Johns Hopkins Technology Ventures:

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Johns Hopkins Technology Ventures: Converting our groundbreaking research to products October 2016 1

Johns Hopkins University + Hospital $1.95B+ national leader in NIH research funding 36 Nobel laureates 39 Lasker Award recipients the American Nobel 54 members of the Institute of Medicine Pioneered approaches to breast cancer, dialysis, open heart surgery, CPR, chemotherapy, restriction enzymes

Our work will help our city to build the pipeline of future jobs and growth Infuse new ideas into our market Attract and retain talent Generate outside investment Promote regional economic development

Our Mission Statement The Johns Hopkins Technology Ventures mission is to maximize the impact of JHU excellence in research by facilitating the translation and commercialization of discoveries into accessible technologies, products, and services for the benefit of society. 5

JHTV is the focal point for technology commercialization at Johns Hopkins CORPORATE PARTNERSHIPS Strategic corporate partnerships/alliances with targeted focus Sponsored research, philanthropy, in-kind Active examples: Bayer, Medimmune, Toshiba, Celgene TECH TRANSFER Over 500 invention disclosures per year and 2,500 active issued patents Licenses and options Non-disclosure agreements & material transfer agreements 19 startup companies currently in-residence Support JHU licensed, student, and DreamIt startups among others Mentorship, space, funding, and other key resources JHTV OVERVIEW 6

Technology Transfer FY 16 Results 7

JHTV s Commitment to You 2 Days 2 Weeks 2 Months JHTV will contact you within 2 business days of receiving your disclosure. JHTV will confer with you regarding your disclosure within 2 weeks. JHTV will provide a written decision on your disclosure within 2 months.

Recent successes in commercialization of Johns Hopkins discoveries JHU IP: Immune system modulation Acquired by MedImmune in 2013 Guaranteed $225M, deferred consideration up to $275M JHU IP: Cardiovascular therapeutics Acquired by Bristol-Myers Squibb in 2015 Up-front near term milestones up to $300M; deferred consideration up to $1.775B JHU IP: Technology to improve DNA vaccines Immunomic originally licensed IP in 2006 and proceeded into clinical trials for allergy indication Astellas deal with Immunomic in Oct 2015 for $300M 9

Corporate Partnerships Advancing translational capabilities to impact human health 2/11/2016 10

JHU + Celgene Collaboration With Other Universities

Collaboration With Government

We want to change this picture Funding of Startups: last 5 years ($1.1b) 83% 13% 4% Companies founded on JHU technology have raised >$1.1b since 2012 But less than 15% of that has stayed in Baltimore % to Baltimore % to Maryland Other Source: Pitchbook data, company searches, company interviews 13

Companies who have recently raised money and are located in Baltimore Founded in 2010 and initially located in Rangos Focused on cancer genetics Raised $21mm from NEA Founded in 2016 Focused on immuno-oncology Raised $10mm from Domain Founded in 2011; research ops remain in Baltimore Focused on ophthalmic drug delivery Raised $44mm from Deerfield, Orbimed, Clarus & Hatteras 14

New accelerator program specializing in Digital Health New accelerator program specializing in Digital Health We are partnering with Village Capital to launch an accelerator program that will support entrepreneurs and empower our innovation ecosystem by: Enabling ecosystem leaders to build effective training programs for entrepreneurs solving real world problems Connecting leaders worldwide to share best practices in building peer groups of entrepreneurs and supporting great businesses Giving investors the tools to make peer-selected investments in their own focus sectors and/or geographies Program Overview 4 month curriculum based program, supporting 10 companies Access to FastForward resources and network Opportunity to connect with Johns Hopkins Healthcare leaders Two Startups selected for investment from Village Capital, followed by Demo Day inviting other investors Emphasis on financial inclusion for women and minority founders

FastForward provides resources to catalyze technology development and commercialization Education Programs, services and access to knowledgeable faculty, staff and industry partners Mentorship From experienced industry, startup, and funding veterans Services Basic legal, accounting, business strategy, IT infrastructure, and equipment Space Affordable and flexible locations with lab and office space 16

FastForward is home to an exciting group of technology-based startups 17

Programs to support the JHU Entrepreneur 18

Services: Mentors in Residence 15 mentors for 2016 Help solve the commercial relevance question MIRs work with students, faculty, and JHTV staff and bring deep domain expertise to help accelerate the path of promising JHU technologies and startups MIRs develop close ties with our inventors, entrepreneurs, and our licensing team to help further these technologies and shift JHU towards an entrepreneurial culture MIRs open their vast network of experts and experience to JHU inventors, faculty and students Areas of expertise include: Life Sciences, Computational Discovery, Software, Medical Device, Engineering, Angel/Venture Investment, IP Strategy, Finance, General Business 19

Social Innovation Lab Accelerating ventures that create change and expand opportunity in Baltimore and beyond. SIL works by providing seed funding, mentorship, office space, and personalized trainings, to help innovative non-profits, mission-driven companies, and disruptive technologies transform novel ideas into thriving ventures that make a measurable impact. Ventures in the cohort receive: $1,000 in unrestricted funding for the venture upon selection, and the potential to receive additional funding based on progress of the venture during the program year Office and event space at Impact Hub Baltimore and JHU locations Dedicated mentors and access to an extensive network of mentors including issue experts, experienced entrepreneurs, and connections within the Johns Hopkins ecosystem Curated workshops and sessions where venture leaders learn from experienced entrepreneurs and social sector leaders Opportunity to pitch potential funders and supporters at SIL events including the annual Impact+Innovation Forum

Funding/Services: I-Corps Program for Startup Training I-Corps to date (JHU joined DC-node in June 2014) JHU I-Corps has put 50 teams through the local and regional program since 2014 26 JHU went through Regional I-Corps cohorts in FY 2016 (representing SOM and WSE) 3 JHU companies went through the National NIH I-Corps; received $50k award Both programs provide real world, hands-on training on how to successfully incorporate innovations into successful products. Benefit: Helps teams make a go/no-go decision by validating their technology's market potential and identifying a solid product-market fit and building a viable business model. 21

Funding: Maryland Innovation Initiative - a TEDCO (State of Maryland) Program 3 dedicated site miners who serve as industry mentors to faculty with a focus on commercial relevance of the invention 93 Awards to date; average grant size ~$120k Funded projects/companies representing SOM, WSE, JHSPH, Peabody including many joint SOM/WSE collaborations 13 funded projects are now Maryland based startups Total JHU funding for PIs and companies ~ $9.3M since 2012 22

Services: Commercialization Academy Supports diverse science career training Supports needs of analytics group within JHTV: reviewing 500+ disclosures received annually across JHU Responsibilities include assessing market value proposition, IP position, competition, and development risk Current Verticals Oncology, general molecular biology, medical imaging technology, robotics, novel materials, novel compounds 23

Student Entrepreneurship Student Venture Coordinator 1 on 1 support Events: Hackathons, Speaker Series, Workshops Programs Summer Entrepreneurship Award Opportunity for 1 student team to work on their startup full time over the summer with support from JHTV Grant of $10,000 for undergraduate team Entrepreneurial Mentorship Office space in FastForward 24

Thank you! Helen Montag hmontag@jhmi.edu