplant Surgery University of Maryland School of Medicine Baltimore, MD Corey E. Ventetuolo, MD, MS Director, Adult Extracorporeal Life Support Program Associate Director, Rhode Island Hospital Pulmonary Hypertension Center Assistant Professor of Medicine, Divisions of Pulmonary, Critical Care & Sleep Medicine and Health Services Policy & Practice Alpert Medical School of Brown University Providence, Rhode Island Kenton J. Zehr, MD Associate Professor of Surgery Assistant Director Dana and Albert Cubby Broccoli Center for Aortic Disease Johns Hopkins Hospital Baltimore, MD

A G E N D A Penn Medicine Adult ECMO Symposium 2017 Friday-Saturday, March 31-April 1, 2017 Friday, March 31, 2017 7:30 8:00 AM Registration and Breakfast 8:00 8:10 AM Welcome INTRODUCTION Moderators: Michael A. Acker, MD and Bartley P. Griffith, MD 8:10 8:40 AM Past, Present and Future of Respiratory Support Devices Bartley P. Griffith, MD 8:40 9:00 AM Developing and Building an ECMO Program Kenton J. Zehr, MD 9:00 9:20 AM Indications for VA and VV ECMO: General Overview of Current Evidence Corey E. Ventetuolo, MD, MS 9:20 9:40 AM Pushing the Limits with ECMO in Trauma for the Civilian and Military Population Matthew D. Bacchetta, MD 9:40 10:00 AM Panel Discussion with Q&A 10:00 10:20 AM Coffee Break ECMO IMPLEMENTATION AND MANAGEMENT Moderators: Jacob T. Gutsche, MD and 10:20 10:40 AM Cannulation Strategies for Cardiac and Respiratory Support Matthew Bacchetta, MD 10:40 11:00 AM Pitfalls in Management of the ECMO Supported Patients Jiri Horak, MD 11:00 11:20 AM Anticoagulation and Blood Conservation During ECMO Support Daniel Brodie, MD 11:20 11:40 AM Mobile ECMO for Rescue: Current Status and Regional Experience Jacob T. Gutsche, MD 11:40 AM 12:00 PM Pharmacology Considerations During ECMO Support Daniel Brodie, MD 12:00 12:30 PM Lunch CARDIAC SESSION Moderators: Aly El Banayosy, MD and Joyce W. Wald, DO, FACC 12:30 12:45 PM Percutaneous VAD Options to Support Patients in CS: Choosing Candidates Based on Evidence David Baran, MD 12:45 1:00 PM ECMO in Cardiogenic Shock as Bridge to Decision: Candidate Selection, Implementation and Exit Strategies 1:00 1:15 PM ECMO in ECPR: Are we Ready for it? Aly El Banayosy, MD 1:15 1:30 PM Myocardial Recovery and ECMO Weaning: Who and When? J. Eduardo Rame, MD 1:30 1:45 PM ECMO Use in Resuscitation of Cardiac Donors for Heart Transplant: The Papworth Experience Ayyaz Ali, MB ChB, PhD 1:45 2:00 PM Panel Discussion with Q&A 2:00 2:20 PM Coffee Break RESPIRATORY SESSION Moderators: Mark E. Mikkelsen, MD, MSCE and William J. Vernick, MD 2:20 2:40 PM Current Overview in ARDS Nuala Meyer, MD 2:40 3:00 PM ECMO in ARDS: What is Next After the Cesar Trial? Jacob T. Gutsche, MD 3:00 3:20 PM ECMO in Lung Transplantation: From Bridge to Primary Graft Dysfunction 3:20 3:40 PM ECMO and other Devices in Acute Pulmonary Embolism Sameer Khandhar, MD 3:40 4:00 PM Awake and Ambulatory ECMO: Where Do We Stand? Aly El Banayosy, MD 4:00 4:20 PM Use of ECMO Technologies to Resuscitate Failing Donor Lungs: The Penn EVLP Experience Edward Cantu, III, MD 4:20 4:40 PM Panel Discussion with Q&A CASE PRESENTATIONS Moderators: Joyce W. Wald, DO, FACC, Aly El Banayosy, MD and Prashanth Vallabhajosyula, MD, MS 4:40 4:45 PM Importance of Proper Time for Referral Cases Joyce W. Wald, DO, FACC 4:45 5:00 PM Penn Medicine: A Case of Acute Right Heart Failure Due to PAH Rescued by ECMO 5:00 5:15 PM Lehigh Valley Hospital: Title TBD 5:15 5:30 PM Lancaster General Hosptial: Title TBD 5:30 5:45 PM Geisinger Medical Center: Title TBD 5:45 6:00 PM Christiana Hospital: Title TBD 6:00 6:15 PM Penn Medicine: Title TBD 6:15 PM Adjourn 6:15 7:15 PM Exhibitor Fair and Cocktail Reception Saturday, April 1, 2017 7:30 8:00 AM Registration and Breakfast THE ECMO TEAM Moderators: J. Eduardo Rame, MD, Jacob T. Gutsche, MD, Kelly Hoenisch, BSN, RN, Kathryn Gray, CCP, MHA and John Haddle, CCP, LP, MBA 8:00 8:20 AM Perfusionist s Role in ECMO Support Kathryn Gray, CCP, MHA 8:20 8:40 AM Role of the Nurse/Specialist in ECMO in the Modern ICU Kelly Hoenisch, BSN, RN 8:40 9:00 AM Role of the ICU Nurse Practitioner in the Management of Patients on ECMO Emily Moyer, MSN, CRNP 9:00 9:20 AM ECMO Rehabilitation: Is it Possible? Joseph Adler, PT, DPT, CCS 9:20 9:40 AM The Surgeon s Role in ECMO Cannulation: Preventing Vascular Complications Matthew L. Williams, MD 9:40 10:00 AM Maintaining Competency in the ECMO Team Mary Frances Quinn, BSN, RN, CCRN 10:00 10:20 AM Panel Discussion: Kathryn Gray, CCP, MHA, Jacob T. Gutsche, MD, John Haddle, CCP, LP, MBA, Kelly Hoenisch, BSN, RN, Emily Moyer, MSN, CRNP, Matthew L. Williams, MD, Joyce W. Wald, DO, FACC SIMULATIONS 10:20 10:45 AM Coffee Break for Simulation Attendees Only 10:45 11:05 AM Overview of Current ECMO Devices and Technologies Peter Arlia, MBA, CCP, LP 11:05 AM 12:05 PM Veno-Arterial and Veno-Venous ECMO Simulation (Group 1) 12:05 1:05 PM Veno-Arterial and Veno-Venous ECMO Simulation (Group 2) 1:05 1:15 PM Closing Remarks 1:15 PM Adjourn

