Dorit Donoviel, Ph.D. Director Part 1: Overview Image courtesy of NASA 1
Mission: Lead a national effort in translating cutting edge emerging terrestrial research into applied space flight human risk mitigation strategies for exploration missions. 2
Funded by NASA HRP through a cooperative agreement (NNX16AO69A) to Baylor College of Medicine in a consortium @bcmspacehealth 3
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Virginia Wotring, Ph.D. Deputy Director Part 2: First Year of Operations Image courtesy of NASA 5
A new way forward TRISH is a new institute, designed to foster innovative and efficient collaboration among companies, universities, clinics, and NASA to best address the needs of humans in space. 6
Organization Dorit Donoviel, Ph.D. Director donoviel@bcm.edu Virginia Wotring, Ph.D. Deputy Director and Chief Scientist wotring@bcm.edu Shaunna BoClair Head of Finance sboclair@bcm.edu Iris Ali Accountant iali@bcm.edu Jeffrey Hoffman, Ph.D. Development Specialist, MIT jhoffma1@mit.edu Stephen Mayo, Ph.D. Development Specialist, Caltech steve@mayo.caltech.edu Gary Strangman, Ph.D. Development Specialist, MGH strang@mgh.harvard.edu Dejan Stojkovski Chief IT Business Solutions Officer stojkovs@bcm.edu Stratis Catacalos Chief Communications and Education Officer catacalo@bcm.edu Emmanuel Urquieta, M.D., M.S. Senior Research Portfolio Manager emmanueo@bcm.edu Catherine Domingo Operations Manager cmmoreno@bcm.edu 7
What have we been doing? Gearing up! 8
TRISH Programs Translational Research Program Identify and fund gamechanging medical technologies to improve astronaut health Supporting Program Serves as the educational & outreach arm of the institute Scientist Program Provides career and exchange opportunities for scientists and postdoctoral fellows 9
Funding Mechanisms TRP TRANSLATIONAL RESEARCH PROGRAM The Translational Research Program encompasses the main research portfolio of the institute. TRI CENTER OF RESEARCH (TCOR) GRANTS TCOR grants involve an interdisciplinary team of investigators working together on a single space health issue (like a program project). TCORs are generally up to ~$3M total funding over 4-years. 10
Funding Mechanisms TRP TRANSLATIONAL RESEARCH PROGRAM The Translational Research Program encompasses the main research portfolio of the institute. SMALL OPENLY COMPETED (SOC) GRANTS SOC grants are best suited for a single principal investigator (like an NIH R01 or R03). SOCs are generally up to ~$1M total funding over 3-years. 11
Funding Mechanisms TRP TRANSLATIONAL RESEARCH PROGRAM The Translational Research Program encompasses the main research portfolio of the institute. FOCUSED INVESTIGATION PROGRAM TRISH welcomes the submission of unsolicited proposals to its Focused Investigation Program (FIP). This funded vehicle is best suited for pilot or proof-ofprinciple projects with a small amount of funding (<$100K) and a short duration (approximately one year). FIP proposals are subject to programmatic relevance and scientific peer review. 12
Funding Mechanisms TRP TRANSLATIONAL RESEARCH PROGRAM Industry grants offer non-dilutive funding with 100 percent of matching funds required. INDUSTRY GRANTS Industry Grants offer non-dilutive funding to U.S.-based companies to develop spacecompatible health solutions from their already existing technologies; 100 percent of matching funds is required to maximize the institute s federal dollars. Just initiated a new partnership with Consortia for Improving Medicine with Innovation & Technology (CIMIT) be on the lookout for a call for proposals soon! 13
Funding Mechanisms TRP TRANSLATIONAL RESEARCH PROGRAM Synergy grants seek collaboration with TRISH funded projects, the overall objective is that the result is bigger and broader than each project. SYNERGY GRANTS Small ( $25k/year), short duration (6 to 12 months) grants designed to enable collaboration with currently funded TRISH projects. Intended to permit sharing of resources and personnel across funded projects and allow researchers and NASA to reap synergies from projects. 14
Announcing Synergy Awards! As part of its annual HRP IWS conference, NASA asked investigators to share their research challenges the obstacles they encounter in their work. Every poster, every presentation will list these challenges. For the HRP IWS 2018 TRISH is offering a special opportunity to fund creative solutions! See the TRISH logo on a poster or presentation? Figure out a collaborative solution to a challenge? This quick-turn grant award is available to the person(s) who identifies the most innovative, most crosscutting, and most synergistic solution with a TRISH-funded investigator. The short-term (approximately 6 months) award grants up to $25,000 in funding and the best part, it s as easy as 1,2,3 and you will know quickly! To apply: 1 2 3 Check it out! Synergy Grant details on our website Apply! Our 3-page application form on our website Email! Your proposal by 4:30 pm CT on Wed, Jan 24 15
Special IWS Synergy Challenge 16
