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Sponsorship prospectus Your guide to exhibition, sponsorship and advertising opportunities Global Spine Congress Milan, Italy May 3 6, 2017 www.gsc2017.org 2016 AOSpine International. All rights reserved. E & OE. 1

SHOWCASE YOUR LATEST TECHNOLOGY, PRODUCTS, AND SERVICES TO AN INFLUENTIAL AND TARGETED AUDIENCE OF KEY DECISION-MAKERS Milan, Italy May 3 6, 2017 For more information: www.gsc2017.org The Global Spine Congress (GSC) is THE international meeting place for over 1,500 spine surgeons and industry professionals dedicated to enhancing their expertise and sharing knowledge in developing new approaches to the treatment of spinal disorders. The 6th Annual Global Spine Congress is the AOSpine International Meeting which includes an audience of global participants, spine surgeons and researchers, and original research presentations. For exhibitors and event sponsors, this is an outstanding opportunity to showcase their products, services and latest innovations to a growing international, precisely targeted audience of skilled, knowledgeable spine surgeons from both neurosurgery and orthopedic surgery institutions. Key benefi ts of exhibiting and sponsoring Reach more than 1,500 spine care professionals in a cost-effective manner, with the visibility and awareness that you demand Build and develop relationships with purchasing infl uencers and senior decision makers Exhibit your products and services in an interactive environment and demonstrate hands-on solutions to hundreds of delegates Educate qualifi ed professionals about your products through scheduled presentations Launch new products and services in a high-profi le venue and capture the attention of an engaged international audience Create a positive and lasting impression in the marketplace Network with key opinion leaders, surgeons, and faculty from a wide variety of organizations from all over the world Organizer AOSpine International, a clinical division of AO Foundation, is a global community of spine care professionals, from spine, neuro, and orthopedic surgeons to researchers and educators. AOSpine places great emphasis on the importance of education and research by providing our members with a large portfolio of advanced academic courses and continuing professional development opportunities. Vision AOSpine is the leading global academic community for innovative education and research in spine care, inspiring lifelong learning and improving patients lives. 2

Overview Regional representation The Global Spine Congress (GSC) provides you with a unique opportunity to support a highly-regarded scientific program and engage an audience of spine care professionals from over 70 countries. Since AOSpine launched the GSC in San Francisco, the paper submission rate and number of participants and speakers has grown rapidly with record numbers expected for the Dubai 2016 edition. With continuing growth expected for Milan, the exposure to such a remarkably specialized group at the top of their respective fields is invaluable. Combined Global Spine Congresses Africa 1% Asia Pacific North America 23% 27% 15% 17% Aligning your organization with this event offers you access to the active community of AOSpine International, the largest international network of spine care professionals, with more than 27,000 members and associates. The AOSpine community is composed of surgeons, researchers, and educators who are key opinion leaders, and serve in decision-making roles. Many of them will attend this event to enhance their expertise, and will look to your products and services to help them make educated decisions in order to provide better care for their patients, and further their knowledge. 4% 5% 33% 35% Europe Milan in Europe provides congress participants from all over the world convenient access to this unqiue spine meeting. Sponsorship and exhibition Use this event as a platform to launch your newest products or services. The GSC offers you ample opportunities to nurture your current client relationships and build new ones. With a wide range of exhibition and sponsorship choices, we offer you high value and flexibility allowing you to connect with a highly engaged and loyal audience. Our exhibition and sponsorship offerings are designed to suit any budget. Take advantage of the many tangible and intangible benefits of exhibiting and sponsoring at the GSC. Global Spine Congress From Wednesday, May 3, 2017 to Saturday, May 6, 2017 Location MiCo Milano Congressi North Wing Entrance, Via Gattamelata, NR5, Gate 14/15 3 24% 15% Latin America Middle East

