CHIPS news. noticias nouvelles notícias nieuws. CHIPS Data Campaign. Database Closure. Please turn to page 3 to find out if your centre has any

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CHIPS news noticias nouvelles notícias nieuws VOLUME 6 ISSUE 8 AUGUST & SEPTEMBER 2013 CHIPS Data Campaign INSIDE THIS ISSUE: Data Campaign progress 1 Database closure date 1 Responding to data queries 2 Final Collaborators Meeting Invites sent 2 We now have all forms for 100% of CHIPS recruits! Thank you to each and every site for helping us to achieve this target! There are 46 sites (49%) with unresolved queries, and so our dataset is not yet completely clean. The last set of data queries was distributed to all relevant sites on August 2, 2013, and we have received responses from all but 8 sites. The next set of queries will be distributed before the end of October 2013. Current Complete and Please turn to page 3 to find out if your centre has any Clean Data Report 3 outstanding queries. SEND US YOUR QUERY REPLIES TODAY! Data query responses (as completed on the CHIPS Data Query Table) may be sent to the DCC by e-mail or fax: Email: chipsdata@sunnybrook.ca Fax: +1-416-480-5633 CHIPS Contacts: CHIPS Clinical Co ordinating Centre (CCC) Email: chips@cw.bc.ca Ph: +1 604 875 2959 CHIPS Data Co ordinating Centre (DCC) Email: chipsdata@sunnybrook.ca Ph: +1 416 480 5629 We appreciate your continued efforts to help us achieve 100% CLEAN data! Database Closure The CHIPS database will be closing on November 30 th, 2013! Please make a special effort to respond to any outstanding queries for your centre as soon as possible!

Responding to data queries When answering queries that request confirmation of particular values, please remember to go back to your primary source records (e.g. maternal antenatal chart or clinic records) to double-check and confirm these values. It is not adequate to only review the value that is written on the original data collection form. Primary source records should be consulted to verify the values being queried. Example: Final International Collaborators Meeting Invitations have been sent! These blood pressure measurements should be confirmed by going back to the patient chart to find and verify the values. The primary results of the CHIPS Trial will be presented at the Final International CHIPS Collaborators Meeting to be held in VANCOUVER, CANADA on THURSDAY, FEBRUARY 20 th, 2014. Formal invitations have now been sent by email to the primary site investigator from sites that recruited at least 5 patients to the trial. If you have not received an invitation, but believe that you should have, please contact the CHIPS Clinical Co-ordinating Centre at chips@cw.bc.ca Please remember to return the meeting response forms by email or fax as soon as possible so that we can plan for your attendance and make a hotel reservation for you. We look forward to welcoming you in Vancouver!

CHIPS Primary Data Report Centre # Patients Data Forms Received Total # of Queries ARGENTINA Hospital LC Lagomaggiore,Mendoza 16 All forms received 12 Hospital Avellaneda,Tucuman 10 All forms received 1 Hospital JR Vidal,Corrientes 8 All forms received 3 Hospital JM Cullen,Santa Fe 2 All forms received 0 Congratulations! AUSTRALIA Ipswich Hospital,Ipswich 36 All forms received 2 Women's and Children's Hospital,Adelaide 18 All forms received 0 Congratulations! King Edward Memorial Hospital,Subiaco 17 All forms received 0 Congratulations! Campbelltown Hospital,Penrith South 8 All forms received 1 Liverpool Hospital,Penrith South 5 All forms received 10 St John of God Hospital,Subiaco 1 All forms received 3 BRAZIL Maternidade de Vila Nova Cachoeirinha,Sao Paulo 7 All forms received 1 Hospital Universitario Antonio Pedro,Niteroi 6 All forms received 5 Maternidade Escola da UFRJ,Rio de Janeiro 4 All forms received 0 Congratulations! Hospital Sao Lucas - PUCRS,Porto Alegre 2 All forms received 2 CANADA Children's & Women's Health Centre of BC,Vancouver 32 All forms received 0 Congratulations! Jim Pattison Outpatient Care and Surgery Centre,Surrey 26 All forms received 0 Congratulations! St Michael's Hospital,Toronto 22 All forms received 7 Calgary Health Region - Foothills Hospital,Calgary 21 All forms received 3 Sunnybrook Health Sciences Centre,Toronto 19 All forms received 0 Congratulations! IWK Health Centre,Halifax 19 All forms received 1 Royal Alexandra Hospital,Edmonton 16 All forms received 0 Congratulations! Hopital Sainte-Justine,Montreal 15 All forms received 0 Congratulations! CHUS Fleurimont,Sherbrooke 13 All forms received 1 Ottawa Hospital Civic Division,Ottawa 13 All forms received 1 Mount Sinai Hospital,Toronto 8 All forms received 1 Royal University Hospital,Saskatoon 6 All forms received 0 Congratulations! St Paul's Hospital,Vancouver 5 All forms received 0 Congratulations! Ottawa Hospital General Division,Ottawa 5 All forms received 0 Congratulations! Toronto East General Hospital,Toronto 5 All forms received 15 London Health Sciences Centre,London 4 All forms received 0 Congratulations! Royal Victoria Hospital,Montreal 2 All forms received 0 Congratulations! Women s Health Centre,St John's 1 All forms received 0 Congratulations! Regina General Hospital,Regina 1 All forms received 1 CHILE Hospital Dr Sotero del Rio,Puente Alto 45 All forms received 3 Thursday, October 03, 2013 Page 1 of 3

