TITLE: Vitamin D and Related Genes, Race and Prostate Cancer Aggressiveness

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1 AD Award Number: W81XWH TITLE: Vitamin D and Related Genes, Race and Prostate Cancer Aggressiveness PRINCIPAL INVESTIGATOR: Susan Steck CONTRACTING ORGANIZATION: South Carolina Research Foundation, Columbia, SC REPORT DATE: October 2013 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland DISTRIBUTION STATEMENT: Approved for Public Release; Distribution Unlimited The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation.

2 REPORT DOCUMENTATION PAGE Form Approved OMB No Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports ( ), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE 2. REPORT TYPE October 2013 Annual 4. TITLE AND SUBTITLE Vitamin D and Related Genes, Race and Prostate Cancer Aggressiveness 3. DATES COVERED 30September September2013 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Susan Steck 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) South Carolina Research Foundation, Columbia, SC d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland SPONSOR/MONITOR S REPORT NUMBER(S) 12. DISTRIBUTION / AVAILABILITY STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT The overall goal of the study is to examine whether altered vitamin D status (as measured by serum metabolites and by functional polymorphisms within genes related to vitamin D transport, metabolism and activity) is associated with increased risk of aggressiveness prostate cancer, and may explain some of the racial disparity seen in aggressive prostate cancer. The project activities, as outlined in the statement of Work Tasks and Milestones, are running on schedule. The study team has been organized and participates in monthly conference calls (or more frequent as needed) to discuss study progress and data collection and analyses. IRB approval was obtained from all local institutions and the DOD HSRRB in year 1. All biospecimens have been shipped the institutions and measurements of circulating concentrations of vitamin D metabolites, calcium, phosphorus and PTH are complete. Data has been requested and obtained from the parent study, PCaP. Data merging and cleaning has been accomplished and preliminary results have been presented or submitted to national scientivic meetings with the large representation of African Americans in this investigation, the proposed research has tremendous potential to provide insights into a chronically underserved population carrying an unequal burden of disease. 15. SUBJECT TERMS- vitamin D, prostate cancer aggressiveness, polymorphisms, racial disparities. 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT a. REPORT U b. ABSTRACT U 18. NUMBER OF PAGES c. THIS PAGE U UU 6 19a. NAME OF RESPONSIBLE PERSON USAMRMC 19b. TELEPHONE NUMBER (include area code)

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