AN EXTENSION OF YOUR MARKETING TEAM Advertising opportunities Advertising helps you to stand out from the crowd, and plays a key role in helping you to achieve your Congress objectives. Advertising ensures the delegates have maximum exposure to your organization and gives you the possibility to show how your organization is a leading provider in the medical device industry, according to the current UEMS-CME regulations. Advertising space is applicable during the licensed period of the Congress.* In addition to the current advertising catalog we offer further tailor-made sponsorship items to fi t your need for maximum visibility. Please contact us with any other ideas that you may have in mind, we will be happy to make it happen. Instructional Course Lectures at lunch time Organizations are invited to sponsor Instructional Course Lectures (ICLs) as part of the GSC.* ICLs enable you to promote your organization and your latest products and services and are allocated a one (1) hour time slot. They offer you the perfect platform to discuss important spine-related medical concerns in a professional and engaging atmosphere. The ICL time slots are intentionally allocated outside of the scientifi c program schedule.** This maximizes the number of delegates who can attend your Instructional Course Lecture. We are happy to provide you with an existing faculty list and help you to select speakers for your workshop (this faculty list will contain names ONLY). Established international network AOSpine International is an active community of the largest international network of spine care professionals, with more than 27,000 members and associates worldwide. Aligning your organization with the Global Spine Congress offers you unparalled access to this vast community. Branding and Sponsorship items Opportunties to align your organisations brand with multiple GSC initatives come in many forms. Branding opportunties with awards and grants, social events, website advertising, sponsorship items and premeeting courses are all available in one document (together with pricing) upon request. * All advertising opportunities are subject to availability, approval by AOSpine and confi rmation by the Organizing Secretariat O.I.C. Srl in accordance with the specifi c instructions and technical regulations of the venue. ** Priority will be given to Diamond Sponsors. For more information: www.gsc2017.org For more details, please contac us at sponsorgsc2017@oic.it today! 4

A QUALITY PROGRAM ENABLES SURGEONS TO PROVIDE BETTER CARE FOR THEIR PATIENTS. Previous editions of the Global Spine Congress have inspired participants to come up with new and innovative approaches to spinal surgery. With over 850 abstracts received for the GSC Dubai, the program has gone from strength to strength in terms of size and quality. The GSC program provides many opportunities for sponsors and exhibitors to engage delegates. The abstract topics for the previous edition are listed below: Abstract topics Degenerative cervical Degenerative lumbar Deformity thoracolumbar (Adult) Deformity thoracolumbar (Adolescent) Deformity cervical Trauma cervical Trauma thoracolumbar Trauma other Tumors Arthroplasty cervical Arthroplasty lumbar Diagnostics clinical How to get involved: Diagnostics non-clinical Imaging Minimally invasive spine surgery Surgical complications Epidemiology Infections Medical economics Nonoperative clinical treatments Spine biologics, bone clinical Spine biologics, bone nonclinical Spine biologics, other clinical Spine biologics, other nonclinical Disc biologics clinical Disc biologics non-clinical Disc degeneration clinical Disc degeneration non-clinical Back/neck pain clinical Back/neck pain non-clinical Basic Science other Biomechanics other Novel technologies clinical Novel technologies non- clinical Navigation clinical Navigation non-clinical LEADERSHIP Establish your organization as one of the leaders in development and innovation by contributing to the cutting edge and interactive content. Options include: Lunchtime symposia (ICL) session Live demonstrations BRANDING Pre-meeting courses Congress bag inserts Place your brand within plain view of some of the most infl uential surgeons and professionals in the industry. Options include: E-poster interaction - exclusive Beacon and notifi cation technology Giant banner advertising EXHIBITING Website banner placement * Floor tiles Pads and Pen - congress bag Providing you with the optimum chance to engage and interact with congress participants. Options include: Two tier exhibitor levels (Premium and Standard) SPACE ONLY Entry level exhibition space 600 per m 2 5

