Health Innovation Ecosystem

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Health Innovation Ecosystem A Health Economy perspective Workshop Active and Healthy ageing in Germany and Korea Thomas Karopka, BioCon Valley GmbH Seoul, 8 th October 2013

ScanBalt organisation ScanBalt fmba, founded in august 2004 Non profit member based association Triple helix (academia industry authorities) Goals: Knowledge formation & education Commercialisation Forum for discussion on life science health society impact ~70 members Bottom up organisation with lean central secretariat in Copenhagen Regional offices and contact points in all Baltic sea states Decentralized and project oriented mode of action Annual ScanBalt Fora 2

Demographic ageing (e.g. Germany)

Regional challenges Population Decline Demographic change Competitiveness Workforce Social Costs Regional Health Care Labour market Regional Development 4

Why Innovation? Total expenditure on health per capita in the Nordic countries, 1998-2007

Opportunities for the regions Employment More employees work in health and health care related sector than in traditional industries Value Generation Investments in health foster long-term growth and sustainability of economies Relevance with respect to exports and internationalisation Sustainability Advances in medicine and natural sciences, e.g. life expectancy Roman Empire ~ 30 years 1900 ~ 46 years 2000 ~ 76 years 2010 ~ 81 years Trends in Health 2020 2030 Economy (Germany) GVA +2,1% +1,9% Employment +1,4% +1,1% Health sector has proven to be Employment resistant to financial and in Export sector economic crisis! 5,1% 6,3% 6

Two questions.. Among many others 1) How do we address the health related challenges of the demographic change? 2) Is our health economy capable of developing the right products and services for this new environment?

How about Innovation? What is Innovation? In a nutshell: Innovation is ideas put into practice which then create value (Cited from Ideas Clinic Aalborg) Ideas can be completely new ones or existing ideas tuned or combined in new ways. Value can be heightened quality, improved economy or increased safety

Creating Shared Value Porter and Kramer 2011 What is Shared Value? Policies and operating practices that enhance the competitiveness of a company while simultaneously advancing economic and social conditions Porter M.E. and Kramer M.R.: Creating Shared Value How to reinvent capitalism and unleash a wave of innovation and growth, Harward Business Review 2011

Health systems are patient centred ecosystems They are complex adaptive systems Wellness Research Processes are not linear! Collaboration Information Exchange Knowledge Management Process Integration Education Delivery Source: Joseph DalMolin, e-cology corp.

We are witnessing a paradigm change in health care! Past The individual Acute diseases dominates Episodic care Cure of disease Reactive Physician provider Paternalism Provider centered Parochial health threats Present Future The community More chronic illness/disability Continous care Preservation of health Prospective Teams of providers Partnership with patients Patient/family centred Global health threats Cohen, 21st Century Challenges for Medical Education; 9th International Medical Workforce Conference; Melbourne, Australia; November 2005

What is Health Economy? Health Economy can be defined as: The provision and commercialization of goods and services, in order to support the maintenance and restoration of health

HealthPort vision A health economy perspective Strengthening cross-sectoral, collaborative, open innovation in health and life sciences to promote sustainable, cost-efficient, citizen-centric health systems, strengthen regional economies and thus improve the health, wellbeing and prosperity in the Baltic Sea Region (BSR)

Open Innovation Source: http://www.openinnovation.eu

From The lab is our world

to.the world is our lab!

HealthPort Innovation Agenda to open the frameworks Lead: Key targets: Promote a Multidimensional Innovation Ecosystem for health economy Promote self-sustainable business innovation support services Figure by Thomas Karopka, BioCon Valley, in Health and life sciences as drivers for regional development and prosperity in the Baltic Sea Region Wolfgang Blank, Peter Frank, Thomas Karopka, East-West Business, in press 18

Innovation Ecosystem for health economy

Innovation Ecosystem for health economy 1. Scouting & Early Evaluation 2. Business Support & Financing 3. Implementation & Marketing 4. Education & Qualification 5. Regulation & Procurement

(1) Scouting & Early Evaluation Recommendation: Challenges: Assess the potential of an idea to become an innovation Set up a platform / meeting point for young entrepreneurs and experts for early evaluation and mentoring. Promote Innovation competitions to filter out innovative ideas Set up user driven idea management platforms to generate early feedback from potential users

(1) Scouting & Early Evaluation Ideas Competition: HealthPort Innovation Award Oxygen Soother