Centre # Patients Data Forms Received Total # of Queries Hospital Base Osorno,Osorno 12 All forms received 4 COLOMBIA Corporacion Comfenalco Valle - Universidad Libre,Cali 20 All forms received 0 Congratulations! Clinica Versalles,Cali 11 All forms received 0 Congratulations! Clinica Materno Infantil Farallones,Cali 5 All forms received 0 Congratulations! ESTONIA Tartu University Hospital - Women's Clinic,Tartu 19 All forms received 2 HUNGARY University of Debrecen,Debrecen 5 All forms received 1 ISRAEL Hillel Yaffe Medical Center,Hadera 6 All forms received 0 Congratulations! Ma'ayney Hayeshua Medical Center,Bnei Brak 3 All forms received 0 Congratulations! Nazareth Hospital (EMMS),Nazareth 3 All forms received 0 Congratulations! JORDAN Islamic Hospital,Amman 13 All forms received 0 Congratulations! NEW ZEALAND Christchurch Women's Hospital,Christchurch 16 All forms received 0 Congratulations! Waitemata Health-North Shore Hospital,Auckland 1 All forms received 0 Congratulations! POLAND Medical University of Gdansk,Gdansk 9 All forms received 0 Congratulations! Polish Mothers Memorial Hospital,Lodz 9 All forms received 0 Congratulations! University School of Medical Sciences,Poznan 3 All forms received 7 THE NETHERLANDS Academic Medical Center,Amsterdam 28 All forms received 2 OLVG,Amsterdam 13 All forms received 2 UMCU,Utrecht 10 All forms received 3 VU Medical Center,Amsterdam 9 All forms received 1 Maxima Medical Centre,Veldhoven 8 All forms received 2 UMCG,Groningen 6 All forms received 0 Congratulations! Tergooiziekenhuizen,Hilversum 5 All forms received 0 Congratulations! Isala Klinieken Zwolle,Zwolle 5 All forms received 0 Congratulations! MUMC Maastricht,Maastricht 4 All forms received 1 St Antonius Ziekenhuis,Nieuwegein 3 All forms received 0 Congratulations! Kennemer Gasthuis Haarlem,Haarlem 2 All forms received 0 Congratulations! Jeroen Bosch Hospital,'s-Hertogenbosch 1 All forms received 0 Congratulations! Flevo ziekenhuis,almere 1 All forms received 0 Congratulations! Diakonessen Ziekenhuis,Utrecht 1 All forms received 0 Congratulations! UK Guy's & St Thomas' Hospital,London 38 All forms received 0 Congratulations! New Cross Hospital,Wolverhampton 31 All forms received 1 Nottingham City Hospital,Nottingham 30 All forms received 0 Congratulations! Royal Victoria Infirmary,Newcastle upon Tyne 22 All forms received 1 Thursday, October 03, 2013 Page 2 of 3

Centre # Patients Data forms received Total # of Queries Queen's Medical Centre,Nottingham 22 All forms received 3 Liverpool Women's Hospital,Liverpool 16 All forms received 1 Bradford Royal Infirmary,Bradford 13 All forms received 8 Wexham Park Hospital,Slough 12 All forms received 1 Leicester Royal Infirmary,Leicester 12 All forms received 0 Congratulations! City Hospitals Sunderland NHS Foundation Trust,Sunderland 10 All forms received 0 Congratulations! South Warwickshire NHS Trust,Warwick 9 All forms received 1 York District Hospital,York 8 All forms received 0 Congratulations! Derriford Hospital,Plymouth 8 All forms received 0 Congratulations! Singleton Hospital,Swansea 7 All forms received 1 St Mary's Hospital,Manchester 6 All forms received 1 Chesterfield Royal Hospital,Chesterfield 6 All forms received 0 Congratulations! Sheffield Teaching Hospitals NHS Foundation Trust,Sheffield 6 All forms received 2 Birmingham Women's Hospital,Birmingham 5 All forms received 4 The Royal Derby Hospital,Derby 3 All forms received 1 Lancashire Teaching Hospitals NHS Foundation Trust,Lancas 3 All forms received 0 Congratulations! Basildon & Thurrock University Hospital,Basildon 1 All forms received 0 Congratulations! USA Cooper University Hospital,Camden 13 All forms received 0 Congratulations! Medical University of South Carolina,Charleston 11 All forms received 3 Beth Israel Deaconess,Boston 8 All forms received 1 Yale-New Haven Hospital,New Haven 8 All forms received 6 Norton Hospital Downtown,Louisville 7 All forms received 0 Congratulations! Meriter Hospital,Madison 6 All forms received 2 East Carolina University,Greenville 6 All forms received 0 Congratulations! Oregon Health & Science University,Portland 5 All forms received 0 Congratulations! University of North Carolina,Chapel Hill 4 All forms received 2 Norton Suburban Hospital,Louisville 2 All forms received 0 Congratulations! 987 patients 0 Forms Outstanding! *The query process is ongoing, and additional queries may be generated between reports as forms are received. Queries may remain on the report if further information is required. **The number of queries outstanding is accurate to October 2, 2013. Please check the next Primary Data Report to see an updated number for any queries resolved after that date. Thursday, October 03, 2013 Page 3 of 3