SPONSORSHIP PACKAGES The GSC offers you a wide range of exclusive sponsorship opportunities, providing an ideal way to promote your organization. Sponsorship Packages are available to assist you in chosing the right package for your organization. However, if you wish to tailor your own specifi c package then a Sponsor Menu is also available as an alternative, à-la-carte option with a complete price list of available sponsorship items on the following pages. All booking requests are accepted on a first-come, first-served basis. Diamond Platinum Gold Price (EUR) 90,000 54,000 23,000 Exhibition space Premium Plus locations 54 sqm (6m x 9m) Premium or Standard locations 36 sqm (6m x 6m) Premium or Standard locations 18 sqm (3m x 6m) Advertisement in final program Two full inside page Two full inside page One full inside page Instructional Course Lecture (ICL)* Lunch or Evening Symposia YES 1x ICL NO NO Website banner advertisement ** (in rotation, 5 months) (in rotation, 3 months) (in rotation, 1 month) Badges (with full access) (10) (6) (2) Badges (access to exhibition only) (15) (10) (8) Bag insert (2) A5 size (2) A5 size (1) A5 size Acknowledgement on congress website (logo on dedicated page) (logo on dedicated page) (logo on dedicated page) Acknowledgement in final program (acknowledgement in exhibitor listing) * LCD projector, screen and basic technical assistance are included and rooms will be allocated on a first-come, first-served basis, depending on availability. Catering services and internet connectivity are extra and organizations should contact the Organizing Secretariat O.I.C srl for dedicated proposals. ** Displayed on top of the Sponsors section. The sponsoring organization is responsible for design. Artworks must be preapproved by the Organizers. Diamond Sponsor additional bonus - a second additional ICL purchased will include a 50% discount. Print advertisement: Final artwork to be submitted by March 27, 2017. 210mm x 297mm with 3mm bleed. Supplied as printready 300 dpi PDF or EPS. JPGs are not acceptable. Website banner advertisement: Two sizes are available: 728px x 90px leaderboard (to appear on content pages) and 220px x 85px half banner (to appear in right hand modules). Images can be supplied as a GIF or JPG with a maximum file of 75Kb for the leaderboard, 50Kb for the half banner. We offer tailor-made sponsorship packages. Contact us at: sponsorgsc2017@oic.it 6

EXHIBITION AREA AND INFORMATION Exhibition specifi cations As part of the Global Spine Congress, an exhibition space will provide exhibitors with a unique opportunity to showcase products and services to an estimated 1,500 delegates The rental fee is for the empty fl oor space only and exhibitors are kindly requested to send their own booth design to the Organizing Secretariat for approval by March 27, 2017 at the latest. The booth layout should be expertly designed to ensure delegate comfort, while optimizing visitor fl ow and maximum exposure for the exhibitor. Shell scheme booths as well as any decoration requirement (carpeting, lighting, furniture, equipment) can be rented through the Organizing Secretariat O.I.C. srl. Upon request, a furniture catalogue and order form will be mailed with the Exhibitor s Technical Manual. Exhibition spaces will be allocated according to the total amount of sponsorship received on fi rst-come, fi rst-served basis. The organizers reserve the right to make the fi nal decision on the exhibition space allocations. Networking events and coffee breaks will take place on the exhibition fl oor, regularly promoting opportunities for the delegates to visit the exhibition area to engage with you. Two (2) complimentary badges per 9m 2 (with access to the exhibition only) are included.* Extra badges required will incur an additional costs (see pricelist on page 9). Exhibition booth specifi cations Description Price (EUR) Premium Prominent areas that allow sponsors immediate and advantageous exposure to participants 750 per sqm Standard All other exhibition space areas 575 per sqm Premium position Standard position Exhibiting sponsors are limited to a minimum (3x3m = 9m 2 ) and a maximum (9x9m = 81m 2 ) exhibition booth space. All extra requirements, e.g, special decoration, extra lighting, furniture, carpeting, offi ce equipment, should be ordered separately. Furniture catalog and order form will be sent out with the Exhibitor s Technical Manual. * Diamond and Platinum packages are allocated additional complimentary badges (see package section for more details). MEETING ROOMS MEETING ROOMS MEETING ROOMS 63 64 61 62 43 44 41 42 23 24 21 22 3 4 1 2 67 68 65 66 47 48 45 46 27 28 25 26 7 8 5 6 71 72 69 70 51 52 49 50 31 32 29 30 11 12 9 10 75 76 73 74 55 56 53 54 35 36 33 34 15 16 13 14 79 80 77 78 59 60 57 58 39 40 37 38 19 20 17 18 81 82 83 84 85 86 87 88 89 90 91 92 93 94 97 95 96 98 REGISTRATION AREA REGISTRATION AREA ENTRANCE CLOAKROOM E-POSTERS 7

