Name of Course: Integrative Learning Experience (capstone). Name of Academic supervisor: Professor Manfred Green. Name of student: Essabela Fewo

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Name of Course: Integrative Learning Experience (capstone). Name of Academic supervisor: Professor Manfred Green. Name of student: Essabela Fewo Program: I-MPH Academic year: 2016-2017

} 1.The problem specification Definition of Hospital acquired infection (HAI) Patient safety Our objectives and aim } 2. Introduction HAI as a global/public health problem Epidemiology of HAI } 3. The Method Literature review search Inclusion criteria Exclusion criteria

} 4. The Results On the risk factors Preventive measures } 5. Conclusion. } 6. Recommendation. } 7. Competences that were demonstrated during the capstone

} Definition of Hospital acquired infection (HAI) Acquired in hospital By a patient Admitted for a reason other than that infection, Not present or incubating at the time of admission, occurring more than 48 hours after admission or 72 hours after discharge (CDC 1998). Forms= endogenous and cross infection (WHO 2002).

} Improving the safety of patients HAIs are among the leading causes of death and has increased the burden of disease among hospitalized patients } In may 2004 WHA approved the creation of an international alliance as a global initiative to improve patient safety } In October 2004, The WAFPS was launched, was incorporated in the WHO patient safety program with the aim to create an environment that ensures the safety of the patient.

} In October 2005, the Clean care as safer care was launched as the 1 st global patient safety challenge. Aim=reducing health care associated infection world wide. } Although progress has been made locally and internationally (CDC,WHO,JCIFPS) in advancing public health and hospital care } Health care establishment are unable to achieve adequate levels of preventing HAI mostly in developing countries (CDC, WHO etc)

} Therefore, the main objective of this paper is focus on patient safety goal number five: To identify the risk factors associated with patient acquisition of hospital infection and to identify the most effective evidence based preventive measures. } With the aim To provide relevant information to decision makers, hospital administrators and leaders working to improve patient safety in hospitals and other health care settings.

} HAI as a global/public health problem Worldwide :Developed & developing countries High prevalence 8.7%(prevalence study under the auspices of WHO in 14 countries ), another 8.4% ( between 1983-1985) In other Developed countries, the prevalence varied 4.6 to 9.9% while in the developing it varied from 14.8 to 19.1%. (WHO 2009). Significant burden for the patient and for public health One of the leading cause of death ( CDC 2007 =2million infections and 99 000 deaths annually world wide) High economic cost- longer stay in hospitals, increase use of drugs Can cause community out breaks

} Epidemiology of HAI - Causes-Bacteria, viruses, parasites and fungi - Sources of HAI: Patients (sick and symptomless )-most common source The hospital environment-contaminated surfaces, food, water The health care personnel-sick/symptomless workers -Routes of transmission of HAI Direct and indirect -Common sites of the body prone to infection UTI, SSI, Pneumonia, BSI-CDC national nosocomial infection SS

} Epidemiology of HAI continuous Risk factors for acquiring HAI The microbial agent-resistance, virulence, amount The patient factor- age, underlying disease, the immune status, malnutrition. The environmental factor- congregate of sick and high risk pts, hospital design, hygiene, duration of stay in hospital. Increasing use of medical devices and procedurescatheterization, intubation, surgery Poor implementation of hospital infection control practices-low adherence to hand hygiene, poor isolation techniques, poor use of personal protective equipment.

} Epidemiology of HAI- continuous Preventive measures for HAI At the national level-national programs At the hospital level-hospital programs To separate the infection source from the rest-isolation To cut the route of infection transmission Hand hygiene, vaccination, Effective nursing practices-oral care, nursing positions Hygiene of the hospital - cleaning Management of hospital waste: body fluids, sharps Effective implementation of decontamination processes Surveillance of HAI-site, unit & priority oriented surveillance

} In this literature review } I search in google search for guidelines for prevention of hospital = 3 guidelines of interest ( WHO,CDC, HICPACG) } I used the student portal entry into the university of Haifa Library=838 articles } Limiting to only full text, and scholarly Journal =762 } Articles between 1997-2017 with free access=14 and 1 from Google search giving total of =15 articles } I tried getting other articles from other sources such as Pubmed but because of lack of free access I could not get them.