REGISTRATION FORM Penn Medicine Adult ECMO Symposium 2017 Friday-Saturday, March 31-April 1, 2017 If you are registering using your credit card, please register online at: www.penncmeonline.com and click on CME Activities/Live Events. Questions? Contact us at: Phone: 215-898-6400 or 215-898-8005 penncme@mail.med.upenn.edu Please note we are unable to accept faxed registration forms. Please print or type Name (First) (Last) Academic Degree Medical Specialty Affiliation (Hospital, Office, or Company) Address ( Affiliation or Home) City State Zip Phone Fax E-mail Registration Fee (pre-payment is required to be officially registered) Practicing Physicians and Industry $500 STS Members $450 Perfusionists, Nurses, Healthcare Professionals, Residents and Fellows $300 Penn Medicine Rates Penn Medicine Practicing Physicians $150 Penn Medicine Perfusionists, Nurses, Healthcare Professionals, Residents and Fellows $100 Penn Medicine ID # ECMO Simulation Training (Optional): Practicing Physicians and Industry $150 Perfusionists, Nurses, Healthcare Professionals, Residents and Fellows $100 Penn Medicine Faculty or Staff $75 Penn Medicine ID # Payment Method If you are paying by credit card, please register online at www.penncmeonline.com and click on CME Activities/Live Events. If you are paying by check, you may mail your completed registration form and check made payable to The Trustees of the University of Pennsylvania/CME to: Conference Coordinator, Perelman School of Medicine at the University of Pennsylvania, Office of Continuing Medical Education 150 Anatomy/Chemistry Building, 3620 Hamilton Walk Philadelphia, PA 19104-6061 Do not include any credit card information on the registration form or email any credit card information Please Note: Walk-in registrants must bring payment to the program. Seating may be limited for walk-in registrants.

150 Anatomy/Chemistry Building 3620 Hamilton Walk Philadelphia, PA 19104-6061 Penn Medicine Adult ECMO Symposium 2017 A C M E / C N E - C E RT I F I E D C O U R S E Friday-Saturday, March 31-April 1, 2017 Smilow Center for Translational Research Perelman School of Medicine University of Pennsylvania 3400 Civic Center Boulevard Philadelphia, PA 19104 Non-Profit Org. U.S. Postage P A I D Permit No. 2563 Phila., PA 19104