GSC 2017 sponsorship and exhibitor application form Please return this form to the Congress Organizing Secretariat O.I.C. srl. - Viale Matteotti, 7-50121 Florence (Italy) Tel. +39 055 50351, fax +39 0555001912, email: sponsorgsc2017@oic.it Please complete in BLOCK LETTERS and where appropriate. ORGANIZATION NAME CATEGORY: Pharmaceutical Technical devices Publisher Other Title Prof Dr Mr Mrs Ms First name Surname Job title Address VAT Number / Tax identification number (compulsory) Town / City State / Region Country Country Postcode / Zip code Email Website Tel (primary contact) Mobile 8

GSC 2017 sponsorship and exhibitor application form We offer a wide variety of sponsorship opportunities as an alternative to our sponsorship packages. As each sponsor has varying requirements, this menu below offers the ability to fl exibly tailor your level of participation. Please complete and submit this form to the congress organizers for a formal quotation based on your menu choices. Items Please Unit Price (EUR) Sponsorship Diamond Sponsor 90,000 Platinum Sponsor 54,000 Gold Sponsor 23,000 Exhibition Space * Standard area 575 per sqm Industry Badges Instructional Course Lecture (ICL)* Social events (logo on invitation cards and promotional materials) Awards & Grants Branding Sponsorship Items Advertisement Premium area Badges (with full access) Early bird 860 Onsite 885 Badges (access to exhibition only) 530 750 per sqm 1 hour Instructional Course Lecture (ICL)* Approx. Lunch time (12.15 13.15) 16,800 Welcome Reception April 14, 2017 (Shared with maximum three sponsors) 26,000 Award Best Poster Presentation 7,100 Award Best Oral Presentation 7,100 Grant Unrestricted educational grant (minimum) increments of 5,000 13,250 Grant Travel grant (each) Faculty or Presenter 1,770 Bookmarks (logo displayed exclusive) 3,100 Bookmarks (logo displayed maximum two sponsors) 1,770 Coffee break (per break) Preferred date/time: 2,200 (per break) Coffee break (per day) Preferred date: 6,600 (per day) Congress bag insert Congress bag tags (logo displayed exclusive) Directional signage, exclusive sponsorship (logo displayed exclusive) 7,100 Directional signage, shared sponsorship (logo displayed maximum two sponsors) 4,400 Pads and pens provided in the congress bag (logo displayed exclusive) Water bottle branding Speakers Ready Room (logo displayed exclusive) 7,100 Promotional banners Exhibition foyer Registration foyer E-poster area Website Banner In rotation 890 per month Final program Foyer area Full page advertisement, any inside page 5,300 Half page advertisement, any inside page 3,100 Main foyer (banners) Top visibility and exclusive 2,650 + supply / production costs 4,400 + supply / production costs 3,100 + supply / production costs 2,200 + supply / production costs 3,500 + supply / production costs 10,000 + supply / production costs 5,000 + supply / production costs 7,100 Pre-meeting courses Please contact the Secretariat O.I.C. srl for availability and quotation On request Industry/Hospitality Suite Please contact the Secretariat O.I.C. srl for availability and quotation On request * The Organizers will make every effort to satisfy your request for your preferred ICL slot or exhibition space if it has already been booked by another company, we will suggest the closest possible alternative. Your reservation is not secure until a non-refundable deposit of 50% has been paid. Exhibition spaces are open spaces to be furnished. Exhibition space to be reconfi rmed according to availability, on fi rstcome, fi rst-served basis. Diamond sponsor included ICL`s to be reconfi rmed and given priority according to availability, thereafter availabilty is on a fi rst-come, fi rst-served basis. **The sponsoring organization is responsible for design, production, shipment and delivery of a minimum of 1,000 pieces to the congress venue, detailed shipment instructions will be available upon confi rmation. Artwork must be pre-approved by the organizers prior to production. Please indicate your top 3 preferences for exhibition booth number(s): Please indicate any organizations you would prefer not to exhibit next to: Preference 1: Preference 2: Preference 3: Set-up of the booth, decoration, and other needs are to be provided directly by the exhibitor or ordered separately through the Organizing Secretariat OIC srl, by using the Exhibitors Technical Manual and order forms available upon confi rmation of the space. 9