(1) Scouting & Early Evaluation Idea Management

(2) Business Support & Financing Recommendation: Challenges: Access to capital especially for early idea evaluation Develop new forms of transnational financing e.g. crowdfunding or special transnationally available funds for health and life sciences. Promote successful models for SME support and development to cover the entire BSR Develop a transnational, cross-sectoral mentoring system for SMEs in health and life sciences

(2) Business Support & Financing Crowdfunding for Health & Life Sciences

(2) Business Support & Financing A Baltic- Scandinavian elite accelerator for health science startups

(3) Implementation & Marketing Challenges: Recommendation: Dissemination of Innovative products and services in a transnational macro-regional context Provide a platform with modular shared services for SMEs that comprise marketing and dissemination of final products or services, Organise platforms for cooperation between SMEs offering complementary services Provide case specific support for transnational market implementation with a focus on BSR macro-region Support strategic communication with all relevant actors for products and services from SME s

(3) Implementation & Marketing

(4) Education & Qualification Recommendations: Challenges: Lack of entrepreneurship skills in health and life sciences Lack of knowledge about regulation, certification and procurement Develop a platform of practical SME tailored courses on specific topics for working individuals (post-education) up to hands on local coaching for SME consortia. Make working conditions innovation friendly Value working conditions and creativity Create room for innovation in the working environment (Improve working conditions, other skill mix (up-/downskilling) change the climate to allow creativeness)

ScanBalt Educational Platform Requirements HealthPort Report Major challenges for SME-s to be commercially successful Grete Kuura and Boo Edgar, from University of Gothenburg, 2011. Method: 21 interviews with SME, cluster organizations, science parks and hospitals within the ScanBalt Health Region: Results Need of knowledge in Entrepreneural education with BioScience focus + Support from cluster organisation Academic Courses Local Mentoring

ScanBalt Educational Platform Educational Plan Potential Courses Project Management Management of innovation and entrepreneurship Idea evaluation and feasability Complementary Courses ScanBalt Educational Platform Venture Financing Sales & Procurement (legal and regionally adapted) Business Plan Clinical verification (Pharmaceuticals/ Biomaterials, Medical Technology All with BioScience-Focus!

(5) Regulation & Procurement The public sector has a dual role in respect to innovation. The public sector acts as regulator and as procurer. In the Nordic countries 80 85% of health spending is funded by public sources. There is a huge potential to stimulate innovation through public procurement.

(5) Regulation & Procurement Recommendations: Understanding differences in regulation and Challenges: It is increasingly difficult to conduct clinical trials. It is increasingly important to proof the efficacy and cost- effectiveness new products and services Late stage failure rate and time-tomarket extremely long procurement (governance) in BSR and make entrepreneurs work with them Support initiatives to coordinate clinical trials in the BSR and offer SME support measures Support the installation of HTA expertise as a parallel process to product development Support in certification and other formal requirements with respect to international markets Support PPI and PCP in the health care sector and further work on harmonizing and minimizing (deregulation) regulations on the EU-level of

Regulation & Procurement PCP to steer the development of solutions towards concrete public sector needs, whilst comparing/validating alternative solution approaches from various vendors PPI to act as launching customer / early adopter / first buyer of innovative commercial end-solutions newly arriving on the market R&D / Pre-commercial Procurement (PCP) Phase 0 Curiosity Driven Research Phase 1 Solution design Supplier A Supplier B Supplier C Supplier D Phase 2 Prototype development Supplier B Supplier C Supplier D Phase 3 Original development of limited volume of first test products / services Supplier B Supplier D Phase 4 Deployment of commercial end-products Diffusion of newly developed products / services Supplier(s) A,B,C,D and/or X in line with WTO proc. rules, EU Treaty, State aid free

Conclusions Product (service) development takes place at a global level From The lab is our world to.the world is our lab! Health care delivery takes place at the regional level 35

Partners Göteborg University (SE) North Denmark Region (DK) Culminatum Innovation (FI) Entrepreneurship Development Centre for Biotechnology and Medicine (EE) BioCon Valley (GE) Turku Science Park (FI) InnoBaltica (PL) Institute of Biotechnology/Vilnius University (LT) ScanBalt (DK Coordinator) 15 associated partners

The take home message LOVE Core value Core principel LOVE YOUR NEIHBOUR AS YOU LOVE YOURSELF

The significant problems we face cannot be solved at the same level of thinking we were at when we created them Albert Einstein

It is hard to learn from experience, But it is even harder not to learn from experience Anonymous