Scientist Program PDF POSTDOCTORAL FELLOWSHIP PROGRAM Two-year fellowships to perform spacerelated research under the guidance of an experienced mentor. POSTDOCTORAL FELLOWSHIP PROGRAM GRANT Enable early career scientists to design, develop and conduct their own space-related research projects under the guidance of experienced faculty mentors. These 2-year fellowships provide a stipend based on NIH guidelines and allowance for healthcare and travel. Dr. Larry Young will mentor TRISH post-docs to become independent researchers in space biomedicine, and to help them develop ties among academic, government and industry laboratories and enable the formation of a community of post-doctoral fellows. 17
Scientist Program SCI SCIENTIST PROGRAM Multiple types of opportunities for researchers at all career levels. SENIOR SCIENCE MANAGERS At NASA s request, the institute finds candidates to fill limited-term senior management and scientist positions at NASA Centers. AEROSPACE MEDICINE RESIDENCY The Clinical Research Opportunities in Space Medicine (CROSM) program provides research and training opportunities to the University of Texas Medical Branch (UTMB) Aerospace Medicine residents. 18
Supporting Programs SP SUPPORTING PROGRAM Educational and outreach activities aimed at growing our community of researchers RADIATION SUMMER SCHOOL The NASA Space Radiation Summer School had a successful run with 16 students last summer but due to HRP s direction, will not be repeated this year. RED RISK SCHOOL The Red Risk School is designed to fill a new need how do people who are new-to-nasa learn about NASA s priorities? Aimed at investigators from academia, clinics & companies who may be working on useful solutions for HRP Risks, and will teach them about those risks, so that they can develop projects & deliverables that will be useful to NASA. We ll gather content experts from NASA and the broader community of spaceflight researchers and effectively inform potential TRISH proposers regarding the challenges and high priority risks to crew health and performance present in the spaceflight environment. 19
Supporting Programs SP SUPPORTING PROGRAM Exploring the leading edge of clinical practice and technical capability. WEBINARS Tech Exploration in Space Health Series is a carefully curated webinar series designed to foster lively conversation among our virtual community. We ll present potentially-transformative, sometimes controversial topics for discussion. Last week, Dr. J. Varon told us how temperature reduction can be used to protect the brain in critical situations, as early as during an ambulance ride. WORKSHOPS coming soon! Workshops to explore new ideas for potential spaceflight applications are in the planning stages. Unlike traditional workshops that require expensive and time-consuming travel, we ll be leaning heavily on our virtual tools this will permit greater participation at lower costs. 20
The Research Lymphatics Omics-Immune Microbiome 21
Lymphatics Lymphatics could provide novel approach to SANS Eva M. Sevick, PhD. University of Texas Health Science Center Houston Dawn Kernagis, Ph.D. Institute for Human & Machine Cognition Lihong Wang, Ph.D. California Institute of Technology Non-invasive measures Head-down tilt and head-out water immersion Measure communication between the brain and the neck Lymphatic vessel diameter, flow direction, flow speed, and the volumetric flow rate Combined with biomarkers associated lymphatic flow 22
Omics-Immune Christopher Porada, Ph.D. Wake Forest University Mouse model with humanized hematopoietic systems Gut-on-a-chip Radiation exposure Test a radiation protection agent Radiation biomarkers for blood and GI systems Charles Chiu, M.D., Ph.D. University of California San Francisco Kasthuri Venkateswaran, Ph.D. NASA Jet Propulsion Laboratory Sequencing of nucleic acids aboard the ISS Monitor bacteria in physiological samples Herpesvirus reactivation and immune system responses of astronauts Hyun Jung Kim. 2012 Jackson Laboratory 23
Microbiome Lawrence David, Ph.D. Duke University Establishes methods for personalizing prebiotic therapies, tailored to the biochemistry of an individual. Robert Langer, Sc.D. Massachusetts Institute of Technology Develops a spaceflight compatible and miniaturized device to host, protect and administer genetically modified therapeutic bacteria. 24
My challenge to you igiant Space Challenge - a partnership with TRISH igiant a nonprofit, announces a challenge to develop concept ideas for design elements, such as products, programs, policies and protocols, to account for differences in the way men and women adapt to space and spaceflight technologies. Special prize from igiant an igiant Space Challenge certificate $100 the opportunity to post a blog about their design on igiant s website and social media Submit your concept description via email to emmanueo@bcm.edu 25
@bcmspacehealth 26
Dorit Donoviel, Ph.D. Director Part 3: The Vision 27 Image courtesy of NASA
Goals 1. Mature Techs 2. Audacious Emerging Techs 3. Increase the N 28
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Partners 31
Collaborative Health Innovation Platform (CHIP) Pitchbook: 880,000 companies Crunchbase: 600,000 companies AngelList: 3.5 million companies +++ Other partners 32
TEXAS MEDICAL CENTER INNOVATION INSTITUTE TMCx 33
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DNA MiniVectors 36
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Butterfly iq: Technology 38
Butterfly iq: Acquisition Assistance 39
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donoviel@bcm.edu O: 713-357-1038 M:713-210-9280 @bcmspacehealth 41 Image courtesy of NASA