} Inclusion criteria Articles on risk factors and /prevention of HAI Full text articles English language Between 1997 and 2017 Free access from the University library Articles from different Hospital setting Surveys, Observation and experimental designs } Exclusion criteria Articles needing payment Before 1997 Article out of the university of Haifa library

} Procedure Classification according to the hospital unit Using the Agent, Host, Environment model (epidemiological triad) Classification according to the risk factors that were associated with acquiring hospital infection Classification according to the effective preventive measures

} Of the 15 peer reviewed articles: } -7 were focusing on the whole hospital-both general and intensive care units } -4 focused on neonatal units } -3 on non intensive care units } -1 on neurological intensive care unit

} 1. Micro-bacteria resistance=2 articles -Patients who received anti microbials had 8.63 higher odds of acquiring HAI } 2. Patient factors=3 articles -Patient age: neonates and elderly had higher risk: one study found that of the 26.9% infection rate, patients > or =60 yrs accounted for 22.6% as compared to 4.3% for those less. With p value <0.01 -Underlying disease= 3 articles : Respiratory diseases, Blood stream infection, Diabetes mellitus: Accounted for 11.7 (p V<0.01) Surgical patients had 2.35 higher odds of HAI

} 3. The Hospital environment= 5 articles Inappropriate hospital designs, Infected surfaces, dusty hospital environment, humid hospital environment longer stay in hospital : patients hospitalized >=7 days=16.7%. Those <7 days 10.2%, different significant at p v<0.05 } 4. Frequent and prolonged use of invasive medical devices= 4 articles Patients on urinary catheters had infection rates of 78% compared to 11% non-catheter patients. Respiratory ventilator use was associated with VAP More intravascular lines for monitoring and nutrition =>BSI

} Hand hygiene practices=4 articles -Appropriate hand hygiene practices One of the study found out that there was a significant reduction in HAI when an educative program was carried on hand hygiene. } Effective/ appropriate nursing care practices=4 articles -Proper positioning of critically ill patients or patients with specific devices In a RCT microbiological confirm pneumonia was lower in patients nursed in semi-recumbent position (5%) vs 23% nursed in supine position. -proper use of antiseptic oral care, -use of basin wipes, - placement and removal of patient diapers

} Maintenance of high hospital hygiene= 2 articles. -Filtration of the hospital air, -dust reduction, -and preventing humidity in the hospital } Reduction in the frequency of use or shorter Duration of use of invasive medical procedures and devices= 5 articles -One of the studies indicated that patients who had a central vascular catheter had 6.91 higher odds of acquiring HAI

} HAI is a global health problem affecting the safety of hospitalized patients } Many of the HAI can be prevented if there is an effective infection control program at national and hospital level. } Surveillance is the first step to identify local problems and evaluate the effectiveness infection control activities } If patient safety is made a priority with resources allocation to preventive measures, most of the morbidity and mortality from HAI and its complication will be avoided.

} Investing in the construction of the hospital paying particular attention to the toilets, automatic water taps and doors = reduction of hand contamination } Consideration of the influence of cultural practices as risk factors for HAI } Continuous research, feedback, improveed Data storage } Considering the personnel point of view and empowering the health care system

} 1. Acquired from the Research method and scientific research Scientific approach =Problem, Background, objectives, method of data collection, results/interpretation, conclusion, report writing and presentation. Knowledge to structure research paper clear title, abstract Knowledge on literature review-questions, identifying relevant publications, assess the quality, interpretation, biases Knowledge from different levels of evidenced based =ABCD Selection of quantitative data collection tools = validated questionnaires on hand hygiene Skills in Write up and Communication of results.

} 2. Acquired from Biostatistics: I did understood the different studies in terms of descriptive statistics and inferential statistics Presentation of results : Calculation percentages, rates of HAI, Analysis and interpreting the results from read articles using concepts eg significance levels-p v, confidence intervals Understanding findings using measures eg OR, RR, AR,

} 3. Acquired from epidemiology: The concept of epidemiology triangle (triad) to present some of the findings The use of the concept on exposure-outcome model ( risk factors) in public health practice Understanding and interpretation other concepts such as incidence and prevalence. Understanding different epidemiological study design help me to understand different results in terms risk of acquiring HAI( relative risk and odd ratio).

} 4. Acquired from Global health and sociology of health and illness The move from the biological and infrastructural factors to Cultural aspects that can exposed patient to HAI (Acting as a change agent ). The concept of health disparity among countries and population. } 5. Acquired from practicum and Health systems. I was able to integrate my practical experience with other studies done in other settings, understanding more on the influence of health care system on infection prevention.