GSC 2017 sponsorship and exhibitor application form Terms of payment and cancellation Payment deadlines Exhibition/Sponsorship Deposit of 50% of value January 27, 2017 Additional Sponsorship Full payment within 10 days of booking Terms of payment All booking requests will be accepted on a fi rst-come, fi rst-served basis. Bookings will not be processed nor exhibition spaces guaranteed without the required 50% deposit at time of confi rmation. All payments need to be settled with the Organizing Secretariat O.I.C. srl in the name of AOSpine International by credit card (Visa or MasterCard) or bank transfer. Payment Method Please your payment method: By credit card (VISA or Mastercard) Bank transfer to O.I.C. srl (AOSpine) Office address: Viale G.Matteotti n.7, 50121 Florence (Italy) Bank Name: BANCA SELLA SPA IBAN: IT56S0326802801052891431560 Swift Code: SELBIT2BXXX Should the balance not be paid by the above terms, the exhibitor will not be allowed to set up their booth. All payments should have the notifi cation code: GSC 2017 If the payment is not received within the time established in the payment conditions, the agreement with O.I.C. srl will automatically be rescinded. In this case O.I.C. srl will send by registered mail a written declaration to the Company (Organization). The missing payment will be intended as cancellation by the client and the penalties indicated below will be applied. The missing balance payment before the Congress will entitle O.I.C. srl to forbid the building up of the booth or not to provide the requested service/s, the penalties indicated below will be applied in any case. **Please include all bank charges and intermediate bank commissions in your payment** Cancellation fee 100% of the total exhibition/sponsorship booking will be applied for cancellations received after January 27, 2017. Important remarks A dedicated contract budget including all booking items and the specifi c terms and conditions of the reservation will be sent by the Organizing Secretariat O.I.C. srl in the name of AOSpine International upon receipt of the application form. This contract should be signed and returned within 10 (ten) days from the date of the offer. This fi nal confi rmation (contract budget) will be liable for both OIC and the Company (Organization) upon signature. Terms and Conditions of Sponsorship are indicated herewith and will be included in the contract budget. In case the client does not fulfi l the payments according to the above-mentioned conditions, O.I.C. srl will consider the agreement automatically cancelled, according to the provisions of art. 1456 of the Italian Civil Code, and notify the client by letter with confi rmation of receipt. The non-fulfi lment by the client will hence be considered as a cancellation with the application of the foreseen consequences of penalties. In case of failure by the client to pay the due amount before the congress, O.I.C. srl will not authorize the set-up of the booth or prevent the fulfi lment of the remaining items stated in the contract. According to art.13 D. Lgs. 196/2003 O.I.C. srl is authorised to use my Company (Organization) and personal data for purposes connected to the Congress. I also state that I have understood and accepted the confi rmation, cancellation and payment policies related to the sponsorship terms and conditions specifi ed herewith. Company (Organization) Stamp Legal Representative Full Name (block capitals) Position Signed Date Please retain a copy of this form for your records. 10

Thank you and see you in Milan! For more information: www.gsc2017.org GSC2017 Organizing Secretariat Elisabetta Salerno, Sponsorship & Exhibition Sales Department O.I.C. srl Viale Matteotti 7 50121 Florence Italy Phone: +39 055 50.35.307 Fax +39 055 5001912 Email: sponsorgsc2017@oic.it Organizer AOSpine International Stettbachstrasse 6 8600 Duebendorf Switzerland William McCrea Project Manager Business Development Phone: +41 44 200 2468 Mobile: +41 79 512 7442 Email: wmccrea@aospine.org Web: www.gsc2017.org 11